Microbial Biofilms Role In Human Infectious Diseases

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Microbial Biofilms

Microbial Biofilms
  • Author : Mukesh Kumar Yadav,Jae Jun Song,Jorge E. Vidal
  • Publisher : Academic Press
  • Release Date : 2023-08-01
  • Total pages : 0
  • ISBN : 0443192529
  • File Size : 16,6 Mb
  • Total Download : 798
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Microbial biofilms can be a serious problem in medical settings as they are associated with significant mortality and morbidity. Infection related to biofilms increases recovery time and the cost of disease management. Biofilms are resistant to known antibiotics and human defense mechanism. In addition, due to close proximity of microbes within biofilms, increase genetic transformation has been detected results in increases frequency of antibiotic gene spread. With the advancement in science and technology, novel strategies and been proposed to combat the impact of biofilms on human health. Microbial biofilms: Role in Human Infectious Diseases focuses on new and emerging concepts in microbial biofilm research, such as the mechanisms of biofilm formation, biofilm-induced pathogenesis, biofilm detection/and diagnosis, gene exchange within biofilms, strategies to control microbial biofilms and the burden of biofilm associated infections. In addition, it highlights the various anti-biofilm strategies such as surface coating, signal quenching, novel compounds that can be translated to curb biofilm-associated infections and the escalation of antimicrobial resistance determinants.

Biofilms in Human Diseases: Treatment and Control

Biofilms in Human Diseases: Treatment and Control
  • Author : Sunil Kumar,Niharika Chandra,Leena Singh,Muhammad Zaffar Hashmi,Ajit Varma
  • Publisher : Springer Nature
  • Release Date : 2019-11-19
  • Total pages : 311
  • ISBN : 9783030307578
  • File Size : 51,5 Mb
  • Total Download : 189
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This book highlights treatment strategies for bacterial biofilms in connection with a variety of human diseases. In particular, it reviews bacterial biofilm formation and its mechanism. Topics covered include biofilms in human health, the role of biofilms in mediating human diseases, and methods for testing bacterial biofilms. Further sections concentrate on biofilm-mediated diseases in different parts of the human gastrointestinal tract, while therapeutic strategies for biofilm control and natural agents that disrupt bacterial biofilms are also covered. Readers will also find the latest advances in probiotics and biofilms, as well as the use of probiotics to counteract biofilm-associated infections. Biofilms and antimicrobial resistance are discussed. Subsequent chapters address the management of inflammatory bowel disease via probiotics biofilms, as well as the role of probiotics bacteria in the treatment of human diseases associated with bacterial biofilms. The book is chiefly intended for clinicians/scientists in the fields of medical microbiology, applied microbiology, biochemistry, and biotechnology.

Biofilms and Veterinary Medicine

Biofilms and Veterinary Medicine
  • Author : Steven L. Percival,Derek C. Knottenbelt,Christine A. Cochrane
  • Publisher : Springer Science & Business Media
  • Release Date : 2011-08-08
  • Total pages : 258
  • ISBN : 3642212891
  • File Size : 30,9 Mb
  • Total Download : 868
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Biofilms are implicated in many common medical problems including urinary tract infections, catheter infections, middle-ear infections, dental plaque, gingivitis, and some less common but more lethal processes such as endocarditis and infections in cystic fibrosis. However, the true importance of biofilms in the overall process of disease pathogenesis has only recently been recognized. Bacterial biofilms are one of the fundamental reasons for incipient wound healing failure in that they may impair natural cutaneous wound healing and reduce topical antimicrobial efficiency in infected skin wounds. Their existence explains many of the enigmas of microbial infection and a better grasp of the process may well serve to establish a different approach to infection control and management. Biofilms and their associated complications have been found to be involved in up to 80% of all infections. A large number of studies targeted at the bacterial biofilms have been conducted, and many of them are referred to in this book, which is the first of its kind. These clinical observations emphasize the importance of biofilm formation to both superficial and systemic infections, and the inability of current antimicrobial therapies to ‘cure’ the resulting diseases even when the in vitro tests suggest that they should be fully effective. In veterinary medicine the concept of biofilms and their role in the pathogenesis of disease has lagged seriously behind that in human medicine. This is all the more extraordinary when one considers that much of the research has been carried out using veterinary species in experimental situations. The clinical features of biofilms in human medicine is certainly mimicked in the veterinary species but there is an inherent and highly regrettable indifference to the failure of antimicrobial therapy in many veterinary disease situations, and this is probably at its most retrograde in veterinary wound management. Biofilms and Veterinary Medicine is specifically focused on discussing the concerns of biofilms to health and disease in animals and provides a definitive text for veterinary practitioners, medical and veterinary students, and researchers.

