Therapeutic Monoclonal Antibodies And Antibody Drug Conjugates Adc

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• Author : David E Thurston,Paul J M Jackson
• Publisher : Royal Society of Chemistry
• Release Date : 2019-07-11
• Total pages : 480
• ISBN : 9781788018456
• File Size : 44,6 Mb
• Total Download : 662
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Download Cytotoxic Payloads for AntibodyDrug Conjugates in PDF, Epub, and Kindle

Antibody–drug conjugates (ADCs) represent one of the most promising and exciting areas of anticancer drug discovery. Five ADCs are now approved in the US and EU [i.e., ado-trastuzumab emtansine (KadcylaTM), brentuximab vedotin (AdcetrisTM), inotuzumab ozogamicin (BesponsaTM), gemtuzumab ozogamicin (MylotargTM) and moxetumomab pasudotox-tdfk (Lumoxiti®)] and over 70 others are in various stages of clinical development, with impressive interim results being reported for many. The technology is based on the concept of delivering a cytotoxic payload selectively to cancer cells by attaching it to an antibody targeted to antigens on the cell surfaces. This approach has several advantages including the ability to select patients as likely responders based on the presence of antigen on the surface of their cancer cells and a wider therapeutic index, given that ADC targeting enables a more efficient delivery of cytotoxic agents to cancer cells than can be achieved by conventional chemotherapy, thus minimising systemic toxicity. Although there are many examples of antibodies that have been developed for this purpose, along with numerous linker technologies used to attach the cytotoxic agent to the antibody, there is presently a relatively small number of payload molecules in clinical use. The purpose of this book is to describe the variety of payloads used to date, along with a discussion of their advantages and disadvantages and to provide information on novel payloads at the research stage that may be used clinically in the future.

• Author : Floris van Delft,John M. Lambert
• Publisher : Royal Society of Chemistry
• Release Date : 2021-12-22
• Total pages : 477
• ISBN : 9781839162633
• File Size : 15,7 Mb
• Total Download : 777
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Download Chemical Linkers in Antibody-Drug Conjugates (ADCs) in PDF, Epub, and Kindle

Chemical Linkers in Antibody-Drug Conjugates aims to shine a detailed light on the various key attributes of chemical linkers in ADCs, for drug-to-antibody ratio, for stability, for release mechanism of payload, for pharmacokinetics, for stability determination, and for efficacy and safety.

• Author : Gail Lewis Phillips
• Publisher : Springer Science & Business Media
• Release Date : 2012-12-13
• Total pages : 378
• ISBN : 9781461454564
• File Size : 33,9 Mb
• Total Download : 716
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Download Antibody-Drug Conjugates and Immunotoxins in PDF, Epub, and Kindle

This volume gathers the leading research on antibody-drug conjugates and immunotoxins. Following a rigorous overview, the volume delves into focused sections on all aspects of ADCs and ITs from clinical development through to targeted therapeutic applications and the latest technologies.

• Author : Laurent Ducry
• Publisher : Humana Press
• Release Date : 2013-08-03
• Total pages : 317
• ISBN : 1627035427
• File Size : 21,6 Mb
• Total Download : 385
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Download Antibody-Drug Conjugates in PDF, Epub, and Kindle

Antibody-drug conjugates (ADCs) represent a promising therapeutic approach for cancer patients by combining the antigen-targeting specificity of monoclonal antibodies (mAbs) with the cytotoxic potency of chemotherapeutic drugs. In Antibody-Drug Conjugates, expert researchers provide detailed protocols for many of the key ADC techniques necessary for working in the field. These chapters and methodologies are aimed at the key tasks necessary to identify a suitable target, properly design the mAb, the linker and the payload, as well as to conjugate them in a reproducible and scalable fashion. Written in the highly successful Methods in Molecular BiologyTM format, these detailed chapters include the kind of practical implementation advice that guarantees quality results. Authoritative and timely, Antibody-Drug Conjugates aims to further drive ADC development and thus help toward improving cancer treatments of the future.

