Metastatic Disease Of The Nervous System

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Metastatic Disease of the Nervous System

Metastatic Disease of the Nervous System
  • Author : David Schiff,M J Van den Bent
  • Publisher : Elsevier
  • Release Date : 2018-01-04
  • Total pages : 304
  • ISBN : 9780444638793
  • File Size : 23,9 Mb
  • Total Download : 694
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Metastatic Disease of the Nervous System, Volume 149, begins with an overview of the impact and range of direct neoplastic involvement of the central and peripheral nervous system, comprehensively reviewing all aspects of brain metastases, from clinical, radiological and neuropathological manifestations, to the roles of surgery, radiation, systemic and palliative therapy in their management, and the complications of these interventions. The clinical manifestations, diagnosis and treatment of leptomeningeal, dural, spinal epidural and plexus metastases are also covered in detail. Covers all aspects of brain metastases, from clinical, radiological and neuropathological manifestations, to the roles of surgery, radiation, systemic and palliative therapy Presents a multidisciplinary review of the evidence regarding accuracy of diagnostic testing and evidence-based reviews of therapies Addresses metastatic diseases of the nervous system for residents, fellows and clinicians in neurology and oncology

Central Nervous System Metastases

Central Nervous System Metastases
  • Author : Rohan Ramakrishna,Rajiv S Magge,Ali A Baaj,Jonathan P S Knisely
  • Publisher : Springer
  • Release Date : 2021-06-11
  • Total pages : 734
  • ISBN : 3030429601
  • File Size : 51,6 Mb
  • Total Download : 807
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This is a multi-specialty book on the diagnosis, evaluation, and treatment of CNS metastases of the brain and spine. Written by renowned experts in their fields, the book covers essential contemporary topics in CNS metastases care. The book is divided into seven parts that begin with chapters that cover the fundamental biology of disease so that subsequent chapters on imaging, diagnosis, treatment, and palliation can be properly contextualized. This text also provides a framework for understanding the biology of radiation therapy so that radiation treatment options of the brain and spine can be more fully understood. New medications and technologies are reviewed from the perspective of maximizing efficacy and minimizing toxicity, independently and as combinatorial therapy. Central Nervous System Metastases: Diagnosis and Treatment serves as a practical reference for health care providers and trainees. It provides the comprehensive, detailed perspective required to provide holistic care to patients with metastatic disease to the brain and spine.

Central Nervous System Metastases

Central Nervous System Metastases
  • Author : Manmeet Ahluwalia,Philippe Metellus,Riccardo Soffietti
  • Publisher : Springer Nature
  • Release Date : 2019-11-05
  • Total pages : 421
  • ISBN : 9783030234171
  • File Size : 38,7 Mb
  • Total Download : 237
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This book provides a comprehensive overview of brain metastases, from the molecular biology aspects to therapeutic management and perspectives. Due to the increasing incidence of these tumors and the urgent need to effectively control brain metastatic diseases in these patients, new therapeutic strategies have emerged in recent years. The volume discusses all these innovative approaches combined with new surgical techniques (fluorescence, functional mapping, integrated navigation), novel radiation therapy techniques (stereotactic radiosurgery) and new systemic treatment approaches such as targeted- and immunotherapy. These combination strategies represent a new therapeutic model in brain metastatic patients in which each medical practitioner (neurosurgeon, neurologist, medical oncologist, radiation oncologist) plays a pivotal role in defining the optimal treatment in a multidisciplinary approach. Written by recognized experts in the field, this book is a valuable tool for neurosurgeons, neuro-oncologists, neuroradiologists, medical oncologists, radiation oncologists, cognitive therapists, basic scientists and students working in the area of brain tumors.

