Slas Discovery

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• Author : Marcello Maresca,Sumit Deswal
• Publisher : John Wiley & Sons
• Release Date : 2022-03-15
• Total pages : 352
• ISBN : 9781119671398
• File Size : 24,7 Mb
• Total Download : 253
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Download Genome Editing in Drug Discovery in PDF, Epub, and Kindle

GENOME EDITING IN DRUG DISCOVERY A practical guide for researchers and professionals applying genome editing techniques to drug discovery In Genome Editing in Drug Discovery, a team of distinguished biologists delivers a comprehensive exploration of genome editing in the drug discovery process, with coverage of the technology’s history, current issues and techniques, and future perspectives and research directions. The book discusses techniques for disease modeling, target identification with CRISPR, safety studies, therapeutic editing, and intellectual property issues. The safety and efficacy of drugs and new target discovery, as well as next-generation therapeutics are also presented. Offering practical suggestions for practitioners and academicians involved in drug discovery, Genome Editing in Drug Discovery is a fulsome treatment of a technology that has become part of nearly every early step in the drug discovery pipeline. Selected contributions also include: A thorough introduction to the applications of CRISPRi and CRISPRa in drug discovery Comprehensive explorations of genome-editing applications in stem cell engineering and regenerative medicine Practical discussions of the safety aspects of genome editing with respect to immunogenicity and the specificity of CRISPR-Cas9 gene editing In-depth examinations of critical socio-economic and bioethical challenges in the CRISPR-Cas9 patent landscape Perfect for academic researchers and professionals in the biotech and pharmaceutical industries, Genome Editing in Drug Discovery will also earn a place in the libraries of medicinal chemists, biochemists, and molecular biologists.

• Author : Beverley Isherwood,Angelique Augustin
• Publisher : Royal Society of Chemistry
• Release Date : 2020-12-10
• Total pages : 272
• ISBN : 9781839160790
• File Size : 12,5 Mb
• Total Download : 373
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Download Phenotypic Drug Discovery in PDF, Epub, and Kindle

Phenotypic drug discovery has been highlighted in the past decade as an important strategy in the discovery of new medical entities. How many marketed drugs are derived from phenotypic screens? From the most recent examples, what were the factors enabling target identification and validation? This book answers these questions by elaborating on fundamental capabilities required for phenotypic drug discovery and using case studies to illustrate approaches and key success factors. Written and edited by experienced practitioners from both industry and academia, this publication will equip researchers with a thought-provoking guide to the application and future development of contemporary phenotypic drug discovery for clinical success.

• Author : Susan Miller,Walter Moos,Barbara Munk,Stephen Munk,Charles Hart,David C. Spellmeyer
• Publisher : Elsevier
• Release Date : 2023-03-09
• Total pages : 684
• ISBN : 9780128243053
• File Size : 46,6 Mb
• Total Download : 837
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Download Managing the Drug Discovery Process in PDF, Epub, and Kindle

Managing the Drug Discovery Process, Second Edition thoroughly examines the current state of pharmaceutical research and development by providing experienced perspectives on biomedical research, drug hunting and innovation, including the requisite educational paths that enable students to chart a career path in this field. The book also considers the interplay of stakeholders, consumers, and drug firms with respect to a myriad of factors. Since drug research can be a high-risk, high-payoff industry, it is important to students and researchers to understand how to effectively and strategically manage both their careers and the drug discovery process. This new edition takes a closer look at the challenges and opportunities for new medicines and examines not only the current research milieu that will deliver novel therapies, but also how the latest discoveries can be deployed to ensure a robust healthcare and pharmacoeconomic future. All chapters have been revised and expanded with new discussions on remarkable advances including CRISPR and the latest gene therapies, RNA-based technologies being deployed as vaccines as well as therapeutics, checkpoint inhibitors and CAR-T approaches that cure cancer, diagnostics and medical devices, entrepreneurship, and AI. Written in an engaging manner and including memorable insights, this book is aimed at anyone interested in helping to save countless more lives through science. A valuable and compelling resource, this is a must-read for all students, educators, practitioners, and researchers at large—indeed, anyone who touches this critical sphere of global impact—in and around academia and the biotechnology/pharmaceutical industry. Considers drug discovery in multiple R&D venues - big pharma, large biotech, start-up ventures, academia, and nonprofit research institutes - with a clear description of the degrees and training that will prepare students well for a career in this arena Analyzes the organization of pharmaceutical R&D, taking into account human resources considerations like recruitment and configuration, management of discovery and development processes, and the coordination of internal research within, and beyond, the organization, including outsourced work Presents a consistent, well-connected, and logical dialogue that readers will find both comprehensive and approachable Addresses new areas such as CRISPR gene editing technologies and RNA-based drugs and vaccines, personalized medicine and ethical and moral issues, AI/machine learning and other in silico approaches, as well as completely updating all chapters

