The Serotonin System

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• Author : Mark Tricklebank,Eileen Daly
• Publisher : Academic Press
• Release Date : 2019-06-15
• Total pages : 306
• ISBN : 9780128133248
• File Size : 34,5 Mb
• Total Download : 616
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Download The Serotonin System in PDF, Epub, and Kindle

The Serotonin System: History, Neuropharmacology, and Pathology provides an up-to-date accounting on the physiology and pathophysiology of serotonin and the role it plays in behavioral functions. In addition, the book explores the potential roles of 5-HT1 in neurodevelopmental disorders and summarizes the history of the discovery and development of serotonergic drugs for the treatment of neuropsychiatric disorders. This concise, yet thorough, volume is the perfect introduction to this critical neurotransmitter. It is ideal for students and researchers new to the study of behavior, neuropsychiatry or neuropharmacology, but is also a great resource for established investigators who want a greater perspective on serotonin. Examines the role of serotonin in physiological functions and neuropsychiatric disorders Provides in-depth knowledge on all aspects of the serotonin system Explores serotonergic receptors as targets for both current and new therapeutic compounds

• Author : Christian P. Muller,Barry Jacobs
• Publisher : Academic Press
• Release Date : 2009-12-30
• Total pages : 836
• ISBN : 0080878172
• File Size : 51,8 Mb
• Total Download : 642
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Download Handbook of the Behavioral Neurobiology of Serotonin in PDF, Epub, and Kindle

Serotonin (5-hydroxytryptamine, often cited as 5-HT) is one of the major excitatory neurotransmitter, and the serotonergic system is one of the best studied and understood transmitter systems. It is crucially involved in the organization of virtually all behaviours and in the regulation of emotion and mood. Alterations in the serotonergic system, induced by e.g. learning or pathological processes, underlie behavioural plasticity and changes in mood, which can finally results in abnormal behaviour and psychiatric conditions. Not surprisingly, the serotonergic system and its functional components appear to be targets for a multitude of pharmacological treatments - examples of very successful drugs targeting the serotoninergic system include Prozac and Zoloft. The last decades of research have not only fundamentally expanded our view on serotonin but also revealed in much more detail an astonishing complexity of this system, which comprises a multitude of receptors and signalling pathways. A detailed view on its role in basal, but also complex, behaviours emerged, and, was presented in a number of single review articles. Although much is known now, the serotonergic system is still a fast growing field of research contributing to our present understanding of the brains function during normal and disturbed behaviour. This handbook aims towards a detailed and comprehensive overview over the many facets of behavioural serotonin research. As such, it will provide the most up to date and thorough reading concerning the serotonergic systems control of behaviour and mood in animals and humans. The goal is to create a systematic overview and first hand reference that can be used by students and scholars alike in the fields of genetics, anatomy, pharmacology, physiology, behavioural neuroscience, pathology, and psychiatry. The chapters in this book will be written by leading scientists in this field. Most of them have already written excellent reviews in their field of expertise. The book is divided in 4 sections. After an historical introduction, illustrating the growth of ideas about serotonin function in behaviour of the last forty years, section A will focus on the functional anatomy of the serotonergic system. Section B provides a review of the neurophysiology of the serotonergic system and its single components. In section C the involvement of serotonin in behavioural organization will be discussed in great detail, while section D deals with the role of serotonin in behavioural pathologies and psychiatric disorders. The first handbook broadly discussing the behavioral neurobiology of the serotonorgic transmitter system Co-edited by one of the pioneers and opinion leaders of the past decades, Barry Jacobs (Princeton), with an international list (10 countries) of highly regarded contributors providing over 50 chapters, and including the leaders in the field in number of articles and citations: K. P. Lesch, T. Sharp, A. Caspi, P. Blier, G.K. Aghajanian, E. C. Azmitia, and others The only integrated and complete resource on the market containing the best information integrating international research, providing a global perspective to an international community Of great value not only for researchers and experts, but also for students and clinicians as a background reference

• Author : Bryan L. Roth
• Publisher : Springer Science & Business Media
• Release Date : 2008-08-17
• Total pages : 618
• ISBN : 9781597450805
• File Size : 36,9 Mb
• Total Download : 833
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Download The Serotonin Receptors in PDF, Epub, and Kindle

A comprehensive, state-of-the-art review of our current understanding of the molecular and structural biology of 5-HT receptors and their potential use for drug discovery. The authors describe the anatomical, cellular, and subcellular distribution of 5-HT receptors and demonstrate a powerful approach to elucidating their physiological role using knockout mice in which the 5-HT receptors were deleted. They also review our understanding of the physiological role(s) of 5-HT receptors based mainly on studies performed in genetically engineered mice. Highlights include discussions of the behavioral phenotypes of 5-HT receptor knockout animals, the molecular biology and pharmacology of 5-HT receptors, and insights into the complexity of 5-HT receptor signal transduction.

