Nucleic Acids As Gene Anticancer Drug Delivery Therapy

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Nucleic Acids as Gene Anticancer Drug Delivery Therapy

Nucleic Acids as Gene Anticancer Drug Delivery Therapy
  • Author : Loutfy H Madkour
  • Publisher : Academic Press
  • Release Date : 2020-01-16
  • Total pages : 644
  • ISBN : 0128197773
  • File Size : 44,7 Mb
  • Total Download : 410
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Nucleic Acids as Gene Anticancer Drug Delivery Therapy highlights the most recent developments in cancer treatment using nucleic acids, nanoparticles, and polymer nanoparticles for genomic nanocarriers as drug delivery, including promising opportunities for targeted and combination therapy. The development of a wide spectrum of nanoscale technologies is beginning to change the scientific landscape in terms of disease diagnosis, treatment, and prevention. This book presents the use of nanotechnology for medical applications, focusing on its use for anticancer drug delivery. Various intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery are discussed. The use of smart drug delivery systems seems to be a promising approach for developing intelligent therapeutic systems for cancer immunotherapies and is discussed in detail along with nucleic acid-targeted drug delivery combination therapy for cancer. Nucleic Acids as Gene Anticancer Drug Delivery Therapy will be a useful reference for pharmaceutical scientists, pharmacologists, and those involved in nanotechnology and cancer research. Discusses intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery Contains a comprehensive comparison of various delivery systems, listing their advantages and limitations Presents combination therapy as a new hope for enhancing current gene-based treatment efficacy

Nucleic Acids as Gene Anticancer Drug Delivery Therapy

Nucleic Acids as Gene Anticancer Drug Delivery Therapy
  • Author : Loutfy H. Madkour
  • Publisher : Academic Press
  • Release Date : 2019-08-27
  • Total pages : 650
  • ISBN : 9780128197783
  • File Size : 39,8 Mb
  • Total Download : 827
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Nucleic Acids as Gene Anticancer Drug Delivery Therapy highlights the most recent developments in cancer treatment using nucleic acids, nanoparticles and polymer nanoparticles for genomic nanocarriers as drug delivery, including promising opportunities for targeted and combination therapy. The development of a wide spectrum of nanoscale technologies is beginning to change the scientific landscape in terms of disease diagnosis, treatment, and prevention. This book presents the use of nanotechnology for medical applications, focusing on its use for anticancer drug delivery. Various intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery are discussed. The use of smart drug delivery systems seems to be a promising approach for developing intelligent therapeutic systems for cancer immunotherapies and is discussed in detail along with nucleic acid-targeted drug delivery combination therapy for cancer. Nucleic Acids as Gene Anticancer Drug Delivery Therapy will be a useful reference for pharmaceutical scientists, pharmacologiests, and those involved in nanotechnology and cancer research. Discusses intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery Contains a comprehensive comparison of various delivery systems, listing their advantages and limitations Presents combination therapy as a new hope for enhancing current gene-based treatment efficacy

Therapeutic Oligonucleotides

Therapeutic Oligonucleotides
  • Author : Jens Kurreck
  • Publisher : Royal Society of Chemistry
  • Release Date : 2008
  • Total pages : 362
  • ISBN : 9780854041169
  • File Size : 51,5 Mb
  • Total Download : 207
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This book provides a compelling overall update on current status of RNA interference

Nanomedicine for Drug Delivery and Therapeutics

Nanomedicine for Drug Delivery and Therapeutics
  • Author : Ajay Kumar Mishra
  • Publisher : John Wiley & Sons
  • Release Date : 2013-02-01
  • Total pages : 536
  • ISBN : 9781118635841
  • File Size : 19,7 Mb
  • Total Download : 628
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This book describes a broad area of nanomedicine which involves mainly applications, diseases, and diagnostics. The comprehensive coverage provides researchers, academics, and health specialists with a great tool, that includes techniques applicable to various uses.