• Author : Katarina Stanoevska,Thomas Wozniak,Santi Ristol
• Publisher : Springer Science & Business Media
• Release Date : 2009-11-04
• Total pages : 274
• ISBN : 9783642051937
• File Size : 13,6 Mb
• Total Download : 549
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Download Grid and Cloud Computing in PDF, Epub, and Kindle

In today’s dynamic business environment, IT departments are under permanent pressure to meet two divergent requirements: to reduce costs and to support business agility with higher flexibility and responsiveness of the IT infrastructure. Grid and Cloud Computing enable a new approach towards IT. They enable increased scalability and more efficient use of IT based on virtualization of heterogeneous and distributed IT resources. This book provides a thorough understanding of the fundamentals of Grids and Clouds and of how companies can benefit from them. A wide array of topics is covered, e.g. business models and legal aspects. The applicability of Grids and Clouds in companies is illustrated with four cases of real business experiments. The experiments illustrate the technical solutions and the organizational and IT governance challenges that arise with the introduction of Grids and Clouds. Practical guidelines on how to successfully introduce Grids and Clouds in companies are provided.

• Author : Xiaoyu Yang,Lizhe Wang,Wei Jie
• Publisher : Springer Science & Business Media
• Release Date : 2011-05-26
• Total pages : 540
• ISBN : 9780857294395
• File Size : 35,5 Mb
• Total Download : 155
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Download Guide to e-Science in PDF, Epub, and Kindle

This guidebook on e-science presents real-world examples of practices and applications, demonstrating how a range of computational technologies and tools can be employed to build essential infrastructures supporting next-generation scientific research. Each chapter provides introductory material on core concepts and principles, as well as descriptions and discussions of relevant e-science methodologies, architectures, tools, systems, services and frameworks. Features: includes contributions from an international selection of preeminent e-science experts and practitioners; discusses use of mainstream grid computing and peer-to-peer grid technology for “open” research and resource sharing in scientific research; presents varied methods for data management in data-intensive research; investigates issues of e-infrastructure interoperability, security, trust and privacy for collaborative research; examines workflow technology for the automation of scientific processes; describes applications of e-science.

• Author : Theo Dimitrakos,Josep Martrat,Stefan Wesner
• Publisher : Springer Science & Business Media
• Release Date : 2009-10-21
• Total pages : 210
• ISBN : 9783642040863
• File Size : 55,6 Mb
• Total Download : 118
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Download Service Oriented Infrastructures and Cloud Service Platforms for the Enterprise in PDF, Epub, and Kindle

Service-Oriented Infrastructures including Grid and Cloud Computing are technologies in a critical transition to wider adoption by business. Their use may enable enterprises to achieve optimal IT utilization, including sharing resources and services across enterprises and on-demand utilization of those made available by business partners over the network. This book is an essential reference for researchers and practitioners in service-oriented IT. It analyses a selection of common capabilities (services capturing reusable functionality of IT solutions) that have been applied to tackle challenging business problems and were validated by the BEinGRID consortium in real-life business trials covering most European market sectors.

