Mesenchymal Stem Cell Derived Exosomes

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• Author : Yaoliang Tang,Buddhadeb Dawn
• Publisher : Academic Press
• Release Date : 2015-09-02
• Total pages : 288
• ISBN : 9780128004975
• File Size : 46,9 Mb
• Total Download : 502
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Download Mesenchymal Stem Cell Derived Exosomes in PDF, Epub, and Kindle

Mesenchymal stem cell-derived exosomes are at the forefront of research in two of the most high profile and funded scientific areas – cardiovascular research and stem cells. Mesenchymal Stem Cell Derived Exosomes provides insight into the biofunction and molecular mechanisms, practical tools for research, and a look toward the clinical applications of this exciting phenomenon which is emerging as an effective diagnostic. Primarily focused on the cardiovascular applications where there have been the greatest advancements toward the clinic, this is the first compendium for clinical and biomedical researchers who are interested in integrating MSC-derived exosomes as a diagnostic and therapeutic tool. Introduces the MSC-exosome mediated cell-cell communication Covers the major functional benefits in current MSC-derived exosome studies Discusses strategies for the use of MSC-derived exosomes in cardiovascular therapies

• Author : Yaoliang Tang,Buddhadeb Dawn
• Publisher : Academic Press
• Release Date : 2015-09-26
• Total pages : 0
• ISBN : 012800164X
• File Size : 53,9 Mb
• Total Download : 745
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Download Mesenchymal Stem Cell Derived Exosomes in PDF, Epub, and Kindle

Mesenchymal stem cell-derived exosomes are at the forefront of research in two of the most high profile and funded scientific areas - cardiovascular research and stem cells. Mesenchymal Stem Cell Derived Exosomes provides insight into the biofunction and molecular mechanisms, practical tools for research, and a look toward the clinical applications of this exciting phenomenon which is emerging as an effective diagnostic. Primarily focused on the cardiovascular applications where there have been the greatest advancements toward the clinic, this is the first compendium for clinical and biomedical researchers who are interested in integrating MSC-derived exosomes as a diagnostic and therapeutic tool.

• Author : Faisal A. Alzahrani,Islam M. Saadeldin
• Publisher : Springer Nature
• Release Date : 2020-11-20
• Total pages : 373
• ISBN : 9789811565991
• File Size : 37,8 Mb
• Total Download : 598
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Download Role of Exosomes in Biological Communication Systems in PDF, Epub, and Kindle

This book reviews the role of exosomes and extracellular vesicles in both normal and pathological conditions. It first explains isolation methods for exosomes, and analyzes their fine structure and biological functions. Further, it highlights exosomes’ role as the key regulator in embryonic-maternal communication, and in the pathogenesis of various diseases, including cancer and urogenital, infectious, and neurodegenerative diseases. Moreover, it reviews the latest advances in using stem-cell-derived exosomes as a cell-free strategy in regenerative medicine, as well as the potential of exosomal microRNA as a promising non-invasive biomarker and targetable factor in cancer diagnosis and treatment. Lastly, it explores the use of natural and synthetic exosomes as nano-vehicles for efficient drug delivery.

• Author : Amin Tamadon,Reza Shirazi,Nader Tanideh
• Publisher : Frontiers Media SA
• Release Date : 2022-03-16
• Total pages : 137
• ISBN : 9782889744718
• File Size : 42,6 Mb
• Total Download : 321
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Download Stem Cell-Derived Exosome Therapy of Microbial Diseases: From Bench to Bed in PDF, Epub, and Kindle

PDF book entitled Stem Cell-Derived Exosome Therapy of Microbial Diseases: From Bench to Bed written by Amin Tamadon,Reza Shirazi,Nader Tanideh and published by Frontiers Media SA which was released on 2022-03-16 with total hardcover pages 137, the book become popular and critical acclaim.

• Author : Nikolai V. Gorbunov
• Publisher : Elsevier
• Release Date : 2021-06-23
• Total pages : 206
• ISBN : 9780128185612
• File Size : 35,9 Mb
• Total Download : 362
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Download Tissue Barriers in Disease, Injury and Regeneration in PDF, Epub, and Kindle

