Physico Chemical Aspects Of Dosage Forms And Biopharmaceutics

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• Author : Amit Kumar Nayak,Kalyan Kumar Sen
• Publisher : Academic Press
• Release Date : 2023-05-01
• Total pages : 0
• ISBN : 0323918182
• File Size : 30,9 Mb
• Total Download : 704
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Download Physico-Chemical Aspects of Dosage Forms and Biopharmaceutics in PDF, Epub, and Kindle

Physico-chemical aspects of dosage forms and biopharmaceutics: Recent and Future Trends in Pharmaceutics, Volume 2 explores aspects of pharmaceutics with an original approach focused on technology, novelties and future trends in the field. The field of pharmaceutics is highly dynamic and rapidly expanding day by day, and it demands a variety of amplified efforts for designing and developing pharmaceutical processes and formulation strategies. This book provides practical information for conducting research in pharmaceutics. Physico-chemical aspects of dosage forms and biopharmaceutics is an essential reference for researchers in academia and industry as well as advanced graduate students in pharmaceutics. This book, the second volume of Recent and Future Trends in Pharmaceutics, discusses in detail the most recent developments in biopharmaceutics. Important and exciting areas such as solubility of drugs, pharmaceutical granulation, routes of drug administration, drug absorption, bioavailability and bioequivalence are included.

• Author : Alexander T Florence,David Attwood
• Publisher : Pharmaceutical Press
• Release Date : 2015-12-01
• Total pages : 665
• ISBN : 9780857111746
• File Size : 37,7 Mb
• Total Download : 292
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Download Physicochemical Principles of Pharmacy in PDF, Epub, and Kindle

This 6th edition of the established textbook covers every aspect of drug properties from the design of dosage forms to their delivery by all routes to sites of action in the body.

• Author : Yihong Qiu,Yisheng Chen,Geoff G.Z. Zhang,Lirong Liu,William Porter
• Publisher : Academic Press
• Release Date : 2009-03-10
• Total pages : 978
• ISBN : 008093272X
• File Size : 24,8 Mb
• Total Download : 857
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Download Developing Solid Oral Dosage Forms in PDF, Epub, and Kindle

Developing Solid Oral Dosage Forms is intended for pharmaceutical professionals engaged in research and development of oral dosage forms. It covers essential principles of physical pharmacy, biopharmaceutics and industrial pharmacy as well as various aspects of state-of-the-art techniques and approaches in pharmaceutical sciences and technologies along with examples and/or case studies in product development. The objective of this book is to offer updated (or current) knowledge and skills required for rational oral product design and development. The specific goals are to provide readers with: Basics of modern theories of physical pharmacy, biopharmaceutics and industrial pharmacy and their applications throughout the entire process of research and development of oral dosage forms Tools and approaches of preformulation investigation, formulation/process design, characterization and scale-up in pharmaceutical sciences and technologies New developments, challenges, trends, opportunities, intellectual property issues and regulations in solid product development The first book (ever) that provides comprehensive and in-depth coverage of what's required for developing high quality pharmaceutical products to meet international standards It covers a broad scope of topics that encompass the entire spectrum of solid dosage form development for the global market, including the most updated science and technologies, practice, applications, regulation, intellectual property protection and new development trends with case studies in every chapter A strong team of more than 50 well-established authors/co-authors of diverse background, knowledge, skills and experience from industry, academia and regulatory agencies

• Author : Anonim
• Publisher : Academic Press
• Release Date : 2018-07-28
• Total pages : 820
• ISBN : 9780128144244
• File Size : 49,9 Mb
• Total Download : 545
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Download Dosage Form Design Considerations in PDF, Epub, and Kindle

Dosage Form Design Parameters, Volume I, examines the history and current state of the field within the pharmaceutical sciences, presenting key developments. Content includes drug development issues, the scale up of formulations, regulatory issues, intellectual property, solid state properties and polymorphism. Written by experts in the field, this volume in the Advances in Pharmaceutical Product Development and Research series deepens our understanding of dosage form design parameters. Chapters delve into a particular aspect of this fundamental field, covering principles, methodologies and the technologies employed by pharmaceutical scientists. In addition, the book contains a comprehensive examination suitable for researchers and advanced students working in pharmaceuticals, cosmetics, biotechnology and related industries. Examines the history and recent developments in drug dosage forms for pharmaceutical sciences Focuses on physicochemical aspects, prefomulation solid state properties and polymorphism Contains extensive references for further discovery and learning that are appropriate for advanced undergraduates, graduate students and those interested in drug dosage design

