Therapeutic Application Of Nitric Oxide In Cancer And Inflammatory Disorders

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• Author : Lucia Morbidelli,Benjamin Bonavida,Jordi Muntané
• Publisher : Elsevier
• Release Date : 2023-04-13
• Total pages : 366
• ISBN : 9780443133435
• File Size : 26,5 Mb
• Total Download : 966
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Download Nitric Oxide in Health and Disease in PDF, Epub, and Kindle

Nitric Oxide in Health and Disease: Therapeutic Applications in Cancer and Inflammatory Disorders presents updated information on the chemistry, signaling of newly derived therapeutic nitric oxide donors/inhibitors, and their complexes in liposomes or nanospheres in both pre-clinical and clinical activities. The book discusses many examples of research related to the application of novel therapeutic compounds that focus on a chemical—nitric oxide—and its applications that have been shown to exert significant therapeutic activities against various resistant cancers unresponsive to current treatments and different inflammatory diseases which continue to require novel treatments. This is a valuable resource for cancer researchers, oncologists, graduate students and researchers from medical and biomedical fields who want to know more about NO and its therapeutic applications in cancer and inflammatory diseases. Provides updated reviews on the chemistry and signaling of newly derived therapeutic nitric oxide (NO) donors/inhibitors and their complexes in liposomes or nanospheres in both pre-clinical and clinical activities Discusses the application of NO in monotherapy or in combination with conventional therapies in a variety of cancers and inflammatory diseases Encompasses real-world examples of recent research related to NO and cancer

• Author : Lucia Morbidelli,Benjamin Bonavida
• Publisher : Academic Press
• Release Date : 2019-02-09
• Total pages : 372
• ISBN : 9780128172797
• File Size : 44,7 Mb
• Total Download : 298
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Download Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders in PDF, Epub, and Kindle

Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders presents updated reviews on the chemistry, signaling, pre-clinical and clinical activities on the role of nitric oxide donors/inhibitors used alone and in combination with other therapeutic agents for the treatment of a variety of diseases. This book examines various studies related to the application of novel therapeutic NO (donors/inhibitors) compounds in the treatment of various cancers. These studies have been shown to exert significant therapeutic activities against various cancers and various inflammatory diseases such as rheumatoid arthritis, Crohn’s disease, allergies, and asthma, where no current effective therapies exist. Pathologies based on functional and structural vascular alterations are also taken into consideration. Edited and written by internationally renowned experts in the field of novel therapeutics for cancer, this book is a valuable source for cancer researchers, medical scientists, clinicians, clinical pharmacologists, and graduate students. Provides readers with a clear overview of the recent findings and references as well as summaries, significant molecular pathways, and conclusions Discusses new ideas proposed and makes suggestions for further investigations that will advance the field Presents introductory and summary information on the contributions of the field, all the findings of the studies discussed, and projects future goals for research

• Author : Benjamin Bonavida
• Publisher : Springer Science & Business Media
• Release Date : 2010-06-16
• Total pages : 250
• ISBN : 1441914323
• File Size : 32,6 Mb
• Total Download : 783
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Download Nitric Oxide (NO) and Cancer in PDF, Epub, and Kindle

Nitric Oxide (NO) is a pleitropic, ubiquitous modulator of cellular functions. Aryl nitrite and glyceryl trinitrate, representative intravasadilators, were introduced as therapeutic agents more than a century ago for relief from acute attacks of angina. The vasodilator action is mediated by the release of NO following treatment. NO has important therapeutic applications in several diseases such as inflammatory diseases, erectile dysfunction, inflammation, pain and neural protective activity. However, the role of NO in cancer and its application in therapy has received little attention. This monograph will be the first to focus on studies that investigate the role of NO in tumor cell pathogenesis, growth, angiogenesis, response to cytotoxic therapies and NO translational applications in cancer therapy, alone or in conjunction with other therapies.

