The Laboratory Rat

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• Author : Henry J. Baker,J. Russell Lindsey,Steven H. Wesibroth
• Publisher : Elsevier
• Release Date : 2013-10-02
• Total pages : 450
• ISBN : 9781483268613
• File Size : 24,5 Mb
• Total Download : 901
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Download The Laboratory Rat in PDF, Epub, and Kindle

The Laboratory Rat, Volume I: Biology and Diseases focuses on the use of rats in specific areas of research, ranging from dental research to toxicology. The first part of this book retraces the biomedical history of early events and personalities involved in the establishment of rats as a leading laboratory animal. The taxonomy, genetics and inbred strains of rats are also elaborated. The next chapters illustrate the hematology, clinical biochemistry, and anatomical and physiological features of the laboratory rat. This text concludes with a description of infectious diseases that may be contracted from laboratory and/or wild rats. This volume is a good source for commercial and institutional organizations involved in producing rats for research use, specialists in laboratory animal, animal care and research technicians, as well as students in graduate and professional curricula.

• Author : George J. Krinke
• Publisher : Elsevier
• Release Date : 2000-06-20
• Total pages : 756
• ISBN : 0080533469
• File Size : 46,6 Mb
• Total Download : 296
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Download The Laboratory Rat in PDF, Epub, and Kindle

This reference series will provide all researchers using laboratory animals with comprehensive practical information on the various species. Each title in the series is devoted to a particular species, and draws together all available data in a "one-stop", easily accessible source. Each has similar format, with sections on the strains available, their husbandry, and special diets. Also included are sections on gross anatomy, endocrinology, and reproduction, followed by more detailed sections on neuroanatomy, vasculature, cell biology, and histology of particular organs and structures, and a section on molecular biology. High quality illustrations are included throughout and a color plate section is provided. A glossary, list of equipment suppliers, and "Quick Reference Section" are added features. The "Quick Reference Section" brings together all tables from the text, allowing readers to find data swiftly. The first volume in The Handbook of Experimental Animals Series, The Laboratory Rat, provides researchers in academia and industry using laboratory animals with comprehensive, practical information on the species. The Laboratory Rat has been divided into eight sections dealing with: * Strains and their selection for research * Housing and maintenance * Pathogens and diseases * Breeding and reproduction * Anatomy * Physiology * Procedures, including experimental surgery * Emerging techniques, including genetic engineering and molecular technology Key Features * Provides a valuable, comprehensive reference source for anybody working with the laboratory rat * Formatted in a two-color, user-friendly layout * Includes high-quality illustrations throughout as well as a color plate section * Glossary * Tables in the text are also arranged into one Quick Reference Section for ease of access to the data * Appendix of equipment suppliers

• Author : Mark A. Suckow,Steven H. Weisbroth,Craig L. Franklin
• Publisher : Elsevier
• Release Date : 2005-12-20
• Total pages : 928
• ISBN : 9780080454320
• File Size : 36,7 Mb
• Total Download : 821
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Download The Laboratory Rat in PDF, Epub, and Kindle

The Laboratory Rat, Second Edition features updated information on a variety of topics including: rat genetics and genomics, both spontaneous and induced disease; state-of-the-art technology for housing and husbandry; occupational health, and experimental models. A premier source of information on the laboratory rat that will be of interest to veterinary and medical students, senior graduate, graduate students, post-docs and researchers who utilize animals in biomedical research. At least 50% new information than first edition Includes topics on rat genetics and genomics, occupational health, and experimental models The premier source of information on the laboratory rat

• Author : Robert L. Maynard,Noel Downes
• Publisher : Academic Press
• Release Date : 2019-02-08
• Total pages : 378
• ISBN : 9780128118719
• File Size : 33,7 Mb
• Total Download : 507
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Download Anatomy and Histology of the Laboratory Rat in Toxicology and Biomedical Research in PDF, Epub, and Kindle