• Author : Petri Mhnen,Klaus Pohl,Thierry Priol
• Publisher : Springer Science & Business Media
• Release Date : 2008-12
• Total pages : 352
• ISBN : 9783540898962
• File Size : 54,7 Mb
• Total Download : 938
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Download Towards a Service-Based Internet in PDF, Epub, and Kindle

This volume constitutes the refereed proceedings of the First European Conference, ServiceWave 2008, held in Madrid, Spain, in December 2008. The 28 revised full papers presented were carefully reviewed and selected from 102 initial submissions. The papers are organized in topical sections on adaption/monitoring, model driven architecture, network services, service oriented architecture, business process management, deployment/invocation, security, workflow as well as SLA/QoS.

• Author : Simon E Ward,Andrew Davis
• Publisher : Royal Society of Chemistry
• Release Date : 2023-02-03
• Total pages : 1051
• ISBN : 9781788018982
• File Size : 11,9 Mb
• Total Download : 325
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Download The Handbook of Medicinal Chemistry: Principles and Practice in PDF, Epub, and Kindle

The 2nd edition of The Handbook of Medicinal Chemistry is a carefully curated compilation of writing from global experts. Using their broad experience of medicinal chemistry, project leadership and drug discovery from both industry, academic and charity perspectives they are able to provide unparalleled insight into the field in a single, invaluable volume.

• Author : Joanna Kołodziej,Florin Pop,Ciprian Dobre
• Publisher : Springer
• Release Date : 2018-01-30
• Total pages : 155
• ISBN : 9783319737676
• File Size : 43,9 Mb
• Total Download : 475
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Download Modeling and Simulation in HPC and Cloud Systems in PDF, Epub, and Kindle

This book consists of eight chapters, five of which provide a summary of the tutorials and workshops organised as part of the cHiPSet Summer School: High-Performance Modelling and Simulation for Big Data Applications Cost Action on “New Trends in Modelling and Simulation in HPC Systems,” which was held in Bucharest (Romania) on September 21–23, 2016. As such it offers a solid foundation for the development of new-generation data-intensive intelligent systems. Modelling and simulation (MS) in the big data era is widely considered the essential tool in science and engineering to substantiate the prediction and analysis of complex systems and natural phenomena. MS offers suitable abstractions to manage the complexity of analysing big data in various scientific and engineering domains. Unfortunately, big data problems are not always easily amenable to efficient MS over HPC (high performance computing). Further, MS communities may lack the detailed expertise required to exploit the full potential of HPC solutions, and HPC architects may not be fully aware of specific MS requirements. The main goal of the Summer School was to improve the participants’ practical skills and knowledge of the novel HPC-driven models and technologies for big data applications. The trainers, who are also the authors of this book, explained how to design, construct, and utilise the complex MS tools that capture many of the HPC modelling needs, from scalability to fault tolerance and beyond. In the final three chapters, the book presents the first outcomes of the school: new ideas and novel results of the research on security aspects in clouds, first prototypes of the complex virtual models of data in big data streams and a data-intensive computing framework for opportunistic networks. It is a valuable reference resource for those wanting to start working in HPC and big data systems, as well as for advanced researchers and practitioners.

• Author : Tiffany Porta Siegel
• Publisher : Royal Society of Chemistry
• Release Date : 2021-11-23
• Total pages : 500
• ISBN : 9781839165207
• File Size : 27,9 Mb
• Total Download : 263
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Download MALDI Mass Spectrometry Imaging in PDF, Epub, and Kindle

This book gathers, in a single resource, knowledge about matrix-assisted laser desorption ionisation (MALDI) mass spectrometry imaging. It includes fundamentals in the MALDI ionisation process, different source geometries and capabilities, detection systems and the latest research and applications in the range of –omics area as well as other broader areas. Chapters will touch on dedicated sample preparation protocols specific for the class of compounds of interest, instrumentation used with strengths and current limitations, strategies for structural analysis and identification and applications. It will be a welcomed addition to the literature in this fast-moving field and provide a guide to new innovations and applications especially in metabolomics and proteomics. With contributions from leading experts, this book will be an authoritative guide to this method. Aimed at postgraduate and professional researchers, in academia and in the industrial market where it has direct application to clinical research. It will be a supporting volume for those just entering the field as well as experienced practitioners.

