Mesenchymal Stromal Cells As Tumor Stromal Modulators

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• Author : Marcela Bolontrade,Mariana García
• Publisher : Academic Press
• Release Date : 2016-10-24
• Total pages : 642
• ISBN : 9780128031032
• File Size : 30,6 Mb
• Total Download : 795
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Download Mesenchymal Stromal Cells as Tumor Stromal Modulators in PDF, Epub, and Kindle

Mesenchymal stromal/ stem cells (MSCs) represent a heterogeneous cell population with immunomodulating, tissue repairing, differentiating, migratory and angiogenic abilities, making them important tools for clinical and translational research. An understanding of the role of MSCs in modulating tumor growth provides a glimpse into their role in non-pathological tissue remodeling and potential regenerative tissue therapies. Mesenchymal Stromal Cells as Tumor Stromal Modulators is a comprehensive source for the understanding of the role of MSCs as ubiquitous connective tissue cell components, which may have both direct and indirect effects on the tumor microenvironment and potential for regenerative therapeutics for various diseases. Using cancer as a model disease, this book explores the transformative role MSCs play in the recruitment of disease cells, cell repair and immunological defenses. Explores the biology of mesenchymal stromal cells (MSCs) and tissue related function Discusses the bidirectional communication between tumor stroma and MSCs derived from bone marrow, from adipose tissue and from other tissue types Provides in-depth analysis of the effects of MSCs on key processes that regulate disease progression, such as angiogenesis, metastatic potential, invasion, proliferation, tumor immune privileges

• Author : Randy Morrison
• Publisher : Unknown
• Release Date : 2017
• Total pages : 97
• ISBN : 1634857208
• File Size : 41,8 Mb
• Total Download : 491
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Download Mesenchymal Stromal Cells (MSCs) in PDF, Epub, and Kindle

Mesenchymal stromal cells (MSCs) are considered an important tool in tissue engineering due to their multilineage potential in vitro as in vivo beyond their capacity to produce bioactive molecules involved in tissue regeneration. MSCs are essential elements of the microenvironment because they are the precursors of all stromal cells. MSCs influence HPC functions, such as proliferation, apoptosis, and clonogenic growth, directly via cell-cell contacts or indirectly via the secretion of soluble factors. This book reviews the biology, mechanisms of action and clinical uses of MSCs. Chapter One analyzes the modulation of adhesion molecules on MSCs to help in understanding their possible contribution to cancer initiation and progression. Chapter Two studies adipose derived MSCs in cancer therapy. Chapter Three discusses the improvement of clinical uses of MSCs by 3D scaffold-free constructs. Chapter Four reviews the application of MSCs in veterinary medicine.

• Author : Ahmed H.K. El-Hashash
• Publisher : Academic Press
• Release Date : 2020-01-07
• Total pages : 228
• ISBN : 9780128205334
• File Size : 19,7 Mb
• Total Download : 638
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Download Mesenchymal Stem Cells in Human Health and Diseases in PDF, Epub, and Kindle

Mesenchymal Stem Cells in Human Health and Diseases provides a contemporary overview of the fast-moving field of MSC biology, regenerative medicine and therapeutics. MSCs offer the potential to dramatically reduce human suffering from disease. Numerous MSC-based studies are ongoing each year, each offering hope for novel treatments in human disease. This book provides information on MSC application in well-studied human diseases and tissue repair/regeneration and recent advances in their research and treatment. These discoveries are placed within the structural context of tissue and developmental biology in sections dealing with recent advances in our understanding of MSC biology. Includes insights ranging from MSC biology and development through the derivation and identification and properties of MSCs Helps to identify potential innovative solutions for restoring normal morphogenesis and/or regeneration of diseased organs Discusses the fact-based promise of MSC therapeutics and regenerative medicine in the real world