• Author : L. Harivardhan Reddy,Patrick Couvreur
• Publisher : Springer Science & Business Media
• Release Date : 2010-03-20
• Total pages : 500
• ISBN : 1441905073
• File Size : 38,7 Mb
• Total Download : 723
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Download Macromolecular Anticancer Therapeutics in PDF, Epub, and Kindle

In spite of the development of various anticancer drugs, the therapy of cancer has remained challenging for decades. The current therapy of cancer is overwhelmed because of the inability to deliver therapeutics to all regions of a tumor in effective therapeutic concentrations, intrinsic or acquired resistance to the treatment with currently available agents via genetic and epigenetic mechanisms, and toxicity. As a result, cancer therapy using conventional therapeutics and different types of treatment regimens using this therapeutics has not led to a convincing survival benefit of the patients. In this context, Macromolecular therapeutics offer several advantages over conventional low molecular therapeutics by various ways such as, enable the use of larger doses of these agents by limiting the toxicity, by enhanced permeability and retention into tumors, by tumor targeting using tumor-specific antibodies, by specific inhibition of oncogenes using anticancer oligonucleotides etc. Cancer treatment using this macromolecular therapeutics has considerably improved the survival benefit for patients. As a result, various macromolecular therapeutics are already commercialized or are under clinical development. Although we are far from a real magic bullet today, looking at the pace of research and current success in this field of macromolecular therapeutics, it appears that we are approaching a magic bullet for the efficient treatment of cancer. Thus, we believe that the subject of this book is very timely, and that the book will fill an unmet need in the market. This book is unique and assembles various types and aspects of macromolecular anticancer therapeutics for cancer therapy in one shell and conveys the importance of this interdisciplinary field to the broad audience. Thus, in a nutshell, this book details the basics of cancer, and various therapeutic strategies such as those based on macromolecular therapeutics hence can become an important reference for practitioners, oncologists, medical pharmacologists, medicinal chemists, biomedical scientists, experimental pharmacologists, pharmaceutical technologists, and particularly it can essentially become a handbook of macromolecular therapeutics for cancer therapy for graduates, post-graduates and Ph.D. students in these fields.

• Author : Gail Lewis Phillips
• Publisher : Springer
• Release Date : 2012-12-12
• Total pages : 378
• ISBN : 1461454573
• File Size : 34,8 Mb
• Total Download : 233
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Download Antibody-Drug Conjugates and Immunotoxins in PDF, Epub, and Kindle

This volume gathers the leading research on antibody-drug conjugates and immunotoxins. Following a rigorous overview, the volume delves into focused sections on all aspects of ADCs and ITs from clinical development through to targeted therapeutic applications and the latest technologies.

• Author : Veysel Kayser
• Publisher : Unknown
• Release Date : 2022
• Total pages : 298
• ISBN : 3036526862
• File Size : 15,6 Mb
• Total Download : 279
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Download Therapeutic Monoclonal Antibodies and Antibody Products, Their Optimization and Drug Design in Cancers in PDF, Epub, and Kindle

The book broadly deals with therapeutic monoclonal antibodies (mAbs) and various relevant topics, including different antibody formats such as Antibody-Drug Conjugates (ADC), bispecifics, nanoparticle-based mAbs and HER2+ cancers, immune checkpoint inhibitors and other closely related topics. Each paper was written by leading active research groups in their fields both from academia and industry. The book should be of interest to those scientists and researchers who develop or use biologics, biotherapeutics, biosimilars and biobetters in cancer treatment.

• Author : Ulf Grawunder,Stefan Barth
• Publisher : Springer
• Release Date : 2017-04-07
• Total pages : 181
• ISBN : 9783319468778
• File Size : 36,9 Mb
• Total Download : 560
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Download Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins in PDF, Epub, and Kindle

This book describes the newest developments in antibody drug conjugates and immunotoxins, paving their way to clinical application. Lessons learned from the current state of the art are used to further improve our understanding of their mechanisms of action and off target activities. The book introduces scientists to all of the prerequisites that must be properly addressed, including identification of the right target, specific traits of target binding antibodies, proper selection of the toxic payload, internalization induced by binding, and next generation conjugation and linker technologies. These knowledge-based, revolutionary new drug principles will form the cornerstone of the future standard of care and will lead to major advances in application, as well as improved quality of life and patient survival rates. This book will be of interest to biotech companies and researchers working in the fields of immunology, pharmacology, and oncology.

