Translational Medicine In Cns Drug Development

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• Author : George G. Nomikos,Douglas E. Feltner
• Publisher : Academic Press
• Release Date : 2019-06-18
• Total pages : 458
• ISBN : 9780128031643
• File Size : 38,8 Mb
• Total Download : 269
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Download Translational Medicine in CNS Drug Development in PDF, Epub, and Kindle

Translational Medicine in CNS Drug Development, Volume 29, is the first book of its kind to offer a comprehensive overview of the latest developments in translational medicine and biomarker techniques. With extensive coverage on all aspects of biomarkers and personalized medicine, and numerous chapters devoted to the best strategies for developing drugs that target specific disorders, this book presents an essential reference for researchers in neuroscience and pharmacology who need the most up-to-date techniques for the successful development of drugs to treat central nervous system disorders. Despite increases in the number of individuals suffering from CNS-related disorders, the development and approval of drugs for their treatment have been hampered by inefficiencies in advancing compounds from preclinical discovery to the clinic. However, in the past decades, game-changing strides have been made in our understanding of the pathophysiology of CNS disorders and the relationship of drug exposure in plasma and CNS to pharmacodynamic measures in both animals and humans. Includes comprehensive coverage of biomarker tools and the role of personalized medicine in CNS drug development Discusses strategies for drug development for a full range of CNS indications, with particular attention to neuropsychiatric and neurocognitive disorders Includes chapters written by international experts from industry and academia

• Author : Robert A. McArthur
• Publisher : Academic Press
• Release Date : 2012-10-05
• Total pages : 464
• ISBN : 9780123869975
• File Size : 14,8 Mb
• Total Download : 479
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Download Translational Neuroimaging in PDF, Epub, and Kindle

Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment combines the experience of academic, clinical and industrial neuroimagers in a unique collaborative approach to provide an integrated perspective of the use of small animal and human brain imaging in developing and validating translational models and biomarkers for the study and treatment of neuropsychiatric disorders. Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment examines the translational role of neuroimaging in model development from preclinical animal models, to human experimental medicine, and finally to clinical studies. The focus of this book is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. This book covers methodical issues in human and animal neuroimaging translational research as well as detailed applied examples of the use of neuroimaging in neuropsychiatric disorders and the development of drugs for their treatment. Offering an accompanying website with illustrations and text available for further knowledge and presentations, Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment appeals to non-clinical and clinical neuroscientists working in and studying neuropsychiatric disorders and their treatment as well as providing the novice researcher or researcher outside of his/her expertise the opportunity to understand the background of translational research and the use of imaging in this field. Provides a background to translational research and the use of brain imaging in neuropsychiatric disorders Critical discussion of the potential and limitations of neuroimaging as a translational tool for identifying and validating biomarkers Identifies cross species neurosystems and common endpoints necessary to help accelerate CNS drug discovery and development for the treatment of neuropsychiatric disorders Features an accompanying website with additional images and text

• Author : Robert A. McArthur,Franco Borsini
• Publisher : Academic Press
• Release Date : 2008-11-17
• Total pages : 528
• ISBN : 9780080920399
• File Size : 9,7 Mb
• Total Download : 288
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Download Animal and Translational Models for CNS Drug Discovery: Psychiatric Disorders in PDF, Epub, and Kindle

Psychiatric Disorders is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for psychiatric disorders such as anxiety, obsessive-compulsive disorder, depression, schizophrenia, bipolar disorder, ADHD, and autistic spectrum disorder. Psychiatric Disorders has introductory chapters expressing the view of the role and relevance of animal models for drug discovery and development for the treatment of psychiatric disorders from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical drug discovery and development, and (c) issues of clinical trial design and regulatory agencies limitations. Each volume examines the rationale, use, robustness and limitations of animal models in each therapeutic area covered and discuss the use of animal models for target identification and validation. The clinical relevance of animal models is discussed in terms of major limitations in cross-species comparisons, clinical trial design of drug candidates, and how clinical trial endpoints could be improved. The aim of this series of volumes on Animal and Translational Models for CNS Drug Discovery is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. This is the first volume in the three volume-set, Animal and Translational Models for CNS Drug Discovery 978-0-12-373861-5, and is also available for purchase individually. Provides clinical, academic, government and industry perspectives fostering integrated communication between principle participants at all stages of the drug discovery process Critical evaluation of animal and translational models improving transition from drug discovery and clinical development Emphasizes what results mean to the overall drug discovery process Explores issues in clinical trial design and conductance in each therapeutic area Psychiatric Disorders is available for purchase individually.