• Author : Khalid Ahmed Al-Anazi
• Publisher : BoD – Books on Demand
• Release Date : 2020-04-22
• Total pages : 150
• ISBN : 9781789238075
• File Size : 18,5 Mb
• Total Download : 430
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Download Update on Mesenchymal and Induced Pluripotent Stem Cells in PDF, Epub, and Kindle

This book represents an updated overview on selected topics related to mesenchymal stem cells as well as induced pluripotent stem cells. The book is divided into three main sections that cover several topics including: sources of both stem cell types, their preparation and general properties, as well as their therapeutic indications and clinical utilization with particular attention given to their use in infectious diseases, osteoarthritis, as well as immunological disorders.

• Author : Marc Feldmann,N. A. Mitchison
• Publisher : Springer Science & Business Media
• Release Date : 2012-12-06
• Total pages : 392
• ISBN : 9781461249962
• File Size : 51,8 Mb
• Total Download : 444
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Download Immune Regulation in PDF, Epub, and Kindle

Leukocyte culture conferences have a long pedigree. This volume records some of the scientific highlights of the 16th such annual con ference, and is a witness to the continuing evolution and popularity of leukocyte culture and of immunology. There is strong evidence of the widening horizons of immunology, both technically, with the obviously major impact of molecular biology into our understanding of cellular processes, and also conceptually. Traditionally, the 'proceedings' of these conferences have been published. But have the books produced really recorded the major part of the conference, the informal, friendly, but intense and some times heated exchanges that take place between workers in tackling very similar problems and systems and which are at the heart of every successful conference? Unfortunately this essence cannot be incorpo rated by soliciting manuscripts. For this reason, we have changed the format of publication, retaining published versions of the symposium papers, but requesting the workshop chairmen to produce a summary of the major new observations and areas of controversy highlighted in their sessions, as a vehicle for defining current areas of interest and debate. Not an easy task, as the workshop topics were culled from the abstracts submitted by the participants, rather than being on predefined topics. The unseasonal warmth in Cambridge was reflected in the atmos phere of the conference, the organization of which benefited from the administrative skills of Jean Bacon, Philippa Wells, Mr. Peter Irving, and Mrs.

• Author : Mani T. Valarmathi
• Publisher : BoD – Books on Demand
• Release Date : 2019-01-23
• Total pages : 262
• ISBN : 9781789849844
• File Size : 22,8 Mb
• Total Download : 531
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Download Stromal Cells in PDF, Epub, and Kindle

Stromal cells are connective tissue cells of any organ, and they support the function of the parenchymal cells of that particular organ. Stromal/stromal stem cells are fundamentally a heterogeneous population of cells with contradictory differentiation potential depending upon their environmental niche. Stromal cell biology is not only intriguing, but equally stromal cell ontogeny in vivo remains challenging. In recent years there has been substantial advances in our understanding of stromal cell biology, especially stromal cell isolation, characterization, differentiation, and interactions in physiological (epithelial-stromal interactions) as well as pathophysiological (stromal-cancer interactions) contexts. In addition, stromal cells are also utilized more and more as a therapeutic tool not only in the field of gene therapy but also in the translational field of tissue engineering and regenerative medicine. Therefore, the goal of this book is to consolidate the recent advances in the area of stromal/stromal stem cell biology covering a broad range of interrelated topics in a timely fashion and to disseminate that knowledge in a lucid way to a greater scientific audience. This book will prove highly useful for students, researchers, and clinicians in stem cell biology, developmental biology, cancer biology, pathology, oncology, as well as tissue engineering and regenerative medicine. This quick reference will benefit anyone desiring a thorough overview of stromal cell structure, function, and its therapeutic implications.

