Receptor Tyrosine Kinases In Neurodegenerative And Psychiatric Disorders

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• Author : Heba Mohamed Mansour,Mahmoud Mohamed Khattab,Aiman Saad Elkhatib
• Publisher : Academic Press
• Release Date : 2023-09-01
• Total pages : 0
• ISBN : 0443186774
• File Size : 44,9 Mb
• Total Download : 977
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Download Receptor Tyrosine Kinases in Neurodegenerative and Psychiatric Disorders in PDF, Epub, and Kindle

Receptor Tyrosine Kinases in Neurodegenerative and Psychiatric Disorders is an up-to-date reference on the significance of these enzyme receptors in the healthy and dysfunctional central nervous system. Chapters examine RTK functions and signalling pathways, gene regulation, and molecular mechanisms of RTK-mediated neurodegeneration. Attention is also paid to potential repurposing of anti-cancer tyrosine kinase inhibitors to treat neurodegenerative diseases as well as obstacles faced by researchers. Shedding light on RTK-mediated neurodegeneration and examining the role of these proteins in the developmental and adult CNS and PNS, this volume is a valuable resource for anyone working in the neurodegeneration field.

• Author : Deric L. Wheeler,Yosef Yarden
• Publisher : Springer
• Release Date : 2015-07-31
• Total pages : 878
• ISBN : 9783319118888
• File Size : 50,8 Mb
• Total Download : 836
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Download Receptor Tyrosine Kinases: Family and Subfamilies in PDF, Epub, and Kindle

This book devotes a chapter to each RTK family and the multiple receptors within each family, thoroughly covering all of the RTKs. The chapters all follow the same structure, presenting this essential information in an accessible and user-friendly format. Each chapter covers one specific family of receptors and begins with a general introduction to that family and a comprehensive discussion of that receptor’s family in development and human disease. Following are in-depth analyses of each family’s receptors with discussions on the gene, protein, ligands, activation, and signaling pathways along with discussion of receptor processing and signal attenuation. Further, cross talk with other receptors systems, post-translational modification and specific unique characteristics to each RTK are discussed. Because it isolates and explains each family, this book is an essential companion volume to Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease, by the same authors, which talks about RTKs more generally and without the family-by-family detail.

• Author : Emilija Veljkovic,Wenhao Xia,Blaine Phillips,Ee Tsin Wong,Jenny Ho,Alberto Oviedo Casado,Julia Hoeng,Manuel Peitsch
• Publisher : Academic Press
• Release Date : 2018-01-15
• Total pages : 164
• ISBN : 9780128129234
• File Size : 43,9 Mb
• Total Download : 693
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Download Nicotine and Other Tobacco Compounds in Neurodegenerative and Psychiatric Diseases in PDF, Epub, and Kindle

Nicotine and Other Tobacco Compounds in Neurodegenerative and Psychiatric Diseases: Epidemiological Data on Smoking and Preclinical and Clinical Data on Nicotine provides a comprehensive summary of the epidemiological data on smoking and several neurological disorders, including Alzheimer’s disease, Parkinson’s disease, Multiple Sclerosis, Tourette’s syndrome, schizophrenia, anxiety, depression and ADHD, as well as preclinical and clinical data on the effects of nicotine. Despite the obvious and undisputed harmful nature of smoking, evidence suggests that some tobacco and tobacco smoke-derived constituents may offer neuroprotective effects, possibly in combinations, rather than individually. This unprecedented book describes the complex relationships between smoking and neurological disease and the bioactive compounds found in tobacco. It provides a comprehensive review of nicotine and other compounds found in tobacco plant, with scientific evidence of neuroprotective and anti-inflammatory effects that may act in conjunction with nicotine to exert neuroprotective effects observed in smokers. By presenting findings beyond harmful cigarette smoke effects, attention can be drawn to individual compounds of tobacco that may serve as inspiration for further therapy development. Presents the first comprehensive, tabulated summary of literature on the epidemiological data on smoking and neurological disease Includes preclinical and clinical data on nicotine in neurological diseases and mechanisms of action of nicotine in neuroprotection Features a comprehensive summary of non-nicotine smoke constituents with potentially neuroprotective and anti-inflammatory properties Discusses Multiple Sclerosis, Alzheimer’s disease, Parkinson’s Disease, Schizophrenia, Depression, ADHD, Anxiety and Tourette’s Syndrome in the context of smoking and nicotine

