Structural Biology Of Amyloid Fibrils

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• Author : Vijay Kumar,Oxana V. Galzitskaya
• Publisher : Academic Press
• Release Date : 2023-09-01
• Total pages : 0
• ISBN : 0323956386
• File Size : 14,6 Mb
• Total Download : 948
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Download Structural Biology of Amyloid Fibrils in PDF, Epub, and Kindle

Structural Biology of Amyloid Fibrils is a comprehensive reference on the structure of protein aggregates in different neurodegenerative diseases and their molecular bases. Chapters describe these structures in detail, highlighting their similarities and differences across different disease states, alongside an unprecedented overview of current developments and new hypotheses emerging in amyloid fibril structure, stability, and mechanisms of formation. This volume also discusses how amyloid structure may affect the ability of fibrils to spread to different sites in a prion-like manner, as well as their role in disease. Featuring chapters on NMR, X-ray crystallography, and Cryo-EM methods, and discussing the structure of amyloid fibrils obtained directly from patients, the book allows readers to understand how polymorphism is associated with disease phenotype and how fibril structure affects and influences the cellular environment. Understanding the molecular architecture of amyloid fibrils and oligomers will be an important step towards developing therapeutic interventions based on targeting the fibrils and oligomers themselves, or the processes that generate them.

• Author : Daniel Erik Otzen
• Publisher : John Wiley & Sons
• Release Date : 2013-06-04
• Total pages : 464
• ISBN : 9783527654208
• File Size : 20,9 Mb
• Total Download : 520
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Download Amyloid Fibrils and Prefibrillar Aggregates in PDF, Epub, and Kindle

Summing up almost a decade of biomedical research, this topical and eagerly awaited handbook is the first reference on the topic to incorporate recent breakthroughs in amyloid research. The first part covers the structural biology of amyloid fibrils and pre-fibrillar assemblies, including a description of current models for amyloid formation. The second part looks at the diagnosis and biomedical study of amyloid in humans and in animal models, while the final section discusses pharmacological approaches to manipulating amyloid and also looks at its physiological roles in lower and higher organisms. For Biochemists, Molecular Biologists, Neurobiologists, Neurophysiologists and those working in the Pharmaceutical Industry.

• Author : Anonim
• Publisher : Academic Press
• Release Date : 2011-08-13
• Total pages : 216
• ISBN : 9780123864840
• File Size : 17,8 Mb
• Total Download : 694
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Download Advances in Protein Chemistry and Structural Biology in PDF, Epub, and Kindle

Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology serial has been a continuous, essential resource for protein chemists. Covering reviews of methodology and research in all aspects of protein chemistry, including purification/expression, proteomics, modeling and structural determination and design, each volume brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics. This volume features articles on Protein Aggregation. Covers reviews of methodology and research in all aspects of protein chemistry Brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics

• Author : Jiapu Zhang
• Publisher : Springer
• Release Date : 2015-09-14
• Total pages : 355
• ISBN : 9789401773188
• File Size : 43,6 Mb
• Total Download : 580
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Download Molecular Structures and Structural Dynamics of Prion Proteins and Prions in PDF, Epub, and Kindle

This monograph is the first easy-to-read-and-understand book on prion proteins' molecular dynamics (MD) simulations and on prions' molecular modelling (MM) constructions. It enables researchers to see what is crucial to the conformational change from normal cellular prion protein (PrPC) to diseased infectious prions (PrPSc), using MD and MM techniques. As we all know, prion diseases, caused by the body's own proteins, are invariably fatal and highly infectious neurodegenerative diseases effecting humans and almost all animals for a major public health concern. Prion contains no nucleic acids and it is a misshapen or conformation-changed protein that acts like an infectious agent; thus prion diseases are called “protein structural conformational” diseases. PrPC is predominant in α-helices but PrPSc are rich in β-sheets in the form as amyloid fibrils; so very amenable to be studied by MD techniques. Through MD, studies on the protein structures and the structural conversion are very important for revealing secrets of prion diseases and for structure-based drug design or discovery. Rabbits, dogs, horses and buffaloes are reported to be the few low susceptibility species to prion diseases; this book's MD studies on these species are clearly helpful to understand the mechanism underlying the resistance to prion diseases. PrP(1-120) usually has no clear molecular structures; this book also studies this unstructured region through MD and especially MM techniques from the global optimization point of view. This book is ideal for practitioners in computing of biophysics, biochemistry, biomedicine, bioinformatics, cheminformatics, materials science and engineering, applied mathematics and theoretical physics, information technology, operations research, biostatistics, etc. As an accessible introduction to these fields, this book is also ideal as a teaching material for students.