• Author : Kenneth J. Olivier, Jr.,Sara A. Hurvitz
• Publisher : John Wiley & Sons
• Release Date : 2016-11-14
• Total pages : 560
• ISBN : 9781119060802
• File Size : 15,5 Mb
• Total Download : 425
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Download Antibody-Drug Conjugates in PDF, Epub, and Kindle

Providing practical and proven solutions for antibody-drug conjugate (ADC) drug discovery success in oncology, this book helps readers improve the drug safety and therapeutic efficacy of ADCs to kill targeted tumor cells. • Discusses the basics, drug delivery strategies, pharmacology and toxicology, and regulatory approval strategies • Covers the conduct and design of oncology clinical trials and the use of ADCs for tumor imaging • Includes case studies of ADCs in oncology drug development • Features contributions from highly-regarded experts on the frontlines of ADC research and development

• Author : Veysel Kayser
• Publisher : Mdpi AG
• Release Date : 2022-01-25
• Total pages : 298
• ISBN : 3036526870
• File Size : 52,8 Mb
• Total Download : 369
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Download Therapeutic Monoclonal Antibodies and Antibody Products, Their Optimization and Drug Design in Cancers in PDF, Epub, and Kindle

The book broadly deals with therapeutic monoclonal antibodies (mAbs) and various relevant topics, including different antibody formats such as Antibody-Drug Conjugates (ADC), bispecifics, nanoparticle-based mAbs and HER2+ cancers, immune checkpoint inhibitors and other closely related topics. Each paper was written by leading active research groups in their fields both from academia and industry. The book should be of interest to those scientists and researchers who develop or use biologics, biotherapeutics, biosimilars and biobetters in cancer treatment.

• Author : Veysel Kayser,Amita Datta-Mannan
• Publisher : Mdpi AG
• Release Date : 2022-01-28
• Total pages : 144
• ISBN : 3036528733
• File Size : 48,5 Mb
• Total Download : 517
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Download Monoclonal Antibody-Directed Therapy in PDF, Epub, and Kindle

The book deals with therapeutic monoclonal antibodies (mAbs) broadly, and relevant topics such as challenges and opportunities, next-generation antibody products, Antibody-Drug-Conjugates (ADC), bispecifics, glycosylation, and T-cell engagers are covered. Each topic has been written by leading groups around the world and the book should be of interest to researchers from both academia and industry.

• Author : Clive R. Wood
• Publisher : World Scientific
• Release Date : 2012
• Total pages : 490
• ISBN : 9781848166288
• File Size : 19,5 Mb
• Total Download : 107
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Download Antibody Drug Discovery in PDF, Epub, and Kindle

Antibody-based therapeutics are a central driver of the success of biopharmaceuticals. The discovery technology of this field is isolated to a limited number of centers of excellence in industry and academia. The objective of this volume is to provide a series of guides to those evaluating and preparing to enter particular areas within the field. Each chapter is written with a historical perspective that sets into context the significance of the key developments, and with the provision of “points to consider” for the reader as a value-added feature of the volume. All contributors are experts in their fields and have played pivotal roles in the creation of the technology.

• Author : Laurent Ducry
• Publisher : Humana
• Release Date : 2016-08-23
• Total pages : 0
• ISBN : 1493960261
• File Size : 41,8 Mb
• Total Download : 245
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Download Antibody-Drug Conjugates in PDF, Epub, and Kindle

Antibody-drug conjugates (ADCs) represent a promising therapeutic approach for cancer patients by combining the antigen-targeting specificity of monoclonal antibodies (mAbs) with the cytotoxic potency of chemotherapeutic drugs. In Antibody-Drug Conjugates, expert researchers provide detailed protocols for many of the key ADC techniques necessary for working in the field. These chapters and methodologies are aimed at the key tasks necessary to identify a suitable target, properly design the mAb, the linker and the payload, as well as to conjugate them in a reproducible and scalable fashion. Written in the highly successful Methods in Molecular BiologyTM format, these detailed chapters include the kind of practical implementation advice that guarantees quality results. Authoritative and timely, Antibody-Drug Conjugates aims to further drive ADC development and thus help toward improving cancer treatments of the future.

• Author : Jeffrey Wang,Wei-Chiang Shen,Jennica L. Zaro
• Publisher : Springer
• Release Date : 2015-03-05
• Total pages : 252
• ISBN : 9783319130811
• File Size : 18,6 Mb
• Total Download : 245
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Download Antibody-Drug Conjugates in PDF, Epub, and Kindle

