The Behavioral Molecular Pharmacological And Clinical Basis Of The Sleep Wake Cycle

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The Behavioral, Molecular, Pharmacological, and Clinical Basis of the Sleep-Wake Cycle

The Behavioral, Molecular, Pharmacological, and Clinical Basis of the Sleep-Wake Cycle
  • Author : Eric Murillo-Rodriguez
  • Publisher : Academic Press
  • Release Date : 2019-03-26
  • Total pages : 220
  • ISBN : 9780128167427
  • File Size : 23,9 Mb
  • Total Download : 486
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The Behavioral, Molecular, Pharmacological, and Clinical Basis of the Sleep-Wake Cycle provides the first comprehensive overview on the molecular methodologies used to evaluate sleep while also examining the cellular, biochemical, genetic, and therapeutic aspects of the sleep-wake cycle. There have been profound changes in the landscape of approaches to the study of sleep – mainly in the areas of molecular biology and molecular techniques. With this great focus on using multidisciplinary molecular methods, chapters address significant advances in the molecular mechanisms underlying sleep and the techniques researchers use to study this phenomenon. Written by world-leading experts in the area, this book is of great interest to researchers working in the sleep field and to anyone interested in one of the most mysterious phenomena in science – why we sleep and why we cannot survive without it. Reviews the neurobiological and cellular mechanisms of the sleep-wake cycle Provides the implications of sleep in health and disease Contrasts different techniques to study molecular mechanisms Contains case studies to better illustrate points Covers sleep disturbance and health problems involved in sleep Includes chapters on the ontogeny of sleep, along with multiple mechanisms for sleep generation

Serotonin and Sleep: Molecular, Functional and Clinical Aspects

Serotonin and Sleep: Molecular, Functional and Clinical Aspects
  • Author : Jaime M. Monti,S. R. Pandi-Perumal,Barry L. Jacobs,David J. Nutt
  • Publisher : Springer Science & Business Media
  • Release Date : 2008-03-04
  • Total pages : 621
  • ISBN : 9783764385613
  • File Size : 11,6 Mb
  • Total Download : 515
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This book focuses on the neuropsychopharmacology of serotonin and its role in sleep and wakefulness, presenting neurochemical, electrophysiological, and neuropharmacological approaches to understand the mechanisms of serotonin and related substances. Covering core and contemporary topics in the area, this volume is valuable for all researchers interested in interdisciplinary studies concerning drugs affecting the central nervous system.

Neuroendocrine Correlates of Sleep/Wakefulness

Neuroendocrine Correlates of Sleep/Wakefulness
  • Author : Daniel P. Cardinali,S. R. Pandi-Perumal
  • Publisher : Springer Science & Business Media
  • Release Date : 2010-03-14
  • Total pages : 627
  • ISBN : 9780387236926
  • File Size : 52,7 Mb
  • Total Download : 596
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As the title suggests, and unlike other existing books on sleep medicine, Neuroendocrine Correlates of Sleep/Wakefulness will be devoted primarily to endocrine regulation of the behavioral state control. It will address a wide spectrum of sleep./wakefulness phenomena (both animals and humans), including pathogenesis, diagnosis, and management. From molecular biology to applied clinical therapy, sleep research has been transformed in the last few years from a research backwater to an important interdisciplinary field. Anyone who regularly reads the literature on sleep, biological rhythms, or neuroendocrinology is aware that one of the subspecialties within sleep medicine, the neuroendocrine correlates of sleep/wakefulness, has in particular experienced a growth rate that is even faster than that of the field as a whole. To a significant extent this has been due to the introduction of new research technologies. The widespread adoption of a range of new methods in sleep research has opened a window into activities at the cellular and molecular level, which previously had been tightly closed. Consequently these activities are being characterized with a degree of precision and sensitivity that is without precedent. This volume invites the reader to explore the new vistas that have been opened onto the neuroendocrine frontier of sleep medicine. The editors have selectively identified a number of key articles having a citation frequency, which is considerably above the norm or which otherwise have contributed importantly to defining the neuroendocrine perspective. This new volume on Neuroendocrine Correlates of Sleep/Wakefulness is an up-to-date resource of research summaries and reviews written by major contributors to the fields of sleep, biological rhythms and neuroendocrinology. Its coverage is broad and its basic and clinical science reviews are detailed. In this volume, an international team of experts discuss their latest ideas, concepts, methods, and interpretations with supporting examples. This volume is intended for advanced students and specialists in psychobiology, neuroscience, neuroendocrinology, and psychiatry but might also be interest to anyone concerned with understanding the Neuroendocrine correlates of sleep/wakefulness. The contributions are directed more towards providing an integrated view of the field from the perspective of the authors, rather than being a compendium of recent results. The intent is to provide a reference book for recent and future workers in this and related areas of medicine and biology. Each topic in this volume has received the attention of a panel of authors who have responded to our request to review and place into perspective the major issues, which will undoubtedly confront newcomers to the field. The topics dealt with in Neuroendocrine correlates of Sleep/wakefulness are both diverse and complex. The editors hope that this volume will provide an authoritative summary of important issues in the neuroendocrine correlates of sleep/wakefulness. We also hope that it will motivate new researchers to join the quest for solutions to the problems that have been identified by our contributing authors.