• Author : Anonim
• Publisher : Elsevier
• Release Date : 2006-10-06
• Total pages : 416
• ISBN : 9780080468976
• File Size : 40,8 Mb
• Total Download : 391
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Download Amyloid, Prions, and Other Protein Aggregates in PDF, Epub, and Kindle

The ability of polypeptides to form alternatively folded, polymeric structures such as amyloids and related aggregates is being increasingly recognized as a major new frontier in protein research. This new volume of Methods in Enzymology along with Part B (volume 412) on Amyloid, Prions and other Protein Aggregates continue in the tradition of the first volume (309) in containing detailed protocols and methodological insights, provided by leaders in the field, into the latest methods for investigating the structures, mechanisms of formation, and biological activities of this important class of protein assemblies. Presents detailed protocols Includes troubleshooting tips Provides coverage on structural biology, computational methods, and biology

• Author : Alexander McPherson
• Publisher : Academic Press
• Release Date : 2010-09-09
• Total pages : 240
• ISBN : 0123819636
• File Size : 23,6 Mb
• Total Download : 325
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Download Advances in Protein Chemistry and Structural Biology in PDF, Epub, and Kindle

Structural genomics is the systematic determination of 3-D structures of proteins representative of the range of protein structure and function found in nature. The goal is to build a body of structural information that will predict the structure and potential function for almost any protein from knowledge of its coding sequence. This is essential information for understanding the functioning of the human proteome, the ensemble of tens of thousands of proteins specified by the human genome. While most structural biologists pursue structures of individual proteins or protein groups, specialists in structural genomics pursue structures of proteins on a genome wide scale. This implies large-scale cloning, expression and purification. One main advantage of this approach is economy of scale. Examines the three dimensional structure of all proteins of a given organism, by experimental methods such as X-ray crystallography and NMR spectroscopy Looks at structural genomics as a foundation of drug discovery as discovering new medicines is becoming more challenging and the pharmaceutical industry is looking to new technologies to help in this mission

• Author : Rossen Donev
• Publisher : Academic Press
• Release Date : 2020-01-17
• Total pages : 450
• ISBN : 9780128177501
• File Size : 21,6 Mb
• Total Download : 589
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Download Protein Misfolding in PDF, Epub, and Kindle

Protein Misfolding, Volume 118, covers the wide spectrum of diseases and disorders that are attributed to protein misfolding, including degenerative and neurodegenerative, cardiovascular, renal, glaucoma, cancer, cystic fibrosis, Gaucher's disease, and many others. Specific chapters cover Mass spectrometric approaches for profiling protein folding and stability, Biomembranes, a key player in protein misfolding, how Genetic and environmental factors interact to disrupt proteostasis and trigger protein misfolding diseases, Formation of oligomers and large amorphous aggregates by intrinsically disordered proteins, Protein misfolding in ER stress with applications to cardiovascular and renal disease, and much more. Integrates methods for studying protein misfolding, factors that trigger this process and its role in a wide spectrum of diseases and disorders Contains timely chapters written by well-renowned authorities in their field Provides data that is well supported by a number of high quality illustrations, figures and tables, and targets a very wide audience of specialists, researchers and students

• Author : John M. Squire,David A.D. Parry,Andrey Kajava
• Publisher : Elsevier
• Release Date : 2006-12-12
• Total pages : 328
• ISBN : 9780080468952
• File Size : 29,8 Mb
• Total Download : 165
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Download Fibrous Proteins: Amyloids, Prions and Beta Proteins in PDF, Epub, and Kindle

