Oxidative Stress
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Oxidative Stress and Antioxidant Protection
- Author : Donald Armstrong,Robert D. Stratton
- Publisher : John Wiley & Sons
- Release Date : 2016-01-14
- Total pages : 600
- ISBN : 9781118832400
- File Size : 18,5 Mb
- Total Download : 573
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Oxidative Stress and Antioxidant Protection: The Science of Free Radical Biology and Disease Oxidative Stress and Antioxidant Protection begins with a historical perspective of pioneers in oxidative stress with an introductory section that explains the basic principles related to oxidative stress in biochemistry and molecular biology, demonstrating both pathways and biomarkers. This section also covers diagnostic imaging and differential diagnostics. The following section covers psychological, physiologic, pharmacologic and pathologic correlates. This section addresses inheritance, gender, nutrition, obesity, family history, behavior modification, natural herbal-botanical products, and supplementation in the treatment of disease. Clinical trials are also summarized for major medical disorders and efficacy of treatment, with particular focus on inflammation, immune response, recycling, disease progression, outcomes and interventions. Each of the chapters describes what biomarker(s) and physiological functions may be relevant to a concept of specific disease and potential alternative therapy. The chapters cover medical terminology, developmental change, effects of aging, senescence, lifespan, and wound healing, and also illustrates cross-over exposure to other fields. The final chapter covers how and when to interpret appropriate data used in entry level biostatistics and epidemiology. Authored and edited by leaders in the field, Oxidative Stress and Antioxidant Protection will be an invaluable resource for students and researchers studying cell biology, molecular biology, and biochemistry, as well professionals in various health science fields.
Oxidative Stress
- Author : Helmut Sies
- Publisher : Elsevier
- Release Date : 2013-10-22
- Total pages : 507
- ISBN : 9781483289113
- File Size : 34,6 Mb
- Total Download : 916
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Oxidative Stress is intended as an in-depth account of knowledge and problems in the field of oxygen-related damage in biological systems. The topics range from an assessment of molecular events in in vitro model systems to complex problems in clinical medicine. Organized into two parts with a total of 18 chapters, this book begins with an introduction to oxidative stress, elucidating specific topics on reactive oxygen species, detoxification system, and nature of oxidative damage. The first part focuses on models used with cells and tissues in the study of oxidative stress, whereas the second part describes the processes elicited by oxidative stress.
Brain Aging
- Author : David R. Riddle
- Publisher : CRC Press
- Release Date : 2007-04-19
- Total pages : 408
- ISBN : 1420005529
- File Size : 32,8 Mb
- Total Download : 782
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Recognition that aging is not the accumulation of disease, but rather comprises fundamental biological processes that are amenable to experimental study, is the basis for the recent growth of experimental biogerontology. As increasingly sophisticated studies provide greater understanding of what occurs in the aging brain and how these changes occur
Oxidative Stress and Biomaterials
- Author : Thomas Dziubla,D Allan Butterfield
- Publisher : Academic Press
- Release Date : 2016-05-31
- Total pages : 404
- ISBN : 9780128032701
- File Size : 31,5 Mb
- Total Download : 835
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Oxidative Stress and Biomaterials provides readers with the latest information on biomaterials and the oxidative stress that can pose an especially troubling challenge to their biocompatibility, especially given the fact that, at the cellular level, the tissue environment is a harsh landscape of precipitating proteins, infiltrating leukocytes, released oxidants, and fluctuations of pH which, even with the slightest shift in stasis, can induce a perpetual state of chronic inflammation. No material is 100% non-inflammatory, non-toxic, non-teratogenic, non-carcinogenic, non-thrombogenic, and non-immunogenic in all biological settings and situations. In this embattled terrain, the most we can hope for from the biomaterials we design is a type of “meso-compatibility, a material which can remain functional and benign for as long as required without succumbing to this cellular onslaught and inducing a local inflammatory reaction. Explores the challenges of designing and using biomaterials in order to minimize oxidative stress, reducing patterns of chronic inflammation and cell death Brings together the two fields of biomaterials and the biology of oxidative stress Provides approaches for the design of biomaterials with improved biocompatibility
Oxidative Stress
- Author : Helmut Sies
- Publisher : Academic Press
- Release Date : 2019-11-07
- Total pages : 876
- ISBN : 9780128196960
- File Size : 43,5 Mb
- Total Download : 197
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Oxidative Stress: Eustress and Distress presents current knowledge on oxidative stress within the framework of redox biology and translational medicine. It describes eustress and distress in molecular terms and with novel imaging and chemogenetic approaches in four sections: A conceptual framework for studying oxidative stress. Processes and oxidative stress responses. Signaling in major enzyme systems (oxidative eustress), and damaging modification of biomolecules (oxidative distress). The exposome addresses lifelong exposure and impact on health, nutrient sensing, exercise and environmental pollution. Health and disease processes, including ischemia-reperfusion injury, developmental and psychological disorders, hepatic encephalopathy, skeletal muscle disorders, pulmonary disease, gut disease, organ fibrosis, and cancer. Oxidative Stress: Eustress and Distress is an informative resource useful for active researchers and students in biochemistry, molecular biology, medicinal chemistry, pharmaceutical science, nutrition, exercise physiology, analytical chemistry, cell biology, pharmacology, clinical medicine, and environmental science. Characterizes oxidative stress within the framework of redox biology, redox signaling, and medicine. Empowers researchers and students to quantify specific reactants noninvasively, identify redox biomarkers, and advance translational studies. Features contributions from international leaders in oxidative stress and redox biology research.