• Author : Robert A. McArthur,Franco Borsini
• Publisher : Academic Press
• Release Date : 2008-11-18
• Total pages : 416
• ISBN : 0080920381
• File Size : 47,8 Mb
• Total Download : 243
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Download Animal and Translational Models for CNS Drug Discovery: Neurological Disorders in PDF, Epub, and Kindle

Neurological Disorders is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for neurological disorders such as neurofibromatosis, Alzheimer’s disease, Parkinson’s disease, Huntington disease, ALS, and the epilepsies. Neurological Disorders has introductory chapters expressing the view of the role and relevance of animal models for drug discovery and development for the treatment of psychiatric disorders from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical drug discovery and development, and (c) issues of clinical trial design and regulatory agencies limitations. Each volume examines the rationale, use, robustness and limitations of animal models in each therapeutic area covered and discuss the use of animal models for target identification and validation. The clinical relevance of animal models is discussed in terms of major limitations in cross-species comparisons, clinical trial design of drug candidates, and how clinical trial endpoints could be improved. The aim of this series of volumes on Animal and Translational Models for CNS Drug Discovery is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. This is the second volume in the three volume-set, Animal and Translational Models for CNS Drug Discovery 978-0-12-373861-5, which is also available for purchase individually. Clinical, academic, government and industry perspectives fostering integrated communication between principle participants at all stages of the drug discovery process Critical evaluation of animal and translational models improving transition from drug discovery and clinical development Emphasis on what results mean to the overall drug discovery process Exploration of issues in clinical trial design and conductance in each therapeutic area

• Author : David Borsook,Lino R. Beccera,Edward Bullmore,Richard J. Hargreaves
• Publisher : Springer Science & Business Media
• Release Date : 2010-03-10
• Total pages : 396
• ISBN : 9781441901347
• File Size : 29,5 Mb
• Total Download : 585
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Download Imaging in CNS Drug Discovery and Development in PDF, Epub, and Kindle

Drug development today needs to balance agility, speed, and risk in defining probability of success for molecules, mechanisms, and therapeutic concepts. New techniques such as fMRI promise to be part of a sequence that could transform drug development. Although numerous review articles exist that discuss the use of imaging in drug development, no one source is available that combines the various techniques and includes a discussion of disease mapping. Imaging in CNS Drug Discovery and Development, Implications for Disease and Therapy will serve to distill the most salient developments in the use of imaging in drug development and disease mapping. It will launch evolving concepts that integrate new imaging technologies and paradigms with molecular medicine and molecular profiling ("monics") as well as consider the ethical issues that arise as a result of disease or state diagnosis and the use of imaging in the public eye.

• Author : Rudy Schreiber
• Publisher : Springer Nature
• Release Date : 2021-06-17
• Total pages : 283
• ISBN : 9783030623517
• File Size : 52,8 Mb
• Total Download : 799
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Download Modern CNS Drug Discovery in PDF, Epub, and Kindle