Sleep Disorders and Sleep Deprivation

Sleep Disorders and Sleep Deprivation
  • Author : Institute of Medicine,Board on Health Sciences Policy,Committee on Sleep Medicine and Research
  • Publisher : National Academies Press
  • Release Date : 2006-10-13
  • Total pages : 425
  • ISBN : 9780309101110
  • File Size : 14,6 Mb
  • Total Download : 433
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Clinical practice related to sleep problems and sleep disorders has been expanding rapidly in the last few years, but scientific research is not keeping pace. Sleep apnea, insomnia, and restless legs syndrome are three examples of very common disorders for which we have little biological information. This new book cuts across a variety of medical disciplines such as neurology, pulmonology, pediatrics, internal medicine, psychiatry, psychology, otolaryngology, and nursing, as well as other medical practices with an interest in the management of sleep pathology. This area of research is not limited to very young and old patientsâ€"sleep disorders reach across all ages and ethnicities. Sleep Disorders and Sleep Deprivation presents a structured analysis that explores the following: Improving awareness among the general public and health care professionals. Increasing investment in interdisciplinary somnology and sleep medicine research training and mentoring activities. Validating and developing new and existing technologies for diagnosis and treatment. This book will be of interest to those looking to learn more about the enormous public health burden of sleep disorders and sleep deprivation and the strikingly limited capacity of the health care enterprise to identify and treat the majority of individuals suffering from sleep problems.

Global Emergency of Mental Disorders

Global Emergency of Mental Disorders
  • Author : Jahangir Moini,Justin Koenitzer,Anthony LoGalbo
  • Publisher : Academic Press
  • Release Date : 2021-05-28
  • Total pages : 500
  • ISBN : 9780323858434
  • File Size : 36,5 Mb
  • Total Download : 713
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Global Emergency of Mental Disorders is a comprehensive, yet easy-to-read overview of the neurodevelopmental basis of multiple mental disorders and their accompanying consequences, including addiction, suicide and homelessness. Compared to other references that examine the treatment of psychiatric disorders, this book uniquely focuses on their neurodevelopment. It is designed for neuroscience, psychiatry, psychology students, and various other clinical professions. With chapters on anxiety, depression, schizophrenia and others, this volume provides information about incidence, prevalence and mortality rates in addition to developmental origins. With millions worldwide affected, this book will be an invaluable resource. Explores psychiatric disorders from a neurodevelopmental perspective Covers multiple disorders, including anxiety, depression and obsessive-compulsive disorder Examines the brain mechanisms that underly disorders Addresses the opioid epidemic and suicide Reviews special patient populations by gender and age

The Orexin System. Basic Science and Role in Sleep Pathology

The Orexin System. Basic Science and Role in Sleep Pathology
  • Author : M.A. Steiner,M. Yanagisawa,M. Clozel
  • Publisher : Karger Medical and Scientific Publishers
  • Release Date : 2021-05-28
  • Total pages : 165
  • ISBN : 9783318068443
  • File Size : 53,5 Mb
  • Total Download : 738
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The orexin system, discovered in 1998, has emerged as a crucial player in regulating the sleep and wake balance inside our brain. This discovery has sparked a burst of novel and dynamic research on the physiology and pathology of sleep. The Orexin System: Basic Science and Role in Sleep Pathology honors this research and the authors share their ideas and perspectives on the novel developments within the field. The book examines the intricate role of the orexin system in regulating sleep and wake, and its interaction with other wake-regulating systems. The orexin system is dissected at the cellular and molecular level to explore the diversity of the orexin-producing neurons, their projections, and their signaling pathways. Additionally, the book discusses the diseases which are associated with a dysfunctional orexin system, such as narcolepsy, insomnia, substance abuse, and Alzheimer’s disease, and explores the new potential therapeutic applications derived from the burst of research around this fascinating system. This publication is essential reading for neurobiologists, neurologists, psychopharmacologists, sleep researchers, and other researchers and clinical scientists interested in sleep, sleep research, insomnia, and medicine in general.