Anatomy and Histology of the Laboratory Rat in Toxicology and Biomedical Research presents the detailed systematic anatomy of the rat, with a focus on toxicological needs. Most large works dealing with the laboratory rat provide a chapter on anatomy, but fall far short of the detailed account in this book which also focuses on the needs of toxicologists and others who use the rat as a laboratory animal. The book includes detailed guides on dissection methods and the location of specific tissues in specific organ systems. Crucially, the book includes classic illustrations from Miss H. G. Q. Rowett, along with new color photo-micrographs. Written by two of the top authors in their fields, this book can be used as a reference guide and teaching aid for students and researchers in toxicology. In addition, veterinary/medical students, researchers who utilize animals in biomedical research, and researchers in zoology, comparative anatomy, physiology and pharmacology will find this book to be a great resource. Illustrated with over 100 black and white and color images to assist understanding Contains detailed descriptions and explanations to accompany all images, thus helping with self-study Designed for toxicologic research for people from diverse backgrounds, including biochemistry, pharmacology, physiology, immunology and general biomedical sciences

• Author : Patrick Sharp,Jason S. Villano
• Publisher : CRC Press
• Release Date : 2012-12-11
• Total pages : 403
• ISBN : 9781439829868
• File Size : 11,9 Mb
• Total Download : 986
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Download The Laboratory Rat, Second Edition in PDF, Epub, and Kindle

Rats have long been recognized as a valuable biomedical research model, notably in the investigation of aging, toxicology, addiction, and common human diseases such as diabetes and hypertension. In many instances, individuals conducting such research studies are charged with important responsibilities, including animal facility management, animal husbandry, veterinary care, regulatory compliance, and various experimental methodologies. With the advent of genetic manipulations and biomedical research technological advances such as bioimaging, the versatility and usefulness of the rat as an animal model has soared. The Laboratory Rat, Second Edition captures the multiple advances in this important animal model’s husbandry, veterinary care, and experimental methodology. This edition features augmented, expanded, and novel information on biology, anesthesia, analgesia, and experimental techniques benefiting personnel working with rats—from the animal care staff to the researcher and everyone in between. The book is also extremely useful to institutional animal care and use program supporters and elements, including animal care and use committees, institutional officials, occupational health and safety professionals, veterinary technicians, and veterinarians.

• Author : Alfredo Rigalli,Veronica Di Loreto
• Publisher : CRC Press
• Release Date : 2016-04-19
• Total pages : 232
• ISBN : 9781420093278
• File Size : 52,8 Mb
• Total Download : 380
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Download Experimental Surgical Models in the Laboratory Rat in PDF, Epub, and Kindle

An All-Inclusive Guide to Surgical Techniques on RatsThe design of an adequate surgical model, like the choice of the animal model itself, is extremely important for obtaining reliable valuable data. Experimental Surgical Models in the Laboratory Rat summarizes a series of techniques that were applied in the Bone Biology Laboratories, School of Med

• Author : Ian Q. Whishaw,Bryan Kolb
• Publisher : Oxford University Press
• Release Date : 2004-09-02
• Total pages : 520
• ISBN : 9780198036845
• File Size : 45,5 Mb
• Total Download : 439
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Download The Behavior of the Laboratory Rat in PDF, Epub, and Kindle

Both seasoned and beginning investigators will be amazed at the range and complexity of rat behavior as described in the 43 chapters of this volume. The behavioral descriptions are closely tied to the laboratory methods from which they were derived, thus allowing the investigator to exploit both the behavior and the methods for their own research. It will also serve as an indispensable reference for other neuroscientists, psychologist, pharmacologists, geneticists, molecular biologists, zoologists, and their students and trainees.