Oxidative Damage to Plants
- Author : Parvaiz Ahmad
- Publisher : Academic Press
- Release Date : 2014-01-29
- Total pages : 672
- ISBN : 9780128004609
- File Size : 28,5 Mb
- Total Download : 502
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With contributions that review research on this topic throughout the world, Oxidative Damage to Plants covers key areas of discovery, from the generation of reactive oxygen species (ROSs), their mechanisms, quenching of these ROSs through enzymatic and non-enzymatic antioxidants, and detailed aspects of such antioxidants as SOD and CAT. Environmental stress is responsible for the generation of oxidative stress, which causes oxidative damage to biomolecules and hence reduces crop yield. To cope up with these problems, scientists have to fully understand the generation of reactive oxygen species, its impact on plants and how plants will be able to withstand these stresses. Provides invaluable information about the role of antioxidants in alleviating oxidative stress Examines both the negative effects (senescence, impaired photosynthesis and necrosis) and positive effects (crucial role that superoxide plays against invading microbes) of ROS on plants Features contributors from a variety of regions globally
Oxidative Stress in Aquatic Ecosystems
- Author : Doris Abele,Jose Pablo Vazquez-Medina,Tania Zenteno-Savin
- Publisher : John Wiley & Sons
- Release Date : 2011-11-03
- Total pages : 548
- ISBN : 9781444345964
- File Size : 42,5 Mb
- Total Download : 401
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Reactive oxygen species (ROS) are increasingly appreciated as down-stream effectors of cellular damage and dysfunction under natural and anthropogenic stress scenarios in aquatic systems. This comprehensive volume describes oxidative stress phenomena in different climatic zones and groups of organisms, taking into account specific habitat conditions and how they affect susceptibility to ROS damage. A comprehensive and detailed methods section is included which supplies complete protocols for analyzing ROS production, oxidative damage, and antioxidant systems. Methods are also evaluated with respect to applicability and constraints for different types of research. The authors are all internationally recognized experts in particular fields of oxidative stress research. This comprehensive reference volume is essential for students, researchers, and technicians in the field of ROS research, and also contains information useful for veterinarians, environmental health professionals, and decision makers.