Sleep and Neuropsychiatric Disorders

Sleep and Neuropsychiatric Disorders
  • Author : Ravi Gupta,David N. Neubauer,S. R. Pandi-Perumal
  • Publisher : Springer Nature
  • Release Date : 2022-02-01
  • Total pages : 833
  • ISBN : 9789811601231
  • File Size : 12,5 Mb
  • Total Download : 528
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This book explores the intricate links between sleep and neuropsychiatric diseases. In clinical settings, understanding the development, treatment, and management of neuropsychiatric diseases poses a substantial challenge. Neuropsychiatric disorders place a significant cost on society, affecting the health of people affected, care providers, and the general community. Sleep and neuropsychiatric disease are inextricably linked. Sleep disorders are widespread in these populations and are frequently overlooked in neurology and psychiatry. The book offers readers up-to-date information on different facets of the bidirectional connections between sleep and neuropsychiatric diseases. Following the initial fundamental science part, a unique series of chapters concentrate on the behavioural manifestations of sleep problems, a hitherto unexplored field. Additional chapters include patient evaluation techniques as well as public health implications of sleep disorders. The individual chapters cover all main mental and neurological diseases where a change in sleep is evident, and recent concepts in pathogenesis, presentation, evaluation, and treatment. Neuropsychotropic drugs must be seen as a double-edged sword when it comes to sleep and sleep disorders. Overall, this book is an excellent resource for learning about neuropsychiatric diseases and how they affect sleep while simultaneously being impacted by sleep.

Neuroscience and Philosophy

Neuroscience and Philosophy
  • Author : Felipe De Brigard,Walter Sinnott-Armstrong
  • Publisher : MIT Press
  • Release Date : 2022-02-01
  • Total pages : 511
  • ISBN : 9780262045438
  • File Size : 16,7 Mb
  • Total Download : 458
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Philosophers and neuroscientists address central issues in both fields, including morality, action, mental illness, consciousness, perception, and memory. Philosophers and neuroscientists grapple with the same profound questions involving consciousness, perception, behavior, and moral judgment, but only recently have the two disciplines begun to work together. This volume offers fourteen original chapters that address these issues, each written by a team that includes at least one philosopher and one neuroscientist who integrate disciplinary perspectives and reflect the latest research in both fields. Topics include morality, empathy, agency, the self, mental illness, neuroprediction, optogenetics, pain, vision, consciousness, memory, concepts, mind wandering, and the neural basis of psychological categories. The chapters first address basic issues about our social and moral lives: how we decide to act and ought to act toward each other, how we understand each other’s mental states and selves, and how we deal with pressing social problems regarding crime and mental or brain health. The following chapters consider basic issues about our mental lives: how we classify and recall what we experience, how we see and feel objects in the world, how we ponder plans and alternatives, and how our brains make us conscious and create specific mental states.

Brain Architecture : Understanding the Basic Plan

Brain Architecture : Understanding the Basic Plan
  • Author : and Director NIBS Neuroscience Program University of Southern California Larry W. Swanson Milo Don and Lucille Appleman Professor of Biological Sciences
  • Publisher : Oxford University Press, USA
  • Release Date : 2002-10-23
  • Total pages : 283
  • ISBN : 9780198026464
  • File Size : 49,6 Mb
  • Total Download : 497
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Depending on your point of view the brain is an organ, a machine, a biological computer, or simply the most important component of the nervous system. How does it work as a whole? What are its major parts and how are they interconnected to generate thinking, feelings, and behavior? This book surveys 2,500 years of scientific thinking about these profoundly important questions from the perspective of fundamental architectural principles, and then proposes a new model for the basic plan of neural systems organization based on an explosion of structural data emerging from the neuroanatomy revolution of the 1970's. The importance of a balance between theoretical and experimental morphology is stressed throughout the book. Great advances in understanding the brain's basic plan have come especially from two traditional lines of biological thought-- evolution and embryology, because each begins with the simple and progresses to the more complex. Understanding the organization of brain circuits, which contain thousands of links or pathways, is much more difficult. It is argued here that a four-system network model can explain the structure-function organization of the brain. Possible relationships between neural networks and gene networks revealed by the human genome project are explored in the final chapter. The book is written in clear and sparkling prose, and it is profusely illustrated. It is designed to be read by anyone with an interest in the basic organization of the brain, from neuroscience to philosophy to computer science to molecular biology. It is suitable for use in neuroscience core courses because it presents basic principles of the structure of the nervous system in a systematic way.