• Author : Patrick Schnider
• Publisher : Royal Society of Chemistry
• Release Date : 2021-08-20
• Total pages : 518
• ISBN : 9781839160493
• File Size : 24,5 Mb
• Total Download : 207
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Download The Medicinal Chemist's Guide to Solving ADMET Challenges in PDF, Epub, and Kindle

The Medicinal Chemist’s Guide to Solving ADMET Challenges summarizes a series of design strategies and tactics that have been successfully employed across pharmaceutical and academic laboratories to solve common ADMET issues. These are exemplified with a curated collection of concrete examples displayed in a highly visual “table-of-contents” style format, allowing readers to rapidly identify the most promising approaches applicable to their own challenges. Each ADMET parameter is introduced in a concise yet comprehensive manner and includes background, relevance and screening strategies. Medicinal chemistry knowledge of how best to modify molecular structure to solve ADMET issues is challenging to retrieve from the literature, public databases and even corporate data warehouses. The Medicinal Chemist’s Guide to Solving ADMET Challenges addresses this gap by presenting state-of-the-art design strategies put together by a global group of experienced medicinal chemists and ADMET experts across academia and the pharmaceutical industry.

• Author : Amalia Stefaniu,Azhar Rasul,Ghulam Hussain
• Publisher : BoD – Books on Demand
• Release Date : 2020-07-15
• Total pages : 192
• ISBN : 9781838800673
• File Size : 24,5 Mb
• Total Download : 588
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Download Cheminformatics and its Applications in PDF, Epub, and Kindle

Cheminformatics has emerged as an applied branch of Chemistry that involves multidisciplinary knowledge, connecting related fields such as chemistry, computer science, biology, pharmacology, physics, and mathematical statistics.The book is organized in two sections, including multiple aspects related to advances in the development of informatic tools and their specific use in compound structure databases with various applications in life sciences, mainly in medicinal chemistry, for identification and development of new therapeutically active molecules. The book covers aspects related to genomic analysis, semantic similarity, chemometrics, pattern recognition techniques, chemical reactivity prediction, drug-likeness assessment, bioavailability, biological target recognition, machine-based drug discovery and design. Results from various computational tools and methods are discussed in the context of new compound design and development, sharing promising opportunities, and perspectives.

• Author : Bernd Krämer
• Publisher : Springer Science & Business Media
• Release Date : 2007-09-12
• Total pages : 655
• ISBN : 9783540749738
• File Size : 32,8 Mb
• Total Download : 298
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Download Service-Oriented Computing - ICSOC 2007 in PDF, Epub, and Kindle

This book constitutes the refereed proceedings of the Fifth International Conference on Service-Oriented Computing, ICSOC 2007. The 30 revised full papers and 14 short papers are organized in topical sections on service deployment, business process design, service discovery, quality of service support, testing and validation, service assembly, service properties, service modeling, SOA composition/experience/runtime/governance and QoS and composite service support.

• Author : Anonim
• Publisher : Academic Press
• Release Date : 2019-06-23
• Total pages : 468
• ISBN : 9780128168325
• File Size : 20,7 Mb
• Total Download : 859
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Download RNA Recognition in PDF, Epub, and Kindle

RNA Recognition, Volume 623, the latest volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This updated volume covers a variety of topics, including The Preparation of cooperative RNA recognition complexes for crystallographic structural studies, Methods for thermal denaturation studies of fluorogenic aptamers, Dynamic combinatorial chemistry as a rapid, fragment-based approach to RNA-targeted compound discovery, Using a click chemistry assay to identify natural product ligands for pre-microRNAs, Lessons from exploration of chemical and structural small molecule:RNA space, Using ligand-observed NMR to study RNA-small molecule interactions, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Enzymology series Includes the latest information on RNA Recognition

