Theranostic Approach For Pancreatic Cancer

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• Author : Ganji Purnachandra Nagaraju,Sarfraz Ahmad
• Publisher : Academic Press
• Release Date : 2019-08-19
• Total pages : 410
• ISBN : 9780128194584
• File Size : 38,8 Mb
• Total Download : 441
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Download Theranostic Approach for Pancreatic Cancer in PDF, Epub, and Kindle

Theranostic Approach for Pancreatic Cancer modulates the biologic properties of stroma in pancreatic cancer by targeting the several chemotherapy resistance mechanisms to impede their malignant property through introducing new strategies and drugs for tackling the disease. It brings information about ongoing research as well as clinical data about pancreatic cancer and provides detailed descriptions about diagnostic and therapeutic options for easy understanding. The book discusses several topics related to pancreatic cancer, such as stem cells, drug resistance and pancreatic tumor microenvironment, the latest developments in chemotherapy for metastatic cancer and chemoprevention, and epigenome as a therapeutic strategy. Additionally, it encompasses a discussion on theranostic clinical applications for personalized treatment and management of pancreatic cancer. The book is a valuable resource for cancer researchers, oncologists, and several members of the biomedical field who need to understand more about the diagnosis and treatment of pancreatic cancer. Provides information on the roadblocks of chemotherapy in patients with newly diagnosed and metastatic pancreatic cancer“/li> Discusses treatment options available currently and prospective options for the future Focuses especially on stroma, tumor microenvironment, stem cells, stellate cells, transcription factors, growth factors, and important signaling pathways as already tested types of treatment

• Author : Ganji Seeta Rama Raju,L.V.K.S. Bhaskar
• Publisher : Springer Nature
• Release Date : 2020-03-04
• Total pages : 250
• ISBN : 9789811520174
• File Size : 30,5 Mb
• Total Download : 321
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Download Theranostics Approaches to Gastric and Colon Cancer in PDF, Epub, and Kindle

This book highlights the importance of understanding gastric and colon cancer metabolism in guiding diagnosis and drug discovery. It summarizes the correlation between adiponectin and matrix metalloproteinase with colorectal cancer. The book also evaluates the divergent role of hypoxia-inducible factor 1 in colorectal cancer growth and metastasis. After discussing the role of genetic polymorphisms in alcohol metabolizing enzymes and EPHX1 with the onset of colorectal cancer, it reviews the molecular mechanisms of chemoresistance in gastric cancer and novel therapeutic strategies to reverse the chemoresistance of tumors. In addition, the book explores the theranostic role of nanoparticles and therapeutic potential of phytochemicals with regard to colorectal cancer. Given its scope, the book offers a valuable guide for oncologists, academic researchers, pharmaceuticals practitioners, and students who are involved in research and treatment of cancer.

• Author : Carolina de Aguiar Ferreira
• Publisher : Unknown
• Release Date : 2019
• Total pages : 112
• ISBN : OCLC:1114266360
• File Size : 36,8 Mb
• Total Download : 334
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Download Radiolabeled Moieties for Molecular Imaging and Cancer Theranostics in PDF, Epub, and Kindle