Brain Metastases from Primary Tumors Volume 1

Brain Metastases from Primary Tumors Volume 1
  • Author : M. A. Hayat
  • Publisher : Academic Press
  • Release Date : 2014-04-03
  • Total pages : 274
  • ISBN : 9780128010952
  • File Size : 53,5 Mb
  • Total Download : 898
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With an annual rate of more than 12 million global diagnoses and 7.6 million deaths, the societal and economic burden of cancer cannot be overstated. Brain metastases are the most common malignant tumors of the central nervous system, yet their incidence appears to be increasing in spite of the advancement of cancer therapies. While much is known about primary cancers (including primary brain tumors), less work has been done to uncover the roots of metastatic disease. Brain Metastases from Primary Tumors Volume 1 fills that gap, serving as the first reference to focus primarily on the link between primary cancers and brain metastases. This link is explored for the most common cancer types – lung, breast, and melanoma. Additionally, biological background as well as therapy for CNS metastases is addressed. Age and gender related trends are also discussed, as is the use of biomarkers for early detection. The only comprehensive reference detailing the link between primary cancers and brain metastases Aids the target audience in determining the incidence of brain metastases in patients with a primary cancer Provided education about the potential use of biomarkers for early detection, diagnosis and prevention of the spread of primary cancer to the brain Documents temporal and gender-related trends in brain metastases from other cancers Edited work with chapters authored by leaders in the field around the globe – the broadest, most expert coverage available

Central Nervous System Metastases in Lung Cancer Patients: From Prevention to Diagnosis and Treatment

Central Nervous System Metastases in Lung Cancer Patients: From Prevention to Diagnosis and Treatment
  • Author : Lizza E.L Hendriks,Deepa S. Subramaniam,Anne-Marie C. Dingemans
  • Publisher : Frontiers Media SA
  • Release Date : 2019-01-21
  • Total pages : 94
  • ISBN : 9782889457076
  • File Size : 25,9 Mb
  • Total Download : 257
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Approximately 40% of lung cancer patients will develop central nervous system (CNS) metastases during the course of their disease. Most of these are brain metastases, but up to 10% will develop leptomeningeal metastases. Known risk factors for CNS metastases development are small cell lung cancer (SCLC), adenocarcinoma histology, epidermal growth factor receptor (EGFR) mutant or anaplastic lymphoma kinase (ALK) rearranged lung cancer, advanced nodal status, tumor stage and younger age. CNS metastases can have a negative impact on quality of life (QoL) and overall survival (OS). The proportion of lung cancer patients diagnosed with CNS metastases has increased over the years due to increased use of brain imaging as part of initial cancer staging, advances in imaging techniques and better systemic disease control. Post contrast gadolinium enhanced magnetic resonance imaging (gd-MRI) is preferred, however when this is contra-indicated a contrast enhanced computed tomography (CE-CT) is mentioned as an alternative option. When CNS metastases are diagnosed, local treatment options consist of radiotherapy (stereotactic or whole brain) and surgery. Local treatment can be complicated by symptomatic radiation necrosis for which no high level evidence based treatment exists. Moreover, differential diagnosis with metastasis progression is difficult. Systemic treatment options have expanded over the last years. Until recently, chemotherapy was the only treatment option with a poor penetration in the CNS. Angiogenesis inhibitors are promising in the treatment of primary CNS tumors as well as radiation necrosis but clinical trials of anti-angiogenic agents in NSCLC have largely excluded patients with CNS metastases. Furthermore, research has also focused on methods to prevent development of CNS disease, for example with prophylactic cranial irradiation. Recently, checkpoint inhibitors have become available for NSCLC patients, and tyrosine kinase inhibitors (TKIs) have improved prognosis significantly in those with a druggable driver mutation. Newer TKIs are often designed to have better CNS penetration compared to first-generation TKIs. Despite advances in treatment options CNS metastases remain a problem in lung cancer and cause morbidity and mortality. This Research Topic provides an extensive resource of articles describing advances in CNS metastases management in lung cancer patients, from prevention to diagnosis and treatment.

Brain Metastases

Brain Metastases
  • Author : Jeffrey Raizer,Lauren E. Abrey
  • Publisher : Springer Science & Business Media
  • Release Date : 2007-10-03
  • Total pages : 240
  • ISBN : 9780387692210
  • File Size : 28,6 Mb
  • Total Download : 128
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Brain metastases are the most dreaded complication of systemic cancer, affecting some 170,000 people a year, a far greater incidence than primary brain tumors. This book presents current information on the presentation and management of patients with brain metastases, providing available data, giving guidelines that can be applied in day to day practice, updated information for neurosurgeons, radiation oncologists, medical oncologists, and neuron-oncologists, and as an overview for physicians in training.