• Author : National Research Council,Board on Agriculture,Committee on Animal Nutrition,Subcommittee on Laboratory Animal Nutrition
• Publisher : National Academies Press
• Release Date : 1995-02-01
• Total pages : 188
• ISBN : 9780309051262
• File Size : 52,8 Mb
• Total Download : 694
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Download Nutrient Requirements of Laboratory Animals, in PDF, Epub, and Kindle

In the years since the third edition of this indispensable reference was published, a great deal has been learned about the nutritional requirements of common laboratory species: rat, mouse, guinea pig, hamster, gerbil, and vole. The Fourth Revised Edition presents the current expert understanding of the lipid, carbohydrate, protein, mineral, vitamin, and other nutritional needs of these animals. The extensive use of tables provides easy access to a wealth of comprehensive data and resource information. The volume also provides an expanded background discussion of general dietary considerations. In addition to a more user-friendly organization, new features in this edition include: A significantly expanded section on dietary requirements for rats, reporting substantial new findings. A new section on nutrients that are not required but that may produce beneficial results. New information on growth and reproductive performance among the most commonly used strains of rats and mice and on several hamster species. An expanded discussion of diet formulation and preparationâ€"including sample diets of both purified and natural ingredients. New information on mineral deficiency and toxicity, including warning signs. This authoritative resource will be important to researchers, laboratory technicians, and manufacturers of laboratory animal feed.

• Author : John J. Bogdanske,Scott Hubbard-Van Stelle,Beth M. Schiffman,Margaret Rankin Riley
• Publisher : CRC Press
• Release Date : 2018-08-06
• Total pages : 92
• ISBN : 1138453897
• File Size : 26,7 Mb
• Total Download : 908
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Download Laboratory Rat Procedural Techniques in PDF, Epub, and Kindle

This combination manual and downloadable resources provide much-needed training on the proper handling of rats used in biomedical research. The downloadable resources include narrated video clips that demonstrate and describe each procedural technique. The manual contains handouts with color illustrations and descriptive text for each technique, including the purpose and application of the procedure, recommended skills, and necessary supplies. It can be used as a training resource and refresher for lab animal veterinarians, veterinary technicians, animal care staff, trainers, and research investigators and staff who work with rats.

• Author : Mark A. Suckow,Karla A. Stevens,Ronald P. Wilson
• Publisher : Academic Press
• Release Date : 2012-01-09
• Total pages : 1289
• ISBN : 9780123809209
• File Size : 28,7 Mb
• Total Download : 636
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Download The Laboratory Rabbit, Guinea Pig, Hamster, and Other Rodents in PDF, Epub, and Kindle

This is a single volume, comprehensive book sanctioned by the American College of Laboratory Animal Medicine (ACLAM), covering the rabbit, guinea pig, hamster, gerbil and other rodents often used in research. This well illustrated reference includes basic biology, anatomy, physiology, behavior, infectious and noninfectious diseases, husbandry and breeding, common experimental methods, and use of the species as a research model. It is a resource for advancements in the humane and responsible care of: rabbit, guinea pig, hamster, gerbil, chinchilla, deer mouse, kangaroo rat, cotton rat, sand rat, and degu Includes up-to-date, common experimental methods. Organized by species for easy access during bench research.

• Author : F. Claire Hankenson
• Publisher : CRC Press
• Release Date : 2013-10-03
• Total pages : 274
• ISBN : 9780849324994
• File Size : 16,5 Mb
• Total Download : 290
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Download Critical Care Management for Laboratory Mice and Rats in PDF, Epub, and Kindle

For critical care of laboratory rodents, there is a scarcity of sources for comprehensive, feasible, and response-oriented information on clinical interventions specific to spontaneous and induced models of disease. With the more complex cases that need critical care management, many treatment approaches to veterinary emergencies cannot be applied directly to the laboratory rodent. The first text of its kind devoted to the challenges of critical care management for laboratory rodents, Critical Care Management for Laboratory Mice and Rats provides a specialized resource for all veterinary, husbandry, technical, and research professionals who utilize rodent models for biomedical research. The book covers the varied approaches to laboratory rodent patient care, health assessments, characteristics of specific disease models, monitoring and scoring of disease parameters, and humane interventions. Giving primary consideration to preservation of animal health and welfare, the text also considers how best to balance welfare with the achievement of proposed scientific objectives. Organized into five chapters, this full-color book covers the following topics: General Approaches for Critical Care Critical Care Management for Laboratory Mice Critical Care Management for Laboratory Rats Special Considerations for Critical Care Management in Laboratory Rodents Resources and Additional Information The author provides treatment guidelines with the expectation that they will be applied with apt professional judgment, allowing for further modification of clinical recommendations for improved patient-based care and welfare for research animals.