Drug Delivery in Oncology

Drug Delivery in Oncology
  • Author : Felix Kratz,Peter Senter,Henning Steinhagen
  • Publisher : John Wiley & Sons
  • Release Date : 2013-09-30
  • Total pages : 1822
  • ISBN : 9783527647750
  • File Size : 50,6 Mb
  • Total Download : 135
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In this first authoritative overview on modern cancer chemotherapy 121 international specialists have contributed their experience and recent data for what is likely to become the gold standard in the field. The authors summarize knowledge gained over the past decade, from basic concepts to successful applications in the clinic, covering active and passive targeting strategies as well as tissue-specific approaches. All current and future targeted delivery systems are discussed, from ligand-based to antibody-based polymer-based systems, right up to micro- and nanoparticulate systems. A special section covers the delivery of nucleic acid therapeutics, such as siRNA, miRNA and antisense nucleotides. In each case, a description of the basic technique is followed by a discussion of the latest preclinical and clinical developments in the field. By virtue of its clear and didactic structure, rich illustrative material and summary chapters, this handbook and ready reference enables the efficient transfer of knowledge between different disciplines, from basic research to the clinician and vice versa. It is equally well suited for professionals, researchers and students in medical oncology and cancer biology, and is also excellent for teaching medical students the foundations of 21st century cancer chemotherapy.

Polymeric Gene Delivery Systems

Polymeric Gene Delivery Systems
  • Author : Yiyun Cheng
  • Publisher : Springer
  • Release Date : 2018-09-04
  • Total pages : 358
  • ISBN : 9783319778662
  • File Size : 26,9 Mb
  • Total Download : 616
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​The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field. The chapter "Polymeric Nanoparticle-Mediated Gene Delivery for Lung Cancer Treatment" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Nucleic Acid Drugs

Nucleic Acid Drugs
  • Author : Akira Murakami
  • Publisher : Springer
  • Release Date : 2012-07-04
  • Total pages : 180
  • ISBN : 9783642304637
  • File Size : 49,6 Mb
  • Total Download : 300
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New Antisense Strategies: Chemical Synthesis of RNA Oligomers, by Junichi Yano und Gerald E. Smyth Development and Modification of Decoy Oligodeoxynucleotides for Clinical Application, by Mariana Kiomy Osako, Hironori Nakagami und Ryuichi Morishita Modulation of Endosomal Toll-Like Receptor-Mediated Immune Responses by Synthetic Oligonucleotides, by Ekambar R. Kandimalla und Sudhir Agrawal Delivery of Nucleic Acid Drugs, by Yan Lee und Kazunori Kataoka Aptamer: Biology to Applications, by Yoshikazu Nakamura Development and Clinical Applications of Nucleic Acid Therapeutics, by Veenu Aishwarya, Anna Kalota und Alan M. Gewirtz

Nanoparticle-Based Drug Delivery in Cancer Treatment

Nanoparticle-Based Drug Delivery in Cancer Treatment
  • Author : Loutfy H. Madkour
  • Publisher : CRC Press
  • Release Date : 2022-03-03
  • Total pages : 558
  • ISBN : 9781000532166
  • File Size : 10,5 Mb
  • Total Download : 115
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The careful choice of nanoparticles as targets and in drug delivery routes enhances therapeutic efficacy in cancer. Nanoparticle-Based Drug Delivery in Cancer Treatment discusses nanotechnological developments of interfering RNA-based nanoparticles, delivery vehicles, and validated therapeutic RNAi–molecular target interactions and explains the results of clinical and preclinical trials. The book also gives strategies for universal methods of constructing hybrid organic–inorganic nanomaterials that can be widely applied in the biomedical field. Key Features: Reviews recent advances of nanoparticle-mediated siRNA delivery systems and their application in clinical trials for cancer therapy Focuses on material platforms that establish NPs and both localized and controlled gene silencing Emphasizes the most promising systems for clinical application Surveys progress in nanoparticle-based nanomedicine in cancer treatment Describes the most advanced of the nonviral nanocarriers for delivery of oligonucleotides to malignant blood cancer cells This book is a valuable resource for researchers, professors, and students researching drug delivery, gene carriers, cancer therapy, nanotechnology, and nanomaterials.