• Author : Ram I. Mahato,Ajit S. Narang
• Publisher : CRC Press
• Release Date : 2017-11-22
• Total pages : 690
• ISBN : 9781482253672
• File Size : 32,5 Mb
• Total Download : 872
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Download Pharmaceutical Dosage Forms and Drug Delivery in PDF, Epub, and Kindle

Completely revised and updated, this third edition of Pharmaceutical Dosage Forms and Drug Delivery elucidates the basic principles of pharmaceutics, biopharmaceutics, dosage form design, and drug delivery – including emerging new biotechnology-based treatment modalities. The authors integrate aspects of physical pharmacy, chemistry, biology, and biopharmaceutics into drug delivery. This book highlights the increased attention that the recent spectacular advances in gene therapy and nanotechnology have brought to dosage form design and drug delivery. With the expiration of older patents and generic competition, the biopharmaceutical industry is evolving faster than ever. Apart from revising and updating existing chapters on the basic principles, this edition highlights the emerging emphasis on drug discovery, antibodies and antibody-drug conjugates as therapeutic moieties, individualized medicine including patient stratification strategies, targeted drug delivery, and the increasing role of modeling and simulation. Although there are numerous books on pharmaceutics and dosage forms, most cover different areas of the discipline and do not provide an integrated approach. The integrated approach of this book not only provides a singular perspective of the overall field, but also supplies a unified source of information for students, instructors and professionals, saving their time and money.

• Author : Yihong Qiu,Yisheng Chen,Geoff G.Z. Zhang,Lawrence Yu,Rao V. Mantri
• Publisher : Academic Press
• Release Date : 2016-11-08
• Total pages : 1176
• ISBN : 9780128026373
• File Size : 18,6 Mb
• Total Download : 584
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Download Developing Solid Oral Dosage Forms in PDF, Epub, and Kindle

Developing Solid Oral Dosage Forms: Pharmaceutical Theory and Practice, Second Edition illustrates how to develop high-quality, safe, and effective pharmaceutical products by discussing the latest techniques, tools, and scientific advances in preformulation investigation, formulation, process design, characterization, scale-up, and production operations. This book covers the essential principles of physical pharmacy, biopharmaceutics, and industrial pharmacy, and their application to the research and development process of oral dosage forms. Chapters have been added, combined, deleted, and completely revised as necessary to produce a comprehensive, well-organized, valuable reference for industry professionals and academics engaged in all aspects of the development process. New and important topics include spray drying, amorphous solid dispersion using hot-melt extrusion, modeling and simulation, bioequivalence of complex modified-released dosage forms, biowaivers, and much more. Written and edited by an international team of leading experts with experience and knowledge across industry, academia, and regulatory settings Includes new chapters covering the pharmaceutical applications of surface phenomenon, predictive biopharmaceutics and pharmacokinetics, the development of formulations for drug discovery support, and much more Presents new case studies throughout, and a section completely devoted to regulatory aspects, including global product regulation and international perspectives

• Author : Cosimo Prantera,Burton I. Korelitz
• Publisher : CRC Press
• Release Date : 1997-07-25
• Total pages : 264
• ISBN : 9780585378008
• File Size : 55,8 Mb
• Total Download : 787
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Download Development of Biopharmaceutical Parenteral Dosage Forms in PDF, Epub, and Kindle