Central Nervous System Metastases

Central Nervous System Metastases
  • Author : Rohan Ramakrishna,Rajiv S. Magge,Ali A. Baaj,Jonathan P.S. Knisely
  • Publisher : Springer Nature
  • Release Date : 2020-05-27
  • Total pages : 734
  • ISBN : 9783030429584
  • File Size : 19,7 Mb
  • Total Download : 360
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This is a multi-specialty book on the diagnosis, evaluation, and treatment of CNS metastases of the brain and spine. Written by renowned experts in their fields, the book covers essential contemporary topics in CNS metastases care. The book is divided into seven parts that begin with chapters that cover the fundamental biology of disease so that subsequent chapters on imaging, diagnosis, treatment, and palliation can be properly contextualized. This text also provides a framework for understanding the biology of radiation therapy so that radiation treatment options of the brain and spine can be more fully understood. New medications and technologies are reviewed from the perspective of maximizing efficacy and minimizing toxicity, independently and as combinatorial therapy. Central Nervous System Metastases: Diagnosis and Treatment serves as a practical reference for health care providers and trainees. It provides the comprehensive, detailed perspective required to provide holistic care to patients with metastatic disease to the brain and spine.

Adult CNS Radiation Oncology

Adult CNS Radiation Oncology
  • Author : Eric L. Chang,Paul D. Brown,Simon S. Lo,Arjun Sahgal,John H. Suh
  • Publisher : Springer
  • Release Date : 2018-07-27
  • Total pages : 766
  • ISBN : 9783319428789
  • File Size : 17,7 Mb
  • Total Download : 305
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This book elucidates the radiation therapy protocols and procedures for the management of adult patients presenting with primary benign and malignant central nervous system tumors. With the development of new treatment strategies and rapid advancement of radiation technology, it is crucial for radiation oncologists to maintain and refine their knowledge and skills. Dedicated exclusively to adult CNS radiation oncology, this textbook explores CNS tumors ranging from the common to the esoteric as well as secondary cancers of metastatic origin. The first half of the book is organized anatomically: tumors of the brain, spinal cord, leptomeninges, optic pathway, ocular choroid, and skull base. The second half covers primary CNS lymphoma, rare CNS tumors, metastatic brain disease, vascular conditions of the CNS, radiation-associated complications, and radiation modalities. Each chapter provides guidance on treatment field design, target delineation, and normal critical structure tolerance constraints in the context of the disease being treated. Learning objectives, case studies, and Maintenance of Certification Self-Assessment Continuing Medical Education-style questions and answers are incorporated throughout the book. This is an ideal guide for radiation oncologists, residents, and fellows, but medical students may also find value in the text.

Metastatic Disease of the Nervous System

Metastatic Disease of the Nervous System
  • Author : M. J. Van den Bent
  • Publisher : Elsevier
  • Release Date : 2018-01-15
  • Total pages : 500
  • ISBN : 0128111615
  • File Size : 55,7 Mb
  • Total Download : 272
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Metastatic Disease of the Nervous System, Volume 149, begins with an overview of the impact and range of direct neoplastic involvement of the central and peripheral nervous system, comprehensively reviewing all aspects of brain metastases, from clinical, radiological and neuropathological manifestations, to the roles of surgery, radiation, systemic and palliative therapy in their management, and the complications of these interventions. The clinical manifestations, diagnosis and treatment of leptomeningeal, dural, spinal epidural and plexus metastases are also covered in detail. Covers all aspects of brain metastases, from clinical, radiological and neuropathological manifestations, to the roles of surgery, radiation, systemic and palliative therapy Presents a multidisciplinary review of the evidence regarding accuracy of diagnostic testing and evidence-based reviews of therapies Addresses metastatic diseases of the nervous system for residents, fellows and clinicians in neurology and oncology

Holland-Frei Cancer Medicine

Holland-Frei Cancer Medicine
  • Author : Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland
  • Publisher : John Wiley & Sons
  • Release Date : 2017-03-10
  • Total pages : 2008
  • ISBN : 9781119000846
  • File Size : 22,8 Mb
  • Total Download : 477
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Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Tumors of the Central Nervous System