• Author : Yaoliang Tang,Buddhadeb Dawn
• Publisher : Academic Press
• Release Date : 2015-09-02
• Total pages : 288
• ISBN : 9780128004975
• File Size : 18,5 Mb
• Total Download : 817
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Download Mesenchymal Stem Cell Derived Exosomes in PDF, Epub, and Kindle

Mesenchymal stem cell-derived exosomes are at the forefront of research in two of the most high profile and funded scientific areas – cardiovascular research and stem cells. Mesenchymal Stem Cell Derived Exosomes provides insight into the biofunction and molecular mechanisms, practical tools for research, and a look toward the clinical applications of this exciting phenomenon which is emerging as an effective diagnostic. Primarily focused on the cardiovascular applications where there have been the greatest advancements toward the clinic, this is the first compendium for clinical and biomedical researchers who are interested in integrating MSC-derived exosomes as a diagnostic and therapeutic tool. Introduces the MSC-exosome mediated cell-cell communication Covers the major functional benefits in current MSC-derived exosome studies Discusses strategies for the use of MSC-derived exosomes in cardiovascular therapies

• Author : Bharat B. Aggarwal,Bokyung Sung,Subash Chandra Gupta
• Publisher : Springer
• Release Date : 2014-05-12
• Total pages : 490
• ISBN : 9783034808378
• File Size : 55,7 Mb
• Total Download : 704
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Download Inflammation and Cancer in PDF, Epub, and Kindle

This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.

• Author : Susie Prof. Nilsson
• Publisher : Academic Press
• Release Date : 2021-01-23
• Total pages : 246
• ISBN : 9780323853262
• File Size : 24,5 Mb
• Total Download : 940
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Download The Cancer Stem Cell Niche in PDF, Epub, and Kindle

The Cancer Stem Cell Niche, Volume Five in the Advances in Stem Cells and their Niches series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Acute lymphoblastic leukemia and the bone marrow microenvironment, Stem cell niches in bone and their roles in cancer metastasis, The role of vasculature in cancer stem cell niches, The lung cancer stem cell niche, The prostate cancer stem cell niche: Genetic drivers and therapeutic approaches, Impact of prostate cancer stem cell niches on prostate cancer tumorigenesis and progression, The testicular cancer stem cell niche. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Advances in Stem Cells and their Niches series Includes the latest information on the Cancer Stem Cell Niche

• Author : Mina Sarani,Abolfazl Heydari,Majid Darroudi
• Publisher : Frontiers Media SA
• Release Date : 2023-01-06
• Total pages : 158
• ISBN : 9782832510926
• File Size : 52,9 Mb
• Total Download : 450
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Download Green synthesis of nanomaterials: cytotoxicity and drug delivery in PDF, Epub, and Kindle

PDF book entitled Green synthesis of nanomaterials: cytotoxicity and drug delivery written by Mina Sarani,Abolfazl Heydari,Majid Darroudi and published by Frontiers Media SA which was released on 2023-01-06 with total hardcover pages 158, the book become popular and critical acclaim.

• Author : Martin Götte,Karin Forsberg-Nilsson
• Publisher : Springer Nature
• Release Date : 2021-06-07
• Total pages : 308
• ISBN : 9783030734534
• File Size : 13,8 Mb
• Total Download : 796
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Download Proteoglycans in Stem Cells in PDF, Epub, and Kindle

This book provides a state-of-the-art compendium on the role of proteoglycans and glycosaminoglycans during development and in cancer. It also suggests directions for novel therapeutic and biotechnological applications in stem cell biology. Proteoglycans and glycosaminoglycans, as part of the extracellular matrix, are multifunctional modulators of growth factor, cytokine, integrin and morphogen signaling, which determine both self-renewal, senescence and/or differentiation of stem cells during development. Since proteoglycans modulate cell adhesion and migration they are important organizers of the extracellular matrix within the proper stem cell niche. A malfunctioning of proteoglycans and glycosaminoglycans contributes to the cancer stem cell phenotype, which is linked to therapeutic resistance and recurrence in malignant disease. This book is essential reading for anyone interested in the extracellular matrix and its role in development. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology.