• Author : Benjamin Bonavida
• Publisher : Springer
• Release Date : 2015-05-12
• Total pages : 308
• ISBN : 9783319136110
• File Size : 51,8 Mb
• Total Download : 308
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Download Nitric Oxide and Cancer: Pathogenesis and Therapy in PDF, Epub, and Kindle

Advances in Nitric Oxide and Cancer is a volume that serves to give the latest research on nitric oxide (NO) and cancer. More specifically, the volume reviews significant advances in the application of NO-mediated drugs. The volume explores nitric oxide and its relationship to cancer spanning from its roles in the pathogenesis, prognosis, gene and protein modifications, regulation of resistance to cytotoxics, and therapeutic applications. With chapters written by leading experts, the volume addresses the burgeoning interest in a rapidly advancing field and provides a valuable resource to scientists who have initiated research as well as clinical investigations in their laboratories on the various roles of NO and cancer.

• Author : Willoughby,Tomlinson
• Publisher : Springer
• Release Date : 2013-03-11
• Total pages : 214
• ISBN : 9783034887472
• File Size : 11,5 Mb
• Total Download : 317
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Download Inducible Enzymes in the Inflammatory Response in PDF, Epub, and Kindle

This volume will be of great value to all those researchers in the area of the inflam matory response, notably academics, clinicians and members of the pharmaceutical industry. The book has in the main been restricted to three inducible enzymes, namely nitric oxide synthase (iNOS), cyclooxygenase (COX-2) and hemeoxygenase (HO-l), although matrix metalloproteinases, xanthine oxidoreductase and tissue transgluta minases are reviewed. The modulation of these enzymes is viewed as possible novel therapeutic advances in the area of inflammation and also cancer. The latter topic may well be the subject of a further book. It will be interesting to observe the progress of such new therapies in the next decade. Already some of these enzyme modulators have been approved for the treat ment of inflammatory disease, as evidenced by the new families of COX-2 inhibitors. We believe such advances will herald a series of new and exciting agents to be included in the clinician's armamentarium in the constant struggle against inflammatory disease. The editors wish to thank all contributors to this volume on inducible enzymes. It should however be stressed that the views expressed by the authors are personal and do not necessarily reflect those of the editors. Indeed, the reader may find con flicting statements in a number of the chapters. We believe that this is entirely appro priate as this volume reflects the latest work in a rapidly developing area.

• Author : Bharat B. Aggarwal,Young-Joon Surh,S. Shishodia
• Publisher : Springer Science & Business Media
• Release Date : 2007-08-06
• Total pages : 490
• ISBN : 9780387464015
• File Size : 38,5 Mb
• Total Download : 966
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Download The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease in PDF, Epub, and Kindle

The medicinal uses of Curcumin (also called turmeric) have been known and described for more than 5000 years. A large body of recent research suggests that curcumin is potentially useful in the treatment of inflammatory diseases, through modulation of numerous molecular targets. This is the first monograph to focus on the potential use of curcumin in the treatment of cancer, diabetes, cardiovascular diseases, arthritis, Alzheimer’s, psoriasis and more.

• Author : Qing-Ping Zeng
• Publisher : Springer
• Release Date : 2015-06-23
• Total pages : 126
• ISBN : 9783662476888
• File Size : 34,6 Mb
• Total Download : 483
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Download Artemisinin and Nitric Oxide in PDF, Epub, and Kindle

This book discusses both the beneficial and harmful aspects of NO in biology and medicine, and also introduces the emerging discovery of artemisinin in antitumor, antibacterial infection, anti-inflammation, and antiaging contexts. In 1992 nitric oxide (NO) was voted “Molecule of the Year” by Science magazine, and the discovery of its physiological roles has led to Nobel Prize-winning work in neuroscience, physiology and immunology. The book explains why we should maintain a steady-state NO level that is derived from neuronal or epithelial NO synthase, and avoid the extremely high NO level resulting from inducible NO synthase. The book offers a valuable resource for medical chemists, clinicians, biologists and all those interested in health and disease.