The Role of Biofilms in Device-Related Infections

The Role of Biofilms in Device-Related Infections
  • Author : Mark Shirtliff,Jeff G. Leid
  • Publisher : Springer Science & Business Media
  • Release Date : 2008-12-19
  • Total pages : 272
  • ISBN : 9783540681199
  • File Size : 53,9 Mb
  • Total Download : 346
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Approximately 60% of all hospital-associated infections, over one million cases per year, are due to biofilms that have formed on indwelling medical devices. Device-related biofilm infections increase hospital stays and add over one billion dollars/year to U.S. hospitalization costs. Since the use and the types of indwelling medical devices commonly used in modern healthcare are continuously expanding, especially with an aging population, the incidence of biofilm infections will also continue to rise. The central problem with microbial biofilm infections of foreign bodies is their propensity to resist clearance by the host immune system and all antimicrobial agents tested to date. In fact, compared to their free floating, planktonic counterparts, microbes within a biofilm are 50 – 500 times more resistant to antimicrobial agents. Therefore, achieving therapeutic and non-lethal dosing regimens within the human host is impossible. The end result is a conversion from an acute infection to one that is persistent, chronic, and recurrent, most often requiring device removal in order to eliminate the infection. This text will describe the major types of device-related infections, and will explain the host, pathogen, and the unique properties of their interactions in order to gain a better understanding of these recalcitrant infections.

Bacterial Biofilms

Bacterial Biofilms
  • Author : Tony Romeo
  • Publisher : Springer Science & Business Media
  • Release Date : 2008-02-26
  • Total pages : 294
  • ISBN : 9783540754183
  • File Size : 55,8 Mb
  • Total Download : 186
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Throughout the biological world, bacteria thrive predominantly in surface-attached, matrix-enclosed, multicellular communities or biofilms, as opposed to isolated planktonic cells. This choice of lifestyle is not trivial, as it involves major shifts in the use of genetic information and cellular energy, and has profound consequences for bacterial physiology and survival. Growth within a biofilm can thwart immune function and antibiotic therapy and thereby complicate the treatment of infectious diseases, especially chronic and foreign device-associated infections. Modern studies of many important biofilms have advanced well beyond the descriptive stage, and have begun to provide molecular details of the structural, biochemical, and genetic processes that drive biofilm formation and its dispersion. There is much diversity in the details of biofilm development among various species, but there are also commonalities. In most species, environmental and nutritional conditions greatly influence biofilm development. Similar kinds of adhesive molecules often promote biofilm formation in diverse species. Signaling and regulatory processes that drive biofilm development are often conserved, especially among related bacteria. Knowledge of such processes holds great promise for efforts to control biofilm growth and combat biofilm-associated infections. This volume focuses on the biology of biofilms that affect human disease, although it is by no means comprehensive. It opens with chapters that provide the reader with current perspectives on biofilm development, physiology, environmental, and regulatory effects, the role of quorum sensing, and resistance/phenotypic persistence to antimicrobial agents during biofilm growth.

Microbial Biofilms

Microbial Biofilms
  • Author : Mahmoud Ghannoum,Matthew Parsek,Marvin Whiteley,Pranab K. Mukherjee
  • Publisher : John Wiley & Sons
  • Release Date : 2020-08-11
  • Total pages : 404
  • ISBN : 9781555817466
  • File Size : 41,9 Mb
  • Total Download : 524
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An examination of the research and translational application to prevent and treat biofilm-associated diseases In the decade since the first edition of Microbial Biofilms was published, the interest in this field has expanded, spurring breakthrough research that has advanced the treatment of biofilm-associated diseases. This second edition takes the reader on an exciting, extensive review of bacterial and fungal biofilms, ranging from basic molecular interactions to innovative therapies, with particular emphasis on the division of labor in biofilms, new approaches to combat the threat of microbial biofilms, and how biofilms evade the host defense. Chapters written by established investigators cover recent findings, and contributions from investigators new to the field provide unique and fresh insights. Specifically, Microbial Biofilms provides state-of-the-art research in the field of bacterial and fungal biofilms detailed descriptions of the in vitro and in vivo models available to evaluate microbial biofilms future areas of research and their translational and clinical applications Microbial Biofilms is a useful reference for researchers and clinicians. It will also provide insight in the dynamic field of microbial biofilms for graduate and postgraduate students.