Amyloids, Prions and Beta Proteins is the last volume of the three-part thematic series on Fibrous Proteins in the Advances in Protein Chemistry serial. Fibrous proteins act as molecular scaffolds in cells providing the supporting structures of our skeletons, bones, tendons, cartilage, and skin. They define the mechanical properties of our internal hollow organs such as the intestines, heart, and blood vessels. This volume covers such topics as Beta-Structures in Fibrous Proteins; B-Silks: Enhancing and Controlling Aggregation; Beta-Rolls, Beta-Helices and Other Beta-Solenoid Proteins; Natural Triple B-Stranded Fibrous Folds; Structure, Function and Amyloidogenesis of Fungal Prions: Filament Polymorphism and Prion Variants; X-Ray Fiber and powder Diffraction of PRP Prion Peptides; From the Polymorphism of Amyloid Fibrils to Their Assembly Mechanism and Cytotoxicity; Structural Models of Amyloid-like Fibrils.

• Author : Anonim
• Publisher : Elsevier
• Release Date : 2006-10-06
• Total pages : 430
• ISBN : 0080522548
• File Size : 20,5 Mb
• Total Download : 365
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Download Amyloid, Prions, and Other Protein Aggregates in PDF, Epub, and Kindle

The ability of polypeptides to form alternatively folded, polymeric structures such as amyloids and related aggregates is being increasingly recognized as a major new frontier in protein research. This new volume of Methods in Enzymology along with Part C (volume 413) on Amyloid, Prions and other Protein Aggregates continue in the tradition of the first volume (309) in containing detailed protocols and methodological insights, provided by leaders in the field, into the latest methods for investigating the structures, mechanisms of formation, and biological activities of this important class of protein assemblies. Presents detailed protocols Includes troubleshooting tips Provides coverage on structural biology, computational methods, and biology

• Author : Annalisa Pastore,Caterina Alfano,Piero Andrea Temussi
• Publisher : Frontiers Media SA
• Release Date : 2022-11-15
• Total pages : 126
• ISBN : 9782832505717
• File Size : 48,7 Mb
• Total Download : 859
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Download Insights in Structural Biology: 2021 in PDF, Epub, and Kindle

PDF book entitled Insights in Structural Biology: 2021 written by Annalisa Pastore,Caterina Alfano,Piero Andrea Temussi and published by Frontiers Media SA which was released on 2022-11-15 with total hardcover pages 126, the book become popular and critical acclaim.

• Author : Judit Ovádi,Ferenc Orosz
• Publisher : Springer Science & Business Media
• Release Date : 2008-12-21
• Total pages : 278
• ISBN : 9781402094347
• File Size : 25,5 Mb
• Total Download : 817
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Download Protein folding and misfolding: neurodegenerative diseases in PDF, Epub, and Kindle

Offering all the latest in the study of neurodegenerative diseases, this book reviews the molecular events initiated by unfolded or misfolded proteins leading to conformational human diseases, especially those found in Parkinson’s and Alzheimer’s diseases.

• Author : A. Aggeli,N. Boden,Zhang Shuguang
• Publisher : Springer Science & Business Media
• Release Date : 2007-05-08
• Total pages : 364
• ISBN : 9780306468902
• File Size : 32,8 Mb
• Total Download : 278
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Download Self-Assembling Peptide Systems in Biology, Medicine and Engineering in PDF, Epub, and Kindle

One ofthe major drivers in biological research is the establishment ofstructures and functions of the 50,000 or so proteins in our bodies. Each has a characteristic- dimensional structure, highly "ordered" yet "disordered"! This structure is essential for a protein's function and, significantly, it must be sustained in the competitive and complex environment of the living cell. It is now being recognised that when a cell loses control, proteins can se- assemble into more complex supermolecular structures such as the amyloid fibres and plaques associated with the pathogenesis of prion (CJD) or age-related (Alzheimer's) diseases. This is a pointer to the wider significance of the self-assembling properties of polypeptides. It has been long known that, in silk, polypeptides are assembled into- sheet structures which impart on the material its highly exploitable properties of flexibility combined with high tensile strength. But only now emerging is the recognition that peptides can Self-assemble into a wide variety of non-protein-like structures, including fibrils, fibres, tubules, sheets and monolayers. These are exciting observations and, more so, the potential for materials and medical exploitations is so wide ranging that over 80 scientists from Europe, USA, Japan and Israel. met 1-6 July 1999 in Crete, to discuss the wide-ranging implications of these novel developments. There was a spirit of excitement about the workshop indicative of an important new endeavor. The emerging perception is that of a new class of materials set to become commercially viable early in the 21st century.