• Author : Paul C. Guest
• Publisher : Springer
• Release Date : 2019-02-12
• Total pages : 328
• ISBN : 9783030055424
• File Size : 48,7 Mb
• Total Download : 487
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Download Reviews on Biomarker Studies in Psychiatric and Neurodegenerative Disorders in PDF, Epub, and Kindle

This book includes a series of reviews on general aspects of biomarker use in the study of psychiatric and neurodegenerative diseases and the development of medications involved in their treatment. It describes the pros and cons of the various approaches and covers the successes and failures in this research field. It is only by a thorough understanding of the shortcomings that progress can be made. The overall goal is to facilitate the understanding and treatment of these disorders, by providing a viable mechanism of catching up with other areas of modern medicine, such as diabetes and heart disease. Finally, it is anticipated that the development and application of valid biomarker tests and the leveraging of novel drug targets will help the fields of psychiatry on neurodegenerative disorders move into the area of personalized medicine where the right patients can receive the right medication at the right time for the best possible outcome.

• Author : Manfred Gerlach,Jürgen Deckert,Kay Double,Eleni Koutsilieri
• Publisher : Springer Science & Business Media
• Release Date : 2007-12-28
• Total pages : 326
• ISBN : 9783211735749
• File Size : 35,8 Mb
• Total Download : 784
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Download Neuropsychiatric Disorders in PDF, Epub, and Kindle

This multidisciplinary book includes current research papers and reviews in the areas of basic neuroscience, neural mechanisms underlying neurodegenerative disorders. It further includes new approaches for neuroprotective treatments, clinical, neurobiological and treatment aspects of psychiatric disorders. The book was conceived as a celebration of the professional life and work of Peter Riederer to mark the occasion of his retirement.

• Author : William Slikker, Jr.,Merle G. Paule,Cheng Wang
• Publisher : Academic Press
• Release Date : 2018-01-04
• Total pages : 616
• ISBN : 9780128093948
• File Size : 26,5 Mb
• Total Download : 523
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Download Handbook of Developmental Neurotoxicology in PDF, Epub, and Kindle

Handbook of Developmental Neurotoxicology, Second Edition, provides a comprehensive view of the fundamental aspects of neurodevelopment, the pathways and agents that affect them, relevant clinical syndromes, and risk assessment procedures for developmental neurotoxicants. The editors and chapter authors are internationally recognized experts whose collaboration heralds a remarkable advance in the field, bridging developmental neuroscience with the principles of neurotoxicology. The book features eight new chapters with newly recruited authors, making it an essential text for students and professionals in toxicology, neurotoxicology, developmental biology, pharmacology, and neuroscience. Presents a comprehensive, up-to-date resource on developmental neurotoxicology with updated chapters from the first edition Contains new chapters that focus on subjects recent to the field Includes well-illustrated material, with diagrams, charts, and tables Contains compelling case studies and chapters written by world experts

• Author : Caterina Scuderi,Mami Noda,Alexei Verkhratsky
• Publisher : Frontiers Media SA
• Release Date : 2019-01-21
• Total pages : 154
• ISBN : 9782889456987
• File Size : 19,8 Mb
• Total Download : 187
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Download Neuroglia Molecular Mechanisms in Psychiatric Disorders in PDF, Epub, and Kindle

Neuropsychiatric disorders have long been considered as specific dysfunctions of neuronal functions. Studies of the recent decade, however, have challenged this simplistic view, highlighting the important role played by neuroglial cells in the onset and/or progression of neuropsychiatric diseases. In the central nervous system (CNS) non-excitable neuroglia are represented by cells of ectodermal origin (astrocytes, mainly responsible for CNS homeostasis and oligodendrocytes that provide myelination and support for axons) and mesodermal origin (microglial cells that are scions of foetal macrophages entering the neural tube early in development; these cells provide for CNS defence and contribute to shaping neuronal networks). Pathological changes of neuroglia are complex; these changes are classified into reactive gliosis (astrogliosis, activation of microglia and hypertrophy of oligodendroglial precursors), gliodegeneration with loss of function and glial pathological remodelling. Combination of these processes defines the evolution of neurological diseases in general and neuropsychiatric disorders in particular. In this research topic we addressed the contribution of neuroglia to major neuropsychiatric pathologies including major depression, schizophrenia, and addictive disorders.