• Author : Anonim
• Publisher : Academic Press
• Release Date : 2022-04-02
• Total pages : 392
• ISBN : 9780323952668
• File Size : 14,6 Mb
• Total Download : 334
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Download Chemical Microbiology Part B in PDF, Epub, and Kindle

Chemical Microbiology, Part B, Volume 665, the latest release in the Methods of Enzymology series, highlights new advances in the field, including comprehensive chapters on the Application of Antibiotic-derived Fluorescent Probes to Bacterial Studies, Metabolomic approaches for enzyme function and pathway discovery in bacteria, Adding a diazo-transfer reagent to culture to generate secondary metabolite probes for click chemistry, Customized Peptidoglycan Surfaces to Investigate Innate Immune Recognition via Surface Plasmon Resonance, Development and application of highly sensitive labeling reagents for amino acids, Bacterial Cell Wall Modification with a Glycolipid Substrate, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Enzymology series Updated release includes the latest information on chemical microbiology

• Author : Kerstin Thurow,Steffen Junginger
• Publisher : John Wiley & Sons
• Release Date : 2022-08-03
• Total pages : 516
• ISBN : 9783527829439
• File Size : 43,7 Mb
• Total Download : 630
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Download Devices and Systems for Laboratory Automation in PDF, Epub, and Kindle

Devices and Systems for Laboratory Automation Structured Overview on the Available Systems and Devices for Laboratory Automation Choosing the right systems and devices for the automation in any given laboratory is an essential part for the process to succeed. As relevant information to make an informed choice is not always readily available, a structured overview is essential for modern scientists. This book provides an introduction into laboratory automation and an overview of the necessary devices and systems. Sample topics discussed by the two well-qualified authors include: Specific requirements the automation needs to fulfill such as liquid delivery, low volume delivery, solid delivery, and sample preparation An overview on robots and mobile robots Common interfaces in laboratory automation For scientists and all individuals working in laboratories, the work serves as an indispensable resource in helping to make laboratory processes more streamlined, effective, and efficient.

• Author : Arpana Parihar,Raju Khan,Ashok Kumar,Ajeet Kumar Kaushik,Hardik Gohel
• Publisher : Academic Press
• Release Date : 2022-07-20
• Total pages : 618
• ISBN : 9780323998000
• File Size : 38,9 Mb
• Total Download : 714
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Download Computational Approaches for Novel Therapeutic and Diagnostic Designing to Mitigate SARS-CoV2 Infection in PDF, Epub, and Kindle

Computational Approaches for Novel Therapeutic and Diagnostic Designing to Mitigate SARS-CoV2 Infection: Revolutionary Strategies to Combat Pandemics compiles information about various computational bioinformatic approaches that can help combat viral infection. The book includes working knowledge of various molecular docking and molecular dynamic simulation approaches that have been exploited for drug repurposing and drug designing purpose. In addition, it sheds light on reverse vaccinomics and immunoinformatic approaches for vaccine designing against SARS-CoV2 infection. This book is an essential resource for researchers, bioinformaticians, computational biologists, computational chemists and pharmaceutical companies who are working on the development of effective and specific therapeutic interventions and point-of-care diagnostic devices using various computational approaches. Covers computational based approaches for designing and repurposing drugs Discusses immunoinformatic and reverse vaccinomic approaches for effective vaccine design Categorizes information about artificial intelligence-based drug screening and diagnostic tools

• Author : Anonim
• Publisher : Elsevier
• Release Date : 2023-02-15
• Total pages : 342
• ISBN : 9780323992015
• File Size : 51,5 Mb
• Total Download : 539
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Download Targeted Protein Degradation in PDF, Epub, and Kindle

Targeted Protein Degradation, Volume 680 in the Methods in Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on a variety of timely topics, with each. Each written by an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in Methods in Enzymology serials Updated release includes the latest information on Targeted Protein Degradation