• Author : Amitabha Chattopadhyay
• Publisher : CRC Press
• Release Date : 2007-05-17
• Total pages : 224
• ISBN : 1420005758
• File Size : 35,8 Mb
• Total Download : 104
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Download Serotonin Receptors in Neurobiology in PDF, Epub, and Kindle

A number of developments spanning a multitude of techniques makes this an exciting time for research in serotonin receptors. A comprehensive review of the subject from a multidisciplinary perspective, Serotonin Receptors in Neurobiology is among the first books to include information on serotonin receptor knockout studies. With contributions from leading experts in their fields, the book explores serotonin receptors from a broad-based, multidisciplinary approach. The approaches described vary from molecular biological techniques to fluorescence microscopy and imaging, to genetic manipulation in animal models, providing a wide range of tools to study serotonergic phenomena. While each of these approaches has its own advantages and limitations, the synthesis of information and knowledge achieved from studies using multiple approaches will result in a comprehensive understanding of the underlying complex phenomena involved in serotonergic signaling and its implications in health and disease. The book provides an overall understanding of these receptors based on currently used methodologies and techniques. It describes specific experimental procedures that will be of use to researchers interested in addressing similar problems involving other G-protein-coupled receptor signaling systems.

• Author : Paul M. Pilowsky
• Publisher : Academic Press
• Release Date : 2018-09-21
• Total pages : 420
• ISBN : 9780128005842
• File Size : 54,5 Mb
• Total Download : 383
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Download Serotonin in PDF, Epub, and Kindle

Serotonin: The Mediator That Spans Evolution provides a comprehensive review of the widespread roles for serotonin in respiratory, cardiovascular and thermoregulatory control, and for growth and development in early life. This important resource highlights serotonin’s role in normal (unstressed) conditions, and in response to a variety of physiological stressors. It focuses on new animal models, comparing and contrasting data from mice and rats. In addition, the book compares and contrasts the physiological effects of brain and blood serotonin systems and includes new data suggesting that the influence of serotonin is in part through the regulation of gene expression. Finally, it discusses the role of serotonin system dysfunction in a variety of pathophysiological conditions, including sleep apnea, obesity and hypertension, and presents compelling evidence that this dysfunction is involved in Sudden Infant Death Syndrome (SIDS). Includes the latest information on new animal models of serotonin system dysfunction Explores the wide scope of serotonin’s influence on multiple organ and physiological systems Highlights the autonomous functioning of the brain and body serotonin systems Provides compelling evidence of serotonin dysfunction in SIDS, a leading cause of death in infancy

• Author : Saleh Bashammakh
• Publisher : Unknown
• Release Date : 2007
• Total pages : 238
• ISBN : OCLC:188304999
• File Size : 43,7 Mb
• Total Download : 513
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Download The Developmental Role of the Serotonin System in PDF, Epub, and Kindle

PDF book entitled The Developmental Role of the Serotonin System written by Saleh Bashammakh and published by Unknown which was released on 2007 with total hardcover pages 238, the book become popular and critical acclaim.

• Author : Fatima Shad Kaneez
• Publisher : BoD – Books on Demand
• Release Date : 2017-07-26
• Total pages : 318
• ISBN : 9789535133612
• File Size : 11,8 Mb
• Total Download : 728
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Download Serotonin in PDF, Epub, and Kindle

Serotonin - A Chemical Messenger Between All Types of Living Cells is a very interesting book on the most ancient neurotransmitter, hormone and trophic factor serotonin or 5-hydroxytryptamine (5-HT). This unique chemical is present in all living cells including plants and animals. This book will take us through a serene journey of the evolutionary history of serotonin and its role from man to mollusk. There are many interesting chapters incorporated in this book, including novel approaches for detecting minor metabolites of serotonin in human plasma, production and function of serotonin in cardiac cells, immuno-thrombotic effects of serotonin in platelets to the identification and localization of serotonin in the nervous system and gonad of bivalve mollusks.