• Author : Stuart A. Montgomery,Siegfried Kasper
• Publisher : John Wiley & Sons
• Release Date : 2013-02-06
• Total pages : 229
• ISBN : 9781118556733
• File Size : 50,7 Mb
• Total Download : 176
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Download Treatment-Resistant Depression in PDF, Epub, and Kindle

Successful management of patients with treatment-resistant depression is going to require a thorough understanding of the biological basis for both the depression and its failure to respond to standard treatments. This book clearly and succinctly summarizes the latest scientific research and its applications in clinical practice. A first step is a clear definition of what constitutes treatment-resistant depression so that clinical trials and other studies are using common criteria, enabling comparison and meta-analysis of their outcomes. The opening chapter reviews definitions and predictors of originating from different fields and discusses their usefulness in clinical practice and clinical research. The next chapter proposes a new definition, adapting terminology from medicine. Biological classification requires identification of genetic risk factors: with gene variants accounting for 50% of the variance in the clinical outcomes of antidepressant treatments this is clearly a fruitful area of research. Chapter 3 describes several genes already associated with treatment-resistant depression and, while further work is needed to translate findings into clinical recommendations, predicts that genetic prediction of TRD could became a widespread clinical reality within a few years. Most patients with TRD will be treated pharmacologically and three chapters review the latest evidence for pharmacological best practice, including switching strategies for antidepressants, the role of antipsychotics and augmentation strategies to complement lithium. There are two major alternatives to pharmacotherapy: neuromodulation and psychotherapy. The brain intervention chapter summarizes clinical research and experience with electroconvulsive therapy, transcranial magnetic stimulation, vagus nerve stimulation, deep brain stimulation and magnetic seizure therapy. The final chapter reviews the literature pertaining to the effectiveness of various forms of psychotherapy in patients who have not responded to antidepressant pharmacotherapy, revealing that patients who have not responded to one or two trials of antidepressant medication have a 30%-50% chance of responding to a focused psychotherapy. It proposes indications for psychotherapy in TRD and summarizes general therapeutic principles.

• Author : Francisco Lopez-Munoz,Cecilio Alamo
• Publisher : CRC Press
• Release Date : 2011-09-09
• Total pages : 531
• ISBN : 9781439838495
• File Size : 49,9 Mb
• Total Download : 618
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Download Neurobiology of Depression in PDF, Epub, and Kindle

Major depressive disorders have recently been associated with impairments in signaling pathways that regulate neuroplasticity and cell survival. Agents designed to directly target molecules in these pathways hold promise as new therapeutics for depression. With the collaboration of the most prestigious international specialists in biochemistry, molecular biology, genomics, psychiatry, psychology, and pharmacology, Neurobiology of Depression discusses the nature of the central nervous system circuits responsible for the modifications of neuronal functioning that lead to depression. The book begins by discussing animal, neurophysiological, and neuropsychological models of depression as well as neural foundations. It explores genetic factors that contribute to depression and describes the effect of monoaminergic systems in the central nervous system. Next, the book profiles the rise of psychopharmacology in the treatment of depression and the research into serotonin and monoamine reuptake inhibitors. It examines the role of the glutamatergic, endocannabinoid, and opioid systems in the pathophysiology of mood disorders, as well as the effect of biological rhythms on the human body. Later chapters review the role of CRF-related ligands, CRF receptors, HPA axis activity, and glucocorticoid receptors in the regulation of the stress response and depression. They also describe cytokine modulation of molecular mechanisms. They examine the role of neuropeptide Y, nitric oxide, beta-arrestins, BDNF, and phosphodiesterases, and discuss the use of tachykinin antagonists in treatment. Finally, they analyze the neurobiological basis for the development of new antidepressant agents. Exploring myriad aspects of a disease that plagues a large percentage of the population worldwide, this volume captures the state of the science of this debilitating disorder, facilitating further research and discovery.

