Organ On A Chip

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Organ-on-a-chip

Organ-on-a-chip
  • Author : Julia Hoeng,David Bovard,Manuel Peitsch
  • Publisher : Academic Press
  • Release Date : 2019-11-09
  • Total pages : 546
  • ISBN : 9780128172032
  • File Size : 55,9 Mb
  • Total Download : 243
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Organ-on-a-Chip: Engineered Microenvironments for Safety and Efficacy Testing contains chapters from world-leading researchers in the field of organ on a chip development and applications, with perspectives from life sciences, medicine, physiology and engineering. The book contains an overview of the field, with sections covering the major organ systems and currently available technologies, platforms and methods. As readers may also be interested in creating biochips, materials and engineering best practice, these topics are also described. Users will learn about the limitations of 2D in-vitro models and the available 3D in-vitro models (what benefits they offer and some examples). Finally, the MOC section shows how the organ on a chip technology can be adapted to improve the physiology of in-vitro models. Includes case studies of other organs on a chip that have been developed and successfully used Provides insights into functional microphysiological organ on a chip platforms for toxicity and efficacy testing, along with opportunities for translational medicine Presented fields (PK/PD, physiology, medicine, safety) are given a definition followed by the challenges and potential of organs on a chip

Organ-on-a-chip

Organ-on-a-chip
  • Author : Marco Rasponi
  • Publisher : Unknown
  • Release Date : 2022
  • Total pages : 322
  • ISBN : 1071616935
  • File Size : 45,8 Mb
  • Total Download : 733
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This book provides a collection of microphysiological systems employed for chemical/drug screening and strategies to mimic various physiological conditions. Chapters guide readers through Organ-on-a-Chip( OoC) platforms such as liver, intestine, blood-brain barrier, kidney, vessels, cardiac and skeletal muscles, articular joint, human fat. Additional chapters detail microfabrication technologies used to fabricate OoC devices such as, standard photo- and soft-lithography, techniques to fabricate membranes, and industrial-oriented fabrication methods.Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Organ-On-a Chip: Methods and Protocols aims to be a useful practical guide to researches to help further their study in this field.

Principles of Human Organs-on-Chips

Principles of Human Organs-on-Chips
  • Author : Masoud Mozafari
  • Publisher : Woodhead Publishing
  • Release Date : 2023-01-27
  • Total pages : 492
  • ISBN : 9780128236109
  • File Size : 52,9 Mb
  • Total Download : 573
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Principles of Human Organs-on-Chips covers all aspects of microfluidic organ-on-a-chip systems, from fabrication to application and commercialization. Organ-on-a-chip models are created to mimic the structural, microenvironmental and physiological functions of human organs, providing the potential to bypass some cell and animal testing methods. This is a useful platform with widespread applications, frequently in drug screening and pathological studies. This book offers a comprehensive and authoritative reference on microfluidic organs-on-chips, spanning all key aspects from fabrication methods, cell culture systems and cell-based analysis, to dedicated chapters on specific tissue types and their associated organ-on-a-chip models, as well as their use as disease models, drug screening platforms and more. Principles of Human Organs-on-Chips helps materials scientists and biomedical engineers to better understand the specific requirements and challenges in the design and fabrication of organ-on-a-chip devices. This book also bridges the knowledge gap between medical device design and subsequent clinical applications, allowing medical professionals to easily learn about related engineering concepts and techniques. Describes various microfluidic systems and fabrication methods Covers models and applications for a broad range of tissue types, including liver, eye, immune, gut, and more Offers an interdisciplinary approach, combining engineering techniques and clinical applications of organs-on-chips

Lab-on-a-Chip Fabrication and Application

Lab-on-a-Chip Fabrication and Application
  • Author : Margarita Stoytcheva,Roumen Zlatev
  • Publisher : BoD – Books on Demand
  • Release Date : 2016-06-29
  • Total pages : 210
  • ISBN : 9789535124573
  • File Size : 14,9 Mb
  • Total Download : 488
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The necessity of on-site, fast, sensitive, and cheap complex laboratory analysis, associated with the advances in the microfabrication technologies and the microfluidics, made it possible for the creation of the innovative device lab-on-a-chip (LOC), by which we would be able to scale a single or multiple laboratory processes down to a chip format. The present book is dedicated to the LOC devices from two points of view: LOC fabrication and LOC application.