• Author : Bernard Haber
• Publisher : Springer Science & Business Media
• Release Date : 2012-12-06
• Total pages : 824
• ISBN : 9781468438604
• File Size : 19,6 Mb
• Total Download : 780
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Download Serotonin in PDF, Epub, and Kindle

The vast growth of knowledge in recent years concerning the functional role of serotonergic systems in central nervous system function prompted the organization of the symposium. The organiz ing committees felt at the onset that the field of serotonin research had grown so rapidly that it would be impossible to cover every aspect of it in individual symposia. Thus it was felt that certain areas of research had to be omitted due to time constraints, and we extend an apology to the researchers in areas not included in these proceedings. Rather it was hoped to provide a balance overview of the field, starting with the anatomy of serotonergic systems and proceeding to the level of the serotonergic receptors at the cell membrane, and then inside the neuron to discuss the regulation of serotonin bisynthesis and integration within indole mine systems. The functional aspects of serotonergic transmission focused on the emerging role of this amine in the processing of nociceptive information, singly or in tandem with other neurotran smitters or neuromodulators. A separate symposium dealt with a variety of animal models suitable for the analysis of the role of serotonin in behavior, and finally led to the evaluation of serotonin metabolism in the study of abnormal human behavior. The editors would like to dedicate these proceedings on /Serotonin - Current Aspects of Neurochemistry and Function/ to two pioneers in this field, Dr. Irving Page and Dr. Maurice Rapport.

• Author : Jack Barchas
• Publisher : Elsevier
• Release Date : 2012-12-02
• Total pages : 670
• ISBN : 9780323143660
• File Size : 9,7 Mb
• Total Download : 717
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Download Serotonin and Behavior in PDF, Epub, and Kindle

Serotonin and Behavior contains the proceedings of the 1972 symposium on the behavioral effects of changes in brain serotonin, held at Stanford University in California. The papers explore the role of serotonin in behavior as well as the key biochemical and pharmacological issues involved in behavioral studies of severe psychiatric disorders in both humans and animals. The book is organized into eight sections comprised of 65 chapters, with topics ranging from the fundamental biochemistry and pharmacology of the enzymes synthesizing serotonin, particularly, tryptophan hydroxylase and its inhibitors, to the physiology and pharmacology of serotonin. Some papers discuss the link between the telencephalic content of serotonin and pain sensitivity. Other papers focus on the effects of altering serotonin on neurons in the central nervous system. There are chapters that explain the effects of altering serotonin on animal behavior, the relationship between serotonin and sleep, the use of high doses of probenecid to estimate central serotonin turnover in affective disorders and addicts, the behavioral and metabolic effects of L-tryptophan in unipolar depressed patients taking methadone, and amygdala unit activity as a reflection of functional changes in brain serotonergic neurons. Biochemists, pharmacologists, psychiatrists, psychologists, and anyone interested in psychopharmacology will find this book extremely useful.

• Author : Robert Vink,Mihai Nechifor
• Publisher : University of Adelaide Press
• Release Date : 2011
• Total pages : 354
• ISBN : 9780987073051
• File Size : 33,5 Mb
• Total Download : 318
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Download Magnesium in the Central Nervous System in PDF, Epub, and Kindle

The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.

• Author : Anonim
• Publisher : Academic Press
• Release Date : 2020-01-23
• Total pages : 1042
• ISBN : 9780444641267
• File Size : 41,6 Mb
• Total Download : 697
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Download Handbook of the Behavioral Neurobiology of Serotonin in PDF, Epub, and Kindle

Handbook of the Behavioral Neurobiology of Serotonin, Second Edition, builds on the success of the first edition by continuing to provide a detailed and comprehensive overview of the many facets of behavioral serotonin research. The text expands on the two key topics, behavioral control (sensory processing, ultrasonic vocalization, and melatonin and sleep control) and psychiatric disorders, including its role on psychostimulant abuse and addiction. The new edition includes two new sections on the serotonin systems interactions and the involvement of serotonin in neurological disorders and associated treatment. Serotonin is a major neurotransmitters in the serotonergic system which one of the best studied and understood transmitter systems. Both are critically involved in the organization of all behaviors and in the regulation of emotion and mood. Features two new sections on serotonin systems interactions and serotonin in neurological disorders Focuses on ionotropic and metabotropic 5-HT receptor involvement in behavior Maps receptors and receptor signaling pathways to neurochemical and behavioral outcomes Covers the interactions between serotonin, melatonin and kynurenine pathways