• Author : National Research Council,Commission on Life Sciences,Institute for Laboratory Animal Research,Committee on Infectious Diseases of Mice and Rats
• Publisher : National Academies Press
• Release Date : 1991-02-01
• Total pages : 106
• ISBN : 9780309042833
• File Size : 21,9 Mb
• Total Download : 400
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Download Companion Guide to Infectious Diseases of Mice and Rats in PDF, Epub, and Kindle

This companion to Infectious Diseases of Mice and Rats makes practical information on rodent diseases readily accessible to researchers. This volume parallels the three parts of the main volume. Part I, Principles of Rodent Disease Prevention, briefly examines the requirements for maintaining pathogen-free rodents, factors in designing health surveillance programs, and other laboratory management issues. Part II, Disease Agents, is an easy-to-use reference section, listing diagnosis and control methods, the potential for interference with research, and other factors for disease agents ranging from adenoviruses to tapeworms. It covers bacteria, viruses, fungi and common ectoparasites, and endoparasites. Part III, Diagnostic Indexes, presents alphabetical listings of clinical signs, pathology, and research complications and lists infectious agents that might be responsible for each.

• Author : Elizabeth Fiona McInnes
• Publisher : Elsevier Health Sciences
• Release Date : 2011-10-24
• Total pages : 256
• ISBN : 9780702049248
• File Size : 52,7 Mb
• Total Download : 310
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Download Background Lesions in Laboratory Animals E-Book in PDF, Epub, and Kindle

Background Lesions in Laboratory Animals will be an invaluable aid to pathologists needing to recognize background and incidental lesions while examining slides taken from laboratory animals in acute and chronic toxicity studies, or while examining exotic species in a diagnostic laboratory. It gives clear descriptions and illustrations of the majority of background lesions likely to be encountered. Many of the lesions covered are unusual and can be mistaken for treatment-related findings in preclinical toxicity studies. The Atlas has been prepared with contributions from experienced toxicological pathologists who are specialists in each of the laboratory animal species covered and who have published extensively in these areas. over 600 high-definition, top-quality color photographs of background lesions found in rats, mice, dogs, minipigs, non-human primates, hamsters, guinea pigs and rabbits a separate chapter on lesions in the reproductive systems of all laboratory animals written by Dr Dianne Creasy, a world expert on testicular lesions in laboratory animals a chapter on common artifacts that may be observed in histological glass slides extensive references to each lesion described aging lesions encountered in all laboratory animal species, particularly in rats in mice which are used for carcinogenicity studies

• Author : Kelly Lambert
• Publisher : National Geographic Books
• Release Date : 2011-06-07
• Total pages : 0
• ISBN : 9780399536632
• File Size : 40,8 Mb
• Total Download : 893
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Download The Lab Rat Chronicles in PDF, Epub, and Kindle

Discover What Rodents Know About the Good Life What can the common laboratory rat tell us about being human? According to behavioral neuroscientist Kelly Lambert, a whole lot. Her twenty- five-year career conducting experiments that involve rats has led her to a surprising conclusion: Through their adaptive strategies and good habits, these unassuming little animals can teach us some essential lessons about how we, as humans, can lead successful lives. From emotional resilience and a strong work ethic to effective parenting and staying healthy, the lab rat is an unlikely but powerful role model for us all. This is a surprising and engaging guided tour into the sophisticated mental, emotional, and behavioral worlds of these frequently maligned and often misunderstood little creatures.