Animal Experimentation

Animal Experimentation
  • Author : Kathrin Herrmann,Kimberley Jayne
  • Publisher : Human-Animal Studies
  • Release Date : 2019
  • Total pages : 714
  • ISBN : 9004356185
  • File Size : 15,6 Mb
  • Total Download : 102
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Animal Experimentation: Working Towards a Paradigm Change critically appraises current animal use in science and discusses ways in which we can contribute to a paradigm change towards human-biology based approaches.

The Organ Thieves

The Organ Thieves
  • Author : Chip Jones
  • Publisher : Simon and Schuster
  • Release Date : 2020-08-18
  • Total pages : 400
  • ISBN : 9781982107543
  • File Size : 33,5 Mb
  • Total Download : 505
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The Immortal Life of Henrietta Lacks meets Get Out in this “startling…powerful” (Kirkus Reviews) investigation of racial inequality at the core of the heart transplant race. In 1968, Bruce Tucker, a black man, went into Virginia’s top research hospital with a head injury, only to have his heart taken out of his body and put into the chest of a white businessman. Now, in The Organ Thieves, Pulitzer Prize–nominated journalist Chip Jones exposes the horrifying inequality surrounding Tucker’s death and how he was used as a human guinea pig without his family’s permission or knowledge. The circumstances surrounding his death reflect the long legacy of mistreating African Americans that began more than a century before with cadaver harvesting and worse. It culminated in efforts to win the heart transplant race in the late 1960s. Featuring years of research and fresh reporting, along with a foreword from social justice activist Ben Jealous, “this powerful book weaves together a medical mystery, a legal drama, and a sweeping history, its characters confronting unprecedented issues of life and death under the shadows of centuries of racial injustice” (Edward L. Ayers, author of The Promise of the New South).

Microfluidic Organ-on-a-Chip: Revolutionary Platforms for Disease Comprehension and Treatment

Microfluidic Organ-on-a-Chip: Revolutionary Platforms for Disease Comprehension and Treatment
  • Author : Shi-Cong Tao,Shang-Chun Guo,Wei Seong Toh,Nuno M. Neves,Owen Gareth Davies
  • Publisher : Frontiers Media SA
  • Release Date : 2022-01-11
  • Total pages : 176
  • ISBN : 9782889740284
  • File Size : 15,6 Mb
  • Total Download : 656
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Existing culture systems have a limited ability to reproduce the complicated and dynamic microenvironment of a functioning organ. To solve the issues of conventional culture techniques, multidisciplinary researchers, involving medical doctors, stem cell and developmental biology experts, engineers and physical scientists, have emerged to innovate methods and devices. A microfluidic organ-on-a-chip (μOOC) is a cell culture device, based on microfluidic technology, which contains continuously perfused chambers with cells to simulate organ-level physiology/pathology. The μOOC is not to build a whole living organ, but rather to synthesize minimal functional units that recapitulate organ-/tissue-level functions. The μOOC can be applied to study not only the convention stimulation on cells by molecular/drugs, but also physical forces (fluid shear stress, cyclic strain and mechanical compression), organ-specific cell-cell intercommunication, and organ-organ coupling responses. There is an emerging need for innovative approaches for the production, control, analysis, and utilization of the μOOC, and even the multiple interconnected μOOC (Human-on-a-Chip). Although the μOOC has attracted much attention and is continuous being studied, there are still many difficult problems to be solved. Some of the most mentioned challenges include microenvironmental (biochemical, biophysical, biomechanical, nutrient, etc.) control, modeling tissue–tissue and multiorgan interactions, and reducing variability (automated control, high-throughput manipulation/analysis, integration of biosensing and etc.).