This textbook provides a comprehensive overview of the currently used concepts, approaches and technologies in the discovery and development of new treatments for the full spectrum of disorders of the central nervous system. It guides the reader through all essential steps, from finding an innovative idea, to the registration of a new drug. Divided into four sections, the book starts by presenting a broad perspective on current approaches in central nervous system (CNS) drug discovery. The second section addresses the generation of ideas for the identification of targets and novel treatment strategies; covers core functions in early discovery, and provides an example of a novel treatment paradigm: brain stimulation. The third section highlights strategies and technologies in translational CNS drug discovery. In an effort to bridge the gap between discovery and clinical development, it also covers brain imaging, EEG and cognitive testing approaches. The fourth section extensively discusses the clinical phase of drug development, covering the basics of early clinical testing for psychopharmacological drugs. The book’s final chapter addresses the registration for newly developed drugs. Written by experts from academia and industry, the book covers important basics and best practices, as well as recent developments in drug discovery. Offering in-depth insights into the world of drug development, it represents essential reading for early researchers who want to prepare for a career in drug discovery in academia or industry.

• Author : Robert A. McArthur
• Publisher : Academic Press
• Release Date : 2012-10-26
• Total pages : 464
• ISBN : 9780123869456
• File Size : 39,9 Mb
• Total Download : 301
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Download Translational Neuroimaging in PDF, Epub, and Kindle

With a unique collaborative approach of author teams from industry and academia, Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment provides an integrated perspective of small animal and human brain imaging in the development of translational models and biomarkers to understand human neuropsychiatric disorders and to accelerate the development of novel drugs for their treatment. The book provides chapters on methodical issues in human and animal neuroimaging translational research, allowing a beginning researcher or researcher outside of his/her expertise the opportunity to understand the background of translational research and the use of imaging in studies. Additional chapters cover selected neuropsychiatric disorders, examining the role of neuroimaging in translational model development from the preclinical, animal model perspective as well as from the human experimental medicine perspective. Offering an accompanying website with illustrations and text available for further knowledge and presentations, Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment appeals to researchers working in and studying CNS drug treatment research across industry and academia. Provides a background of translational research and the use of imaging in studies Dicusses the application of imaging in specific disease states Features an accompanying website with additional images and text

• Author : Robert A. McArthur,Franco Borsini
• Publisher : Unknown
• Release Date : 2008-12
• Total pages : 229
• ISBN : 012373861X
• File Size : 36,9 Mb
• Total Download : 633
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Download Animal and Translational Models for CNS Drug Discovery, 3 Vols. Set in PDF, Epub, and Kindle

PDF book entitled Animal and Translational Models for CNS Drug Discovery, 3 Vols. Set written by Robert A. McArthur,Franco Borsini and published by Unknown which was released on 2008-12 with total hardcover pages 229, the book become popular and critical acclaim.

• Author : Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
• Publisher : National Academies Press
• Release Date : 2013-04-25
• Total pages : 111
• ISBN : 9780309266338
• File Size : 45,7 Mb
• Total Download : 867
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Download Improving the Utility and Translation of Animal Models for Nervous System Disorders in PDF, Epub, and Kindle

Nervous system diseases and disorders are highly prevalent and substantially contribute to the overall disease burden. Despite significant information provided by the use of animal models in the understanding of the biology of nervous system disorders and the development of therapeutics; limitations have also been identified. Treatment options that are high in efficacy and low in side effects are still lacking for many diseases and, in some cases are nonexistent. A particular problem in drug development is the high rate of attrition in Phase II and III clinical trials. Why do many therapeutics show promise in preclinical animal models but then fail to elicit predicted effects when tested in humans? On March 28 and 29, 2012, the Institute of Medicine Forum on Neuroscience and Nervous System Disorders convened the workshop "Improving Translation of Animal Models for Nervous System Disorders" to discuss potential opportunities for maximizing the translation of new therapies from animal models to clinical practice. The primary focus of the workshop was to examine mechanisms for increasing the efficiency of translational neuroscience research through discussions about how and when to use animal models most effectively and then best approaches for the interpretation of the data collected. Specifically, the workshop objectives were to: discuss key issues that contribute to poor translation of animal models in nervous system disorders, examine case studies that highlight successes and failures in the development and application of animal models, consider strategies to increase the scientific rigor of preclinical efficacy testing, explore the benefits and challenges to developing standardized animal and behavioral models. Improving the Utility and Translation of Animal Models for Nervous System Disorders: Workshop Summary also identifies methods to facilitate development of corresponding animal and clinical endpoints, indentifies methods that would maximize bidirectional translation between basic and clinical research and determines the next steps that will be critical for improvement of the development and testing of animal models of disorders of the nervous system.