• Author : Andrew W. Suttie,Joel R. Leininger,Alys E. Bradley
• Publisher : Academic Press
• Release Date : 2017-12-18
• Total pages : 748
• ISBN : 9780123914897
• File Size : 40,9 Mb
• Total Download : 782
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Download Boorman's Pathology of the Rat in PDF, Epub, and Kindle

Boorman’s Pathology of the Rat: Reference and Atlas, Second Edition, continues its history as the most comprehensive pathology reference on rat strains for researchers across science and medicine using rat models in the laboratory. It offers readers an added emphasis on the Sprague-Dawley and Wistar rat strains that is consistent with current research across academia, government, and industry. In addition, the book provides standard diagnostic criteria, basic content on histology, histological changes that result from drug toxicity and neoplasm, pathology terminology, and four-color photographs from the NTP archive and database. With updated references and photographs, as well as coverage of all rat strains, this book is not only the standard in the field, but also an invaluable resource for toxicologists, biologists, and other scientists engaged in regulatory toxicology who must make the transition from pathology results to the promulgation of meaningful regulations. Contains full, four color photographs from the NTP archive and database and coverage of all rat strains Provides an organ-by-organ and system-by-system approach that presents standard diagnostic criteria and basic content on histology and histological changes Includes comprehensive and detailed background incidence data Presents detailed descriptive content regarding changes in rat models during research

• Author : National Research Council,Institute for Laboratory Animal Research,International Committee of the Institute for Laboratory Animal Research
• Publisher : National Academies Press
• Release Date : 2000-10-30
• Total pages : 166
• ISBN : 9780309171472
• File Size : 28,6 Mb
• Total Download : 909
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Download Microbial Status and Genetic Evaluation of Mice and Rats in PDF, Epub, and Kindle

US/Japan meetings on laboratory animal science have been held virtually every year since 1980 under the US/Japan Cooperative Program on Science and Technology. Over the years these meetings have resulted in a number of important documents including the Manual of Microbiologic Monitoring of Laboratory Animals published in 1994 and the article Establishment and Preservation of Reference Inbred Strains of Rats for General Purposes. In addition to these publications, the meetings have been instrumental in increasing awareness of the need for microbiologic monitoring of laboratory rodents and the need for genetic definition and monitoring of mice and rats. In cooperation with the Comparative Medicine section of NCRR/NIH, the ILAR Council and staff are pleased to become the host for this important annual meeting and look forward to participating in future meetings. The support and sponsorship of NCRR (P40 RR 11611) in the United States and the Central Institute for Experimental Animals in Japan are gratefully acknowledged. Bringing together the leading scientists in the field of laboratory animal care has resulted in increased understanding of American and Japanese approaches to laboratory animal science and should continue to strengthen efforts to harmonize approaches aimed at resolving common challenges in the use of animal models for biomedical research and testing. This effort to improve understanding and cooperation between Japan and the United States should also be useful in developing similar interaction with other regions of the world including Europe, Australia, and Southeast Asia.

• Author : National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Committee for the Update of the Guide for the Care and Use of Laboratory Animals
• Publisher : National Academies Press
• Release Date : 2011-01-27
• Total pages : 246
• ISBN : 9780309154000
• File Size : 16,7 Mb
• Total Download : 327
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Download Guide for the Care and Use of Laboratory Animals in PDF, Epub, and Kindle