Biomedical Applications of Microfluidic Devices

Biomedical Applications of Microfluidic Devices
  • Author : Michael R. Hamblin,Mahdi Karimi
  • Publisher : Academic Press
  • Release Date : 2020-11-12
  • Total pages : 350
  • ISBN : 9780128187920
  • File Size : 27,5 Mb
  • Total Download : 579
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Biomedical Applications of Microfluidic Devices introduces the subject of microfluidics and covers the basic principles of design and synthesis of actual microchannels. The book then explores how the devices are coupled to signal read-outs and calibrated, including applications of microfluidics in areas such as tissue engineering, organ-on-a-chip devices, pathogen identification, and drug/gene delivery. This book covers high-impact fields (microarrays, organ-on-a-chip, pathogen detection, cancer research, drug delivery systems, gene delivery, and tissue engineering) and shows how microfluidics is playing a key role in these areas, which are big drivers in biomedical engineering research. This book addresses the fundamental concepts and fabrication methods of microfluidic systems for those who want to start working in the area or who want to learn about the latest advances being made. The subjects covered are also an asset to companies working in this field that need to understand the current state-of-the-art. The book is ideal for courses on microfluidics, biosensors, drug targeting, and BioMEMs, and as a reference for PhD students. The book covers the emerging and most promising areas of biomedical applications of microfluidic devices in a single place and offers a vision of the future. Covers basic principles and design of microfluidics devices Explores biomedical applications to areas such as tissue engineering, organ-on-a-chip, pathogen identification, and drug and gene delivery Includes chemical applications in organic and inorganic chemistry Serves as an ideal text for courses on microfluidics, biosensors, drug targeting, and BioMEMs, as well as a reference for PhD students

Multidisciplinary Microfluidic and Nanofluidic Lab-on-a-Chip

Multidisciplinary Microfluidic and Nanofluidic Lab-on-a-Chip
  • Author : Xiujun James Li,Chaoyong Yang,Paul C. H. Li
  • Publisher : Newnes
  • Release Date : 2021-09-19
  • Total pages : 484
  • ISBN : 9780444594617
  • File Size : 46,9 Mb
  • Total Download : 493
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Multidisciplinary Microfluidic and Nanofluidic Lab-on-a-Chip: Principles and Applications provides chemists, biophysicists, engineers, life scientists, biotechnologists, and pharmaceutical scientists with the principles behind the design, manufacture, and testing of life sciences microfluidic systems. This book serves as a reference for technologies and applications in multidisciplinary areas, with an emphasis on quickly developing or new emerging areas, including digital microfluidics, nanofluidics, papers-based microfluidics, and cell biology. The book offers practical guidance on how to design, analyze, fabricate, and test microfluidic devices and systems for a wide variety of applications including separations, disease detection, cellular analysis, DNA analysis, proteomics, and drug delivery. Calculations, solved problems, data tables, and design rules are provided to help researchers understand microfluidic basic theory and principles and apply this knowledge to their own unique designs. Recent advances in microfluidics and microsystems for life sciences are impacting chemistry, biophysics, molecular, cell biology, and medicine for applications that include DNA analysis, drug discovery, disease research, and biofluid and environmental monitoring. Provides calculations, solved problems, data tables and design rules to help understand microfluidic basic theory and principles Gives an applied understanding of the principles behind the design, manufacture, and testing of microfluidic systems Emphasizes on quickly developing and emerging areas, including digital microfluidics, nanofluidics, papers-based microfluidics, and cell biology

Cardiac Cell Culture Technologies

Cardiac Cell Culture Technologies
  • Author : Zbigniew Brzozka,Elzbieta Jastrzebska
  • Publisher : Springer
  • Release Date : 2017-11-21
  • Total pages : 234
  • ISBN : 9783319706856
  • File Size : 32,8 Mb
  • Total Download : 170
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This book provides an introduction to the biological background of heart functioning and analyzes the various materials and technologies used for the development of microfluidic systems dedicated to cell culture, with an emphasis on cardiac cells. The authors describe the characterization of microfluidic systems for cardiac cell culture and center their discussion of the use of stem cell stimulation based on four different types: electrical, biochemical, physical, and mechanical. This book is appropriate for researchers focused on on-chip technologies and heart studies, students in bioengineering and microengineering courses, and a variety of professionals, such as biotechnologists, biomedical engineers, and clinicians working in the cardiac diseases field.

Applications of Microfluidic Systems in Biology and Medicine

Applications of Microfluidic Systems in Biology and Medicine
  • Author : Manabu Tokeshi
  • Publisher : Springer
  • Release Date : 2019-04-25
  • Total pages : 382
  • ISBN : 9789811362293
  • File Size : 41,5 Mb
  • Total Download : 805
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This book focuses on state-of-the-art microfluidic research in medical and biological applications. The top-level researchers in this research field explain carefully and clearly what can be done by using microfluidic devices. Beginners in the field —undergraduates, engineers, biologists, medical researchers—will easily learn to understand microfluidic-based medical and biological applications. Because a wide range of topics is summarized here, it also helps experts to learn more about fields outside their own specialties. The book covers many interesting subjects, including cell separation, protein crystallization, single-cell analysis, cell diagnosis, point-of-care testing, immunoassay, embyos/worms on a chip and organ-on-a-chip. Readers will be convinced that microfluidic devices have great potential for medical and biological applications.