Current Advances for Development of Functional Foods Modulating Inflammation and Oxidative Stress
- Author : Blanca Hernandez-Ledesma,Cristina Martinez-Villaluenga
- Publisher : Academic Press
- Release Date : 2021-12-16
- Total pages : 688
- ISBN : 9780128225844
- File Size : 22,6 Mb
- Total Download : 654
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Current Advances for Development of Functional Foods Modulating Inflammation and Oxidative Stress presents the nutritional and technological aspects related to the development of functional foods with anti-inflammatory and antioxidant effects. Specifically, analytical approaches for the characterization of anti-inflammatory and antioxidant properties of healthy foods and functional constituents, as well as technological strategies for the extraction of compounds and fractions from raw materials to produce anti-inflammatory and antioxidant ingredients are addressed. In addition, the molecular mechanisms by which foods and their components can modulate inflammation and their oxidative stress effects on disease prevention are explored. Finally, clinical research addressing nutritional needs in pathological subjects with inflammatory diseases are considered. Covers methods of analysis and extraction of anti-inflammatory and antioxidant compounds Offers an overview of the main anti-inflammatory and antioxidant compounds in foods Provides a guide on the mechanisms of action and health benefits of anti-inflammatory and antioxidant dietary bioactives
Oxidative Stress and Dietary Antioxidants in Neurological Diseases
- Author : Colin R. Martin,Victor R Preedy
- Publisher : Academic Press
- Release Date : 2020-06-12
- Total pages : 444
- ISBN : 9780128177815
- File Size : 42,5 Mb
- Total Download : 467
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Oxidative Stress and Dietary Antioxidants in Neurological Diseases provides an overview of oxidative stress in neurological diseases and associated conditions, including behavioral aspects and the potentially therapeutic usage of natural antioxidants in the diet. The processes within the science of oxidative stress are described in concert with other processes, such as apoptosis, cell signaling, and receptor mediated responses. This approach recognizes that diseases are often multifactorial and oxidative stress is a single component of this. The book examines basic processes of oxidative stress—from molecular biology to whole organs—relative to cellular defense systems, and across a range of neurological diseases. Sections discuss antioxidants in foods, including plants and components of the diet, examining the underlying mechanisms associated with therapeutic potential and clinical applications. Although some of this material is exploratory or preclinical, it can provide the framework for further in-depth analysis or studies via well-designed clinical trials or the analysis of pathways, mechanisms, and components in order to devise new therapeutic strategies. Very often oxidative stress is a feature of neurological disease and associated conditions which either centers on or around molecular and cellular processes. Oxidative stress can also arise due to nutritional imbalance during a spectrum of timeframes before the onset of disease or during its development. Offers an overview of oxidative stress from molecular biology to whole organs Discusses the potentially therapeutic usage of natural antioxidants in the patient diet Provides the framework for further in-depth analysis or studies of potential treatments
Oxidative Stress and Aging
- Author : R.C. Cutler,L. Packer,J. Bertram,A. Mori
- Publisher : Birkhäuser
- Release Date : 2012-12-06
- Total pages : 399
- ISBN : 9783034873376
- File Size : 13,9 Mb
- Total Download : 719
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Oxidative stress and aging Over the past several years there has been an extraordinarily rapid growth in our knowledge of free radical chemistry and its possible involvement in both normal essential biology and age related disease and dysfunction. Much of this growth in the traditionally separate sciences of chemistry and molecular gerontology occurred independently, with little interaction or communi cation between the scientists working in these two fields. In view of the growing maturity of the two fields and the potential importance of advancing our knowledge in the area of oxidative stress and aging, we perceived a critical need to organize an international conference the "First Inter national Conference on Oxidative Stress and Aging" in Hawaii in 1994 to bring together the world's leading scientists in the fields of reactive oxygen species and molecular gerontology. The objective of this conference was to provide a unique opportunity for scholars working in these two related and rapidly growing fields to participate in the exchange, integration, and synthesis of new concepts and ideas, to engage in constructive criticism and to initiate new collaborative research projects. The conference focused on the molecular and cellular aspects of aging as related to oxidative stress. It was one of the largest and most comprehensive international conferences held in molecular gerontology. At this conference a call was made for submission of papers to be used in the publication of a book covering the major contributions of the meeting.
Oxidative Stress and Vascular Disease
- Author : John F. Keaney Jr.
- Publisher : Springer Science & Business Media
- Release Date : 2012-12-06
- Total pages : 373
- ISBN : 9781461546498
- File Size : 12,6 Mb
- Total Download : 236
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One of the major biomedical triumphs of the post-World War II era was the defmitive demonstration that hypercholesterolemia is a key causative factor in atherosclerosis; that hypercholesterolemia can be effectively treated; and that treatment significantly reduces not only coronary disease mortality but also all cause mortality. Treatment to lower plasma levels of cholesterol - primarily low density lipoprotein (LDL) cholesterol - is now accepted as best medical practice and both physicians and patients are being educated to take aggressive measures to lower LDL. We can confidently look forward to important decreases in the toll of coronary artery disease over the coming decades. However, there is still uncertainty as to the exact mechanisms by which elevated plasma cholesterol and LDL levels initiate and favor the progression of lesions. There is general consensus that one of the earliest responses to hypercholesterolemia is the adhesion of monocytes to aortic endothelial cells followed by their penetration into the subendothelial space, where they differentiate into macrophages. These cells, and also medial smooth muscle cells that have migrated into the subendothelial space, then become loaded with mUltiple, large droplets of cholesterol esters . . . the hallmark of the earliest visible atherosclerotic lesion, the so-called fatty streak. This lesion is the precursor of the more advanced lesions, both in animal models and in humans. Thus the centrality of hypercholesterolemia cannot be overstated. Still, the atherogenic process is complex and evolves over a long period of time.