Nuclear medicine, including the use of radioactive materials for imaging and therapy, has its role well estabilished. For nuclear medicine applications, not only the choice of radioisotope with characteristics that matchs the application purpose, but also the isotope "carrier" needs to be taken into account, as it "controls" the radiotracer biodistribution and other important biological interactions. Noteworthy, these "carriers" can be of any type, such as nanomaterial or antibodybased. Since nuclear medicine can be as multidisciplinary as the biomedical engineering field, herein, I have chosen to explore both routes of achieving molecular imaging and cancer theranostics: using nanoparticle and antibody-based probes. In chapter 2, we have demonstrated the synthesis of size-optimized ultrasmall porous silica nanoparticles (UPSN), with improved pharmacokinetics, i.e. prolonged blood circulation half-life and reasonably fast systemic clearance. We have systematically investigated the influence of vascular architecture and stromal microenvironment on the accumulation and retention of as-designed UPSN in two different triplenegative breast cancer models. After successfully determining that UPSN can highly accumulate in tumor tissues through EPR effect, we decided, in chapter 3, to evaluate if the same nanoparticles could act as a nanocarrier of a theranostic isotopic pair 86/90Y. In that chapter, we demonstrated that the nanoparticles, when radiolabeled with 86Y, were selectively taken up by tumors cells and were clearly visualized through PET imaging at all time points investigated. 90YDOTA-UPSN provided promising therapeutic results by significantly reducing tumor volumes when compared to all the other groups investigated and by significantly increasing average survival. In chapter 4, we have employed a theranostic approach using the isotopic pair 86Y/90Y targeting tissue factor in a pancreatic cancer model through the use of ALT836 monoclonal antibody. We demonstrated that the anti-TF monoclonal antibody, when radiolabeled with 86Y, allowed PET imaging of pancreatic cancer tumor tissue with excellent tumor contrast and could allow for dosimetric calculation of potential dose that would be received with its isotopic pair 90Y. When radiolabeled with 90Y, ALT836 provided evidence of anti-tumor effects and increased average survival. We have evaluated and characterized the ability of 52Mn-labeled YY146, a specific antibody targeting human CD146 to act as a CD146-specific breast tumor imaging agent, with capability of delineating different CD146 expressions. PET imaging, for up to 7 days, of mice bearing three different breast tumors were carried out and revealed radiotracer uptake in tumors that strongly (r2=0.98, p

• Author : Gianni Ciofani,Attilio Marino,Christos Tapeinos
• Publisher : Frontiers Media SA
• Release Date : 2020-03-18
• Total pages : 187
• ISBN : 9782889636211
• File Size : 22,8 Mb
• Total Download : 392
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Download Advanced Theranostic Nanomedicine in Oncology in PDF, Epub, and Kindle

PDF book entitled Advanced Theranostic Nanomedicine in Oncology written by Gianni Ciofani,Attilio Marino,Christos Tapeinos and published by Frontiers Media SA which was released on 2020-03-18 with total hardcover pages 187, the book become popular and critical acclaim.

• Author : Rama Rao Malla,Ganji Purnachandra Nagaraju
• Publisher : Academic Press
• Release Date : 2020-11-06
• Total pages : 318
• ISBN : 9780128226926
• File Size : 14,8 Mb
• Total Download : 961
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Download A Theranostic and Precision Medicine Approach for Female-Specific Cancers in PDF, Epub, and Kindle

A Theranostic and Precision Medicine Approach for Female-Specific Cancers provides information regarding ongoing research and clinical data surrounding female specific cancers (breast, cervical, ovarian and endometrial cancers). The book encompasses detailed descriptions about diagnostics and therapeutic options for easy understanding, focusing on the subject matter with a broader range of treatment options. In addition, it explores new theranostics, i.e., diagnostic, therapeutic and precision medicine strategies currently being developed for FSCs. This book is a valuable resource for cancer researchers, clinicians, graduate students and other members of biomedical field who need to understand the most recent and promising approaches to manage FSCs. Explores new diagnostic biomarkers surrounding the early detection and prognosis of FSCs Examines new genetic and molecularly targeted approaches for the treatment of these aggressive diseases Discusses new theranostic approaches that combine diagnosis and treatment through the use of nanotechnology in FSCs Addresses how these various advances can be integrated into a precision and personalized medicine approach that can eventually enhance patient care

• Author : Kamal Dua,Meenu Mehta,Terezinha de Jesus Andreoli Pinto,Lisa G. Pont,Kylie A. Williams,Michael Rathbone
• Publisher : Elsevier
• Release Date : 2021-06-24
• Total pages : 572
• ISBN : 9780323900799
• File Size : 10,9 Mb
• Total Download : 101
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Download Advanced Drug Delivery Systems in the Management of Cancer in PDF, Epub, and Kindle