• Author : Allan V. Kalueff (LaPorte, Justin L.)
• Publisher : Unknown
• Release Date : 2010
• Total pages : 229
• ISBN : 1107190320
• File Size : 11,9 Mb
• Total Download : 635
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Download Experimental Models in Serotonin Transporter Research in PDF, Epub, and Kindle

The serotonin transporter is a key brain protein that modulates the reuptake of the neurotransmitter serotonin from synaptic spaces back into the presynaptic neuron. This control over neuronal signalling makes it a prime area of neuroscientific study. In this book an international team of top experts introduce and explicate the role of serotonin and the serotonin transporter in both human and animal brains. They demonstrate the relevance of the transporter and indeed the serotonergic system to substrates of neuropsychiatric disorders, and explain how this knowledge is translated into valid animal models that will help foster new discoveries in human neurobiology. Writing for graduate students and academic researchers, they provide a comprehensive coverage of a wide spectrum of data from animal experimentation to clinical psychiatry, creating the only book exclusively dedicated to this exciting new avenue of brain research.

• Author : Luc Maroteaux,Laurent Monassier
• Publisher : Springer Nature
• Release Date : 2021-03-12
• Total pages : 401
• ISBN : 9783030559205
• File Size : 30,6 Mb
• Total Download : 332
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Download 5-HT2B Receptors in PDF, Epub, and Kindle

This contributed volume provides a comprehensive assessment of the roles played by 5-HT2B receptors in humans. These receptors have been shown to play an important role is the cardiac, intestinal, and central nervous systems as well as in bone marrow formation and growth. In this book, expert researchers present their findings on molecular and physiological/pathological aspects of 5-HT2B receptors. The molecular section includes a discussion of the genetics of 5-HT2B receptors and impulse control. The physiological section covers their role in many biological systems including the nervous system, the heart, and the lungs.​

• Author : Carla E. M. Hollak,Robin Lachmann
• Publisher : Oxford University Press
• Release Date : 2016
• Total pages : 657
• ISBN : 9780199972135
• File Size : 24,5 Mb
• Total Download : 807
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Download Inherited Metabolic Disease in Adults in PDF, Epub, and Kindle

As clinical management of inherited metabolic diseases (IMDs) has improved, more patients affected by these conditions are surviving into adulthood. This trend, coupled with the widespread recognition that IMDs can present differently and for the first time during adulthood, makes the need for a working knowledge of these diseases more important than ever. Inherited Metabolic Disease in Adults offers an authoritative clinical guide to the adult manifestations of these challenging and myriad conditions. These include both the classic pediatric-onset conditions and a number of new diseases that can manifest at any age. It is the first book to give a clear and concise overview of how this group of conditions affects adult patients, a that topic will become a growing imperative for physicians across primary and specialized care.

• Author : Laurival Antonio De Luca Jr.,Jose Vanderlei Menani,Alan Kim Johnson
• Publisher : CRC Press
• Release Date : 2013-10-01
• Total pages : 340
• ISBN : 9781466506930
• File Size : 38,5 Mb
• Total Download : 662
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Download Neurobiology of Body Fluid Homeostasis in PDF, Epub, and Kindle

A timely symposium entitled Body-Fluid Homeostasis: Transduction and Integration was held at Araraquara, São Paulo, Brazil in 2011. This meeting was convened as an official satellite of a joint gathering of the International Society for Autonomic Neuroscience (ISAN) and the American Autonomic Society (AAS) held in Buzios, Rio de Janeiro. Broad international participation at this event generated stimulating discussion among the invited speakers, leading to the publication of Neurobiology of Body Fluid Homeostasis: Transduction and Integration. Drawn from the proceedings and filled with rich examples of integrative neurobiology and regulatory physiology, this volume: Provides updated research using human and animal models for the control of bodily fluids, thirst, and salt appetite Explores neural and endocrine control of body fluid balance, arterial pressure, thermoregulation, and ingestive behavior Discusses recent developments in molecular genetics, cell biology, and behavioral plasticity Reviews key aspects of brain serotonin and steroid and peptide control of fluid consumption and arterial pressure The book highlights research conducted by leading scientists on signal transduction and sensory afferent mechanisms, molecular genetics, perinatal and adult long-term influences on regulation, central neural integrative circuitry, and autonomic/neuroendocrine effector systems. The findings discussed by the learned contributors are relevant for a basic understanding of disorders such as heat injury, hypertension, and excess salt intake. A unique reference on the neurobiology of body fluid homeostasis, this volume is certain to fuel additional research and stimulate further debate on the topic.