• Author : Eran Hornstein
• Publisher : Academic Press
• Release Date : 2012-03-02
• Total pages : 327
• ISBN : 9780123870384
• File Size : 35,7 Mb
• Total Download : 317
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Download MicroRNAs in Development in PDF, Epub, and Kindle

This new volume in the Current topics in Developmental Biology series concentrates on MicroRNAs in Development. It includes chapters on such topics as miRNA networks in neuronal development, let-7 in development, and Hox networks and miRNA. With an international team of authors, this volume is a must-have addition for researchers and students alike. Concentrates on microRNAs in development Includes chapters on such topics as miRNA networks in neuronal development, let-7 in development, and Hox networks and miRNA With an international team of authors, this volume is a must-have addition for researchers and students alike

• Author : Kerry Atkinson
• Publisher : John Wiley & Sons
• Release Date : 2017-01-17
• Total pages : 1080
• ISBN : 9781118907511
• File Size : 46,6 Mb
• Total Download : 922
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Download The Biology and Therapeutic Application of Mesenchymal Cells, 2 Volume Set in PDF, Epub, and Kindle

The Biology and Therapeutic Application of Mesenchymal Cells comprehensively describes the cellular and molecular biology of mesenchymal stem cells and mesenchymal stromal cells, describing their therapeutic potential in a wide variety of preclinical models of human diseases and their mechanism of action in these preclinical models. Chapters also discuss the current status of the use of mesenchymal stem and stromal cells in clinical trials in a wide range of human diseases and disorders, for many of which there are limited, or no other, therapeutic avenues. Provides coverage on both the biology of mesenchymal stem cells and stromal cells, and their therapeutic applications Describes the therapeutic potential of mesenchymal stem and stromal cells in a wide variety of preclinical models of human diseases and their mechanism of action in these preclinical models Discusses the current status of mesenchymal stem and stromal cells in clinical trials in a wide range of human diseases and disorders, for many of which there are limited, or no other, therapeutic avenues Written and edited by leaders in the field The Biology and Therapeutic Application of Mesenchymal Cells is an invaluable resource for those studying stem cells, cell biology, genetics, gene or cell therapy, or regenerative medicine.

• Author : Charles J. Malemud,Eben Alsberg
• Publisher : Springer
• Release Date : 2018-07-13
• Total pages : 85
• ISBN : 3319835734
• File Size : 27,8 Mb
• Total Download : 189
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Download Mesenchymal Stem Cells and Immunomodulation in PDF, Epub, and Kindle

This essential volume explores mesenchymal stem cells (MSCs) and their potential to suppress immune-mediated inflammation. The chapters examine applications in autoimmune diseases such as lupus, rheumatoid arthritis and multiple sclerosis; blood cancers such as leukemia and lymphoma; and reproductive complications, specifically pre-term labor and use of MSCs in vitro and in animal models to discover methods of suppressing the causal inflammatory response. It also further defines the methodologies required to develop research on MSCs in vitro into established preclinical animal models including those which are proven replicas of autoimmunity and pre-term labor, to name but two. Mesenchymal Stem Cells and Immunomodulation, part of Springer’s Stem Cell Biology and Regenerative Medicine, is an invaluable resource for researchers and clinicians working with stem cells, autoimmune disease, oncology, and reproductive medicine.

• Author : Seyyed Shamsadin Athari
• Publisher : BoD – Books on Demand
• Release Date : 2018-08-01
• Total pages : 242
• ISBN : 9781789235081
• File Size : 46,5 Mb
• Total Download : 294
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Download Immunoregulatory Aspects of Immunotherapy in PDF, Epub, and Kindle