Advanced Drug Delivery Systems in the Management of Cancer discusses recent developments in nanomedicine and nano-based drug delivery systems used in the treatment of cancers affecting the blood, lungs, brain, and kidneys. The research presented in this book includes international collaborations in the area of novel drug delivery for the treatment of cancer. Cancer therapy remains one of the greatest challenges in modern medicine, as successful treatment requires the elimination of malignant cells that are closely related to normal cells within the body. Advanced drug delivery systems are carriers for a wide range of pharmacotherapies used in many applications, including cancer treatment. The use of such carrier systems in cancer treatment is growing rapidly as they help overcome the limitations associated with conventional drug delivery systems. Some of the conventional limitations that these advanced drug delivery systems help overcome include nonspecific targeting, systemic toxicity, poor oral bioavailability, reduced efficacy, and low therapeutic index. This book begins with a brief introduction to cancer biology. This is followed by an overview of the current landscape in pharmacotherapy for the cancer management. The need for advanced drug delivery systems in oncology and cancer treatment is established, and the systems that can be used for several specific cancers are discussed. Several chapters of the book are devoted to discussing the latest technologies and advances in nanotechnology. These include practical solutions on how to design a more effective nanocarrier for the drugs used in cancer therapeutics. Each chapter is written with the goal of informing readers about the latest advancements in drug delivery system technologies while reinforcing understanding through various detailed tables, figures, and illustrations. Advanced Drug Delivery Systems in the Management of Cancer is a valuable resource for anyone working in the fields of cancer biology and drug delivery, whether in academia, research, or industry. The book will be especially useful for researchers in drug formulation and drug delivery as well as for biological and translational researchers working in the field of cancer. Presents an overview of the recent perspectives and challenges within the management and diagnosis of cancer Provides insights into how advanced drug delivery systems can effectively be used in the management of a wide range of cancers Includes up-to-date information on diagnostic methods and treatment strategies using controlled drug delivery systems

• Author : Ganji Purnachandra Nagaraju
• Publisher : Academic Press
• Release Date : 2019-02-26
• Total pages : 223
• ISBN : 9780128176627
• File Size : 9,8 Mb
• Total Download : 530
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Download Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy in PDF, Epub, and Kindle

Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy edited by Dr. Nagaraju, PhD., DSc. focuses on overriding the resistance from chemotherapeutic drugs with a broader range of treatment options. It particularly focuses on stroma, tumor microenvironment, stem cells, stellate cells, transcription factors, growth factors, and important signaling pathways. This volume discusses topics such as pancreatic cancer biology, current therapeutic options, EMT, chemotherapy resistance mechanisms, and genetic manipulations and natural products to enhance the sensitivity of pancreatic cancer to chemotherapy. Additionally, it discusses small targeted molecules and pancreatic cancer trials, and nanotechnology-based drug delivery. Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy is a valuable source for researchers and advanced students in cancer and oncology as well as clinicians and medical students who are interested in learning more about ways to break pancreatic cancer resistance to chemotherapy. Modulates the biologic properties of stroma in pancreatic cancer by targeting the several chemotherapy resistance mechanisms to impede their malignant property by introducing new strategies and drugs Provides information about on-going research as well as clinical data on pancreatic cancer and detailed descriptions about therapeutic options for easy understanding Utilizes full color figures to help the understanding of the content and tables for easy comparison of information as well as quick access to it

• Author : Maria Focarete,Anna Tampieri
• Publisher : Woodhead Publishing
• Release Date : 2018-06-29
• Total pages : 466
• ISBN : 9780081021996
• File Size : 19,6 Mb
• Total Download : 812
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Download Core-Shell Nanostructures for Drug Delivery and Theranostics in PDF, Epub, and Kindle

Core-Shell Nanostructures for Drug Delivery and Theranostics: Challenges, Strategies and Prospects for Novel Carrier Systems contains valuable chapters that deal with the fundamentals of nanotechnology for drug delivery, recent developments and research in core-shell nanoparticles for drug-delivery and theranostic applications, and the potential and applications of core-shell nanofiber. This book is a highly valuable resource for scientists interested in the design and development of innovative drug delivery systems, researchers and graduate/postdoctoral students engaged in biomaterials for drug delivery, and R&D managers in the biomaterials and pharmaceutical industry. Focuses on core-shell nanoparticles and nanofiber for innovative applications, including cancer therapy, controlled release and multi-drug release Considers future prospects and potential new applications of core-shell nanostructures for drug delivery and theranostics Explains the principles and essential concepts of nanotechnology for drug delivery systems

• Author : Mahfoozur Rahman
• Publisher : Springer Nature
• Release Date : 2022
• Total pages : 355
• ISBN : 9789811955587
• File Size : 25,8 Mb
• Total Download : 269
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Download Hormone Related Cancer Mechanistic and Nanomedicines in PDF, Epub, and Kindle

The nanotheranostics sector provides a very promising strategy for monitoring drug biodistribution and pathology longitudinal processes by integrating the imaging and drug delivery functions in one single nanoformulation, providing vital insights into the identification of tumour and predicting the efficacy of nanomedicine. For its unique properties, which include their small size and biocompatibility and ability to permeate the cellular membrane with carrying drugs, nanomaterials have been used for various biomedical applications. This book covers the progress made in hormone-related cancer and their management by nonmedicinal therapy for targeting the hormone regulated cancer with their clinical progress and clinical hurdles.