The Pharmacology of Sleep

The Pharmacology of Sleep
  • Author : Anthony Kales
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-06
  • Total pages : 583
  • ISBN : 9783642578366
  • File Size : 40,8 Mb
  • Total Download : 275
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A review of the current state of the clinical and basic science of the pharmacology of sleep. The information provided ranges from a historical perspective to current concepts of sleep mechanisms, including the interaction between pharmacology and sleep-wake regulation and between chronopahrmacology and sleep-wake rhythms. For the first time in one single volume, both the basic mechanisms of sleep, and the basic and clinical aspects of the pharmacology of sleep are dealt with in a thorough, comprehensive and authoritative manner. The chapters, written by the foremost scientific authorities in this field, integrate the latest information on the basic mechanisms of drugs as they relate to their effects on sleep.

Fundamentals of Sleep Technology

Fundamentals of Sleep Technology
  • Author : Teofilo Lee-Chiong, M.D.
  • Publisher : Lippincott Williams & Wilkins
  • Release Date : 2012-06-01
  • Total pages : 681
  • ISBN : 9781451132038
  • File Size : 38,8 Mb
  • Total Download : 689
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Fundamentals of Sleep Technology provides a thorough understanding of the use of polysomnography and other technologies in the evaluation and management of sleep disorders. Coverage includes in-depth reviews of the neurophysiology and cardiopulmonary aspects of sleep, along with the pathophysiology of sleep disorders. Detailed sections on polysomnography include recording procedures, identifying and scoring sleep stages and sleep-related events, and report generation. Chapters discuss therapeutic interventions including positive airway pressure, supplemental oxygen, surgical and pharmacologic treatments, and patient education. A section focuses on pediatric sleep disorders and polysomnography. Also included are chapters on establishing and managing a sleep center and accrediting a sleep program. Fundamentals of Sleep Technology is endorsed by American Association of Sleep Technologists (AAST). AAST committees oversaw the development of this book, defining the table of contents, recruiting the Editors, and providing most of the contributors.

Anesthetic Pharmacology

Anesthetic Pharmacology
  • Author : Alex S. Evers,Mervyn Maze,Evan D. Kharasch
  • Publisher : Cambridge University Press
  • Release Date : 2011-03-10
  • Total pages : 229
  • ISBN : 9781139497022
  • File Size : 40,6 Mb
  • Total Download : 152
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In recent years our understanding of molecular mechanisms of drug action and interindividual variability in drug response has grown enormously. Meanwhile, the practice of anesthesiology has expanded to the preoperative environment and numerous locations outside the OR. Anesthetic Pharmacology: Basic Principles and Clinical Practice, 2nd edition, is an outstanding therapeutic resource in anesthesia and critical care: Section 1 introduces the principles of drug action, Section 2 presents the molecular, cellular and integrated physiology of the target organ/functional system and Section 3 reviews the pharmacology and toxicology of anesthetic drugs. The new Section 4, Therapeutics of Clinical Practice, provides integrated and comparative pharmacology and the practical application of drugs in daily clinical practice. Edited by three highly acclaimed academic anesthetic pharmacologists, with contributions from an international team of experts, and illustrated in full colour, this is a sophisticated, user-friendly resource for all practitioners providing care in the perioperative period.

The Oxford Handbook of Sleep and Sleep Disorders

The Oxford Handbook of Sleep and Sleep Disorders
  • Author : Charles M. Morin,Colin A. Espie
  • Publisher : OUP USA
  • Release Date : 2012-03
  • Total pages : 913
  • ISBN : 9780195376203
  • File Size : 18,7 Mb
  • Total Download : 797
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A great deal of progress has been made in the characterization assessment and treatment of sleep disorders in recent years. Detailing the functions of sleep and its effect on cognition and development, this book offers a comprehensive, practical approach to the evaluation and treatment of patients with sleep disorders.