• Author : Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
• Publisher : National Academies Press
• Release Date : 2014-02-06
• Total pages : 118
• ISBN : 9780309292498
• File Size : 37,8 Mb
• Total Download : 177
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Download Improving and Accelerating Therapeutic Development for Nervous System Disorders in PDF, Epub, and Kindle

Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.

• Author : Margareta Hammarlund-Udenaes,Elizabeth C.M. de Lange,Robert G. Thorne
• Publisher : Springer Science & Business Media
• Release Date : 2013-12-03
• Total pages : 731
• ISBN : 9781461491057
• File Size : 38,9 Mb
• Total Download : 348
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Download Drug Delivery to the Brain in PDF, Epub, and Kindle

The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, the most important being the blood –brain barrier (BBB). Many factors are therefore critical to consider for CNS drug delivery, e.g. active/passive transport across the BBB, intra-brain distribution, and central/systemic pharmacokinetics, to name a few. Neurological disease and trauma conditions add further complexity because CNS barriers, drug distribution and pharmacokinetics are dynamic and often changed by disease/trauma. Knowledge of all these factors and their interplay in different conditions is of utmost importance for proper CNS drug development and disease treatment. In recent years much information has become available for a better understanding of the many factors important for CNS drug delivery and how they interact to affect drug action. This book describes small and large drug delivery to the brain with an emphasis on the physiology of the BBB and the principles and concepts for drug delivery across the BBB and distribution within the brain. It contains methods descriptions for studying drug delivery, routes and approaches of administering drugs into the brain, the influence of disease, and drug industry perspectives. Therewith, it contributes to an in-depth understanding of the interplay between brain (patho)-physiology and drug characteristics. Furthermore, the content is designed to be both cutting-edge and educational, so that the book can be used in high-level training of academic and industry scientists with full references to original publications. ​

• Author : RICHARD A. SMITH
• Publisher : Elsevier
• Release Date : 2021
• Total pages : 518
• ISBN : 9780323907262
• File Size : 51,9 Mb
• Total Download : 435
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Download NEUROTHERAPEUTICS IN THE ERA OF TRANSLATIONAL MEDICINE. in PDF, Epub, and Kindle

PDF book entitled NEUROTHERAPEUTICS IN THE ERA OF TRANSLATIONAL MEDICINE. written by RICHARD A. SMITH and published by Elsevier which was released on 2021 with total hardcover pages 518, the book become popular and critical acclaim.

• Author : Robert A. McArthur,Franco Borsini
• Publisher : Academic Press
• Release Date : 2009-02-24
• Total pages : 432
• ISBN : 9780080920405
• File Size : 26,8 Mb
• Total Download : 975
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Download Animal and Translational Models for CNS Drug Discovery: Reward Deficit Disorders in PDF, Epub, and Kindle

Reward Deficit Disorders is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for reward deficit disorders such as alcohol dependence, nicotine dependence, heroin and cocaine addiction, obesity, and gambling and impulse control disorders. Reward Deficit Disorders has introductory chapters expressing the view of the role and relevance of animal models for drug discovery and development for the treatment of psychiatric disorders from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical drug discovery and development, and (c) issues of clinical trial design and regulatory agencies limitations. Each volume examines the rationale, use, robustness and limitations of animal models in each therapeutic area covered and discuss the use of animal models for target identification and validation. The clinical relevance of animal models is discussed in terms of major limitations in cross-species comparisons, clinical trial design of drug candidates, and how clinical trial endpoints could be improved. Reward Deficit Disorders also has a section dedicated to the specifics of the regulatory aspects to abuse liability testing. The aim of this series of volumes on Animal and Translational Models for CNS Drug Discovery is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. This is the third volume in the three volume-set, Animal and Translational Models for CNS Drug Discovery 978-0-12-373861-5, which is also available for purchase individually. Provides clinical, academic, government and industry perspectives fostering integrated communication between principle participants at all stages of the drug discovery process Critical evaluation of animal and translational models improving transition from drug discovery and clinical development Emphasizes what results mean to the overall drug discovery process Explores issues in clinical trial design and conductance in each therapeutic area Neurological Disorders is available for purchase individually.