• Author : Somasree Ray,Amit Kumar Nayak
• Publisher : Woodhead Publishing
• Release Date : 2022-09-10
• Total pages : 436
• ISBN : 9780323885980
• File Size : 26,5 Mb
• Total Download : 783
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Download Design and Applications of Theranostic Nanomedicines in PDF, Epub, and Kindle

Design and Applications of Theranostic Nanomedicines reviews the composition and design of various nanomedicines for theranostic applications, helping readers to make informed decisions when exploring novel treatments for disease. This book introduces readers to theranostic nanostructures as nanomedicines, beginning with a balanced look at the associated challenges, costs and benefits. The next section goes on to detail a range of different theranostic nanomedicines and their design, from nanodispersions and nanogels to exosomes and polymeric micelles. A variety of applications is covered, including in the treatment of pulmonary diseases, neurological disorders, cancers and more. The book also takes a look at the toxicological implications of nanotheranostics, an important aspect of any therapy or treatment. Design and Applications of Theranostic Nanomedicines provides a snapshot of the state-of-the-art, and will be of use to materials scientists, biomedical engineers and pharmaceutical scientists with an interest in nanotechnology and theranostics. Explores the challenges, costs, benefits and toxicological implications of nanotheranostics Reviews a range of nanomedicines and their design, including liposomes, nanohydrogels, nanocochleate and more Details a variety of applications, such as in drug delivery, neurological disorders, cardiovascular diseases and so on

• Author : Ramakrishna Vadde,Ganji Purnachandra Nagaraju
• Publisher : Springer Nature
• Release Date : 2021-01-31
• Total pages : 251
• ISBN : 9789811564871
• File Size : 39,6 Mb
• Total Download : 644
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Download Immunotherapy for Gastrointestinal Malignancies in PDF, Epub, and Kindle

This book reviews current immunotherapeutic strategies for gastrointestinal (GI) malignancies, including immune composition, immune checkpoint inhibitors, cell therapy, and peptide vaccines used to protect against esophageal, gastric, hepato-biliary, pancreatic and colorectal cancers. It also discusses the current challenges of using immunotherapy for the treatment of gastrointestinal malignancies. The book reviews highly sensitive and specific immunomarkers for the detection of GI malignancies, and examines therapeutic vaccines and the major cytokines involved in GI immunotherapy, as well as their basic biology and clinical applications. In closing, the book explores various aspects of computational biology for the detection and treatment of GI malignancies.

• Author : Tomas Koltai,Stephan J. Reshkin,Fatima Baltazar,Larry Fliegel
• Publisher : Academic Press
• Release Date : 2021-06-25
• Total pages : 416
• ISBN : 9780323905510
• File Size : 36,7 Mb
• Total Download : 402
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Download Prostate Cancer Metabolism in PDF, Epub, and Kindle

Prostate Cancer Metabolism: From Biochemistry to Therapeutics shows the peculiarities of prostate cancer metabolism, emphasizing the targetable aspects – that have not been considered in conventional treatment protocols. The book specifically addresses treatment of the castration-resistant stage of prostate cancer proposing many repurposed drugs and nutraceuticals to complement, not replace, standard therapies. The large body of evidence supporting these concepts makes them deserving of further research and well-designed clinical trials. It discusses lipid, cholesterol, glutamine, and glucose metabolisms and their impact on prostate cancer. Additionally, it explains how current established drugs can be repurposed to improve treatment outcomes. The concepts set out in the book, that deal with cancer at the cellular/molecular level, help identify new avenues of research and treatments to pursue that do not affect well-being whilst offer consistent benefits. Since most practicing physicians have not studied basic biochemistry since medical school, each chapter begins with a brief review of the topic to facilitate an understanding of the metabolically-oriented approach to targeting prostate cancer. Conventional treatments are not discussed here since they are covered in textbooks and specialized updates that abound in the medical literature. It is a valuable resource for cancer researchers, oncologists, clinicians and members of biomedical field who want to learn more about prostate cancer metabolism and how to apply recent findings in the field to bedside. Explains the basic aspects of prostate cancer metabolism, including its biochemistry which has a pivotal role in clinical practice Discusses new drugs and nutraceuticals with a metabolism-centered approach Offers practical bedside approach in combination with molecular and biochemical fundamentals to help readers identify and provide the best treatment to their patients