Novel Therapeutic Approaches Targeting Oxidative Stress
- Author : Pawan Kumar Maurya,Imteyaz Qamar
- Publisher : Academic Press
- Release Date : 2022-02-18
- Total pages : 292
- ISBN : 9780323909068
- File Size : 53,5 Mb
- Total Download : 571
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Novel Therapeutic Approaches Targeting Oxidative Stress investigates the role of oxidative stress in disease and explores the latest methods and approaches to targeting oxidative stress for treatment and diagnosis. The book begins with an introduction to oxidative stress and its significance. Subsequent sections cover biochemical methods for detecting free radicals and novel therapeutic approaches for targeting oxidative stress in a number of different diseases. This includes age-related illnesses, neuropsychiatric disorders such as schizophrenia and bipolar disorder, and neurodegenerative diseases like Alzheimer’s and Parkinson’s disease. Novel approaches for targeting oxidative stress in cancer and cardiovascular diseases are also explored. The book then moves on to discuss advances in drug delivery systems and detecting oxidative stress biomarkers using biosensors. It concludes with case studies that illustrate the targeting of oxidative stress and future perspectives. Explores oxidative stress in a variety of diseases, including neurological disorders, cardiovascular diseases, age-related diseases, and cancer Covers a range of therapeutic approaches to target oxidative stress Includes chapters on the application of novel drug delivery systems and diagnostic biosensors to oxidative stress Features case studies illustrating the targeting of oxidative stress
Handbook of Oxidative Stress in Cancer: Therapeutic Aspects
- Author : Sajal Chakraborti
- Publisher : Springer Nature
- Release Date : 2022-09-28
- Total pages : 4078
- ISBN : 9789811654220
- File Size : 37,8 Mb
- Total Download : 248
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This reference book, which is the second volume of Targeting Oxidative Stress in Cancer, explores oxidative stress as the potential therapeutic target for cancer therapy. The initial chapters discuss the molecular mechanisms of oxidative stress and its effects on different signaling pathways. Subsequently, the sections examine the impact of redox signaling on tumor cell proliferation and consider the therapeutic potential of dietary phytochemicals and nutraceuticals in reactive oxygen species (ROS)-induced cancer. In turn, it examines the evidence supporting the use of Vitamin C in cancer management, before presenting various synthetic and natural compounds that have therapeutic implications for oxidative stress-induced cancer. It also explores the correlation between non-coding RNA and oxidative stress. Furthermore, the book summarizes the role of stem cells in ROS-induced cancer therapy and reviews the therapeutic applications of nanoparticles to alter redox haemostasis in cancer cells. Lastly, it explores heat-shock proteins, ubiquitin ligases, and probiotics as potential therapeutic agents in ROS-mediated cancer. This book is a useful resource for basic and translational scientists as well as clinicians interested in the field of oxidative stress and cancer therapy.
Aging Research in Yeast
- Author : Michael Breitenbach,S. Michal Jazwinski,Peter Laun
- Publisher : Springer Science & Business Media
- Release Date : 2011-11-19
- Total pages : 368
- ISBN : 9400725612
- File Size : 46,5 Mb
- Total Download : 751
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This volume includes contributions by the leading experts in the field of yeast aging. Budding yeast (Saccharomyces cerevisiae) and other fungal organisms provide models for aging research that are relevant to organismic aging and to the aging processes occurring in the human body. Replicative aging, in which only the mother cell ages while the daughter cell resets the clock to zero is a model for the aging of stem cell populations in humans, while chronological aging (measured by survival in stationary phase) is a model for the aging processes in postmitotic cells (for instance, neurons of the brain). Most mechanisms of aging are studied in yeast. Among them, this book discusses: mitochondrial theories of aging, emphasizing oxidative stress and retrograde responses; the role of autophagy and mitophagy; the relationship of apoptosis to aging processes; the role of asymmetric segregation of damage in replicative aging; the role of replication stress; and the role of the cytoskeleton in aging. Modern methods of yeast genetics and genomics are described that can be used to search for aging-specific functions in a genome-wide unbiased fashion. The similarities in the pathology of senescence (studied in yeast) and of cancer cells, including genome instability, are examined.