RNA Delivery Function for Anticancer Therapeutics

RNA Delivery Function for Anticancer Therapeutics
  • Author : Loutfy H. Madkour
  • Publisher : CRC Press
  • Release Date : 2022-01-26
  • Total pages : 424
  • ISBN : 9781000532234
  • File Size : 15,8 Mb
  • Total Download : 682
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This book presents an overview of the current status of translating the RNAi cancer therapeutics in the clinic, a brief description of the biological barriers in drug delivery, and the roles of imaging in aspects of administration route, systemic circulation, and cellular barriers for the clinical translation of RNAi cancer therapeutics, and with partial content for discussing the safety concerns. It then focuses on imaging-guided delivery of RNAi therapeutics in preclinical development, including the basic principles of different imaging modalities, and their advantages and limitations for biological imaging. With growing number of RNAi therapeutics entering the clinic, various imaging methods will play an important role in facilitating the translation of RNAi cancer therapeutics from bench to bedside. RNAi technique has become a powerful tool for basic research to selectively knock down gene expression in vitro and in vivo. Our scientific and industrial communities have started to develop RNAi therapeutics as the next class of drugs for treating a variety of genetic disorders, such as cancer and other diseases that are particularly hard to address with current treatment strategies. Key Features Provides insight into the current advances and hurdles of RNAi therapeutics. Accelerates RNAi, miRNAs, and siRNA drug development for cancer therapy from bench to bedside. Addresses various modifications and novel delivery strategies for miRNAs, piRNAs and siRNA delivery in anticancer therapeutics. Explores the need for the interaction of hematologists,cell biologists, immunologists, and material scientists in the development of novel cancer therapies. Describes the current status of clinical trials related to miRNA and siRNA-based cancer therapy Presents remaining issues that need to be overcome to establish successful therapies.

Chemistry of Nucleic Acids

Chemistry of Nucleic Acids
  • Author : Harri Lönnberg
  • Publisher : Walter de Gruyter GmbH & Co KG
  • Release Date : 2020-08-10
  • Total pages : 364
  • ISBN : 9783110609295
  • File Size : 48,7 Mb
  • Total Download : 596
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Life in all its forms is based on nucleic acids which store and transfer genetic information. The book addresses the main aspects of synthesis, hydrolytic stability, solution equilibria of nucleosides and nucleotides as well as base modifications of nucleic acids. The author further describes their structural analogues used as therapeutic drugs, such as antivirals and anticancer agents, and prodrug strategies of nucleotides.

Functional Lipid Nanosystems in Cancer

Functional Lipid Nanosystems in Cancer
  • Author : Marlene Lúcio,Carla M. Lopes,Maria Elisabete C.D. Real Oliveira
  • Publisher : CRC Press
  • Release Date : 2021-11-30
  • Total pages : 712
  • ISBN : 9781000093162
  • File Size : 18,5 Mb
  • Total Download : 488
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Cancer remains one of the most challenging issues in modern medicine, being responsible for a high number of deaths every year. Recent important developments in cancer diagnosis and therapy based on the versatility of nanosystems have made it possible to incorporate multifunctional synergistic actions into a single delivery system. This book compiles the research on the use of functional lipid nanosystems that combine different strategies in one single nanosystem to enhance overall cancer treatment. Besides providing an overview of the current functional nanosystem strategies, it also offers researchers essential theoretical background on cancer, the physiological barriers to its treatment, aspects related to the design and optimization of nanocarriers for cancer treatment, and clinical developments, including promises, safety issues, and the expected future. The editors bring together a group of scientists from all over the world to discuss the most relevant issues and to provide updates on functional lipid nanosystems and cancer.

Cancer Nanotechnology

Cancer Nanotechnology
  • Author : Stephen R. Grobmyer,Brij M. Moudgil
  • Publisher : Humana
  • Release Date : 2016-08-23
  • Total pages : 396
  • ISBN : 1493961209
  • File Size : 53,9 Mb
  • Total Download : 720
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Early detection of cancer at the cellular level, even before anatomic anomalies are visible, is critical to more efficacious and cost effective diagnosis and therapeutic advances. In Cancer Nanotechnology: Methods and Protocols, an international panel of experts provide the most recent, cutting-edge, "how-to" approaches developed and employed by researchers in a variety of disciplines to identify cancer specific biomarkers, construct suitable multifunctional targeted nanostructure platforms, along with enhanced imaging and therapeutic applications. Covering such topics as multifunctional and multimodal nanoparticles, nanoparticle mediated cancer theranostics, molecular targets for cancer nanotechnology, and nanoparticles for non-invasive image-guided cancer therapy, the volume addresses the key challenges of the field today, specifically targeted and localized delivery of the drugs. As a volume in the highly successful Methods in Molecular BiologyTM series, the protocols chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Cancer Nanotechnology: Methods and Protocols integrates cancer biology, clinical oncology, molecular cancer imaging, materials science and chemical engineering, biomedical engineering, toxicology, computer science, electrical engineering, chemistry, physics, and mathematics in order to achieve the vital goals of nanotechnology-mediated early cancer detection and more efficacious and less toxic therapies for these devastating diseases.