• Author : Daniel D. Von Hoff,Haiyong Han
• Publisher : Springer
• Release Date : 2019-06-17
• Total pages : 283
• ISBN : 9783030163914
• File Size : 9,9 Mb
• Total Download : 187
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Download Precision Medicine in Cancer Therapy in PDF, Epub, and Kindle

This book presents the latest advances in precision medicine in some of the most common cancer types, including hematological, lung and breast malignancies. It also discusses emerging technologies that are making a significant impact on precision medicine in cancer therapy. In addition to describing specific approaches that have already entered clinical practice, the book explores new concepts and tools that are being developed. Precision medicine aims to deliver personalized healthcare tailored to a patient’s genetics, lifestyle and environment, and cancer therapy is one of the areas in which it has flourished in recent years. Documenting the latest advances, this book is of interest to physicians and clinical fellows in the front line of the war on cancer, as well as to basic scientists working in the fields of cancer biology, drug development, biomarker discovery, and biomedical engineering. The contributing authors include translational physicians with first-hand experience in precision patient care.

• Author : Yoshiaki Toyama,Atsushi Miyawaki,Masaya Nakamura,Masahiro Jinzaki
• Publisher : Springer Nature
• Release Date : 2019-10-02
• Total pages : 292
• ISBN : 9789811379086
• File Size : 10,5 Mb
• Total Download : 641
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Download Make Life Visible in PDF, Epub, and Kindle

This open access book describes marked advances in imaging technology that have enabled the visualization of phenomena in ways formerly believed to be completelyimpossible. These technologies have made major contributions to the elucidation of the pathology of diseases as well as to their diagnosis and therapy. The volume presents various studies from molecular imaging to clinical imaging. It also focuses on innovative, creative, advanced research that gives full play to imaging technology inthe broad sense, while exploring cross-disciplinary areas in which individual research fields interact and pursuing the development of new techniques where they fuse together. The book is separated into three parts, the first of which addresses the topic of visualizing and controlling molecules for life. Th e second part is devoted to imaging of disease mechanisms, while the final part comprises studies on the application of imaging technologies to diagnosis and therapy. Th e book contains the proceedings of the 12th Uehara International Symposium 2017, “Make Life Visible” sponsored by the Uehara Memorial Foundation and held from June 12 to 14, 2017. It is written by leading scientists in the field and is an open access publication under a CC BY 4.0 license.

• Author : Naveen Kumar Vishvakarma,Ganji Purnachandra Nagaraju,Dhananjay Shukla
• Publisher : Springer Nature
• Release Date : 2021-06-04
• Total pages : 453
• ISBN : 9783030646684
• File Size : 46,7 Mb
• Total Download : 825
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Download Colon Cancer Diagnosis and Therapy in PDF, Epub, and Kindle

Colorectal cancer (CRC) is a major global health challenge as the third leading cause for cancer related mortalities worldwide. Despite advances in therapeutic strategies, the five-year survival rate for CRC patients has remained the same over time due to the fact that patients are often diagnosed in advanced metastatic stages. Drug resistance is another common reason for poor prognosis. Researchers are now developing advanced therapeutic strategies such as immunotherapy, targeted therapy, and combination nanotechnology for drug delivery. In addition, the identification of new biomarkers will potentiate early stage diagnosis. This book is the second of three volumes on recent developments in colorectal diagnosis and therapy. Each volume can be read on its own, or together. Each volume focuses on different novel therapeutic advances, biomarkers, and identifies therapeutic targets for treatment. Written by leading international experts in the field, coverage addresses the role of diet habits and lifestyle in reducing gastrointestinal disorders and incidence of CRC. Chapters discuss current and future diagnostic and therapeutic options for colorectal cancer patients, focusing on immunotherapeutics, nanomedicine, biomarkers, and dietary factors for the effective management of colon cancer.