Microsystems for Pharmatechnology

Microsystems for Pharmatechnology
  • Author : Andreas Dietzel
  • Publisher : Springer
  • Release Date : 2016-01-22
  • Total pages : 348
  • ISBN : 9783319269207
  • File Size : 51,5 Mb
  • Total Download : 295
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This book provides a comprehensive, state-of-the-art review of microfluidic approaches and applications in pharmatechnology. It is appropriate for students with an interdisciplinary interest in both the pharmaceutical and engineering fields, as well as process developers and scientists in the pharmaceutical industry. The authors cover new and advanced technologies for screening, production by micro reaction technology and micro bioreactors, small-scale processing of drug formulations, and drug delivery that will meet the need for fast and effective screening methods for drugs in different formulations, as well as the production of drugs in very small volumes. Readers will find detailed chapters on the materials and techniques for fabrication of microfluidic devices, microbioreactors, microsystems for emulsification, on-chip fabrication of drug delivery systems, respiratory drug delivery and delivery through microneedles, organs-on-chip, and more.

Biomaterials for Organ and Tissue Regeneration

Biomaterials for Organ and Tissue Regeneration
  • Author : Nihal Vrana,Helena Knopf-Marques,Julien Barthes
  • Publisher : Woodhead Publishing
  • Release Date : 2020-03-20
  • Total pages : 846
  • ISBN : 9780081029077
  • File Size : 43,5 Mb
  • Total Download : 243
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Biomaterials for Organ and Tissue Regeneration: New Technologies and Future Prospects examines the use of biomaterials in applications related to artificial tissues and organs. With a strong focus on fundamental and traditional tissue engineering strategies, the book also examines how emerging and enabling technologies are being developed and applied. Sections provide essential information on biomaterial, cell properties and cell types used in organ generation. A section on state-of-the-art in organ regeneration for clinical purposes is followed by a discussion on enabling technologies, such as bioprinting, on chip organ systems and in silico simulations. Provides a systematic overview of the field, from fundamentals, to current challenges and opportunities Encompasses the classic paradigm of tissue engineering for creation of new functional tissue Discusses enabling technologies such as bioprinting, organ-on-chip systems and in silico simulations

Biomaterials- and Microfluidics-Based Tissue Engineered 3D Models

Biomaterials- and Microfluidics-Based Tissue Engineered 3D Models
  • Author : J. Miguel Oliveira,Rui L. Reis
  • Publisher : Springer Nature
  • Release Date : 2020-04-13
  • Total pages : 175
  • ISBN : 9783030365882
  • File Size : 20,7 Mb
  • Total Download : 809
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This contributed volume reviews the latest advances on relevant 3D tissue engineered in vitro models of disease making use of biomaterials and microfluidics. The main focus of this book is on advanced biomaterials and microfluidics technologies that have been used in in vitro mimetic 3D models of human diseases and show great promise in revolutionizing personalized medicine. Readers will discover important topics involving biomaterials and microfluidics design, advanced processing techniques, and development and validation of organ- and body-on-a-chip models for bone, liver, and cancer research. An in depth discussion of microfabrication methods for microfluidics development is also provided. This work is edited by two truly multidisciplinary scientists and includes important contributions from well-known experts in their fields. The work is written for both early stage and experienced researchers, and well-established scientists enrolled in the fields of biomaterials, microfluidics, and tissue engineering, and is especially suited to those who wish to become acquainted with the principles and latest developments of in vitro models of diseases, such as professionals working in pharma, medicine, and engineering.