• Author : Divya Vohora,Gursharan Singh
• Publisher : Academic Press
• Release Date : 2017-11-14
• Total pages : 526
• ISBN : 9780128020982
• File Size : 17,8 Mb
• Total Download : 422
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Download Pharmaceutical Medicine and Translational Clinical Research in PDF, Epub, and Kindle

Pharmaceutical Medicine and Translational Clinical Research covers clinical testing of medicines and the translation of pharmaceutical drug research into new medicines, also focusing on the need to understand the safety profile of medicine and the benefit-risk balance. Pharmacoeconomics and the social impact of healthcare on patients and public health are also featured. It is written in a clear and straightforward manner to enable rapid review and assimilation of complex information and contains reader-friendly features. As a greater understanding of these aspects is critical for students in the areas of pharmaceutical medicine, clinical research, pharmacology and pharmacy, as well as professionals working in the pharmaceutical industry, this book is an ideal resource. Includes detailed coverage of current trends and key topics in pharmaceutical medicine, including biosimilars, biobetters, super generics, and Provides a comprehensive look at current and important aspects of the science and regulation of drug and biologics discovery

• Author : Robert A. McArthur,Franco Borsini
• Publisher : Unknown
• Release Date : 2008
• Total pages : 229
• ISBN : OCLC:229026149
• File Size : 11,9 Mb
• Total Download : 658
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Download Animal and Translational Models for CNS Drug Discovery: Neurological disorders in PDF, Epub, and Kindle

PDF book entitled Animal and Translational Models for CNS Drug Discovery: Neurological disorders written by Robert A. McArthur,Franco Borsini and published by Unknown which was released on 2008 with total hardcover pages 229, the book become popular and critical acclaim.

• Author : Jeffrey Cummings,Jefferson Kinney,Howard Fillit
• Publisher : Cambridge University Press
• Release Date : 2022-03-31
• Total pages : 575
• ISBN : 9781108838665
• File Size : 41,8 Mb
• Total Download : 562
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Download Alzheimer's Disease Drug Development in PDF, Epub, and Kindle

Provides a definitive overview of the complex ecosystem facilitating Alzheimer's Disease drug research and development. Demonstrates a drug's journey from in the lab, clinical trial testing, regulatory review, and marketing by pharmaceutical companies. Details the use of artificial intelligence, clinical trial management, and financing models.

• Author : Li Di,Edward H. Kerns
• Publisher : John Wiley & Sons
• Release Date : 2015-02-02
• Total pages : 604
• ISBN : 9781118788356
• File Size : 10,9 Mb
• Total Download : 807
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Download Blood-Brain Barrier in Drug Discovery in PDF, Epub, and Kindle

Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant – and most challenging – areas of drug discovery. • Written by world experts to provide practical solutions to increase brain penetration or minimize CNS side-effects • Reviews state-of-the-art in silico, in vitro, and in vivo tools to assess brain penetration and advanced CNS drug delivery strategies • Covers BBB physiology, medicinal chemistry design principles, free drug hypothesis for the BBB, and transport mechanisms including passive diffusion, uptake/efflux transporters, and receptor-mediated processes • Highlights the advances in modelling BBB pharmacokinetics and dynamics relationships (PK/PD) and physiologically-based pharmacokinetics (PBPK) • Discusses case studies of successful CNS and non-CNS drugs, lessons learned and paths to the market

• Author : Arjun Singh
• Publisher : LAP Lambert Academic Publishing
• Release Date : 2013
• Total pages : 112
• ISBN : 3659415022
• File Size : 10,7 Mb
• Total Download : 573
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Download Drug Discovery Technology in PDF, Epub, and Kindle