• Author : Ganji Purnachandra Nagaraju,Dhananjay Shukla,Naveen Kumar Vishvakarma
• Publisher : Springer Nature
• Release Date : 2021
• Total pages : 369
• ISBN : 9783030633691
• File Size : 40,7 Mb
• Total Download : 715
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Download Colon Cancer Diagnosis and Therapy in PDF, Epub, and Kindle

Colorectal cancer (CRC) is a major global health challenge as the third leading cause for cancer related mortalities worldwide. Despite advances in therapeutic strategies, the five-year survival rate for CRC patients has remained the same over time due to the fact that patients are often diagnosed in advanced metastatic stages. Drug resistance is another common reason for poor prognosis. Researchers are now developing advanced therapeutic strategies such as immunotherapy, targeted therapy, and combination nanotechnology for drug delivery. In addition, the identification of new biomarkers will potentiate early stage diagnosis. This book is the first of three volumes on recent developments in colorectal diagnosis and therapy. Each volume can be read on its own, or together. Each volume focuses on different novel therapeutic advances, biomarkers, and identifies therapeutic targets for treatment. Written by leading international experts in the field, coverage also addresses the role of diet habits and lifestyle in reducing gastrointestinal disorders and incidence of CRC. Chapters discuss current and future diagnostic and therapeutic options for colorectal cancer patients, focusing on immunotherapeutic, nanomedicine, biomarkers, and dietary factors for the effective management of colon cancer.

• Author : Ganji Purnachandra Nagaraju
• Publisher : Springer Nature
• Release Date : 2020-10-07
• Total pages : 340
• ISBN : 9783030484057
• File Size : 21,8 Mb
• Total Download : 990
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Download Phytochemicals Targeting Tumor Microenvironment in Gastrointestinal Cancers in PDF, Epub, and Kindle

Gastrointestinal (GI) malignancies account for a large portion of cancers worldwide. Although incidence of esophageal, gastric, and colorectal cancers has decreased in recent years, pancreatic and liver cancer have increased. The mainstay of GI cancer therapy is chemoradiation and surgery. Despite significant medical advancements, diagnosis and therapy for GI cancers remain challenging due to tumor cell resistance to chemoradiotherapy. The tumor’s increased cell signalling due to excessive transcription factor activation and increased stellate cell activity leads to collagen deposition formation of a dense stroma around the tumor, which prevents drugs from reaching the malignant cells. This leads to tumor chemoresistance. To circumvent these difficulties, drug therapy targeting the tumor’s specific microenvironment and the additive anticancer effect of phytochemicals can allow for more effective treatment. This volume will be the first on the market on the topic of phytochemicals and their effect on the tumor microenvironment (TME). TME is an emerging area of research and the book will be a welcome introductory addition to the field.

• Author : Dhananjay Shukla,Naveen Kumar Vishvakarma,Ganji Purnachandra Nagaraju
• Publisher : Springer Nature
• Release Date : 2022-02-14
• Total pages : 459
• ISBN : 9783030727024
• File Size : 15,8 Mb
• Total Download : 177
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Download Colon Cancer Diagnosis and Therapy Vol. 3 in PDF, Epub, and Kindle

Colorectal cancer (CRC) is a major global health challenge as the third leading cause for cancer related mortalities worldwide. Despite advances in therapeutic strategies, the five-year survival rate for CRC patients has remained the same over time due to the fact that patients are often diagnosed in advanced metastatic stages. Drug resistance is another common reason for poor prognosis. Researchers are now developing advanced therapeutic strategies such as immunotherapy, targeted therapy, and combination nanotechnology for drug delivery. In addition, the identification of new biomarkers will potentiate early stage diagnosis. This book is the third of three volumes on recent developments in colorectal diagnosis and therapy. Each volume can be read on its own, or together. Each volume focuses on different novel therapeutic advances, biomarkers, and identifies therapeutic targets for treatment. Written by leading international experts in the field, coverage addresses the role of diet habits and lifestyle in reducing gastrointestinal disorders and incidence of CRC. Chapters discuss current and future diagnostic and therapeutic options for colorectal cancer patients, focusing on immunotherapeutics, nanomedicine, biomarkers, and dietary factors for the effective management of colon cancer.