Regenerative Medicine Technology

Regenerative Medicine Technology
  • Author : Sean V. Murphy,Anthony Atala
  • Publisher : CRC Press
  • Release Date : 2016-11-30
  • Total pages : 507
  • ISBN : 9781315354156
  • File Size : 54,6 Mb
  • Total Download : 757
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Miniaturization in the fields of chemistry and molecular biology has resulted in the "lab-on-a-chip." Such systems are micro-fabricated devices capable of handling extremely small fluid volumes facilitating the scaling of single or multiple lab processes down to a microchip-sized format. The convergence of lab-on-a-chip technology with the field of cell biology facilitated the development of "organ-on-a-chip" systems. Such systems simulate the function of tissues and organs, having the potential to bypass some cell and animal testing methods. These technologies have generated high interest as applications for disease modeling and drug discovery. This book, edited by Drs. Sean Murphy and Anthony Atala, provides a comprehensive coverage of the technologies that have been used to develop organ-on-a-chip systems. Known leaders cover the basics to the most relevant and novel topics in the field, including micro-fabrication, 3D bio-printing, 3D cell culture techniques, biosensor design and microelectronics, micro-fluidics, data collection, and predictive analysis. The book describes specific tissue types amenable for disease modeling and drug discovery applications. Lung, liver, heart, skin and kidney "on-a-chip" technologies are included as well as a progress report on designing an entire "body-on-a-chip" system. Additionally, the book covers applications of various systems for modeling tissue-specific cancers, metastasis, and tumor microenvironments; and provides an overview of current and potential applications of these systems to disease modeling, toxicity testing, and individualized medicine.

Stem Cells

Stem Cells
  • Author : Christine Mummery,Anja van de Stolpe,Bernard Roelen,Hans Clevers
  • Publisher : Academic Press
  • Release Date : 2014-05-23
  • Total pages : 448
  • ISBN : 9780124115675
  • File Size : 26,6 Mb
  • Total Download : 953
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The second edition of Stem Cells: Scientific Facts and Fiction provides the non-stem cell expert with an understandable review of the history, current state of affairs, and facts and fiction of the promises of stem cells. Building on success of its award-winning preceding edition, the second edition features new chapters on embryonic and iPS cells and stem cells in veterinary science and medicine. It contains major revisions on cancer stem cells to include new culture models, additional interviews with leaders in progenitor cells, engineered eye tissue, and xeno organs from stem cells, as well as new information on "organs on chips" and adult progenitor cells. In the past decades our understanding of stem cell biology has increased tremendously. Many types of stem cells have been discovered in tissues that everyone presumed were unable to regenerate in adults, the heart and the brain in particular. There is vast interest in stem cells from biologists and clinicians who see the potential for regenerative medicine and future treatments for chronic diseases like Parkinson's, diabetes, and spinal cord lesions, based on the use of stem cells; and from entrepreneurs in biotechnology who expect new commercial applications ranging from drug discovery to transplantation therapies. Explains in straightforward, non-specialist language the basic biology of stem cells and their applications in modern medicine and future therapy Includes extensive coverage of adult and embryonic stem cells both historically and in contemporary practice Richly illustrated to assist in understanding how research is done and the current hurdles to clinical practice

Biochip Technology

Biochip Technology
  • Author : Jing Cheng,Larry J. Kricka
  • Publisher : CRC Press
  • Release Date : 2003-09-02
  • Total pages : 453
  • ISBN : 9780203305041
  • File Size : 34,5 Mb
  • Total Download : 769
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Biochip technology has experienced explosive growth in recent years and Biochip technology describes the basic manufacturing and fabrication processes and the current range of applications of these chips. Top scientists from the biochip industry and related areas explain the diverse applications of biochips in gene sequencing, expression monitoring, disease diagnosis, tumor examination, ligand assay and drug discovery.

“What is Organ-on-a-Chip?”- A Promising Technology for Pharmaceutical Analysis & New Drug Development.

“What is Organ-on-a-Chip?”- A Promising Technology for Pharmaceutical Analysis & New Drug Development.
  • Author : Dr.Hakim Saboowala
  • Publisher : Dr.Hakim Saboowala
  • Release Date : 2020-01-07
  • Total pages : 40
  • ISBN : 1230987654XX
  • File Size : 23,7 Mb
  • Total Download : 425
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The capability of traditional platforms, such as well plate, does not match researchers’ demands for precise and creative experiments any more. Direct detection and analysis of biomolecules and cells in physiological microenvironment is urgently needed for fast evaluation of biology and pharmacy. The past several years have witnessed remarkable development opportunities in vitro organs and tissues models with multiple functions based on microfluidic devices, termed as “organ-on-a-chip”. It is a promising technology in rebuilding physiological functions of tissues and organs, featuring mammalian cell co-culture and artificial microenvironment created by microchannel networks. An attempt has been made in this Booklet to summarize the advances in studies of heart-, vessel-, liver-, neuron-, kidney- and Multi-organs-on-a-chip and discuss some noteworthy potential on-chip detection schemes along with several illustrations. Further, related techniques of organs and tissues of great interest to drug developers, such as heart, vessel, liver, neuron, and kidney are also being covered. …… Dr. H.K.Saboowala. M.B.(Bom)M.R.S.H.(London)