A respected resource for decades, the Guide for the Care and Use of Laboratory Animals has been updated by a committee of experts, taking into consideration input from the scientific and laboratory animal communities and the public at large. The Guide incorporates new scientific information on common laboratory animals, including aquatic species, and includes extensive references. It is organized around major components of animal use: Key concepts of animal care and use. The Guide sets the framework for the humane care and use of laboratory animals. Animal care and use program. The Guide discusses the concept of a broad Program of Animal Care and Use, including roles and responsibilities of the Institutional Official, Attending Veterinarian and the Institutional Animal Care and Use Committee. Animal environment, husbandry, and management. A chapter on this topic is now divided into sections on terrestrial and aquatic animals and provides recommendations for housing and environment, husbandry, behavioral and population management, and more. Veterinary care. The Guide discusses veterinary care and the responsibilities of the Attending Veterinarian. It includes recommendations on animal procurement and transportation, preventive medicine (including animal biosecurity), and clinical care and management. The Guide addresses distress and pain recognition and relief, and issues surrounding euthanasia. Physical plant. The Guide identifies design issues, providing construction guidelines for functional areas; considerations such as drainage, vibration and noise control, and environmental monitoring; and specialized facilities for animal housing and research needs. The Guide for the Care and Use of Laboratory Animals provides a framework for the judgments required in the management of animal facilities. This updated and expanded resource of proven value will be important to scientists and researchers, veterinarians, animal care personnel, facilities managers, institutional administrators, policy makers involved in research issues, and animal welfare advocates.

• Author : Hans Hedrich
• Publisher : Academic Press
• Release Date : 2012-06-14
• Total pages : 868
• ISBN : 9780123820099
• File Size : 54,8 Mb
• Total Download : 812
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Download The Laboratory Mouse in PDF, Epub, and Kindle

The Laboratory Mouse, Second Edition is a comprehensive book written by international experts. With inclusions of the newly revised European standards on laboratory animals, this will be the most current, global authority on the care of mice in laboratory research. This well-illustrated edition offers new and updated chapters including immunology, viruses and parasites, behavior, enrichment and care standards of laboratory mice across the life sciences, medical and veterinary fields. Features four-color illustrations with complete instruction on mouse surgery, anatomy, behavior and care of the mouse in laboratory research Offers additional chapters on new mouse strains, phenotyping of strains, bacteria and parasites, and immunology Includes the newly revised EU standards on care, as well as, comparisons to standards and regulations in the US and other countries

• Author : Bryan Howard,Timo Nevalainen,Gemma Perretta
• Publisher : CRC Press
• Release Date : 2016-04-19
• Total pages : 439
• ISBN : 9781439824931
• File Size : 46,7 Mb
• Total Download : 716
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Download The COST Manual of Laboratory Animal Care and Use in PDF, Epub, and Kindle

COST (European Cooperation in the field of Scientific and Technical Research) is an intergovernmental initiative in science and research intended to promote the coordination of nationally funded research in Europe. Four working groups discuss the housing of animals, their environmental needs, refinement of procedures, genetically modified animals, and cost-benefit analysis. Based on the activities of these working groups, this book provides the European best practices for individuals and institutions working with laboratory animals. The text also discusses the ethical evaluation of experiments and procedures involving animals.

• Author : Patrick E. Sharp,Marie C. LaRegina
• Publisher : CRC-Press
• Release Date : 1998-08-01
• Total pages : 214
• ISBN : 084932565X
• File Size : 54,6 Mb
• Total Download : 111
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Download The Laboratory Rat in PDF, Epub, and Kindle

Laboratory animals, play an important role in biomedical research and advances. The humane care and management of these animals is an ongoing concern. This guide was created especially for individuals performing research with rats whose duties include animal facility management, animal husbandry, regulatory compliance, and technical procedures involved with their research. Basic information and common procedures are presented in detail.

• Author : Christopher J. Gordon
• Publisher : Cambridge University Press
• Release Date : 1993-08-27
• Total pages : 293
• ISBN : 9780521414265
• File Size : 26,5 Mb
• Total Download : 715
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Download Temperature Regulation in Laboratory Rodents in PDF, Epub, and Kindle

With the help of extensive data tables and figures, this book explains the key facets of rodent thermal physiology, including neurological control and gender and intraspecies variations. The book should therefore find use in government, academic or industrial laboratories whose researchers are working with rodents.