Biofilm-Mediated Diseases: Causes and Controls

Biofilm-Mediated Diseases: Causes and Controls
  • Author : Rina Rani Ray,Moupriya Nag,Dibyajit Lahiri
  • Publisher : Springer Nature
  • Release Date : 2021-05-05
  • Total pages : 284
  • ISBN : 9789811607455
  • File Size : 9,5 Mb
  • Total Download : 537
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This book reviews the current concepts in biofilm formation and its implications in human health and disease. The initial chapters introduce the mechanisms of biofilm formation and its composition. Subsequently, the chapters discuss the role of biofilm in acute and chronic infections. It also explores the pivotal role of both innate and adaptive immunity on the course of biofilm infection. In addition, the book elucidates the bacterial biofilm formation on implantable devices and the current approaches to its treatment and prevention. It analyzes the possible relationship between antimicrobial resistance and biofilm formation. Finally, the book also summarizes the current state-of-the-art therapeutic approaches for preventing and treating biofilms. This book is a useful resource for researchers in the field of microbiology, clinical microbiology, and also medical practitioners.

Biofilm Infections

Biofilm Infections
  • Author : Thomas Bjarnsholt,Peter Østrup Jensen,Claus Moser,Niels Høiby
  • Publisher : Springer
  • Release Date : 2014-10-11
  • Total pages : 0
  • ISBN : 1489982280
  • File Size : 25,5 Mb
  • Total Download : 844
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This book will cover both the evidence for biofilms in many chronic bacterial infections as well as the problems facing these infections such as diagnostics and treatment regimes. A still increasing interest and emphasis on the sessile bacterial lifestyle biofilms has been seen since it was realized that that less than 0.1% of the total microbial biomass lives in the planktonic mode of growth. The term was coined in 1978 by Costerton et al. who defined the term biofilm for the first time.In 1993 the American Society for Microbiology (ASM) recognised that the biofilmmode of growth was relevant to microbiology. Lately many articles have been published on the clinical implications of bacterial biofilms. Both original articles and reviews concerning the biofilm problem are available.

Microbial Biofilms

Microbial Biofilms
  • Author : Chaminda Jayampath Seneviratne
  • Publisher : CRC Press
  • Release Date : 2017-07-12
  • Total pages : 274
  • ISBN : 9781351646420
  • File Size : 9,8 Mb
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Microbial Biofilms: Omics Biology, Antimicrobials and Clinical Implications is a comprehensive survey of microbial biofilms and their role in human health and disease with contributions from world renowned experts in molecular microbiology, proteomics, genomics, metabolomics and infectious diseases. The book is intended to serve as a guide for students, as well as a reference for researchers, clinicians and industry professionals. The chapters cover bacterial and fungal microbiomes, and the latest omics techniques organized in a clear and up-to-date manner. One of the highlights of this book is the comprehensive information on "omics of microbial biofilms". The chapters dedicated to metagenomics, proteomics and metabolomics are designed to provide a simple and holistic review of the current knowledge and, the applications of these techniques in the field of microbial biofilms. In addition to introductory chapters on microbial biofilms and their clinical implications, subsequent chapters delve into oral biofilms, their composition, and metagenomic diversity. Thereafter, mechanisms of drug resistance in microbial biofilms are reviewed, as well as the proteomic and metabolomic characterization of this resistance. The book includes a comprehensive discussion of persister cells and host–microbial interactions on mucosal surfaces. Finally, the book concludes with a summary of novel therapeutic approaches for biofilms such as synbiotics and biogenics.