• Author : Gauri Misra,Jyotika Rajawat
• Publisher : Academic Press
• Release Date : 2021-02-12
• Total pages : 216
• ISBN : 9780323898171
• File Size : 46,9 Mb
• Total Download : 498
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Download Protocol Handbook for Cancer Biology in PDF, Epub, and Kindle

Protocol Handbook for Cancer Biology brings together a comprehensive collection of the methods used for cancer assessment, diagnostics, and therapeutics. Various protocols are discussed along with alternative strategies, including the advantages and limitations of techniques that have been used in labs globally. These protocols are presented by cancer biology experts based on their real-world experience. The protocols in this book will be a valuable resource for cancer researchers and graduate students, who can utilize the techniques described to conduct research more efficiently and successfully. Presents comprehensive protocols used for cancer assessment, diagnostics, and therapeutics all in one place Encompasses alternative strategies considering the requirements of the end user and taking into consideration diverse research settings Discusses limitations and advantages of each method in experimental design and execution, thus saving time during the research process

• Author : Anonim
• Publisher : Academic Press
• Release Date : 2020-08-24
• Total pages : 1589
• ISBN : 9780128160787
• File Size : 34,7 Mb
• Total Download : 578
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Download Systems Medicine in PDF, Epub, and Kindle

Technological advances in generated molecular and cell biological data are transforming biomedical research. Sequencing, multi-omics and imaging technologies are likely to have deep impact on the future of medical practice. In parallel to technological developments, methodologies to gather, integrate, visualize and analyze heterogeneous and large-scale data sets are needed to develop new approaches for diagnosis, prognosis and therapy. Systems Medicine: Integrative, Qualitative and Computational Approaches is an innovative, interdisciplinary and integrative approach that extends the concept of systems biology and the unprecedented insights that computational methods and mathematical modeling offer of the interactions and network behavior of complex biological systems, to novel clinically relevant applications for the design of more successful prognostic, diagnostic and therapeutic approaches. This 3 volume work features 132 entries from renowned experts in the fields and covers the tools, methods, algorithms and data analysis workflows used for integrating and analyzing multi-dimensional data routinely generated in clinical settings with the aim of providing medical practitioners with robust clinical decision support systems. Importantly the work delves into the applications of systems medicine in areas such as tumor systems biology, metabolic and cardiovascular diseases as well as immunology and infectious diseases amongst others. This is a fundamental resource for biomedical students and researchers as well as medical practitioners who need to need to adopt advances in computational tools and methods into the clinical practice. Encyclopedic coverage: ‘one-stop’ resource for access to information written by world-leading scholars in the field of Systems Biology and Systems Medicine, with easy cross-referencing of related articles to promote understanding and further research Authoritative: the whole work is authored and edited by recognized experts in the field, with a range of different expertise, ensuring a high quality standard Digitally innovative: Hyperlinked references and further readings, cross-references and diagrams/images will allow readers to easily navigate a wealth of information

• Author : Anonim
• Publisher : Academic Press
• Release Date : 2022-05-15
• Total pages : 836
• ISBN : 9780323915427
• File Size : 54,7 Mb
• Total Download : 127
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Download Pseudokinases in PDF, Epub, and Kindle

Pseudokinases, Volume 667, the latest release in the Methods in Enzymology serial, highlights new advances in the field with this new volume presenting interesting chapters, including the Production and Purification of the PEAK pseudokinases for structural and functional studies, Structural biology and biophysical characterization of Tribbles pseudokinases, Detecting endogenous TRIB protein expression and its downstream signaling, Analysis of human Tribbles 2 pseudokinase, Expression, purification and examination of ligand-binding to IRAK pseudokinases, Characterization of pseudokinase ILK-mediated actin assembly, Biochemical examination of Titin pseudokinase, Approaches to study pseudokinase conformations, CRISPR editing cell lines for reconstitution studies of pseudokinase function, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in Methods in Enzymology serials Includes the latest information on Pseudokinases