• Author : Vladimir N. Uversky,Anthony Fink
• Publisher : Springer Science & Business Media
• Release Date : 2007-11-24
• Total pages : 419
• ISBN : 9780387259192
• File Size : 16,9 Mb
• Total Download : 506
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Download Protein Misfolding, Aggregation and Conformational Diseases in PDF, Epub, and Kindle

Research indicates that most neurodegenerative diseases, systemic amyloidoses and many others, arise from the misfolding and aggregation of an underlying protein. This is the first book to discuss significant achievements in protein structure-function relationships in biochemistry, molecular biology and molecular medicine. The authors summarize recent progress in the understanding of the relationships between protein misfolding, aggregation and development of protein deposition disorders.

• Author : Alasdair C. Steven,Wolfgang Baumeister,Louise N. Johnson,Richard N. Perham
• Publisher : Garland Science
• Release Date : 2016-02-18
• Total pages : 888
• ISBN : 9781134982820
• File Size : 45,7 Mb
• Total Download : 662
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Download Molecular Biology of Assemblies and Machines in PDF, Epub, and Kindle

Molecular Biology of Assemblies and Machines presents a comprehensive narrative describing the structures of macromolecular complexes and how they assemble and interact. Richly illustrated, it is written for advanced undergraduates, graduate students, and researchers in biochemistry, structural biology, molecular biology, biophysics, cell biology, and microbiology, and will also appeal to those in chemistry, immunology, and medicine. Essentially all major biological activities are performed by assemblies of macromolecules (proteins, RNA, and DNA) acting in concert. These assemblies are dynamic and many are endowed with machine-like properties. This unique book explores the molecular mechanisms employed at the critical level between individual macromolecules and cells and organelles.

• Author : Olga Gursky
• Publisher : Springer
• Release Date : 2015-07-06
• Total pages : 260
• ISBN : 9783319173443
• File Size : 32,9 Mb
• Total Download : 237
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Download Lipids in Protein Misfolding in PDF, Epub, and Kindle

​Protein conversion from a water-soluble native conformation to the insoluble aggregates and fibrils, which can deposit in amyloid plaques, underlies more than 20 human diseases, representing a major public health problem and a scientific challenge. Such a conversion is called protein misfolding. Protein misfolding can also involve errors in the topology of the folded proteins and their assembly in lipid membranes. Lipids are found in nearly all amyloid deposits in vivo, and can critically influence protein misfolding in vitro and in vivo in many different ways. This book focuses on recent advances in our understanding of the role of lipids in modulating the misfolding of various proteins. The main emphasis is on the basic biophysical studies that address molecular basis of protein misfolding and amyloid formation, and the role of lipids in this complex process.

• Author : Cláudio M. Gomes,Patrícia F.N. Faísca
• Publisher : Springer
• Release Date : 2019-02-25
• Total pages : 63
• ISBN : 9783319008820
• File Size : 49,9 Mb
• Total Download : 909
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Download Protein Folding in PDF, Epub, and Kindle

This snapshot volume is designed to provide a smooth entry into the field of protein folding. Presented in a concise manner, each section introduces key concepts while providing a brief overview of the relevant literature. Outlook subsections will pinpoint specific aspects related to emerging methodologies, concepts and trends.

• Author : Yee-Foong Mok
• Publisher : Unknown
• Release Date : 2007
• Total pages : 366
• ISBN : OCLC:271368190
• File Size : 12,6 Mb
• Total Download : 587
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Download Structure and Self-assembly of Human Apolipoprotein C-II Amyloid Fibrils in PDF, Epub, and Kindle

PDF book entitled Structure and Self-assembly of Human Apolipoprotein C-II Amyloid Fibrils written by Yee-Foong Mok and published by Unknown which was released on 2007 with total hardcover pages 366, the book become popular and critical acclaim.