• Author : David Blum,Luisa V. Lopes
• Publisher : Academic Press
• Release Date : 2017-03-10
• Total pages : 280
• ISBN : 9780128037454
• File Size : 25,5 Mb
• Total Download : 147
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Download Adenosine Receptors in Neurodegenerative Diseases in PDF, Epub, and Kindle

Adenosine Receptors in Neurodegenerative Diseases covers the role of adenosine receptors in brain function, also focusing on related methodologies and perspectives in therapeutics. The book provides an up-to-date overview by the best specialists in the field, helping readers consider the importance of adenosine and expand the global impact and visibility of adenosine research in the CNS field. Chapters include adenosine biology and signaling, gene regulation, control of motor function, and novel adenosine-based therapies in the CNS. It is an ideal resource for researchers, advanced graduate students, clinicians, and industry scientists working in the fields of clinical neuroscience and molecular and cellular neuroscience. Comprehensive reference that details adenosine receptors in neurodegenerative disorders, with details on brain function and possible therapeutics Gives insights on how these receptors modulate the neurodegenerative outcomes in different disorders Edited by two of the leading researchers in the field regarding adenosine role in the brain in aging and neurodegenerative conditions

• Author : Michael Aschner,Lucio G. Costa
• Publisher : Academic Press
• Release Date : 2015-06-18
• Total pages : 450
• ISBN : 9780128004074
• File Size : 55,9 Mb
• Total Download : 482
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Download Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders in PDF, Epub, and Kindle

Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders presents a state-of-the-art review of the effects of environmental contaminants on the development and degeneration of the human nervous system, brought together by world-leading experts in the field. Part One describes the adverse effects that the environment can have on neurological development, and how these effects may exhibit. Specific contaminants and their possible consequences of exposure are addressed (lead, methylmercury, alcohol), as well as specific disorders and the environmental factors associated with them, such as the effect of diet on attention deficit and hyperactivity disorders. Part Two tackles neurodegenerative disorders, specifically addressing their potential neurotoxic origins, and discussing the increasing interest in the effects that early exposure may have in later life. Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders is an invaluable reference for those professionals working in the fields of toxicology, environmental health and neuroscience. Provides, for the first time, the cutting-edge theory of environmental impacts on both neurodegenerative and neurodevelopmental disorders Written by an international selection of the world’s foremost experts in the field of neurotoxicology Full-colour throughout, providing accurate and illustrative examples of neurotoxic effects in action An invaluable reference for those professionals working in the fields of toxicology, environmental health, and neuroscience

• Author : Anonim
• Publisher : Academic Press
• Release Date : 2017-02-15
• Total pages : 550
• ISBN : 9780128122648
• File Size : 38,8 Mb
• Total Download : 391
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Download Neurotrophins in PDF, Epub, and Kindle

Neurotrophins, the latest volume in the Vitamins and Hormones series first published in 1943, and the longest-running serial published by Academic Press, provides up-to-date information on crystal structures and basic structural studies on neurotrophins and their receptors, neurotrophin functions, and the biological actions of neurotrophins related to clinical conditions and disease. Each volume is thoroughly reviewed and focuses on a single molecule or disease that is related to vitamins or hormones, with the topic broadly interpreted to include related substances such as transmitters, cytokines, growth factors, and others. Provides cutting-edge reviews concerning the molecular and cellular biology of vitamins and hormones Contains expertise from world-renowned contributors Focuses on a single molecule or disease that is related to vitamins or hormones, with the topic broadly interpreted to include related substances such as transmitters, cytokines, growth factors, and others Presents in-depth, current information from the molecular to clinical level

• Author : Tahira Farooqui,Akhlaq A. Farooqui
• Publisher : Academic Press
• Release Date : 2019-03-16
• Total pages : 544
• ISBN : 9780128154625
• File Size : 12,9 Mb
• Total Download : 397
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Download Curcumin for Neurological and Psychiatric Disorders in PDF, Epub, and Kindle