• Author : Vivek Borse
• Publisher : Springer Nature
• Release Date : 2023
• Total pages : 229
• ISBN : 9789811627828
• File Size : 41,9 Mb
• Total Download : 872
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Download BioSensing, Theranostics, and Medical Devices in PDF, Epub, and Kindle

PDF book entitled BioSensing, Theranostics, and Medical Devices written by Vivek Borse and published by Springer Nature which was released on 2023 with total hardcover pages 229, the book become popular and critical acclaim.

• Author : Saji Uthaman,In-Kyu Park,Kang Moo Huh,James J. Lai,Mitsuhiro Ebara
• Publisher : Frontiers Media SA
• Release Date : 2022-01-07
• Total pages : 148
• ISBN : 9782889740024
• File Size : 27,8 Mb
• Total Download : 121
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Download Stimuli Responsive Nanoparticles for Anti-Cancer Therapy in PDF, Epub, and Kindle

PDF book entitled Stimuli Responsive Nanoparticles for Anti-Cancer Therapy written by Saji Uthaman,In-Kyu Park,Kang Moo Huh,James J. Lai,Mitsuhiro Ebara and published by Frontiers Media SA which was released on 2022-01-07 with total hardcover pages 148, the book become popular and critical acclaim.

• Author : Zhao Li
• Publisher : Unknown
• Release Date : 2015
• Total pages : 184
• ISBN : OCLC:927469096
• File Size : 55,5 Mb
• Total Download : 432
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Download Early Cancer Detection and Targeted Therapy by Magnetic Resonance Molecular Imaging and Nano Medicine in PDF, Epub, and Kindle

The common theme of my 5-year PhD research is to channel progress in spin physics and nano-bio-materials into meaningful improvements in the theoretical studies, methodological developments, and advanced applications of magnetic resonance (MR) to: 1) MR Molecular Imaging: to detect lesions (especially cancers) at early stages through imaging the existence and locations of physiologically important biomarkers; and 2) MR Nano Medicine: to cure diseases (especially cancers) by targeted therapy through nanodrugs and hyperthermia. The research activities had encompassed a balanced approach to develop a rigorous theoretical understanding on sensitively imaging magnetic nanoparticles by active- feedback spin dynamics of selective self-excitation and fixed-point dynamics on one hand and sound methodology with biomedical applicability to early pancreatic cancers and brain tumors detection on the other. Computer simulations, phantom experiments of superparamagnetic nanoparticles, and in vivo experiments of orthotopic pancreatic cancer and brain tumor mouse models had been used to validate the applicability and efficacy of our proposed methods. The major research projects and achievements with my coworkers under the supervision of Prof. Yung-Ya Lin include: 1) Developed original MR method, "Active-Feedback Fixed-Point Imaging", for early cancer detection, with both quantum and classical formulation of the spin dynamics. 2) Demonstrated 3-5 times of enhancement in the contrast-to-noise ratio (CNR) of early pancreatic cancers which were targeted and labeled by CA19-9 conjugated magnetic nanoparticles by our "Spin Avalanche Amplification" method, based on statistics from 7 orthotopic pancreatic cancer mouse models. 3) Demonstrated 4-10 times of enhancement in the CNR of early GBM (glioblastoma multiforme, the most common and aggressive form of brain cancers) by our "Active-Feedback Fixed-Point Imaging" method, based on statistics from 20 orthotopic GBM mouse models. 4) Developed novel multifunctional, theranostic, smart nanoparticles, called "UCS-Gd-Dox" for MR imaging and targeted cancer therapy. By conjugating Gd3+ at the stable core of unibody core-shell polymer (UCS) and encapsulating doxorubicin (Dox) at the shell in a pH-sensitive manner, we achieved a selective drug release (75% difference between pH 7.4 and 5.5) and MR imaging (r1 = 0.9 and 14.5 mM-1s-1 at pH 7.4 and 5.5, respectively). The anti-cancer effect is significantly better than free cancer drugs in tumor-bearing mouse models, presumably due to enhanced permeability and retention effect and pH-triggered release. 5) Formulated more accurate theoretical description to magnetic resonance hyperthermia, including aggregation/disruption of monomers/clusters and nonlinear response under strong external magnetic field.