This up-to-the-minute reference delineates-in a systematic fashion-the appropriate, sequential steps for the formulation of safe, effective, stable, and marketable liquid parenteral biopharmaceutical products-covering fundamentals and essential pathways for each phase as well as its purpose, function, and relation to other stages in the product development process. Written by experts currently involved in state-of-the-art advances in the pharmaceutical drug industry, Development of Biopharmaceutical Parenteral Dosage Forms details biopharmaceuticals that are licensed or undergoing clinical development, including genetically engineered cell and engineered vectors in the fermentation process describes purification and characterization techniques for rDNA therapeutics, discussing several types of unit operations for isolation, purification, and characterization considers preformulation and formulation requirements, such as physicochemical properties, drug delivery, stability studies programs, deactivation/denaturation routes, selection of compatible excipients, and regulatory compliance elucidates basics of analytical techniques, methods development, separation methods using chromatographic and electrophoretic techniques, and bioactivity methods covering bioassays and immunoassays for quantifying the stability of biological activity shows how to select the appropriate filter for maximizing compatibility and minimizing adsorption and inactivation, examining topics from basic filtration theories to future trends reviews the selection process for compatible elastomeric closures, analyzing physical, chemical, toxicological properties, protein adsorption on elastomeric surfaces, strategies to reduce/eliminate adsorption, and specialized containers for biotechnological applications and more! Furnished with helpful references, tables, and drawings, this practical guide is indispensable for pharmaceutical, medicinal, and protein chemists; molecular biologists; process engineers; purification scientists; biopharmaceutical and pharmaceutical formulators and product developers; quality control, quality assurance, and regulatory compliance personnel; and upper-level undergraduate and graduate students in these disciplines.

• Author : Mark Gibson
• Publisher : CRC Press
• Release Date : 2016-04-19
• Total pages : 560
• ISBN : 9781420073188
• File Size : 14,9 Mb
• Total Download : 792
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Download Pharmaceutical Preformulation and Formulation in PDF, Epub, and Kindle

Pharmaceutical Preformulation and Formulation: A Practical Guide from Candidate Drug Selection to Commercial Dosage Form reflects the mounting pressure on pharmaceutical companies to accelerate the new drug development and launch process, as well as the shift from developing small molecules to the growth of biopharmaceuticals. The book meets the need for advanced information for drug preformulation and formulation and addresses the current trends in the continually evolving pharmaceutical industry. Topics include: Candidate drug selection Drug discovery and development Preformulation predictions and drug selections Product design to commercial dosage form Biopharmaceutical support in formulation Development The book is ideal for practitioners working in the pharmaceutical arena—including R&D scientists, technicians, and managers—as well as for undergraduate and postgraduate courses in industrial pharmacy and pharmaceutical technology.

• Author : Alexander Taylor Florence,D. Attwood
• Publisher : Unknown
• Release Date : 1988
• Total pages : 485
• ISBN : 0333449959
• File Size : 48,6 Mb
• Total Download : 861
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Download Physicochemical Principles of Pharmacy in PDF, Epub, and Kindle

This book provides the physicochemical background to the design and use of pharmaceutical dosage forms. It goes beyond the introductory aspects of the subject to show how basic physicochemical principles are essential to an understanding of every aspect of drug action, from the dosage form to the site of action in the body. This is not a textbook of physical chemistry for pharmacists, but is a book which bridges the gap between basic first-year physical chemistry and the more applied practice of later years. This extensively revised second edition includes much new material, illustrations and references to take into account recent scientific developments and curriculum changes.

• Author : Hong Wen,Kinam Park
• Publisher : John Wiley & Sons
• Release Date : 2011-01-14
• Total pages : 376
• ISBN : 1118060326
• File Size : 31,8 Mb
• Total Download : 111
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Download Oral Controlled Release Formulation Design and Drug Delivery in PDF, Epub, and Kindle

This book describes the theories, applications, and challenges for different oral controlled release formulations. This book differs from most in its focus on oral controlled release formulation design and process development. It also covers the related areas like preformulation, biopharmaceutics, in vitro-in vivo correlations (IVIVC), quality by design (QbD), and regulatory issues.

• Author : Allen C Templeton,Stephen R. Byrn,Roy J Haskell,Thomas E. Prisinzano
• Publisher : Springer
• Release Date : 2014-10-31
• Total pages : 511
• ISBN : 9781493913992
• File Size : 48,7 Mb
• Total Download : 245
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Download Discovering and Developing Molecules with Optimal Drug-Like Properties in PDF, Epub, and Kindle

This authoritative volume provides a contemporary view on the latest research in molecules with optimal drug-like properties. It is a valuable source to access current best practices as well as new research techniques and strategies. Written by leading scientists in their fields, the text consists of fourteen chapters with an underlying theme of early collaborative opportunities between pharmaceutical and discovery sciences. The book explores the practical realities of performing physical pharmaceutical and biopharmaceutical research in the context of drug discovery with short timelines and low compound availability. Chapters cover strategies and tactics to enable discovery as well as predictive approaches to establish, understand and communicate risks in early development. It also examines the detection, characterization, and assessment of risks on the solid state properties of advanced discovery and early development candidates, highlighting the link between solid state properties and critical development parameters such as solubility and stability. Final chapters center on techniques to improve molecular solubilization and prevent precipitation, with particularly emphasis on linking physiochemical properties of molecules to formulation selection in preclinical and clinical settings.