Reactive Oxygen, Nitrogen and Sulfur Species in Plants
- Author : Mirza Hasanuzzaman,Vasileios Fotopoulos,Kamrun Nahar,Masayuki Fujita
- Publisher : John Wiley & Sons
- Release Date : 2019-07-02
- Total pages : 1024
- ISBN : 9781119468646
- File Size : 24,7 Mb
- Total Download : 967
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Presents a multidisciplinary analysis of the integration among reactive oxygen species (ROS), reactive nitrogen species (RNS), and reactive sulfur species (RSS). Since plants are the main source of our food, the improvement of their productivity is the most important task for plant biologists. In this book, leading experts accumulate the recent development in the research on oxidative stress and approaches to enhance antioxidant defense system in crop plants. They discuss both the plant responses to oxidative stress and mechanisms of abiotic stress tolerance, and cover all of the recent approaches towards understanding oxidative stress in plants, providing comprehensive information about the topics. It also discusses how reactive nitrogen species and reactive sulfur species regulate plant physiology and plant tolerance to environmental stresses. Reactive Oxygen, Nitrogen and Sulfur Species in Plants: Production, Metabolism, Signaling and Defense Mechanisms covers everything readers need to know in four comprehensive sections. It starts by looking at reactive oxygen species metabolism and antioxidant defense. Next, it covers reactive nitrogen species metabolism and signaling before going on to reactive sulfur species metabolism and signaling. The book finishes with a section that looks at crosstalk among reactive oxygen, nitrogen, and sulfur species based on current research done by experts. Presents the newest method for understanding oxidative stress in plants. Covers both the plant responses to oxidative stress and mechanisms of abiotic stress tolerance Details the integration among reactive oxygen species (ROS), reactive nitrogen species (RNS) and reactive sulfur species (RSS) Written by 140 experts in the field of plant stress physiology, crop improvement, and genetic engineering Providing a comprehensive collection of up-to-date knowledge spanning from biosynthesis and metabolism to signaling pathways implicated in the involvement of RONSS to plant defense mechanisms, Reactive Oxygen, Nitrogen and Sulfur Species in Plants: Production, Metabolism, Signaling and Defense Mechanisms is an excellent book for plant breeders, molecular biologists, and plant physiologists, as well as a guide for students in the field of Plant Science.
Oxidative Stress and Redox Regulation
- Author : Ursula Jakob,Dana Reichmann
- Publisher : Springer Science & Business Media
- Release Date : 2013-03-15
- Total pages : 486
- ISBN : 9789400757875
- File Size : 30,6 Mb
- Total Download : 745
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Many physiological conditions such as host defense or aging and pathological conditions such as neurodegenerative diseases, and diabetes are associated with the accumulation of high levels of reactive oxygen species and reactive nitrogen species. This generates a condition called oxidative stress. Low levels of reactive oxygen species, however, which are continuously produced during aerobic metabolism, function as important signaling molecules, setting the metabolic pace of cells and regulating processes ranging from gene expression to apoptosis. For this book we would like to recruit the experts in the field of redox chemistry, bioinformatics and proteomics, redox signaling and oxidative stress biology to discuss how organisms achieve the appropriate redox balance, the mechanisms that lead to oxidative stress conditions and the physiological consequences that contribute to aging and disease.