Hypothalamus in Health and Diseases

Hypothalamus in Health and Diseases
  • Author : Stavros Baloyannis,Jan Gordeladze
  • Publisher : BoD – Books on Demand
  • Release Date : 2018-12-05
  • Total pages : 144
  • ISBN : 9781789844443
  • File Size : 34,5 Mb
  • Total Download : 924
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The human hypothalamus, a small structure at the base of the brain, has strategic importance for the harmonic function of the human body. It controls the autonomic nervous system, neuroendocrine function, circadian and circannual rhythms, somatic activities, and behavior, and is situated at the borders between the brain and the body and the brain and the soul, meeting points for mind and body. The hypothalamus is involved in a wide range of higher mental functions, including attention, learning and reinforcement of mnemonic processes, emotional control, mood stability, and cognitive-emotional interactions. It also has a role to play in behavioral disorders, panic reactions, cluster headache, gelastic epilepsy, mental deficiency, periodic disorders, depression, autism, and schizophrenia, and in a substantial number of neurodegenerative diseases. It enlarges greatly the dimensions of the hypothalamic contribution in controlling psychosomatic equilibrium and retaining internal unity of the human existence.

Hypocretins

Hypocretins
  • Author : Luis De Lecea,J. Gregor Sutcliffe
  • Publisher : Springer Science & Business Media
  • Release Date : 2007-04-25
  • Total pages : 441
  • ISBN : 9780387254463
  • File Size : 25,6 Mb
  • Total Download : 242
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The first report that rapid eye movements occur in sleep in humans was published in 1953. The research journey from this point to the realization that sleep consists of two entirely independent states of being (eventually labeled REM sleep and non-REM sleep) was convoluted, but by 1960 the fundamental duality of sleep was well established including the description of REM sleep in cats associated with “wide awake” EEG patterns and EMG suppression. The first report linking REM sleep to a pathology occurred in 1961 and a clear association of sleep onset REM periods, cataplexy, hypnagogic hallucinations and sleep paralysis was fully established by 1966. When a naïve individual happens to observe a full-blown cataplexy attack, it is both dramatic and unnerving. Usually the observer assumes that the loss of muscle tone represents syncope or seizure. In order to educate health professionals and the general public, Christian Guilleminault and I made movies of full-blown cataplectic episodes (not an easy task). We showed these movies of cataplexy attacks to a number of professional audiences, and were eventually rewarded with the report of a similar abrupt loss of muscle tone in a dog. We were able to bring the dog to Stanford University and with this as the trigger, we were able to develop the Stanford Canine Narcolepsy Colony. Breeding studies revealed the genetic determinants of canine narcolepsy, an autosomal recessive gene we termed canarc1. Emmanuel Mignot took over the colony in 1986 and began sequencing DNA, finally isolating canarc1 in 1999.

Behavioral Pharmacology

Behavioral Pharmacology
  • Author : Juan Francisco Rodríguez-Landa,Jonathan Cueto-Escobedo
  • Publisher : BoD – Books on Demand
  • Release Date : 2020-10-14
  • Total pages : 170
  • ISBN : 9781789856798
  • File Size : 43,8 Mb
  • Total Download : 687
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Behavioral pharmacology studies the biological bases of behavior and the pharmacological effects of natural or synthetic drugs through behavioral analysis, with the identification of substances that could contribute to improvement of the quality of life for humans. Through behavioral pharmacology, it is possible to generate knowledge about pharmacological bases that influence the normal or altered behavior from a multidisciplinary point of view, and which includes diverse areas of science. The purpose of this book “Behavioral Pharmacology- From Basic to Clinical Research” is to show some of the advances in the identification of pharmacological properties of natural and synthetic molecules that may be used in the development of pharmacological therapies destined for the treatment of illness and disorders that affect the wellness of humans.

Circadian Rhythm Sleep-Wake Disorders

Circadian Rhythm Sleep-Wake Disorders
  • Author : R. Robert Auger
  • Publisher : Springer Nature
  • Release Date : 2020-05-26
  • Total pages : 247
  • ISBN : 9783030438036
  • File Size : 17,9 Mb
  • Total Download : 831
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This book resolves to bridge the communication gap between research and clinical practice for circadian rhythm sleep-wake disorders. Beginning with a scientific background on biological timekeeping, opening chapters describe the crucial nature of maintaining delicate temporal organization of physiological and molecular events within the body. Following this are discussions on circadian physiology and methods of circadian assessments. Subsequent chapters then relay comprehensive information regarding the International Classification of Sleep Disorders-defined circadian rhythm sleep-wake disorders (CRSWDs), specifically discussing etiology and epidemiology, but focusing on evidence-based treatment data. Concluding discussions provide guidance for the application of light therapy and discuss future roles for optimized lighting environments. Nuanced and market-demanded, Circadian Rhythm Sleep-Wake Disorders: An Evidence-Based Guide for Clinicians and Investigators is an invaluable resource for Sleep Medicine clinicians, circadian researchers, and other interested parties.