Tumors of the Central Nervous System
  • Author : Lee Roy Morgan
  • Publisher : BoD – Books on Demand
  • Release Date : 2014-06-11
  • Total pages : 274
  • ISBN : 9789535115762
  • File Size : 34,9 Mb
  • Total Download : 872
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A novel concept that is reviewed and discussed in several chapters in the book alludes to the transport of drugs bound to red blood cells into the highly vascular CNS tumors - both primary and metastatic. Such a transport mechanism is unique and of significant therapeutic potential. It is hopeful that the novel information presented in this book will result in new approaches to the treatment CNS tumors.

Childhood Cancer and Functional Impacts Across the Care Continuum

Childhood Cancer and Functional Impacts Across the Care Continuum
  • Author : National Academies of Sciences Engineering and Medicine,Health and Medicine Division,Board on Health Care Services,Committee on Childhood Cancers and Disability
  • Publisher : Unknown
  • Release Date : 2021-09-09
  • Total pages : 229
  • ISBN : 0309683491
  • File Size : 55,8 Mb
  • Total Download : 854
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Since the late 1960s, the survival rate in children and adolescents diagnosed with cancer has steadily improved, with a corresponding decline in the cancer-specific death rate. Although the improvements in survival are encouraging, they have come at the cost of acute, chronic, and late adverse effects precipitated by the toxicities associated with the individual or combined use of different types of treatment (e.g., surgery, radiation, chemotherapy). In some cases, the impairments resulting from cancer and its treatment are severe enough to qualify a child for U.S. Social Security Administration disability benefits. At the request of Social Security Administration, Childhood Cancer and Functional Impacts Across the Care Continuum provides current information and findings and conclusions regarding the diagnosis, treatment, and prognosis of selected childhood cancers, including different types of malignant solid tumors, and the effect of those cancers on childrenâ (TM)s health and functional capacity, including the relative levels of functional limitation typically associated with the cancers and their treatment. This report also provides a summary of selected treatments currently being studied in clinical trials and identifies any limitations on the availability of these treatments, such as whether treatments are available only in certain geographic areas.

Advanced Techniques in Central Nervous System Metastases

Advanced Techniques in Central Nervous System Metastases
  • Author : Robert J. Maciunas
  • Publisher : Thieme
  • Release Date : 1998
  • Total pages : 344
  • ISBN : 1879284472
  • File Size : 18,8 Mb
  • Total Download : 217
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The neurosurgical treatment of metastatic tumors involving the central nervous system is being transformed by recent advances in interactive image-guided technologies and cell-specific targeted biotherapeutics. This text presents the reseachr and developments currently being incorporated into clinical practice.

Central Nervous System Metastasis, the Biological Basis and Clinical Considerations

Central Nervous System Metastasis, the Biological Basis and Clinical Considerations
  • Author : Diane Palmieri
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-30
  • Total pages : 228
  • ISBN : 9789400752917
  • File Size : 55,6 Mb
  • Total Download : 135
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Here is a thorough survey of the biology and treatment of CNS metastasis, including natural history, risk factors, molecular biology, the blood-brain barrier, imaging, quality of life, surgery, chemotherapy, radiation and the future of targeted therapies.

TxNxM1

TxNxM1
  • Author : J.M. Debois
  • Publisher : Springer Science & Business Media
  • Release Date : 2006-05-08
  • Total pages : 757
  • ISBN : 9780306476785
  • File Size : 51,5 Mb
  • Total Download : 480
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Although distant metastases are the most dreaded situation in the evolution of cancer of every organ, the medical literature has surprisingly given little attention to the anatomical relationship between the primary tumor and metastasic sites. Only risk factors, treatment possibilities, and survival results are extensively examined. Stimulated by the occurrence in his practice of some puzzling and unexpected metastases, the author reviewed more than 12,000 references. He looked for anatomical relationships highlighting the relation between the location of the primary tumors and the particular patterns of metastasis observed. It would seem that the `pathways and flows' are apparently a more decisive factor in the implantation of the metastases than the `seed and soil' properties of the cancer cells and the metastatic site. Aided by his colleague Dr. T. Geukens, M.D., the author includes original anatomical drawings, illustrating the sometimes unexpected pathways the cancer cells follow in order to reach the organs where they will become lodged and give rise to metastatic tumors. The subject has apparently not been exhausted in the literature and several ideas are given for further research.