Molecular Basis of Oxidative Stress
- Author : Frederick A. Villamena
- Publisher : John Wiley & Sons
- Release Date : 2013-06-06
- Total pages : 446
- ISBN : 9781118355879
- File Size : 11,5 Mb
- Total Download : 810
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Sets the stage for the development of better diagnostictechniques and therapeutics Featuring contributions from an international team of leadingclinicians and biomedical researchers, Molecular Basis ofOxidative Stress reviews the molecular and chemical bases ofoxidative stress, describing how oxidative stress can lead to thedevelopment of cancer and cardiovascular and neurodegenerativediseases. Moreover, it explains the potential role of free radicalsin both the diagnosis and the development of therapeutics to treatdisease. Molecular Basis of Oxidative Stress is logicallyorganized, beginning with a comprehensive discussion of thefundamental chemistry of reactive species. Next, the book: Presents new mechanistic insights into how oxidative damage ofbiomolecules occurs Examines how these oxidative events effect cellularmetabolism Investigates the role of oxidative stress in the pathogenesisof cancer, neurodegenerative disease, cardiovascular disease, andcystic fibrosis Explores opportunities to improve the diagnosis of disease andthe design of new therapeutic agents Readers will find much novel information, including new radicalchemistries and the latest discoveries of how free radicals reactwith biomolecules. The contributors also present recent findingsthat help us better understand the initiation of oxidative stressand the mechanisms leading to the pathogenesis of variousdiseases. Throughout the book, the use of molecular structures helpsreaders better understand redox chemistry. In addition, plenty ofdetailed figures illustrate the mechanisms of oxidative stress anddisease pathogenesis. Examining everything from the basic chemistry of oxidativestress to the pathogenesis of disease, Molecular Basis ofOxidative Stress will help readers continue to explore thenature of oxidative stress and then use that knowledge to developnew approaches to prevent, detect, and treat a broad range ofdisease conditions.
Antioxidants in Sport Nutrition
- Author : Manfred Lamprecht
- Publisher : CRC Press
- Release Date : 2014-09-17
- Total pages : 304
- ISBN : 9781466567573
- File Size : 40,8 Mb
- Total Download : 754
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The use of antioxidants in sports is controversial due to existing evidence that they both support and hinder athletic performance. Antioxidants in Sport Nutrition covers antioxidant use in the athlete ́s basic nutrition and discusses the controversies surrounding the usefulness of antioxidant supplementation. The book also stresses how antioxidants may affect immunity, health, and exercise performance. The book contains scientifically based chapters explaining the basic mechanisms of exercise-induced oxidative damage. Also covered are methodological approaches to assess the effectiveness of antioxidant treatment. Biomarkers are discussed as a method to estimate the bioefficacy of dietary/supplemental antioxidants in sports. This book is useful for sport nutrition scientists, physicians, exercise physiologists, product developers, sport practitioners, coaches, top athletes, and recreational athletes. In it, they will find objective information and practical guidance.
Measuring Oxidants and Oxidative Stress in Biological Systems
- Author : Lawrence J. Berliner,Narasimham L. Parinandi
- Publisher : Springer Nature
- Release Date : 2020-08-08
- Total pages : 237
- ISBN : 9783030473181
- File Size : 10,7 Mb
- Total Download : 421
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This book describes the methods of analysis and determination of oxidants and oxidative stress in biological systems. Reviews and protocols on select methods of analysis of ROS, RNS, oxygen, redox status, and oxidative stress in biological systems are described in detail. It is an essential resource for both novices and experts in the field of oxidant and oxidative stress biology.
Oxidative Stress in Cancer, AIDS, and Neurodegenerative Diseases
- Author : Luc Montagnier,Rene Olivier,Catherine Pasquier
- Publisher : CRC Press
- Release Date : 1997-10-06
- Total pages : 578
- ISBN : 1420002929
- File Size : 20,5 Mb
- Total Download : 760
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Based on a conference on Oxidative Stress and Redox Regulation, held at the Pasteur Institute, Paris, this work examines fundamental, chemical, biological and medical studies of free radicals on different targets and the consequences of their reactivity. It covers the chemistry and biochemistry of free radicals, free radicals as second messengers that group the activation of transcription factors and enzymes, the importance of the antioxidant system in cell metabolism regulation, and the role of free radicals and antioxidants in disease management. The editors of this work are three of the most respected pioneers in the field. Dr. Montagnier is credited as the discoverer of HIV.
The Effects of Tert-Butyl Kydroperoxide- and Iron-induced Oxidative Stress on Retinal Pigment Epithelium Physiology and Function
- Author : Ludmila Anatolievna Voloboueva
- Publisher : Unknown
- Release Date : 2004
- Total pages : 392
- ISBN : UCAL:C3497407
- File Size : 54,7 Mb
- Total Download : 347
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PDF book entitled The Effects of Tert-Butyl Kydroperoxide- and Iron-induced Oxidative Stress on Retinal Pigment Epithelium Physiology and Function written by Ludmila Anatolievna Voloboueva and published by Unknown which was released on 2004 with total hardcover pages 392, the book become popular and critical acclaim.