• Author : Claire Louisa Tinker-Mill
• Publisher : Springer
• Release Date : 2016-07-05
• Total pages : 149
• ISBN : 9783319395340
• File Size : 17,9 Mb
• Total Download : 904
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Download Nanoscale Imaging and Characterisation of Amyloid-β in PDF, Epub, and Kindle

This thesis presents a method for reliably and robustly producing samples of amyloid-β (Aβ) by capturing them at various stages of aggregation, as well as the results of subsequent imaging with various atomic force microscopy (AFM) methods, all of which add value to the data gathered by collecting information on the peptide’s nanomechanical, elastic, thermal or spectroscopical properties. Amyloid-β (Aβ) undergoes a hierarchy of aggregation following a structural transition, making it an ideal subject of study using scanning probe microscopy (SPM), dynamic light scattering (DLS) and other physical techniques. By imaging samples of Aβ with Ultrasonic Force Microscopy, a detailed substructure to the morphology is revealed, which correlates well with the most advanced cryo-EM work. Early stage work in the area of thermal and spectroscopical AFM is also presented, and indicates the promise these techniques may hold for imaging sensitive and complex biological materials. This thesis demonstrates that physical techniques can be highly complementary when studying the aggregation of amyloid peptides, and allow the detection of subtle differences in their aggregation processes.

• Author : Kevin Downard
• Publisher : John Wiley & Sons
• Release Date : 2007-08-24
• Total pages : 220
• ISBN : 047014632X
• File Size : 12,7 Mb
• Total Download : 554
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Download Mass Spectrometry of Protein Interactions in PDF, Epub, and Kindle

The authoritative guide to analyzing protein interactions by mass spectrometry Mass spectrometry (MS) is playing an increasingly important role in the study of protein interactions. Mass Spectrometry of Protein Interactionspresents timely and definitive discussions of the diverse range of approaches for studying protein interactions by mass spectrometry with an extensive set of references to the primary literature. Each chapter is written by authors or teams of authors who are international authorities in their fields. This leading reference text: * Discusses the direct detection of protein interactions through electrospray ionization (ESI-MS); ion mobility analysis; and matrix-assisted laser desorption/ionization (MALDI-MS) * Covers the indirect analysis of protein interactions through hydrogen-deuterium exchange (HX-MS); limited proteolysis; cross-linking; and radial probe (RP-MS) * Guides researchers in the use of mass spectrometry in structural biology, biochemistry, and protein science to map and define the huge number and diversity of protein interactions * Reviews the latest discoveries and applications and addresses new and ongoing challenges This is a comprehensive reference for researchers in academia and industry engaged in studies of protein interactions and an excellent text for graduate and postgraduate students.

• Author : Suzi Jarvis,Anika Mostaert
• Publisher : CRC Press
• Release Date : 2012-08-23
• Total pages : 200
• ISBN : 9789814267403
• File Size : 34,5 Mb
• Total Download : 578
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Download The Functional Fold in PDF, Epub, and Kindle

Bringing together a wide variety of examples of functional amyloid in a single volume, this book explores the importance of amyloid fibrils in fungi, bacteria, algae, invertebrate, and vertebrate animals for providing environmental protection, structural integrity, and regulating biochemical processes. It highlights many of the extraordinary examples of functional amyloid found to date. It provides an exciting perspective for the study of amyloid deposits as important and useful protein structures widespread in nature.

• Author : Anonim
• Publisher : ScholarlyEditions
• Release Date : 2013-06-21
• Total pages : 200
• ISBN : 9781481679626
• File Size : 13,8 Mb
• Total Download : 286
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Download Proteins—Advances in Research and Application: 2013 Edition in PDF, Epub, and Kindle

Proteins—Advances in Research and Application: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about ZZZAdditional Research in a concise format. The editors have built Proteins—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Proteins—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.