Basic Concepts on 3D Cell Culture

Basic Concepts on 3D Cell Culture
  • Author : Cornelia Kasper,Dominik Egger,Antonina Lavrentieva
  • Publisher : Springer Nature
  • Release Date : 2021-06-09
  • Total pages : 252
  • ISBN : 9783030667498
  • File Size : 37,7 Mb
  • Total Download : 386
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This textbook shall introduce the students to 3D cell culture approaches and applications. An overview on existing techniques and equipment is provided and insight into various aspects and challenges that researchers need to consider and face during culture of 3D cells is given. The reader will learn the importance of physiological cell, tissue and organ models and gains important knowledge on 3D analytics. This textbook deepens selected aspects of the textbook “Cell Culture Technology”, which also is published in this series, while offering extended insight into 3D cell culture. The concept of the textbook encompasses various lectures ranging from basics in cell cultivation, tissue engineering, biomaterials and biocompatibility, in vitro test systems and regenerative medicine. The textbook addresses Master- and PhD students interested and/or working in the field of modern cell culture applications and will support the understanding of the essential strategies in 3D cell culture and waken awareness for the potentials and challenges of this application.

Tumor Organoids

Tumor Organoids
  • Author : Shay Soker,Aleksander Skardal
  • Publisher : Humana Press
  • Release Date : 2017-10-20
  • Total pages : 213
  • ISBN : 9783319605111
  • File Size : 16,5 Mb
  • Total Download : 766
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Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell–cell, cell–ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.

Platforms, Markets and Innovation

Platforms, Markets and Innovation
  • Author : Annabelle Gawer
  • Publisher : Edward Elgar Publishing
  • Release Date : 2011-01-01
  • Total pages : 416
  • ISBN : 9781849803311
  • File Size : 13,9 Mb
  • Total Download : 719
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In her pioneering book Platform Leadership (with Michael Cusumano), Gawer gave us the strategy of building coalitions of customers, suppliers, and complementors. Now, she brings together a number of the leading researchers in the area of platform strategy to give us a book that will be a key reference for both practitioners and academics. Adam Brandenburger, New York University, US Annabelle Gawer s collected volume of research shows that a vibrant community of scholars has arisen around platforms and innovation. Each of the chapters is first rate, with top researchers offering some of their latest work. This will be an indispensable book for students of innovation and technology management everywhere. Henry Chesbrough, University of California, Berkeley, US Annabelle Gawer s Platforms, Markets and Innovation is the first serious exploration of the critical but subtle role that platforms play in business, society and our personal lives. As digital technologies penetrate every nook and cranny of the world around us, we rely on platforms to both help us use the new technologies, as well as to organize new markets of innovation that add applications on top of the platforms and make them far more valuable. Dr Gawer s excellent book is designed to help us understand the mysterious nature of platforms. It brings together the insights of twenty-four experts around the world who contributed to the fourteen chapters of the book. Dr Gawer s book is invaluable to anyone trying to understand the nuanced nature of platforms, and their implications for the evolution of innovation in the 21st century. Irving Wladawsky-Berger, IBM Academy of Technology, US The emergence of platforms is a novel phenomenon impacting most industries, from products to services. Industry platforms such as Microsoft Windows or Google, embedded within industrial ecosystems, have redesigned our industrial landscapes, upset the balance of power between firms, fostered innovation and raised new questions on competition and innovation. Annabelle Gawer presents cutting-edge contributions from 24 top international scholars from 19 universities across Europe, the USA and Asia, from the disciplines of strategy, economics, innovation, organization studies and knowledge management. The novel insights assembled in this volume constitute a fundamental step towards an empirically based, nuanced understanding of the nature of platforms and the implications they hold for the evolution of industrial innovation. The book provides an overview of platforms and discusses governance, management, design and knowledge issues. With a multidisciplinary approach, this book will strongly appeal to academics and advanced students in management, innovation, strategy, economics and design. It will also prove an enlightening read for business managers in IT industries.