Abeloff's Clinical Oncology E-Book

Abeloff's Clinical Oncology E-Book
  • Author : Martin D. Abeloff,James O. Armitage,John E. Niederhuber,Michael B. Kastan,W. Gillies McKenna
  • Publisher : Elsevier Health Sciences
  • Release Date : 2008-06-30
  • Total pages : 2592
  • ISBN : 9781437720563
  • File Size : 30,8 Mb
  • Total Download : 104
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Carrying on the tradition established by its founding editor, the late Dr. Martin Abeloff, the 4th Edition of this respected reference synthesizes all of the latest oncology knowledge in one practical, clinically focused, easy-to-use volume. It incorporates basic science, pathology, diagnosis, management, outcomes, rehabilitation, and prevention – all in one convenient resource – equipping you to overcome your toughest clinical challenges. What's more, you can access the complete contents of this Expert Consult title online, and tap into its unparalleled guidance wherever and whenever you need it most! Equips you to select the most appropriate tests and imaging studies for diagnosing and staging each type of cancer, and manage your patients most effectively using all of the latest techniques and approaches. Explores all of the latest scientific discoveries' implications for cancer diagnosis and management. Employs a multidisciplinary approach - with contributions from pathologists, radiation oncologists, medical oncologists, and surgical oncologists - for well-rounded perspectives on the problems you face. Offers a user-friendly layout with a consistent chapter format • summary boxes • a full-color design • and more than 1,445 illustrations (1,200 in full color), to make reference easy and efficient. Offers access to the book's complete contents online – fully searchable – from anyplace with an Internet connection. Presents discussions on cutting-edge new topics including nanotechnology, functional imaging, signal transduction inhibitors, hormone modulators, complications of transplantation, and much more. Includes an expanded color art program that highlights key points, illustrates relevant science and clinical problems, and enhances your understanding of complex concepts.

Intracranial Metastases

Intracranial Metastases
  • Author : Raymond Sawaya
  • Publisher : John Wiley & Sons
  • Release Date : 2008-04-15
  • Total pages : 512
  • ISBN : 9781405146142
  • File Size : 45,5 Mb
  • Total Download : 739
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This is the first comprehensive textbook on intracranial metastases in over 20 years with an update on current methods for their management, including the use of newer technologies. Each of the various histological types of cancer metastasizing to the brain is presented separately in a detailed analysis and discussion. This volume includes a consideration of the epidemiology of brain metastases and the quality of life in patients who have them. Special topics not previously covered are reviewed, including metastasis to the skull base and strategies for preventing cancer from metastasizing to the brain. A novel feature is a chapter devoted to the use of recent techniques such as functional magnetic resonance (MR) imaging, MR spectroscopy (metabolite mapping), and dynamic susceptibility contrast imaging (regional cerebral blood volume mapping) to characterize brain metastases in terms of the sensorimotor perturbations they produce, their metabolic response to therapy, and their degree of vascularization, respectively.

Therapeutic Potential of Melatonin

Therapeutic Potential of Melatonin
  • Author : Georges J. M. Maestroni,Ario Conti,Russel J. Reiter
  • Publisher : Karger Medical and Scientific Publishers
  • Release Date : 1997-01-01
  • Total pages : 182
  • ISBN : 9783805564397
  • File Size : 10,8 Mb
  • Total Download : 415
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Over the past decade, the potential of the pineal hormone melatonin as a therapeutic agent in a variety of diseases has been recognized. This book is the first to review the effect of melatonin in sleep disorders, its possible use as an immunoregulatory agent and clinical results obtained in cancer immunotherapy. Several papers are devoted to the pharmacological and molecular characterization of melatonin receptors in a variety of cell types. Other contributions further investigate the immunoenhancing effect of melatonin, such as in viral encephalitis and bacterial infections, and consider possible therapeutic indications. Melatonin is also reported to exert important hematopoietic effects by stimulating the production of novel T helper cell opioid cytokines. Other basic studies introduce new perspectives describing melatonin as a potent free radical scavenger. This book should be read by clinicians working in the fields of sleep disorders, oncology and infectious diseases as well as by scientists active in the field of neuroimmunomodulation. It will also be very useful to all those interested in melatonin as a therapeutic agent.