• Author : Ram I. Mahato,Ajit S. Narang
• Publisher : CRC Press
• Release Date : 2007-06-07
• Total pages : 334
• ISBN : 9781420009200
• File Size : 28,8 Mb
• Total Download : 165
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Download Pharmaceutical Dosage Forms and Drug Delivery in PDF, Epub, and Kindle

Integrating aspects of physical pharmacy, biopharmaceuticals, drug delivery, and biotechnology, Pharmaceutical Dosage Forms and Drug Delivery elucidates basic physicochemical principles and their application in the design of dosage forms. The author addresses the relevance of these principles to the biopharmaceutical aspects of drugs. He explores the latest developments in the application of biomaterials, including polymers and biotechnology-based agents, to the development of novel dosage forms. The book covers physicochemical principles of dosage design, biopharmaceutical and physiological considerations, types of commonly used pharmaceutical dosage forms, introduction to polymeric biomaterials, protein and nucleic acid-based dosage forms, and novel and targeted drug delivery systems. It highlights the physicochemical parameters used for the design, development, and evaluation of biotechnological dosage forms and describes the biological barriers to drug absorption. Containing the right blend of mathematics, equations, diagrams, pictorials, and other pertinent information, this book provides a unified perspective that creates a greater overall understanding of basic science and cutting-edge technology.

• Author : Alfred N. Martin,Patrick J. Sinko
• Publisher : Lippincott Williams & Wilkins
• Release Date : 2010-02-01
• Total pages : 659
• ISBN : 1609134028
• File Size : 12,5 Mb
• Total Download : 665
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Download Martin's Physical Pharmacy and Pharmaceutical Sciences in PDF, Epub, and Kindle

Martin's Physical Pharmacy and Pharmaceutical Sciences is considered the most comprehensive text available on the application of the physical, chemical and biological principles in the pharmaceutical sciences. It helps students, teachers, researchers, and industrial pharmaceutical scientists use elements of biology, physics, and chemistry in their work and study. Since the first edition was published in 1960, the text has been and continues to be a required text for the core courses of Pharmaceutics, Drug Delivery, and Physical Pharmacy. The Sixth Edition features expanded content on drug delivery, solid oral dosage forms, pharmaceutical polymers and pharmaceutical biotechnology, and updated sections to cover advances in nanotechnology.

• Author : Yogeshwar Bachhav
• Publisher : John Wiley & Sons
• Release Date : 2019-08-09
• Total pages : 352
• ISBN : 9783527812202
• File Size : 55,7 Mb
• Total Download : 982
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Download Innovative Dosage Forms in PDF, Epub, and Kindle

Teaches future and current drug developers the latest innovations in drug formulation design and optimization This highly accessible, practice-oriented book examines current approaches in the development of drug formulations for preclinical and clinical studies, including the use of functional excipients to enhance solubility and stability. It covers oral, intravenous, topical, and parenteral administration routes. The book also discusses safety aspects of drugs and excipients, as well as regulatory issues relevant to formulation. Innovative Dosage Forms: Design and Development at Early Stage starts with a look at the impact of the polymorphic form of drugs on the preformulation and formulation development. It then offers readers reliable strategies for the formulation development of poorly soluble drugs. The book also studies the role of reactive impurities from the excipients on the formulation shelf life; preclinical formulation assessment of new chemical entities; and regulatory aspects for formulation design. Other chapters cover innovative formulations for special indications, including oncology injectables, delayed release and depot formulations; accessing pharmacokinetics of various dosage forms; physical characterization techniques to assess amorphous nature; novel formulations for protein oral dosage; and more. -Provides information that is essential for the drug development effort -Presents the latest advances in the field and describes in detail innovative formulations, such as nanosuspensions, micelles, and cocrystals -Describes current approaches in early pre-formulation to achieve the best in vivo results -Addresses regulatory and safety aspects, which are key considerations for pharmaceutical companies -Includes case studies from recent drug development programs to illustrate the practical challenges of preformulation design Innovative Dosage Forms: Design and Development at Early Stage provides valuable benefits to interdisciplinary drug discovery teams working in industry and academia and will appeal to medicinal chemists, pharmaceutical chemists, and pharmacologists.