Bacterial Biofilms

Bacterial Biofilms
  • Author : Sadik Dincer,Melis Sümengen Özdenefe,Afet Arkut
  • Publisher : BoD – Books on Demand
  • Release Date : 2020-10-07
  • Total pages : 362
  • ISBN : 9781789858990
  • File Size : 45,5 Mb
  • Total Download : 239
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This book examines biofilms in nature. Organized into four parts, this book addresses biofilms in wastewater treatment, inhibition of biofilm formation, biofilms and infection, and ecology of biofilms. It is designed for clinicians, researchers, and industry professionals in the fields of microbiology, biotechnology, ecology, and medicine as well as graduate and postgraduate students.

Control of Biofilm Infections by Signal Manipulation

Control of Biofilm Infections by Signal Manipulation
  • Author : Naomi Balaban
  • Publisher : Springer Science & Business Media
  • Release Date : 2007-11-28
  • Total pages : 175
  • ISBN : 9783540738534
  • File Size : 43,5 Mb
  • Total Download : 632
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The number of patients affected by and dying from what can be considered as a "biofilm disease" is higher than heart disease and cancer combined. Thus, this is a hugely important work that describes the molecular mechanisms of cell-to-cell communication among bacterial cells in a biofilm, the development of antibiofilm inhibitors such as quorum-sensing inhibitors, and the use of biofilm inhibitors to prevent and treat bacterial infections in humans and other animals.

Medical Implications of Biofilms

Medical Implications of Biofilms
  • Author : Michael Wilson,Deirdre Devine
  • Publisher : Cambridge University Press
  • Release Date : 2003-09-01
  • Total pages : 340
  • ISBN : 1139438018
  • File Size : 32,7 Mb
  • Total Download : 707
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Human tissues often support large, complex microbial communities growing as biofilms that can cause a variety of infections. As a result of an increased use of implanted medical devices, the incidence of these biofilm-associated diseases is increasing: the non-shedding surfaces of these devices provide ideal substrata for colonisation by biofilm-forming microbes. The consequences of this mode of growth are far-reaching. As microbes in biofilms exhibit increased tolerance towards antimicrobial agents and decreased susceptibility to host defence systems, biofilm-associated diseases are becoming increasingly difficult to treat. Not surprisingly, therefore, interest in biofilms has increased dramatically. The application of microscopic and molecular techniques has revolutionised our understanding of biofilm structure, composition, organisation, and activities, resulting in important advances in the prevention and treatment of biofilm-related diseases. The purpose of this book, which was first published in 2003, is to bring these advances to the attention of clinicians and medical researchers.

Microbial Biofilms in Healthcare

Microbial Biofilms in Healthcare
  • Author : Karen Vickery
  • Publisher : MDPI
  • Release Date : 2020-03-16
  • Total pages : 166
  • ISBN : 9783039284108
  • File Size : 16,7 Mb
  • Total Download : 527
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Biofilms are ubiquitous and their presence in industry can lead to production losses. However, nowhere do biofilms impact human health and welfare as much as those that are found contaminating the healthcare environment, surgical instruments, equipment, and medical implantable devices. Approximately 70% of healthcare-associated infections are due to biofilm formation, resulting in increased patient morbidity and mortality. Biofilms formed on medical implants are recalcitrant to antibiotic treatment, which leaves implant removal as the principal treatment option. In this book, we investigate the role of biofilms in breast and dental implant disease and cancer. We include in vitro models for investigating treatment of chronic wounds and disinfectant action against Candida sp. Also included are papers on the most recent strategies for treating biofilm infection ranging from antibiotics incorporated into bone void fillers to antimicrobial peptides and quorum sensing.

The Connections Between Ecology and Infectious Disease

The Connections Between Ecology and Infectious Disease
  • Author : Christon J. Hurst
  • Publisher : Springer
  • Release Date : 2018-08-30
  • Total pages : 317
  • ISBN : 9783319923734
  • File Size : 34,7 Mb
  • Total Download : 653
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This book summarizes current advances in our understanding of how infectious disease represents an ecological interaction between a pathogenic microorganism and the host species in which that microbe causes illness. The contributing authors explain that pathogenic microorganisms often also have broader ecological connections, which can include a natural environmental presence; possible transmission by vehicles such as air, water, and food; and interactions with other host species, including vectors for which the microbe either may or may not be pathogenic. This field of science has been dubbed disease ecology, and the chapters that examine it have been grouped into three sections. The first section introduces both the role of biological community interactions and the impact of biodiversity on infectious disease. In turn, the second section considers those diseases directly affecting humans, with a focus on waterborne and foodborne illnesses, while also examining the critical aspect of microbial biofilms. Lastly, the third section presents the ecology of infectious diseases from the perspective of their impact on mammalian livestock and wildlife as well as on humans. Given its breadth of coverage, the volume offers a valuable resource for microbial ecologists and biomedical scientists alike.