Curcumin for Neurological and Psychiatric Disorders: Neurochemical and Pharmacological Properties focuses on the different molecular mechanisms underlying curcumin-mediated beneficial effects in neurological diseases. The book's editors discuss the neurochemical and pharmacological properties of curcumin, followed by the effect of curcumin in neurotraumatic diseases, neurodegenerative diseases, and neuropsychiatric diseases. The book also offers a perspective on future studies on the treatment of neurological disorders. The beneficial effects of curcumin have been observed both in cultured cells and in animal models, thus paving the way for ongoing present and future human clinical trials. Curcumin produces antioxidant and anti-inflammatory effects not only by blocking oxidative stress and neuroinflammation in neurotraumatic and neurodegenerative diseases, but also by restoring cellular homeostasis and rebalancing redox equilibrium. Identifies molecular mechanisms of curcumin effects in neurological diseases Includes effects on neurotraumatic, neurodegenerative and psychiatric diseases Covers the antioxidant, anti-inflammatory and immunomodulatory effects of curcumin Examines curcumin’s potential in developing new therapeutic drugs

• Author : Anna R. Carta,Nigel H. Greig,Cesar V. Borlongan
• Publisher : Frontiers Media SA
• Release Date : 2022-01-25
• Total pages : 337
• ISBN : 9782889741687
• File Size : 20,7 Mb
• Total Download : 962
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Download Drug Repurposing in Neurodegenerative and Neuropsychiatric Disorders in PDF, Epub, and Kindle

PDF book entitled Drug Repurposing in Neurodegenerative and Neuropsychiatric Disorders written by Anna R. Carta,Nigel H. Greig,Cesar V. Borlongan and published by Frontiers Media SA which was released on 2022-01-25 with total hardcover pages 337, the book become popular and critical acclaim.

• Author : Giuseppe Tridente
• Publisher : Academic Press
• Release Date : 2017-05-08
• Total pages : 736
• ISBN : 9780128094457
• File Size : 31,8 Mb
• Total Download : 468
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Download Adverse Events and Oncotargeted Kinase Inhibitors in PDF, Epub, and Kindle

Adverse Events and Oncotargeted Kinase Inhibitors gathers and evaluates data on adverse events associated with tyrosine kinase inhibitors (TKIs), a powerful anti-tumor drug class that has recently been introduced for human therapy. This book compiles a comprehensive safety profile of each TKI from experiences in official therapeutic indications, also exploring off-label exploratory investigations and postmarketing pharmaceutical surveillance databases. A brief history of each drug’s development and submission is provided, along with a more detailed analysis of the mechanism(s) of action involved in therapeutic activity or related to the insurgence of specific adverse events. Early chapters focus on general characteristics of TKIs, typology, and classification of adverse events, while the final chapters analyze TKIs as AE inducers and classes of AEs by system or organ involvement. This comprehensive resource compiles and critically reviews all of the relevant safety data for this class of drugs, with the goal of improving the understanding of pathogenesis and facilitating the prevention, monitoring, and management of these adverse events. Offers a unique and comprehensive publication on the adverse events associated with a new and fast-growing class of medicines Provides a systematic analysis of adverse events aimed at better prevention through understanding and offering insights for the development of safer drugs Uses practical guidelines to establish a leading reference on this class of drugs for educators, researchers, drug developers, clinicians, safety professionals, and more

• Author : Anonim
• Publisher : Academic Press
• Release Date : 2010-07-07
• Total pages : 464
• ISBN : 0123815320
• File Size : 42,8 Mb
• Total Download : 300
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Download Hormones of the Limbic System in PDF, Epub, and Kindle

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines. This volume focuses on hormones of the limbic system. Longest running series published by Academic Press Contributions by leading international authorities

• Author : Irving E. Vega,Timothy J. Collier
• Publisher : Frontiers Media SA
• Release Date : 2016-09-15
• Total pages : 133
• ISBN : 9782889199563
• File Size : 54,9 Mb
• Total Download : 785
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Download Unraveling Neuroprotective and Neurodegenerative Signals in Neurodegeneration in PDF, Epub, and Kindle