• Author : Benjamin Bonavida
• Publisher : Academic Press
• Release Date : 2017-06-28
• Total pages : 250
• ISBN : 9780128110218
• File Size : 44,8 Mb
• Total Download : 415
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Download Nitric Oxide (Donor/Induced) in Chemosensitization in PDF, Epub, and Kindle

Nitric Oxide as a Chemosensitizing Agent, Volume One is the first book to describe several reviews by authoritative scientists and clinicians on novel findings in the reversal of drug resistant cancers by the combination treatment of Nitric Oxide and sub toxic concentrations of chemotherapeutic drugs that have been reported in both in vitro, in vivo and preclinical models. The book describes the various underlying chemical, molecular and genetic mechanisms by which NO and NO reactive species mediate the anti-cancer activity, thus reducing the threshold of drug resistance and enabling chemo therapeutic drugs to induce their cytotoxic activity and reversal of resistance. This book exposes scientists and clinicians to this highly beneficial topic for research investigations and pharmaceutical companies to new avenues for R&D. It is a valuable resource for cancer researchers, oncologists and members of several areas of the biomedical field who are interested in understanding how to use Nitric Oxide as a sensitizing agent for chemotherapy. Brings updated information as reviewed by experts in the field Presents expert analysis and summary of reported and novel findings and potential translational application in cancer patients Describes molecular mechanisms with new and helpful approaches that can be used in reader investigations

• Author : Bharat B. Aggarwal,Bokyung Sung,Subash Chandra Gupta
• Publisher : Springer
• Release Date : 2014-05-12
• Total pages : 490
• ISBN : 9783034808378
• File Size : 49,7 Mb
• Total Download : 485
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Download Inflammation and Cancer in PDF, Epub, and Kindle

This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.

• Author : Asghar Ghasemi,Khosrow Kashfi,Zahra Bahadoran
• Publisher : Bentham Science Publishers
• Release Date : 2022-12-01
• Total pages : 386
• ISBN : 9789815079821
• File Size : 9,9 Mb
• Total Download : 476
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Download The Role of Nitric Oxide in Type 2 Diabetes in PDF, Epub, and Kindle

Type 2 diabetes (T2D) is a complex metabolic disorder characterized by impaired glucose metabolism and pancreatic β-cell dysfunction. No effective treatments are available for T2D, although there have been many developments in the therapeutic arena. Nitric oxide (NO) is an endocrine agent with multiple and important biological roles in most mammalian tissues. NO has emerged as a central regulator of energy metabolism and body composition. NO bioavailability is decreased in T2D. Several of the pharmaceuticals used in T2D affect the NO system and perhaps even more so by the drugs we use to treat diabetic cardiovascular complications. Experimental works in animal models of T2D show promising results with interventions aimed to increase NO signaling. However, translation into human studies has so far been less successful, but more large-scale prolonged studies are clearly needed to understand its role. This book is a collection of reviews that deal with the role of nitric oxide in type 2 diabetes, providing a unique overview of NO signaling, and pointing out key areas for more detailed research. The book includes contributions about the pathophysiology of T2D, a brief history of discovery and timeline of NO research, a comprehensive overview of impaired NO metabolism in T2D, precursors of NO (i.e., L-arginine, L-citrulline, nitrate, nitrites, and NO donors), NO and T2D from genetic points of view, NO and diabetic wound healing, NO and osteoporosis, NO and hyperuricemia, NO and Alzheimer’s Disease, therapeutic applications of NO and NO donors in T2D. The compilation is of great value to anyone interested in the biochemistry of NO and its relationship to diabetes.

• Author : Raquel Soares,Carla Costa
• Publisher : Springer Science & Business Media
• Release Date : 2009-02-25
• Total pages : 210
• ISBN : 9781402097010
• File Size : 24,7 Mb
• Total Download : 606
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Download Oxidative Stress, Inflammation and Angiogenesis in the Metabolic Syndrome in PDF, Epub, and Kindle