Drug Discovery Technology is versatile research area in the field of medicine, biotechnology, and pharmacology. Drug Discovery Technologies has been established to provide comprehensive overviews of all the major modern techniques, tools and technologies used in drug discovery and development technology. The major techniques and tools are used in drug discovery, drug design, clinical trial studies and thematic issues describing novel approaches and cutting edge technologies used in all stages of drug discovery. The Book addresses the multidimensional challenges of drug discovery science including integration issues of the drug discovery process. This Book is essential for all science students, biological scientists and researchers involved in drug discovery who wish to keep abreast of all the modern techniques and technologies used in drug discovery and development. The major topics of discussion related to drug, discovery and therapy will included in the next volume: Pharmaceutical Research & Development, Translational Medicine, Regenerative Medicine, Enabling Technologies, Structural Biology, Drug Delivery & Targeting, Antiinfectives, Biologics, CNS Drug Discovery & Therapy.

• Author : Amir Kalali,Sheldon Preskorn,Joseph Kwentus,Stephen M. Stahl
• Publisher : Cambridge University Press
• Release Date : 2012-06-07
• Total pages : 229
• ISBN : 9781139576529
• File Size : 35,6 Mb
• Total Download : 802
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Download Essential CNS Drug Development in PDF, Epub, and Kindle

Central Nervous System disorders have an enormous impact on individuals and on society as a whole. The development of better treatments is crucial and is a major focus of pharmaceutical and biotechnology companies. This book explains the complicated process of CNS drug development in a way that is engaging for any interested professional or student. Chapters cover each stage of drug development, from pre-clinical research through all phases of clinical trials, to reporting to the regulatory authorities. Other key issues covered include strategic considerations, regulatory constraints, dissemination of results and ethical considerations. The user-friendly format and style enable readers to find important information quickly and easily. Written and edited by experts from different sectors actively engaged in CNS drug development, this is a unique resource for drug developers, investigators, academics and clinicians.

• Author : Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
• Publisher : National Academies Press
• Release Date : 2011-07-05
• Total pages : 74
• ISBN : 9780309212243
• File Size : 43,8 Mb
• Total Download : 528
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Download Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System in PDF, Epub, and Kindle

Glutamate is the most pervasive neurotransmitter in the central nervous system (CNS). Despite this fact, no validated biological markers, or biomarkers, currently exist for measuring glutamate pathology in CNS disorders or injuries. Glutamate dysfunction has been associated with an extensive range of nervous system diseases and disorders. Problems with how the neurotransmitter glutamate functions in the brain have been linked to a wide variety of disorders, including schizophrenia, Alzheimer's, substance abuse, and traumatic brain injury. These conditions are widespread, affecting a large portion of the United States population, and remain difficult to treat. Efforts to understand, treat, and prevent glutamate-related disorders can be aided by the identification of valid biomarkers. The Institute of Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop on June 21-22, 2010, to explore ways to accelerate the development, validation, and implementation of such biomarkers. Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System: Workshop Summary investigates promising current and emerging technologies, and outlines strategies to procure resources and tools to advance drug development for associated nervous system disorders. Moreover, this report highlights presentations by expert panelists, and the open panel discussions that occurred during the workshop.

• Author : Markus Müller
• Publisher : Springer Science & Business Media
• Release Date : 2012-09-13
• Total pages : 340
• ISBN : 9781461448150
• File Size : 17,8 Mb
• Total Download : 500
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Download Microdialysis in Drug Development in PDF, Epub, and Kindle

A vast number of diagnostic and therapeutic decisions are based on measuring blood concentrations of molecules, yet most biochemical and pharmacological events actually take place in the tissues. Microdialysis is a key semi-invasive sampling technique to measure in vivo drug penetration to the target site in humans, the method being feasible in virtually every organ. Authored by international experts in this cutting edge field, this book will provide a comprehensive overview of microdialysis and its application for measuring drug distribution in drug development.