Proteinopathy is a collective term used to classified neurodegenerative diseases associated with the progressive accumulation of toxic protein molecules in specific brain regions. Alzheimer’s disease (AD) is a well-known proteinopathy characterize by the accumulation of A peptides and tau proteins. The accumulation of these toxic molecules in the brain starts many years before any clinical presentation, being the onset in the range of 65 to 72 years of age. Therefore, age is considered a risk factor due, in part, to the loss of molecular competence to clear the brain from these toxic protein molecules. This fact, supported by years of research, demonstrates that brain cells activate a neuroprotective mechanism upon detection of a pathobiological signal that (if the detrimental conditions persist) precedes the activation of the neurodegeneration pathway. The progressive brain region specific neuronal death in neurodegenerative diseases also indicates that the transition from neuroprotection to neurodegeneration is individually triggered in cells of the affected brain region. Thus, molecular understanding of the pathophysiology associated with proteinopathies needs to take in consideration this intricate transition process, especially when genomics and proteomics approaches are used.

• Author : Catherine Rabouille,Georg Haase
• Publisher : Frontiers Media SA
• Release Date : 2016-03-09
• Total pages : 121
• ISBN : 9782889197576
• File Size : 12,9 Mb
• Total Download : 933
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Download Golgi Pathology in Neurodegenerative Diseases in PDF, Epub, and Kindle

The Golgi apparatus is a central organelle that lies at the heart of the secretory pathway. It ensures post-translational protein modifications such as glycosylation and cleavage as well as protein sorting to neuronal axons and dendrites. Structural and functional alterations of the Golgi apparatus (fragmentation and atrophy), which are collectively termed Golgi pathology, are now recognized as a constant feature of many neuro-degenerative diseases. However, the molecular mechanisms underlying these changes and their precise relevance to neurodegeneration have not yet been completely elucidated. This eBook contains 13 reviews that address the molecular mechanisms of Golgi pathology in Parkinson and Alzheimer diseases, amyotrophic lateral sclerosis (ALS) and spinal muscular atrophies, and discuss their potential relevance to the pathological loss of neuronal cell bodies, axons and synapses.

• Author : Oksana Kaidanovich-Beilin,Jean-Martin Beaulieu,Richard S. Jope,Jim R. Woodgett
• Publisher : Frontiers E-books
• Release Date : 2023
• Total pages : 240
• ISBN : 9782889190478
• File Size : 47,8 Mb
• Total Download : 624
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Download Neurological Functions of the Masterswitch Protein Kinase – GSK-3 in PDF, Epub, and Kindle