Immunotherapy is an innovative, leading and valuable approach to the treatment and control of many diseases. It can solve many problems of public health worldwide. Many people in numerous countries are suffering from a wide range of diseases (communicable and non-communicable) that can be cured or controlled by the immune system and immunotherapy. Some immunological diseases (i.e. allergic reactions and asthma, autoimmune disease, immunodeficiency disease, hypersensitivity reactions, etc.) have immune response pathophysiology and by controlling immune system mechanisms, these diseases can be controlled and cured. Immunoregulatory Aspects of Immunotherapy focuses on immune system mechanism, diagnosis, treatment and other related problems. The chapters have applicable and scientific data in immunotherapeutic approaches based on medical sciences, and would be of benefit to all researchers in immunology, allergy and asthma fields. The book discusses the prevention, diagnosis, treatment and follow-up of patients who have dangerous diseases. We hope this book will be a new approach to the immunotherapy of diseases and will improve public health and wellbeing.

• Author : Guido Moll,Martin Johannes Hoogduijn,James A. Ankrum
• Publisher : Frontiers Media SA
• Release Date : 2020-07-24
• Total pages : 296
• ISBN : 9782889636006
• File Size : 31,6 Mb
• Total Download : 449
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Download Safety, Efficacy and Mechanisms of Action of Mesenchymal Stem Cell Therapies in PDF, Epub, and Kindle

PDF book entitled Safety, Efficacy and Mechanisms of Action of Mesenchymal Stem Cell Therapies written by Guido Moll,Martin Johannes Hoogduijn,James A. Ankrum and published by Frontiers Media SA which was released on 2020-07-24 with total hardcover pages 296, the book become popular and critical acclaim.

• Author : Marina De Bernard,Maria Kaparakis-Liaskos,Mario M. D’Elios
• Publisher : Frontiers Media SA
• Release Date : 2023-04-10
• Total pages : 227
• ISBN : 9782832520222
• File Size : 32,8 Mb
• Total Download : 662
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Download Modulation of the immune system by bacteria: from evasion to therapy in PDF, Epub, and Kindle

PDF book entitled Modulation of the immune system by bacteria: from evasion to therapy written by Marina De Bernard,Maria Kaparakis-Liaskos,Mario M. D’Elios and published by Frontiers Media SA which was released on 2023-04-10 with total hardcover pages 227, the book become popular and critical acclaim.

• Author : Phuc Van Pham
• Publisher : Springer
• Release Date : 2019-08-14
• Total pages : 225
• ISBN : 9783030198572
• File Size : 33,8 Mb
• Total Download : 807
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Download Tissue Engineering and Regenerative Medicine in PDF, Epub, and Kindle

This new series, based on a bi-annual conference and its topics, represents a major contribution to the emerging science of cancer research and regenerative medicine. Each volume brings together some of the most pre-eminent scientists working on cancer biology, cancer treatment, cancer diagnosis, cancer prevention and regenerative medicine to share information on currently ongoing work which will help shape future therapies. These volumes are invaluable resources not only for already active researchers or clinicians but also for those entering these fields, plus those in industry. Tissue Engineering and Regenerative Medicine is a proceedings volume which reflects papers presented at the 3rd bi-annual Innovations in Regenerative Medicine and Cancer Research conference; taken with its companion volume Stem Cells: Biology and Engineering it provides a complete overview of the papers from that meeting of international experts.

• Author : Anthony Atala,Kyle J. Cetrulo,Rouzbeh R. Taghizadeh,Curtis L Cetrulo,Sean Murphy
• Publisher : Academic Press
• Release Date : 2018-06-14
• Total pages : 418
• ISBN : 9780128120637
• File Size : 44,5 Mb
• Total Download : 346
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Download Perinatal Stem Cells in PDF, Epub, and Kindle