Metabolic Syndrome (MS) is a highly prevalent condition in developed countries and is a cluster of several risk factors for type 2 diabetes and cardiovascular disease that includes increased body mass index/waist circumference, visceral obesity, insulin resistance, hyperclycaemia, dyslipidaemia and hypertension, which are all major causes of morbidity and death. This volume provides a critical review and discussion of the knowledge gathered on MS and analyzes the interplay between oxidative stress, chronic inflammation and angiogenesis features. There is a special focus on recent discoveries and progress toward possible therapeutic strategies, such as the role of glucose transporters within MS; the effects of polyphenols as anti-oxidant, anti-inflammatory and anti-angiogenic compounds. The role of NFkB, nitric oxide synthases, hypoxia-inducible factors, and many other molecules that play a part in the development of oxidative stress and inflammation as well as angiogenesis is also covered. This book fills the gap between basic science and medical care, and provides the reader with the skills to apply rigorous basic science to clinical settings of metabolic syndrome-associated disorders.

• Author : Daniela Salvemini,Timothy Billiar,Yoram Vodovotz
• Publisher : Unknown
• Release Date : 2014-01-15
• Total pages : 296
• ISBN : 3034882424
• File Size : 51,5 Mb
• Total Download : 269
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Download Nitric Oxide and Inflammation in PDF, Epub, and Kindle

PDF book entitled Nitric Oxide and Inflammation written by Daniela Salvemini,Timothy Billiar,Yoram Vodovotz and published by Unknown which was released on 2014-01-15 with total hardcover pages 296, the book become popular and critical acclaim.

• Author : Amedea Seabra
• Publisher : Academic Press
• Release Date : 2017-03-17
• Total pages : 364
• ISBN : 9780128134597
• File Size : 37,6 Mb
• Total Download : 264
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Download Nitric Oxide Donors in PDF, Epub, and Kindle

Nitric Oxide Donors: Biomedical Applications and Perspectives presents the current state of art, challenges and innovations in the design of therapeutics nitric oxide donors with great impact in several aspects of human physiology and pathophysiology. Although considerable innovative progress has been achieved using Nitric Oxide donors in biomedical applications, certain drawbacks still need to be overcome to successfully translate these research innovations into clinical applications. This book encompasses several topics on nitric oxide such as its sources and biological properties; its performance in the cardiovascular and neurologic systems, in the human skin and its application in the treatment of neglected diseases, neurodegenerative disorders, and cancer. Additionally, it covers its role in inflammation and immunity, penile erection function, photodynamic therapy, antimicrobial activities. It also discusses the future of nitric oxide donors in combination with other therapeutic drugs, in implantable sensors, and nitric oxide releasing hydrogels and medical devices for topical applications. The book is a valuable source for researchers on different areas of biomedical field who are interested in the improvements that these molecules can make in the treatment of several conditions. Provides background information about biology and chemistry of nitric oxide Discusses the state-of-the-art in the design of nitric oxide releasing nanomaterials for biomedical applications Covers the usage of nitric oxide donors in the treatment of several conditions, such as cancer, human skin, cardiovascular system, and immunity Discusses the future of nitric oxide donors and their FDA approval

• Author : Paul G. Winyard,Derek A. Willoughby
• Publisher : Springer Science & Business Media
• Release Date : 2008-02-03
• Total pages : 380
• ISBN : 9781592593743
• File Size : 26,8 Mb
• Total Download : 424
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Download Inflammation Protocols in PDF, Epub, and Kindle

Inflammation has been described as the basis of many pathologies of human disease. When one considers the updated signs of inflammation, they would be vasodilation, cell migration, and, in the case of chronic inflam- tion, cell proliferation, often with an underlying autoimmune basis. Gen- ally, inflammation may be divided into acute, chronic, and autoimmune, - though the editors believe that most, if not all, chronic states are often the result of an autoimmune response to an endogenous antigen. Thus, a proper understanding of the inflammatory basis may provide clues to new therap- tic targets not only in classical inflammatory diseases, but atherosclerosis, cancer, and ischemic heart disease as well. The lack of advances in classical inflammatory diseases, such as rh- matoid arthritis, may in part arise from a failure to classify the disease into different forms. That different forms exist is exemplified in patients with d- fering responses to existing antiinflammatory drugs, ranging from nonresponders to very positive responders for a particular nonsteroidal an- inflammatory drug (NSAID). Though researchers have progressively unr- eled the mechanisms, the story is far from complete. It should also be noted that the inflammatory response is part of the innate immune response, or to use John Hunter’s words in 1795, “inflammation is a salutary response.” That may be applied in particular to the defensive response to invading micro- ganisms.