The functions of the brain that allow us to think, feel, move, and perceive the world are the result of an exchange of information within a network composed of millions of specialized cells called neurons and glia. Neurons use neurotransmitters and other extracellular messengers to communicate with each other, and to constantly update and re-organize their network of connections in a process known as neural plasticity. In order to respond to these extracellular signals, neurons are equipped with specialized receptors that can recognize a single neurotransmitter a bit like a lock would recognize a key. They do this by activating or inhibiting a class of specialized signaling proteins and second messengers. Typically, signaling proteins are themselves organized in networks or pathways in which they activate or inhibit each other in order to integrate the mass of information received by a single cell and to regulate the biological functions of this cell. As we can see, rather than simply being a network of neurons, the brain can be seen as a sort of “Russian doll” in which each neuron is at the same time a part of networks with other neurons and the receptacle of many networks composed of signaling proteins. Two individual genes encode two paralogous signaling proteins: Glycogen Synthase Kinase -3 alpha and beta (GSK-3a, GSK-3b), named for its ability to phosphorylate a key metabolic enzyme of glycogen synthesis, glycogen synthase. This unique “glamour and gloom” protein kinase, has been intriguing many researches for over 30 years by its unusual features, still unknown mechanisms of its activation, its regulation by multiple “key” intracellular pathways, and its capacity to influence the functions of many substrates. Since GSK-3 was discovered, there has been significant progress in elucidating its regulatory roles in the neuron and the structure and functions of the brain. Lithium has been used as a gold standard in the treatment of bipolar disorder for 60 years; and “GSK-3’s renaissance” in psychiatry began with the discovery of GSK-3 as lithium's intracellular target. Since then, GSK3 has been implicated in the pathogenesis of mood disorders, schizophrenia, Alzheimer’s disease, ADHD, multiple sclerosis, Fragile X syndrome and Huntington disease. Connections to these and other diseases has led over the last 10 years to the generation of multiple types of GSK-3 inhibitors as promising therapeutic treatments for the aforementioned pathological conditions. During last couple years new genetic models have been generated, including conventional and conditional mouse models, allowing the discovery of new roles of GSK-3 in the mechanism of neurotransmitter action, neurodevelopment, learning and memory formation, GSK-3’s gene - effect on mouse behavior, and other functions. Thus, GSK-3 has been well-established as an intracellular second messenger for several neurotransmitter systems, and as an important therapeutic target of mood stabilizers, antipsychotics and psychomimetic drugs. The proposed Specific Topic for Frontiers in Neuroscience will be focused on the latest advances from leading laboratories in this area, subdivided into 5 topics: (1) GSK-3 history, mechanism of regulation, substrate specificity and comparison between the brain function of two GSK-3 genes through new animal models and cell biology approaches; (2) role of GSK-3 in neurodevelopment and neuronal structure; (3) involvement of GSK-3 in synaptic functions, learning and memory, and in serotonin and dopamine pathways; (4) role of GSK-3 in neuroinflammation, and application to the pathogenesis of multiple sclerosis, AD, schizophrenia, Fragile X, brain tumors, stroke and bipolar disorder; (5) development of GSK-3 inhibitors and their application in psychiatry, including special discussion about the mechanism of lithium action.

• Author : Luca Saba
• Publisher : OUP Oxford
• Release Date : 2015-01-08
• Total pages : 640
• ISBN : 9780191651397
• File Size : 25,6 Mb
• Total Download : 854
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Download Imaging in Neurodegenerative Disorders in PDF, Epub, and Kindle

Diagnosing neurodegenerative diseases can prove particularly intimidating to clinicians, because many times the diagnosis cannot be critically "confirmed" by a simple test. New imaging modalities have advanced to the point of high resolution, morphological, metabolic and functional analysis. Computed tomography, magnetic resonance, nuclear medicine and molecular imaging have recently emerged as outstanding non-invasive techniques for the study of the neurodegenerative disorders. Imaging in Neurodegenerative Disorders covers all the imaging techniques and new exciting methods like new tracers, biomarker, metabolomic and gene-array profiling, potential for applying such techniques clinically, and offers present and future applications as applied to the neurodegenerative disorders with the most world renowned scientists in these fields. This book is an invaluable resource for researchers, clinicians, and trainees in neuroscience, neurology, psychiatry, and radiology.

• Author : Md. Imtaiyaz Hassan,Saba Noor
• Publisher : Academic Press
• Release Date : 2022-05-19
• Total pages : 830
• ISBN : 9780323913492
• File Size : 47,8 Mb
• Total Download : 922
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Download Protein Kinase Inhibitors in PDF, Epub, and Kindle

Protein Kinase Inhibitors: From Discovery to Therapeutics offers a foundational, pragmatic overview of protein kinases inhibitors and their potential role in disease modulation and treatment. Here, international experts in the field offer an integrated discussion of kinase inhibitor biology, biomarker discovery, and methods for drug design and development. After a brief overview of kinases and kinase inhibitors, subsequent chapters discuss individual kinases that are representative of the wider kinases and kinase families, including their roles in disease pathogenesis, underlying mechanisms, potential inhibitors and their modes of action for therapeutic modulation. Several potential drugs under different stages of clinical trials are discussed, including their relevance to cancer, diabetes, obesity, cardiovascular, neurological, and auto-immune and inflammatory disease, among other disorders. The book also addresses the challenges and opportunities for future kinase inhibitor development. Provides a thorough overview of kinase inhibitor biology and its role in disease progression and modulation Examines protein kinase inhibitor drugs in various stages of clinical trials and development Offers methods and protocols for protein kinase inhibitor research studies and drug design and development Includes chapter contributions from international leaders in the field