Microbial Biofilms

Microbial Biofilms
  • Author : Dharumadurai Dhanasekaran,Nooruddin Thajuddin
  • Publisher : BoD – Books on Demand
  • Release Date : 2016-07-13
  • Total pages : 526
  • ISBN : 9789535124351
  • File Size : 17,5 Mb
  • Total Download : 190
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In the book Microbial Biofilms: Importance and applications, eminent scientists provide an up-to-date review of the present and future trends on biofilm-related research. This book is divided with four subdivisions as biofilm fundamentals, applications, health aspects, and their control. Moreover, this book also provides a comprehensive account on microbial interactions in biofilms, pyocyanin, and extracellular DNA in facilitating Pseudomonas aeruginosa biofilm formation, atomic force microscopic studies of biofilms, and biofilms in beverage industry. The book comprises a total of 21 chapters from valued contributions from world leading experts in Australia, Bulgaria, Canada, China, Serbia, Germany, Italy, Japan, the United Kingdom, the Kingdom of Saudi Arabia, Republic of Korea, Mexico, Poland, Portugal, and Turkey. This book may be used as a text or reference for everyone interested in biofilms and their applications. It is also highly recommended for environmental microbiologists, soil scientists, medical microbiologists, bioremediation experts, and microbiologists working in biocorrosion, biofouling, biodegradation, water microbiology, quorum sensing, and many other related areas. Scientists in academia, research laboratories, and industry will also find it of interest.

Biofilm-based Healthcare-associated Infections

Biofilm-based Healthcare-associated Infections
  • Author : Gianfranco Donelli
  • Publisher : Springer
  • Release Date : 2014-11-03
  • Total pages : 185
  • ISBN : 9783319110387
  • File Size : 14,9 Mb
  • Total Download : 135
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The aim of this book is to provide readers with a wide overview of the main healthcare-associated infections caused by bacteria and fungi able to grow as biofilm. The recently acquired knowledge on the pivotal role played by biofilm-growing microorganisms in healthcare-related infections has given a new dynamic to detection, prevention and treatment of these infections in patients admitted to both acute care hospitals and long-term care facilities. Clinicians, hygienists and microbiologists will be updated by leading scientists on the state-of-art of biofilm-based infections and on the most innovative strategies for prevention and treatment of these infections, often caused by emerging multidrug-resistant biofilm-growing microorganisms.

Biofilms in Infection Prevention and Control

Biofilms in Infection Prevention and Control
  • Author : Steven L. Percival,David Williams,Tracey Cooper,Jacqueline Randle
  • Publisher : Academic Press
  • Release Date : 2014-01-30
  • Total pages : 394
  • ISBN : 9780123977519
  • File Size : 14,8 Mb
  • Total Download : 845
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Biofilms in Infection and Disease Control: A Healthcare Handbook outlines the scientific evidence and rationale for the prevention of infection, the role biofilms play in infection control, and the issues concerning their resistance to antimicrobials. This book provides practical guidance for healthcare and infection control professionals, as well as students, for preventing and controlling infection. Biofilms are the most common mode of bacterial growth in nature. Highly resistant to antibiotics and antimicrobials, biofilms are the source of more than 65 percent of health care associated infections (HCAI), which, according to the WHO, affect 1.4 million people annually. Biofilms are involved in 80 percent of all microbial infections in the body, including those associated with medical devices such as catheters, endotracheal tubes, joint prostheses, and heart valves. Biofilms are also the principle causes of infections of the middle-ear, dental caries, gingivitis, prostatitis and cystic fibrosis. Importantly, biofilms also significantly delay wound healing and reduce antimicrobial efficiency in at-risk or infected skin wounds. Provides specific procedures for controlling and preventing infection Includes case studies of HCAI, and identifies appropriate treatments Presents national government standards for infection prevention and control Includes extensive references and links to websites for further information