• Author : Bente Steffansen,Birger Brodin,Carsten Uhd Nielsen
• Publisher : Unknown
• Release Date : 2010
• Total pages : 0
• ISBN : 0853697221
• File Size : 37,8 Mb
• Total Download : 220
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Download Molecular Biopharmaceutics in PDF, Epub, and Kindle

Molecular biopharmaceutics involves the study of drug absorption, transport and delivery at the molecular level. In particular, increasing knowledge of the molecular structure and function of membrane transporter proteins and the understanding that they play a significant role in drug transport across biological membranes has lead to growing interest in this area from the pharmaceutical industry. This emerging knowledge of membrane transporter proteins has implications for understanding drug disposition and in turn for the development of more effective drug delivery strategies. The proposed text will provide an overview of the field of molecular biopharmaceutics, and will explain its importance in drug development. It will focus on describing the interplay between the chemistry of drug molecules and membrane transporters, and will guide researchers in setting up experiments that may help in understanding the mechanisms and kinetics involved in drug absorption, transport and delivery.

• Author : Geoffrey D Tovey
• Publisher : Royal Society of Chemistry
• Release Date : 2018-06-25
• Total pages : 432
• ISBN : 9781849739412
• File Size : 45,8 Mb
• Total Download : 210
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Download Pharmaceutical Formulation in PDF, Epub, and Kindle

Formulation is a key step in the drug design process, where the active drug is combined with other substances that maximise the therapeutic potential, safety and stability of the final medicinal product. Modern formulation science deals with biologics as well as small molecules. Regulatory and quality demands, in addition to advances in processing technologies, result in growing challenges as well as possibilities for the field. Pharmaceutical Formulation provides an up to date source of information for all who wish to understand the principles and practice of formulation in the drug industry. The book provides an understanding of the links between formulation theory and the practicalities of processing in a commercial environment, giving researchers the knowledge to produce effective pharmaceutical products that can be approved and manufactured. The first chapters introduce readers to different dosage forms, including oral liquid products, topical products and solid dosage forms such as tablets and capsules. Subsequent chapters cover pharmaceutical coatings, controlled release drug delivery and dosage forms designed specifically for paediatric and geriatric patients. The final chapter provides an introduction to the vital role intellectual property plays in drug development. Covering modern processing methods and recent changes in the regulatory and quality demands of the industry, Pharmaceutical Formulation is an essential, up to date resource for students and researchers working in academia and in the pharmaceutical industry.

• Author : Richard A. Storey,Ingvar Ymén
• Publisher : John Wiley & Sons
• Release Date : 2011-03-31
• Total pages : 528
• ISBN : 9781119970170
• File Size : 49,8 Mb
• Total Download : 585
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Download Solid State Characterization of Pharmaceuticals in PDF, Epub, and Kindle

The field of solid state characterization is central to the pharmaceutical industry, as drug products are, in an overwhelming number of cases, produced as solid materials. Selection of the optimum solid form is a critical aspect of the development of pharmaceutical compounds, due to their ability to exist in more than one form or crystal structure (polymorphism). These polymorphs exhibit different physical properties which can affect their biopharmaceutical properties. This book provides an up-to-date review of the current techniques used to characterize pharmaceutical solids. Ensuring balanced, practical coverage with industrial relevance, it covers a range of key applications in the field. The following topics are included: Physical properties and processes Thermodynamics Intellectual guidance X-ray diffraction Spectroscopy Microscopy Particle sizing Mechanical properties Vapour sorption Thermal analysis & Calorimetry Polymorph prediction Form selection