• Author : Randall E. Harris
• Publisher : Springer Science & Business Media
• Release Date : 2007-05-09
• Total pages : 324
• ISBN : 9781402056888
• File Size : 44,5 Mb
• Total Download : 898
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Download Inflammation in the Pathogenesis of Chronic Diseases in PDF, Epub, and Kindle

In this book, a worldwide panel of leading experts discuss the role of inflammation in the pathogenesis of major chronic diseases and the current controversy regarding risk versus benefit of selective cyclooxygenase-2 (COX-2) inhibitors. The authors provide exciting and enlightening perspectives on COX-2 and related molecular targets in the future of medicine, including historical perspectives.

• Author : Vinood B. Patel,Victor R. Preedy,Rajkumar Rajendram
• Publisher : Humana Press
• Release Date : 2016-08-23
• Total pages : 645
• ISBN : 9783319260099
• File Size : 15,6 Mb
• Total Download : 890
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Download L-Arginine in Clinical Nutrition in PDF, Epub, and Kindle

This text presents the application of current nutritional knowledge by physicians and dietitians and incorporates emerging fields of science and important discoveries. It contains seven major sections. Section 1: Basic Processes at the Cellular Levels, Section 2: Arginine Metabolism and Functions, Section 3: Arginine Status in Cells Related to Organ Damage and Disease, Section 4: Arginine Status and Use in Healthy Individuals, Section 5: Arginine and Diseases of the Gastrointestinal Tract, Section 6: Therapeutic uses of Arginine: Diabetes, Obesity and Cardiovascular Diseases and Section 7: Therapeutic Uses of Arginine: Cancer, Wound Healing and Infectious Disease. Written by authors of international and national standing, leaders in the field and trendsetters, Arginine in Clinical Nutrition is essential reading for nutritionists and dietitians, public health scientists, doctors, epidemiologists, health care professionals of various disciplines, policy makers and marketing and economic strategists.

• Author : Arunabha Ray,Kavita Gulati
• Publisher : Springer Nature
• Release Date : 2023-03-07
• Total pages : 469
• ISBN : 9783031247781
• File Size : 50,5 Mb
• Total Download : 224
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Download Nitric Oxide: From Research to Therapeutics in PDF, Epub, and Kindle

This book entitled "Nitric Oxide: From Research to Therapeutics" includes the most recent information about the role of Nitric Oxide (NO) in physiology, pathophysiology and its translation to therapeutics. The Editors are vastly experienced in the field of NO research. The international panels of contributors to the various chapters of the book are all well-established researchers and health professionals who have worked in different areas of NO physiology and pathophysiology, and have made a considerable impact in the field. The book is a comprehensive collection of the most recent information on NO as a physiological regulator and its diverse potential as a therapeutic target for the treatment for a variety of disease states. This compilation is aimed at professionals and students from both academia and the industry in the areas of basic biomedical and clinical sciences.

• Author : Hirokazu Tsukahara,Kazunari Kaneko
• Publisher : Springer
• Release Date : 2014-05-23
• Total pages : 494
• ISBN : 9781493906796
• File Size : 12,7 Mb
• Total Download : 398
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Download Studies on Pediatric Disorders in PDF, Epub, and Kindle

This volume examines the role of oxidative stress in the pathology of numerous pediatric disorders. It covers a wide range of topics including the chemistry and biology of reactive oxygen species and nitric oxide, molecular biology of the enzymes generating these species, clinically useful biomarkers for evaluating oxidative stress status in humans, and the pathophysiology, clinical course and management of a variety of pediatric disorders, among others. The book also describes current diagnostic tools, laboratory methods and technology for treatment and prevention of pediatric disorders. It explores emerging technology and medical applications including discussions of biomarkers and antioxidants as therapeutic agents. Written by an international team of experts in both pediatrics and free radical and antioxidant research, Studies on Pediatric Disorders is an invaluable addition to the Oxidative Stress in Applied Basic Research and Clinical Practice series.