Focus on Bacterial Biofilms

Focus on Bacterial Biofilms
  • Author : Theerthankar Das
  • Publisher : BoD – Books on Demand
  • Release Date : 2022-11-02
  • Total pages : 393
  • ISBN : 9781803557953
  • File Size : 47,9 Mb
  • Total Download : 153
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Bacterial biofilms are colonies of bacterial cells embedded in their self-produced matrix composed of polysaccharides, DNA, and proteins. They protect bacterial cells against antibiotics, antibacterial agents, soaps and detergents, and shear stress. Some of the most common biofilm-associated infections in humans include urinary tract infections, infection of wounds and surgical sites, diabetic foot ulcers, dental caries (tooth decay) and gingivitis (gum inflammation), ventilator-associated infections, sinusitis, microbial keratitis, secondary infection related to Covid-19 and other viral infections, and so on. Bacterial resistance to common antibiotics (e.g., penicillin, gentamycin, erythromycin, ciprofloxacin, etc.) is driving us to a catastrophic failure of our health systems. Strategies to develop novel antibacterial agents and technology must be prioritized to combat and eradicate biofilms and their associated challenges. This book provides a comprehensive overview of biofilms with chapters on bacterial virulence factors, quorum sensing in bacteria, antimicrobial resistance in bacteria, strategies to develop new antibacterial agents, and much more.

Advances in Microbiology, Infectious Diseases and Public Health

Advances in Microbiology, Infectious Diseases and Public Health
  • Author : Gianfranco Donelli
  • Publisher : Springer Nature
  • Release Date : 2020-08-03
  • Total pages : 152
  • ISBN : 9783030536473
  • File Size : 44,6 Mb
  • Total Download : 147
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This book series focuses on current progress in the broad field of medical microbiology, and covers both basic and applied topics related to the study of microbes, their interactions with human and animals, and emerging issues relevant for public health. Original research and review articles present and discuss multidisciplinary findings and developments on various aspects of microbiology, infectious diseases, and their diagnosis, treatment and prevention. Advances in Microbiology, Infectious Diseases and Public Health is a subseries of Advances in Experimental Medicine and Biology, which has been publishing significant contributions in the field for over 30 years and is indexed in Medline, Scopus, EMBASE, BIOSIS, Biological Abstracts, CSA, Biological Sciences and Living Resources (ASFA-1), and Biological Sciences. 2018 Impact Factor: 2.126.

Polymicrobial Diseases

Polymicrobial Diseases
  • Author : Kim A. Brogden,Janet M. Guthmiller
  • Publisher : Unknown
  • Release Date : 2002
  • Total pages : 460
  • ISBN : UOM:39015055170446
  • File Size : 40,5 Mb
  • Total Download : 517
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Polymicrobial diseases, those involving more than one etiologic agent, are more common than is generally realized and include respiratory diseases, gastroenteritis, conjunctivitis, keratitis, hepatitis, periodontal diseases, multiple sclerosis, genital infections, intra -- abdominal infections, and pertussis.

Microbial Inhabitants of Humans

Microbial Inhabitants of Humans
  • Author : Michael Wilson
  • Publisher : Cambridge University Press
  • Release Date : 2005
  • Total pages : 480
  • ISBN : 0521841585
  • File Size : 22,7 Mb
  • Total Download : 806
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This advanced textbook provides a unique overview of the microbial communities (normal indigenous microbiota) inhabiting those regions of the human body that are exposed to the external environment, including the skin, eyes, oral cavity and the respiratory, urinary, reproductive and gastrointestinal tracts. In order to understand why particular organisms are able to colonise an anatomical region and why the resulting microbial community has a particular composition, an ecological approach is essential. Consequently, the key anatomical and physiological characteristics of each body site are described throughout the book. The crucial roles of the indigenous microbiota in protecting against exogenous pathogens, regulating the development of our immune system and mucosae, and providing nutrients are also discussed. The involvement of these organisms in infections of healthy and debilitated individuals are discussed throughout and methods of manipulating the composition of the indigenous microbiota for the benefit of human health are also described.