This authoritative volume provides a holistic picture of antibody-drug conjugates (ADCs). Fourteen comprehensive chapters are divided into six sections including an introduction to ADCs, the ADC construct, development issues, landscape, IP and pharmacoeconomics, case studies, and the future of the field. The book examines everything from the selection of the antibody, the drug, and the linker to a discussion of developmental issues such as formulations, bio-analysis, pharmacokinetic-pharmacodynamic relationships, and toxicological and regulatory challenges. It also explores pharmacoecomonics and intellectual properties, including recently issued patents and the cost analysis of drug therapy. Case studies are presented for the three ADCs that have received FDA approval: gemtuzumab ozogamicin (Mylotarg®), Brentuximab vedotin (Adcetris®), and ado-trastuzumab emtansine (Kadcyla®), as well as an ADC in late-stage clinical trials, glembatumumab vedotin (CDX-011). Finally, the volume presents a perspective by the editors on the future directions of ADC development and clinical applications. Antibody-Drug Conjugates is a practical and systematic resource for scientists, professors, and students interested in expanding their knowledge of cutting-edge research in this exciting field.

• Author : Veysel Kayser,Amita Datta-Mannan
• Publisher : Unknown
• Release Date : 2022
• Total pages : 142
• ISBN : 3036528725
• File Size : 29,8 Mb
• Total Download : 860
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Download Monoclonal Antibody-Directed Therapy in PDF, Epub, and Kindle

The book deals with therapeutic monoclonal antibodies (mAbs) broadly, and relevant topics such as challenges and opportunities, next-generation antibody products, Antibody-Drug-Conjugates (ADC), bispecifics, glycosylation, and T-cell engagers are covered. Each topic has been written by leading groups around the world and the book should be of interest to researchers from both academia and industry.

• Author : Marc Damelin
• Publisher : Springer
• Release Date : 2018-05-29
• Total pages : 357
• ISBN : 9783319781549
• File Size : 52,9 Mb
• Total Download : 234
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Download Innovations for Next-Generation Antibody-Drug Conjugates in PDF, Epub, and Kindle

Antibody-drug conjugates (ADCs) stand at the verge of a transformation. Scores of clinical programs have yielded only a few regulatory approvals, but a wave of technological innovation now empowers us to overcome past technical challenges. This volume focuses on the next generation of ADCs and the innovations that will enable them. The book inspires the future by integrating the field’s history with novel strategies and cutting-edge technologies. While the book primarily addresses ADCs for solid tumors, the last chapter explores the emerging interest in using ADCs to treat other diseases. The therapeutic rationale of ADCs is strong: to direct small molecules to the desired site of action (and away from normal tissues) by conjugation to antibodies or other targeting moieties. However, the combination of small and large molecules imposes deep complexity to lead optimization, pharmacokinetics, toxicology, analytics and manufacturing. The field has made significant advances in all of these areas by improving target selection, ADC design, manufacturing methods and clinical strategies. These innovations will inspire and educate scientists who are designing next-generation ADCs with the potential to transform the lives of patients.

• Author : Nicola Giuliani,Fabio Malavasi,Vito Pistoia
• Publisher : Frontiers Media SA
• Release Date : 2019-11-26
• Total pages : 207
• ISBN : 9782889631919
• File Size : 53,7 Mb
• Total Download : 601
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Download Immunotherapy in Multiple Myeloma in PDF, Epub, and Kindle

PDF book entitled Immunotherapy in Multiple Myeloma written by Nicola Giuliani,Fabio Malavasi,Vito Pistoia and published by Frontiers Media SA which was released on 2019-11-26 with total hardcover pages 207, the book become popular and critical acclaim.

• Author : Cell Press
• Publisher : Elsevier
• Release Date : 2013-12-10
• Total pages : 322
• ISBN : 9780127999173
• File Size : 15,6 Mb
• Total Download : 553
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Download Cell Press Reviews: Cancer Therapeutics in PDF, Epub, and Kindle

Cell Press Reviews: Cancer Therapeutics informs, inspires, and connects cancer researchers at all stages in their careers with timely, comprehensive reviews written by leaders in the field and curated by Cell Press editors. The publicatio offers a broad view of some of the most compelling topics in cancer therapeutics including: Genetic approaches for personal oncology Targeting epigenetic dysregulation and protein interaction networks Vaccines and antibodies in cancer immunotherapy Tumor heterogeneity and chemotherapy resistance Tumor associated macrophages in anticancer treatment Contributions come from leading voices in the field, including: - Daniel A. Haber, Director of Massachusetts General Hospital Cancer Center and Professor at Harvard Medical School - Tony Kouzarides, Professor at the University of Cambridge, Deputy Director of the Wellcome Trust/Cancer Research UK Gurdon Institute, and a founder of the cancer drug discovery company Chroma Therapeutics - Charles L. Sawyers, Chair of the Human Oncology and Pathogenesis Program at Memorial Sloan Kettering Cancer Center, President of the American Association for Cancer Research, member of the presidentially appointed National Cancer Advisory Board, and recipient of the 2013 Breakthrough Prize in Life Sciences Cell Press Reviews: Cancer Therapeutics is part of the Cell Press Reviews series, which features reviews published in Cell Press primary research and Trends reviews journals. Provides timely, comprehensive articles on a wide range of topics in cancer therapeutics Offers insight from experts on genetic, molecular, and cellular aspects of cancer therapy Features reviews on basic science advances translated into drug discovery and therapeutic approaches Includes articles originally published in Cell, Cancer Cell, Trends in Genetics, Trends in Molecular Medicine, and Trends in Pharmacological Sciences