• Author : Undurti N. Das
• Publisher : Springer Science & Business Media
• Release Date : 2011-04-02
• Total pages : 583
• ISBN : 9789400704954
• File Size : 18,7 Mb
• Total Download : 530
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Download Molecular Basis of Health and Disease in PDF, Epub, and Kindle

The book describes how the balance between pro- and anti-inflammatory molecules is related to health and disease. It is suggested that many diseases are initiated and their progress is influenced by inflammatory molecules and a decrease in the production and/or action of anti-inflammatory molecules and this imbalance between pro- and anti-inflammatory molecules seems to have been initiated in the perinatal period. This implies that strategies to prevent and manage various adult diseases should start in the perinatal period. An alteration in the metaolism of essential fatty acids and their anti-inflammatory molecules such as lipoxins, resolvins, protecitns, maresins and nitrolipids seems to play a major role in the pathobiology of several adult diseases. Based on these concepts, novel therapeutic approaches in the management of insulin resistance, obesity, type 2 diabetes mellitus, metabolic syndrome, cancer, lupus, rheumatoid arthritis and other auto-immune diseases are presented. Based on all these evidences, a unified concept that several adult diseases are due to an alteration in the balance between pro- and anti-inflammatory molecules is discussed and novel methods of their management are presented.

• Author : Derek J. Chadwick,Jamie A. Goode
• Publisher : John Wiley & Sons
• Release Date : 2007-02-06
• Total pages : 304
• ISBN : 9780470059586
• File Size : 46,9 Mb
• Total Download : 390
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Download Sepsis in PDF, Epub, and Kindle

Sepsis: New Insights, New Therapies brings together contributions from an international group of experts in diverse fields to consider how the various pathways implicated in early and late sepsis interact, with a particular emphasis on novel concepts and potential new therapeutic approaches. Topics covered include adaptive immunity, inflammation, neuroendocrinology, bioenergetics and metabolism. Several chapters in the latter half of the book are particularly concerned with treatment strategies involving modulation of the neuroendocrine response. Addresses the frequent, but under-recognised condition of sepsis and discusses new ways to prevent and treat it Describes numerous pharmacological approaches to therapy for early and late sepsis Includes detailed discussion of the various physiological systems implicated in sepsis Presents an international perspective, featuring contributions from experts from laboratories worldwide involved in the study of sepsis Sepsis: New Insights, New Therapies is an invaluable resource for all critical care physicians and researchers. It is also informative reading for immunologists, endocrinologists, neuroendocrinologists, physiologists, and pharmacologists.

• Author : Undurti N. Das
• Publisher : Springer Nature
• Release Date : 2020-05-30
• Total pages : 254
• ISBN : 9781071607411
• File Size : 32,8 Mb
• Total Download : 815
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Download Molecular Biochemical Aspects of Cancer in PDF, Epub, and Kindle

This book discusses the role of genes, oncogenes, anti-oncogenes, free radicals, PUFAs, anti-oxidants, lipid peroxidation process, telomere, and angiogenesis on the origin of cancer, cell proliferation, and cancer in general. It includes a broad introduction to cancer cells; genes, oncogenes, and anti-oncogenes; and free radicals. In later chapters, it discusses in depth the relationship among free radicals, lipid peroxidation and anti-oxidants in cell proliferation. It also discusses aerobic and anaerobic metabolism and their relationship to cancer, as well as the Warburg effect and its potential in the development of new targets for cancer management. Based on these and other evidences, Molecular Biochemical Aspects of Cancer introduces a novel concept that suggests that selective enhancement of free radical generation in tumor cells could form a strategy to induce apoptosis of cancer cells employing bioactive lipids. It presents a new method of treatment of cancer using in vitro, in vivo and clinical data. This book will interest oncologists, scientists, molecular biologists, life scientists.