Metastatic Cancer: Clinical and Biological Perspectives

Metastatic Cancer: Clinical and Biological Perspectives
  • Author : Rahul Jandial
  • Publisher : CRC Press
  • Release Date : 2013-08-08
  • Total pages : 312
  • ISBN : 1587066599
  • File Size : 14,6 Mb
  • Total Download : 895
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Most cancer deaths are a result of metastasis. The spread of a primary tumor to colonize neighboring and distant organs is the relentless endgame that defines the neoplastic process. Patients who have been diagnosed with cancer are treated to prevent both the recurrence of the tumor at the site of origin and metastasis that would re-stage them as advanced stage IV cancer. Historically and still with some types of cancer, stage IV is perceived by patients as “terminal.” Fortunately, recent molecular therapies have extended the lives of patients with advanced cancer and reassuringly people living with metastatic disease increasingly visit our clinics. What is the path forward? Given that the consilience of science and medicine is a dynamic art from which therapies arise, it would be misguided to consider any single work adequate at capturing the horizon for research. So with humility we constructed this text as primer for scientists. It begins with a broad introduction to the clinical management of common cancers. This is intended to serve as a foundation for investigators to consider when developing basic science hypotheses. Unquestionably, medical and surgical care of cancer patients reveals biology and dictates how novel therapeutics will ultimately be evaluated in clinical trials. The second section of this text offers provocative and evolving insights that underscore the breadth of science involved in the elucidation of cancer metastasis biology. The text concludes with information that integrates scientific and clinical foundations to highlight translational research. This book serves as a framework for scientists to conceptualize clinical and translational knowledge on the complexity of disease that is metastatic cancer.

Comparative Oncology

Comparative Oncology
  • Author : Alecsandru Ioan Baba,Cornel Cătoi
  • Publisher : Unknown
  • Release Date : 2007
  • Total pages : 787
  • ISBN : 9732714573
  • File Size : 29,7 Mb
  • Total Download : 957
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PDF book entitled Comparative Oncology written by Alecsandru Ioan Baba,Cornel Cătoi and published by Unknown which was released on 2007 with total hardcover pages 787, the book become popular and critical acclaim.

Tumors of the Central Nervous System, Volume 13

Tumors of the Central Nervous System, Volume 13
  • Author : M.A. Hayat
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-12-16
  • Total pages : 308
  • ISBN : 9789400776029
  • File Size : 21,8 Mb
  • Total Download : 358
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Volume 13: Pineal, Pituitary, and Spinal Tumors is organized in six sections, for convenience and quick access to critical information. Section I, Types of Tumors includes a chapter on molecular characterization of Embryonal tumors, a chapter on diagnosis of metastatic oligodendroglioma using fine-needle aspiration cytology, one covering intra-arterial chemotherapy of oligodendroglial tumors and another on the role of cyclooxygenase-2 in the development and growth of Schwannomas, and others, closing with a chapter on trigeminal neuralgia with cerebellopontine angle tumors. Section II, Diagnosis, includes two chapters on cell counting in histopathologic slides of tumors. Section III offers three chapters which discuss aspects of intraoperative ultrasonography. Section IV covers brain tumor surgery, and Section V surveys Brain Metastasis. The final section offers a wide-ranging review of General Diseases, with chapters on, among others, Alexander Disease; Lipoma; Transplantation of human umbilical cord blood mononuclear cells in cases of neonatal hypoxic-ischemic brain damage; and a chapter discussing the use of mobile phones and brain cancer risk in children. Like its twelve predecessors in the series, this volume merits distinction for its thorough approach, its roster of 78 distinguished contributors representing 14 different countries and its detailed examination of leading-edge technology and methods.