• Author : Floris van Delft,John M. Lambert
• Publisher : Royal Society of Chemistry
• Release Date : 2021-12-22
• Total pages : 460
• ISBN : 9781839165160
• File Size : 36,7 Mb
• Total Download : 592
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Download Chemical Linkers in Antibody-Drug Conjugates (ADCs) in PDF, Epub, and Kindle

The covalent conjugation of potent cytotoxic agents to monoclonal antibodies, known as antibody-drug conjugates (ADCs) is a powerful approach in the field of targeted treatment of cancer. Clearly, both monoclonal antibody and cytotoxic payload are crucial elements in determining the clinical value of an ADC and have receive ample attention. However, the structural element connecting the two –the chemical linker– also plays an essential role in mode-of-action, efficacy, pharmacokinetics and safety profile of an ADC, but is often underappreciated in considerations of ADC design. Chemical Linkers in Antibody–Drug Conjugates aims to shine a detailed light on the various key attributes of chemical linkers in ADCs, for drug-to-antibody ratio, for stability, for release mechanism of payload, for pharmacokinetics, for stability determination, and for efficacy and safety. Ideal for postgraduate students and active researchers in drug discovery and development, this book provides a comprehensive description of linkers used in ADCs (clinical and late preclinical), insight into key quality attributes of linkers for ADCs, and aids the reader in understanding the role of linker chemistry and designing new ADCs.

• Author : Steven T. Rosen,Timothy M. Kuzel
• Publisher : Springer Science & Business Media
• Release Date : 2012-12-06
• Total pages : 205
• ISBN : 9781461530763
• File Size : 48,6 Mb
• Total Download : 812
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Download Immunoconjugate Therapy of Hematologic Malignancies in PDF, Epub, and Kindle

The hybridoma technique for producing monoclonal antibodies, developed by Drs. Kohler and Millstein in 1975, revolutionized the field of tumor immunology. It is now clear that there are antigens associated with or restricted to human neoplasms that have biologic significance. Monoclonal antibodies have already been demonstrated to have great immunodiagnostic value and it is anticipated that they will become a component of our therapeutic armamentarium. Most investigators in the field, however, feel that the true potential of monoclonal antibodies in cancer therapy remains to be determined. Clearly the most encouraging results have been witnessed in the treatment of hematologic malignancies. This volume of CANCER TREATMENT AND RESEARCH explores the current state of the art of immunoconjugate therapy of hematologic malignancies. Immunoconjugate Therapy of Hematologic Malignancies provides an update of a rapidly advancing field. The preliminary experience of a number of investigators suggests a role for targeted therapy in the treatment of hematologic malignancies. At the present time, immunoconjugates have, in most instances, been reserved for patients with advanced refractory disease. However, it is anticipated in the future that these reagents will be utilized as a complement to traditional therapy or as post-remission consolidation in patients with minimal residual disease. The obstacles have been defined; solutions will require further research and creative imagination.

• Author : Yashwant Pathak,Simon Benita
• Publisher : John Wiley & Sons
• Release Date : 2012-04-17
• Total pages : 528
• ISBN : 9781118228890
• File Size : 42,6 Mb
• Total Download : 998
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Download Antibody-Mediated Drug Delivery Systems in PDF, Epub, and Kindle

This book covers various aspects of antibody mediated drug deliverysystems – theoretical aspects, processing, viral andnon-viral vectors, and fields where these systems find and /or arebeing evaluated for applications as therapeutics and diagnostictreatment. Chapters discuss actual applications of techniques usedfor formulation and characterization. Applications areas includecancer, pulmonary, ocular diseases; brain drug delivery; andvaccine delivery. The contributing authors represent over 10different countries, covering recent developments happening aroundthe globe.