Neurochemistry of Sleep and Wakefulness

Neurochemistry of Sleep and Wakefulness
  • Author : Jaime Monti,S. R. Pandi-Perumal,Christopher M. Sinton
  • Publisher : Cambridge University Press
  • Release Date : 2008-01-17
  • Total pages : 229
  • ISBN : 9781139467896
  • File Size : 29,5 Mb
  • Total Download : 195
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Pharmacological approaches to our understanding of sleep have been at the forefront of sleep research for many years. Traditional techniques have included the use of pharmacological agonists and antagonists, as well as transmitter-specific lesions. These have been enhanced by the introduction of molecular genetics and the use of transgenes and targeted gene deletion. Neurochemistry of Sleep and Wakefulness is an exceptional, single source of information on the role of the major mammalian neurotransmitter systems involved in the regulation of sleep and waking. With contributions from internationally recognized experts, this book clearly describes how researchers have made use of the myriad techniques in their armamentarium to characterize the role of a given neurotransmitter in the regulation of sleep and waking. Suitable for experimental and clinical pharmacologists, the book will have wider appeal to sleep researchers, psychiatrists and any professional interested in the interdisciplinary areas of neurobiology and pharmacology.

Foundations of Psychiatric Sleep Medicine

Foundations of Psychiatric Sleep Medicine
  • Author : John W. Winkelman,David T. Plante
  • Publisher : Cambridge University Press
  • Release Date : 2010-12-23
  • Total pages : 229
  • ISBN : 9781139494342
  • File Size : 45,9 Mb
  • Total Download : 543
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Sleep-related complaints are extremely common across the spectrum of psychiatric illness. Accurate diagnosis and management of sleep disturbances requires an understanding of the neurobiological mechanisms underlying sleep and wakefulness, the characteristics of sleep disturbance inherent to psychiatric illness and primary sleep disorders, as well as the psychopharmacologic and behavioral treatments available. Foundations of Psychiatric Sleep Medicine provides a uniquely accessible, practical, and expert summary of current clinical concepts at the sleep-psychiatry interface. Topics covered include: basic principles in sleep science, clinical sleep history taking, primary sleep disorders in psychiatric contexts, and sleep disturbance across a range of mood, anxiety, psychotic, substance use, cognitive and developmental disorders. Written by outstanding experts in the field of sleep medicine and psychiatry, this academically rigorous and clinically useful text is an essential resource for psychiatrists, psychologists and other health professionals interested in the relationship between sleep and mental illness.

Sleep-Wake Neurobiology and Pharmacology

Sleep-Wake Neurobiology and Pharmacology
  • Author : Hans-Peter Landolt,Derk-Jan Dijk
  • Publisher : Springer Nature
  • Release Date : 2019-09-03
  • Total pages : 481
  • ISBN : 9783030112721
  • File Size : 31,8 Mb
  • Total Download : 379
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This volume connects current ideas and concepts about sleep functions and circadian rhythms with the search for novel target-selective sleep-wake therapeutics. To do so, it provides a timely, state-of-the-art overview of sleep-wake mechanisms in health and disease, ongoing developments in drug discovery, and their prospects for the clinical treatment of sleep-disordered patients. It particularly focuses on the concept that sleep and wakefulness mutually affect each other, and the future therapeutic interventions with either sleep- or wake-promoting agents that are expected to not only improve the quality of sleep but also the waking behavior, cognition, mood and other sleep-associated physiological functions. The chapter 'Sleep Physiology, Circadian Rhythms, Waking Performance and the Development of Sleep-Wake Therapeutics' available open access under a CC BY 4.0 license at link.springer.com

Sleep and Wakefulness

Sleep and Wakefulness
  • Author : Nathaniel Kleitman
  • Publisher : University of Chicago Press
  • Release Date : 1987-09-15
  • Total pages : 566
  • ISBN : 0226440737
  • File Size : 42,5 Mb
  • Total Download : 524
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For half a century, Sleep and Wakefulness has been a valuable reference work. It discusses phases of the sleep cycle, experimental work on sleep and wakefulness, sleep disorders and their treatment, and such sleep-like states as hypnosis and hibernation.