New Strategies Targeting Cancer Metabolism

New Strategies Targeting Cancer Metabolism
  • Author : Galal Elgemeie,Reham A. Mohamed-Ezzat
  • Publisher : Elsevier
  • Release Date : 2022-05-17
  • Total pages : 628
  • ISBN : 9780128217849
  • File Size : 17,9 Mb
  • Total Download : 133
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New Strategies Targeting Cancer Metabolism: Anticancer Drugs, Synthetic Analogues and Antitumor Agents presents up-to-date synthetic strategies for three categories of antimetabolites: antifolates, purines and pyrimidines, the main classes of antimetabolites which are integrated into various pharmaceutical agents. Many of these antimetabolites are considered potent chemotherapeutic agents which have great potential impact on medical research. These main classes of antimetabolites are used in the treatment of critical diseases including cancer, malignancies, autoimmune diseases, and many other non-malignant diseases. Antineoplastic drugs such as alkylating agents which have significant effects are described. Novel synthetic strategies for many anticancer alkylating agents including nitrogen mustards, chlorambucil, melphalan, ifosamide, oxaliplatin and temozolomide are explored. Natural products have offered some of the most significant drugs for treating cancer, as many drugs currently in clinical use are derived from natural products as camptothecins, vinca alkaloids, and derivatives of podophyllotoxin. They provide a contribution that is essential for modern drug discovery and development. In this book, insights into a broad array of novel compounds are reviewed, well-recognized synthetic approaches are emphasized for further anticancer drug development and discovery, and the biological evaluation of novel synthesized compounds are included. This comprehensive reference is a valuable resource for medical chemists working in drug discovery and development, as well as pharmacologists and biochemists working in related fields. Provides the only resource dedicated to synthetic strategies of antimetabolites Features synthetic strategies for nucleosides and their analogues Includes coverage of purine-, pyrimidine- and antifolate-based anticancer drugs The most significant anticancer alkylating agents and natural products are demonstrated

Phytochemical Nanodelivery Systems as Potential Biopharmaceuticals

Phytochemical Nanodelivery Systems as Potential Biopharmaceuticals
  • Author : J. Basilio Heredia,Erick P. Gutierrez-Grijalva,Angel Licea-Claverie,Janet Alejandra Gutierrez-Uribe,Jayanta Kumar Patra
  • Publisher : Elsevier
  • Release Date : 2023-01-20
  • Total pages : 368
  • ISBN : 9780323904155
  • File Size : 9,5 Mb
  • Total Download : 686
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Phytochemical Nanodelivery Systems as Potential Biopharmaceuticals comprehensively reviews current information on nanotechnology applied to phytochemical nanoencapsulation to enhance their bioavailability and bioactivity. The book is divided into two sections, the first section critically reviews current information on the field of nanotechnology and phytochemicals, and the second section highlights the pre-clinical and clinical studies of phytochemicals to comprehensively review the efficacy of these molecules as drugs of human use. Phytochemical Nanodelivery Systems as Potential Biopharmaceuticals provides a useful overview of this rapidly evolving field for materials scientists and pharmaceutical scientists, as well as for those with an interest in biopharmaceuticals from plant sources, such as organic chemists and food scientists. Provides an introduction to both phytochemicals and nanomaterials for use in biopharmaceutics, allowing both materials scientists and pharmaceutical scientists to gain a basic understanding of each field Reviews key phytochemical types for use as biopharmaceuticals, including terpenes, alkaloids, glucosinolates and more Explores the various nanomaterials and nanoencapsulation techniques for administration of phytochemical nanoformulations