Perinatal Stem Cells provides researchers and clinicians with a comprehensive description of the current clinical and pre-clinical applications of stem cells derived from perinatal sources, such as amniotic fluid, placenta and placental membranes, the umbilical cord and Wharton’s jelly. It's compiled by leading experts in the field, offering readers detailed insights into sources of perinatal stem cells and their potential for disease treatment. Therapeutic applications of perinatal stem cells include the treatment of in utero and pregnancy related diseases, cardiac disease, liver disease, pulmonary disease, inflammatory diseases, for hematopoietic regeneration, and for neural protection after stroke or traumatic brain injury. In addition, the rapid advance in clinical translation and commercialization of perinatal stem cell therapies is highlighted in a section on Clinical and Industry Perspective which provides insight into the new opportunities and challenges involved in this novel and exciting industry. Explores current clinical and pre-clinical application of stem cells derived from perinatal sources Offers detailed insight into sources of perinatal stem cells and their potential for disease treatment Discusses progress in the manufacturing, banking and clinical translation of perinatal stem cells Edited by a world-renowned team to present a complete story of the development and promise of perinatal stem cells

• Author : Mojca Frank Bertoncelj,Katja Lakota
• Publisher : Unknown
• Release Date : 2021
• Total pages : 0
• ISBN : 1838805788
• File Size : 40,7 Mb
• Total Download : 523
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Download Fibroblasts in PDF, Epub, and Kindle

Fibroblasts - Advances in Inflammation, Autoimmunity and Cancer presents recent advances in understanding the roles of fibroblasts and mesenchymal stem cells in tissue homeostasis and the development of human disease. The book delves into general principles of fibroblast and mesenchymal stem cell biology and their diversity across the human body. It highlights these cells' unique and shared characteristics across organs (e.g., vasculature, kidney, joints and exocrine glands) and specific pathologies (e.g., tissue damage, inflammation, fibrosis and cancer). A particular focus is set on the roles of fibroblasts in disease chronicity, recurrence, progression, therapeutic resistance and utilisation of the advancing knowledge for developing new therapeutic approaches within and beyond disease boundaries.

• Author : Lucas G. Chase,Mohan C Vemuri
• Publisher : Springer Science & Business Media
• Release Date : 2012-12-12
• Total pages : 456
• ISBN : 9781627032001
• File Size : 55,5 Mb
• Total Download : 128
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Download Mesenchymal Stem Cell Therapy in PDF, Epub, and Kindle

Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), appear to hold great promise in regards to a regenerative cell-based therapy for the treatment of these diseases. Currently, more than 200 clinical trials are underway worldwide exploring the use of MSCs for the treatment of a wide range of disorders including bone, cartilage and tendon damage, myocardial infarction, graft-versus-host disease, Crohn’s disease, diabetes, multiple sclerosis, critical limb ischemia and many others. MSCs were first identified by Friendenstein and colleagues as an adherent stromal cell population within the bone marrow with the ability to form clonogenic colonies in vitro. In regards to the basic biology associated with MSCs, there has been tremendous progress towards understanding this cell population’s phenotype and function from a range of tissue sources. Despite enormous progress and an overall increased understanding of MSCs at the molecular and cellular level, several critical questions remain to be answered in regards to the use of these cells in therapeutic applications. Clinically, both autologous and allogenic approaches for the transplantation of MSCs are being explored. Several of the processing steps needed for the clinical application of MSCs, including isolation from various tissues, scalable in vitro expansion, cell banking, dose preparation, quality control parameters, delivery methods and numerous others are being extensively studied. Despite a significant number of ongoing clinical trials, none of the current therapeutic approaches have, at this point, become a standard of care treatment. Although exceptionally promising, the clinical translation of MSC-based therapies is still a work in progress. The extensive number of ongoing clinical trials is expected to provide a clearer path forward for the realization and implementation of MSCs in regenerative medicine. Towards this end, reviews of current clinical trial results and discussions of relevant topics association with the clinical application of MSCs are compiled in this book from some of the leading researchers in this exciting and rapidly advancing field. Although not absolutely all-inclusive, we hope the chapters within this book can promote and enable a better understanding of the translation of MSCs from bench-to-bedside and inspire researchers to further explore this promising and quickly evolving field.