• Author : George J. Siegel,Bernard W. Agranoff
• Publisher : Lippincott Raven
• Release Date : 1999
• Total pages : 1216
• ISBN : UOM:39015045578211
• File Size : 11,7 Mb
• Total Download : 669
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Download Basic Neurochemistry in PDF, Epub, and Kindle

Illustrations by Lorie M. Gavulic, MFA Sponsored by the American Society for Neurochemistry.

• Author : Daniel Lam
• Publisher : Unknown
• Release Date : 2010
• Total pages : 229
• ISBN : OCLC:890149547
• File Size : 55,9 Mb
• Total Download : 118
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Download Brain Serotonin System in the Coordination of Food Intake and Body Weight in PDF, Epub, and Kindle

PDF book entitled Brain Serotonin System in the Coordination of Food Intake and Body Weight written by Daniel Lam and published by Unknown which was released on 2010 with total hardcover pages 229, the book become popular and critical acclaim.

• Author : J.J. Dudok
• Publisher : Unknown
• Release Date : 2010
• Total pages : 165
• ISBN : 9085705851
• File Size : 47,7 Mb
• Total Download : 773
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Download Cellular Characterization of the Outgrowth and Connectivity of the Brain Serotonin System in PDF, Epub, and Kindle

PDF book entitled Cellular Characterization of the Outgrowth and Connectivity of the Brain Serotonin System written by J.J. Dudok and published by Unknown which was released on 2010 with total hardcover pages 165, the book become popular and critical acclaim.

• Author : Carol Hart
• Publisher : St. Martin's Griffin
• Release Date : 2008-04-15
• Total pages : 288
• ISBN : 9781429998659
• File Size : 14,9 Mb
• Total Download : 547
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Download Secrets of Serotonin, Revised Edition in PDF, Epub, and Kindle

DRAMATICALLY IMPROVE YOUR MOOD, ENERGY LEVELS, AND MORE! Serotonin has a powerful effect on the brain: enough and you feel great; too little and you may binge on food and alcohol, get a migraine, suffer from insomnia, or become depressed. In fact, millions of people take prescription antidepressants every day to compensate for their low serotonin levels, without knowing that changes in diet and lifestyle may be all they need to improve their mood. This revised and updated edition features the latest research on serotonin, including: *The link between yo-yo dieting and serotonin deficiencies *How serotonin is connected to eating disorders *Why migraines and depression are far more common among women than men *Serotonin's role in relieving irritable bowel syndrome, fibromyalgia, and other chronic pain conditions The complete eating and activity program in Secrets of Serotonin will guide you toward relatively simple changes in your eating and sleep habits, bright light exposure, and activity level that will boost serotonin naturally and have an enormous benefit for your overall health and well-being. CAROL HART, PH.D., is a respected biomedical writer, editor, and researcher. She is the author of Good Food Tastes Good: An Argument for Trusting Your Senses and Ignoring the Nutritionists and co-author of Traditional Chinese Medicine: The A-Z Guide to Natural Healing from the Orient. She lives in Pennsylvania.

• Author : Giuseppe Di Giovanni,Philippe De Deurwaerdère
• Publisher : Elsevier
• Release Date : 2021-03-24
• Total pages : 482
• ISBN : 9780444642585
• File Size : 29,7 Mb
• Total Download : 673
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Download 5-HT Interaction with Other Neurotransmitters: Experimental Evidence and Therapeutic Relevance Part B in PDF, Epub, and Kindle

The Progress in Brain Research series highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. Covers all key aspects of current research on 5-HT interaction with other neurotransmitters Provides extensively referenced chapters, thus giving readers a comprehensive list of resources on topics covered Includes comprehensive and in-depth background information written in a clear form that is accessible to both specialists and non-specialists

• Author : Heidi Fuller,Monte Gates
• Publisher : BoD – Books on Demand
• Release Date : 2016-08-17
• Total pages : 332
• ISBN : 9789535124979
• File Size : 23,9 Mb
• Total Download : 384
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Download Recovery of Motor Function Following Spinal Cord Injury in PDF, Epub, and Kindle

Restoration of motor function following spinal cord injury is a complex and challenging task. By reviewing emerging cellular, pharmacological, rehabilitative, as well as surgical approaches, this book seeks to highlight promising therapeutic strategies for the repair and regeneration of motor circuitry. The multidisciplinary nature of these approaches illustrates various routes to bridging the gap between the bench and the bedside and to identify the challenges that must be overcome in order to bring about a viable therapeutic strategy for spinal cord injury patients.