Nanoparticles in Angiogenesis and Cancer

Nanoparticles in Angiogenesis and Cancer
  • Author : Sudip Mukherjee,Vijay Sagar Madamsetty
  • Publisher : Springer Nature
  • Release Date : 2022-09-27
  • Total pages : 85
  • ISBN : 9783031112843
  • File Size : 47,8 Mb
  • Total Download : 864
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This book highlights recent developments of organic and inorganic nanomedicine that play a major role in anti-angiogenic cancer therapy. In addition, the authors present examples of nanomedicine based anti-angiogenic agents and their applications in cancer therapy. Angiogenesis is a pathophysiological phenomenon that modulates cell proliferation and cell migration and plays important roles in cancer. Anti-angiogenic nanotherapies have gained immense attention in recent times as alternative cost-effective therapies that opened a new dimension in cancer theranostics. Further the challenges of the anti-angiogenic nanotherapies and possible future perspective are detailed.

Molecular Medicines for Cancer

Molecular Medicines for Cancer
  • Author : Deepak Chitkara,Anupama Mittal,Ram I. Mahato
  • Publisher : CRC Press
  • Release Date : 2018-09-03
  • Total pages : 756
  • ISBN : 9781351978361
  • File Size : 10,7 Mb
  • Total Download : 867
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The field of molecular medicine covers the medical interventions targeting molecular structures and mechanisms that are involved in disease progression. In cancer, several molecular mechanisms have been shown to impact its progression, aggressiveness and chemoresistance. Increasing evidence demonstrates the role of nanotechnology and outcome of molecular therapy. Several books have discussed molecular biology and mechanisms involved in cancer, but this text gives an account of molecular therapeutics in cancer relating to advancements of nanotechnology. It provides a description of the multidisciplinary field of molecular medicines and its targeted delivery to cancer using nanotechnology. Key Features: Provides current information in the multidisciplinary field of molecular medicines and its targeted delivery to cancer using nanotechnology Presents important aspects of nanotechnology in the site-specific delivery of anticancer agents Includes up to date information on oligonucleotide and gene based therapies in cancer Describes small targeted molecules, antibodies and oligonucleotides which have shown to selectively target the molecular structures thereby influencing signal transduction Facilitates discussion between researchers involved in cancer therapy and nanoscientists

Drug Delivery

Drug Delivery
  • Author : Binghe Wang,Longqin Hu,Teruna J. Siahaan
  • Publisher : John Wiley & Sons
  • Release Date : 2016-03-09
  • Total pages : 720
  • ISBN : 9781118833230
  • File Size : 39,6 Mb
  • Total Download : 972
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Following its successful predecessor, this book covers the fundamentals, delivery routes and vehicles, and practical applications of drug delivery. In the 2nd edition, almost all chapters from the previous are retained and updated and several new chapters added to make a more complete resource and reference. • Helps readers understand progress in drug delivery research and applications • Updates and expands coverage to reflect advances in materials for delivery vehicles, drug delivery approaches, and therapeutics • Covers recent developments including transdermal and mucosal delivery, lymphatic system delivery, theranostics • Adds new chapters on nanoparticles, controlled drug release systems, theranostics, protein and peptide drugs, and biologics delivery

Cyclodextrin

Cyclodextrin
  • Author : Poonam Arora,Neelima Dhingra
  • Publisher : BoD – Books on Demand
  • Release Date : 2018-04-18
  • Total pages : 334
  • ISBN : 9781789230680
  • File Size : 33,6 Mb
  • Total Download : 524
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The book is devoted to the highly versatile and potential ingredient Cyclodextrin, a family of cyclic oligosaccharides composed of ?-(1,4)-linked glucopyranose subunits. Its molecular complexation phenomena and negligible cytotoxic effects attribute toward its application such as in pharmaceuticals, cosmetics, food, agriculture, textile, separation process, analytical methods, catalysis, environment protection, and diagnostics. Efforts have also been made to concentrate on recent research outcomes along with future prospects of cyclodextrins to attract the interest of scientists from the industry and academia. The contributions of the authors are greatly acknowledged, without which this compilation would not have been possible.