• Author : Ram I. Mahato,Ajit S. Narang
• Publisher : CRC Press
• Release Date : 2016-12-26
• Total pages : 0
• ISBN : 1482253623
• File Size : 50,6 Mb
• Total Download : 335
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Download Pharmaceutical Dosage Forms and Drug Delivery, Third Edition in PDF, Epub, and Kindle

Completely revised and updated, this third edition of Pharmaceutical Dosage Forms and Drug Delivery elucidates the basic principles of pharmaceutics, biopharmaceutics, dosage form design, and drug delivery - including emerging new biotechnology-based treatment modalities. The authors integrate aspects of physical pharmacy, chemistry, biology, and biopharmaceutics into drug delivery. This book highlights the increased attention that the recent spectacular advances in gene therapy and nanotechnology have brought to dosage form design and drug delivery. With the expiration of older patents and generic competition, the biopharmaceutical industry is evolving faster than ever. Apart from revising and updating existing chapters on the basic principles, this edition highlights the emerging emphasis on drug discovery, antibodies and antibody-drug conjugates as therapeutic moieties, individualized medicine including patient stratification strategies, targeted drug delivery, and the increasing role of modeling and simulation. Although there are numerous books on pharmaceutics and dosage forms, most cover different areas of the discipline and do not provide an integrated approach. The integrated approach of this book not only provides a singular perspective of the overall field, but also supplies a unified source of information for students, instructors and professionals, saving their time and money.

• Author : Thomas L. Lemke,David A. Williams
• Publisher : Lippincott Williams & Wilkins
• Release Date : 2008
• Total pages : 1406
• ISBN : 0781768799
• File Size : 49,8 Mb
• Total Download : 441
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Download Foye's Principles of Medicinal Chemistry in PDF, Epub, and Kindle

The Sixth Edition of this well-known text has been fully revised and updated to meet the changing curricula of medicinal chemistry courses. Emphasis is on patient-focused pharmaceutical care and on the pharmacist as a therapeutic consultant, rather than a chemist. A new disease state management section explains appropriate therapeutic options for asthma, chronic obstructive pulmonary disease, and men's and women's health problems. Also new to this edition: Clinical Significance boxes, Drug Lists at the beginning of appropriate chapters, and an eight-page color insert with detailed illustrations of drug structures. Case studies from previous editions and answers to this edition's case studies are available online at thePoint.

• Author : Patrick J. Sinko
• Publisher : Lippincott Williams & Wilkins
• Release Date : 2023-02-08
• Total pages : 1848
• ISBN : 9781975174828
• File Size : 49,9 Mb
• Total Download : 995
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Download Martin's Physical Pharmacy and Pharmaceutical Sciences in PDF, Epub, and Kindle

Consistently revised and updated for more than 60 years to reflect the most current research and practice, Martin’s Physical Pharmacy and Pharmaceutical Sciences, 8th Edition, is the original and most comprehensive text available on the physical, chemical, and biological principles that underlie pharmacology and the pharmaceutical sciences. An ideal resource for PharmD and pharmacy students worldwide, teachers, researchers, or industrial pharmaceutical scientists, this 8th Edition has been thoroughly revised, enhanced, and reorganized to provide readers with a clear, consistent learning experience that puts essential principles and concepts in a practical, approachable context. Updated content reflects the latest developments and perspectives across the full spectrum of physical pharmacy and a new full-color design makes it easier than ever to discover, distinguish, and understand information—providing users the most robust support available for applying the elements of biology, physics, and chemistry in work or study.

• Author : David A. Williams,William O. Foye,Thomas L. Lemke
• Publisher : Lippincott Williams & Wilkins
• Release Date : 2002
• Total pages : 1136
• ISBN : 9780683307375
• File Size : 26,7 Mb
• Total Download : 985
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Download Foye's Principles of Medicinal Chemistry in PDF, Epub, and Kindle

This comprehensive Fifth Edition has been fully revised and updated to meet the changing curricula of medicinal chemistry courses. The new emphasis is on pharmaceutical care that focuses on the patient, and on the pharmacist a therapeutic clinical consultant, rather than chemist. Approximately 45 contributors, respected in the field of pharmacy education, augment this exhaustive reference. New to this edition are chapters with standardized formats and features, such as Case Studies, Therapeutic Actions, Drug Interactions, and more. Over 700 illustrations supplement this must-have resource.