Peptide Nucleic Acids

Peptide Nucleic Acids
  • Author : Peter E. Nielsen
  • Publisher : Springer Science & Business Media
  • Release Date : 2008-02-04
  • Total pages : 274
  • ISBN : 9781592592906
  • File Size : 49,7 Mb
  • Total Download : 298
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Peptide nucleic acids (PNAs) have now existed for slightly more than ten years, with the interest in and applications of this pseudopeptide DNA mimic steadily increasing during the entire period. PNAs have rapidly attracted the attention of scientists from a diversity of fields ranging from (bio)organic and biophysical chemistry to prebiotic evolution, and from molecular biology to genetic diagnostics and drug development. Many of the applications take advantage of the unique properties of PNA—an uncharged pseudopeptide—that distinguish this DNA mimic from more traditional DNA analogs. Rather than trying to create a comprehensive collection of all published methods and protocols involving PNA—many of which have not yet been validated— I have decided to concentrate on select protocols that are either very well established by several groups around the world, such as PCR-clamping and in situ hybridization, or on new methods that may have broader future impact. Basic methods for PNA oligomer synthesis and analyses have also been included. I am very grateful to those friends and colleagues who have enthusiastically contributed their work, discussions, and writing, and thereby made this book possible. Peter E. Nielsen v Contents Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v Contributors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ix IINTRODUCTION 1 PNA Technology Peter E. Nielsen. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 II CHEMISTRY 2 Solid Phase Synthesis of PNA Oligomers Frederik Beck. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 29 3 Synthesis of PNA-Peptide Conjugates Satish Kumar Awasthi and Peter E. Nielsen. . . . . . . . . . . . . . . . . . 43 4 Parallel Synthesis of PNA-Peptide Conjugate Libraries Satish Kumar Awasthi and Peter E. Nielsen. . . . . . . . . . . . . . . . . .

Pharmaceutical Perspectives of Cancer Therapeutics

Pharmaceutical Perspectives of Cancer Therapeutics
  • Author : Ramj Mahato,Yi Lu
  • Publisher : Springer
  • Release Date : 2016-04-01
  • Total pages : 712
  • ISBN : 1493939564
  • File Size : 48,7 Mb
  • Total Download : 493
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Pharmaceutical Perspectives of Cancer Therapeutics covers a wide range of therapeutic approaches. In addition, clinical application, the development of DNA diagnosis biomarkers and cancer prevention, and the use of imaging in cancer therapy are discussed.

Advances and Challenges in Nanomedicine

Advances and Challenges in Nanomedicine
  • Author : Susan Hua,Sherry Y. Wu
  • Publisher : Frontiers Media SA
  • Release Date : 2019-02-28
  • Total pages : 155
  • ISBN : 9782889457458
  • File Size : 46,8 Mb
  • Total Download : 973
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Nanotechnology is a multidisciplinary field that is revolutionizing the way we detect and treat damage to the human body. Nanomedicine applies nanotechnology to highly specific medical interventions for the prevention, diagnosis, and treatment of diseases. They are increasingly being used to overcome biological barriers in the body to improve the way we deliver compounds to specific tissues and organs. In particular, nanomedicines have been shown to be beneficial for stabilizing therapeutic compounds, overcoming obstacles to cellular and tissue uptake, and improving biodistribution of compounds to target sites in vivo. Nanomedicines have demonstrated significant therapeutic advantages for a multitude of biomedical applications, however the clinical translation of these nanotechnology platforms has not progressed as quickly as the plethora of positive results would have suggested. Understanding the advances in nanomedicine to date and the challenges that still need to be overcome, will allow future research to improve on existing platforms and to address the current translational and regulatory limitations. This eBook “Advances and Challenges in Nanomedicine” has brought together experts in the fields of nanomedicine, nanotechnology, nanotoxicology, pharmaceutics, manufacturing, and translation to discuss the application of nanotechnology to drug delivery. This information is presented as original research, opinion, perspective, and review articles. The goal of this eBook is to generate collaborative discussion on the current status, general trends, challenges, strategies, and future direction of pharmaceutical nanotechnology, as well as highlight current and emerging nanoparticulate platforms with potential medical applications.