Tissue Barriers in Disease, Injury and Regeneration focuses on the molecular and cellular fundamentals of homeostatic and defense responses of tissue barriers, covering the damaging impacts and exposure to pathogens and engineered nanomaterials. Sections emphasize the role of mesenchymal stoma, vascular, epithelial, telocyte, myofibroblast, lymphoid and reticuloendothelial cells, along with reactions that bridge the effects of ambient factors, medical treatments, drag delivery systems with alterations in barrier integrity, tissue/organ functions, and metabolic status. Other sections cover the role of progenitor cells of different origins in the remodeling and regeneration of tissue stroma, vasculature of blood-tissue barriers, and more. Includes special emphasis on the role of mesenchymal stoma, vascular, epithelial, telocyte, myofibroblast, lymphoid and reticuloendothelial cells in the development of reactions that bridge the effects of ambient factors, medical treatments, drag delivery systems with alterations in barrier integrity, tissue/organ functions, and in metabolic status Examines the role of progenitor cells of different origins in the remodeling and regeneration of tissue stroma, the vasculature of blood-tissue barriers, and mucosa and external epithelium

• Author : Hiranmoy Das
• Publisher : Unknown
• Release Date : 2020
• Total pages : 207
• ISBN : 1071608452
• File Size : 22,9 Mb
• Total Download : 371
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Download Wound Regeneration in PDF, Epub, and Kindle

This detailed book explores a diverse range of topics related to wound healing. Some areas include wound generation as a tool to study cellular interactions and growth, mechanisms by which different tissues regenerate, ischemic wounds and their treatment, repairing corneal wound, as well as a number of emerging technologies to help promote wound regeneration, such as techniques with miRNA, nanomaterials, biomaterials, and stem cell therapies. Written for the highly successful Methods in Molecular Biology series, chapters feature introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Wound Regeneration: Methods and Protocols serves as a vital collection of wound model development and regeneration studies that will be of great use in both the academic and industrial fields of research.

• Author : Anonim
• Publisher : Academic Press
• Release Date : 2020-10-24
• Total pages : 314
• ISBN : 9780128206638
• File Size : 29,6 Mb
• Total Download : 956
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Download Extracellular Vesicles in PDF, Epub, and Kindle

Extracellular Vesicles, Volume 645 in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Chapters in this new release include Genetic labeling of extracellular vesicle exosomes for studying biogenesis and uptake in living mammalian cells, Fluorescent Labeling of Extracellular Vesicles, Isolation of extracellular vesicles from lymph, Transgenic rats for tracking body fluid/tissue-derived extracellular vesicles, Isolation of amniotic extracellular vesicles, Urinary extracellular vesicle isolation, Immunocapture-based ELISA to Characterize and Quantify Extracellular Vesicles in Both Cell Culture Supernatants and Body Fluids, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Enzymology series

• Author : Haisheng Yang
• Publisher : BoD – Books on Demand
• Release Date : 2019-04-24
• Total pages : 143
• ISBN : 9781789857672
• File Size : 11,5 Mb
• Total Download : 214
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Download Osteogenesis and Bone Regeneration in PDF, Epub, and Kindle

Osteogenesis is a core component of the skeletal system and depends on the well-coordinated proliferation and differentiation of osteogenic cells. Multiple signaling pathways and transcriptional factors tightly regulate the process of osteogenesis. Any abnormities in bone formation could cause severe disorders such as osteogenesis imperfecta and osteoporosis. Bone regeneration, a complex and well-orchestrated physiological process of osteogenesis, remains a medical challenge in the field of orthopedics and maxillofacial surgery. This book provides an overview of the current developments in osteogenesis and bone regeneration, including molecular and cellular mechanisms, physical therapies (low-level laser, distraction osteogenesis), biological therapies (mesenchymal stem cells, stem cell derived exosomes, inflammatory factor, Chinese medicine), as well as tissue engineering approaches promoting bone regeneration by targeting osteogenesis.

• Author : Lucas G. Chase,Mohan C Vemuri
• Publisher : Springer Science & Business Media
• Release Date : 2012-12-12
• Total pages : 456
• ISBN : 9781627032001
• File Size : 53,9 Mb
• Total Download : 480
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Download Mesenchymal Stem Cell Therapy in PDF, Epub, and Kindle

Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), appear to hold great promise in regards to a regenerative cell-based therapy for the treatment of these diseases. Currently, more than 200 clinical trials are underway worldwide exploring the use of MSCs for the treatment of a wide range of disorders including bone, cartilage and tendon damage, myocardial infarction, graft-versus-host disease, Crohn’s disease, diabetes, multiple sclerosis, critical limb ischemia and many others. MSCs were first identified by Friendenstein and colleagues as an adherent stromal cell population within the bone marrow with the ability to form clonogenic colonies in vitro. In regards to the basic biology associated with MSCs, there has been tremendous progress towards understanding this cell population’s phenotype and function from a range of tissue sources. Despite enormous progress and an overall increased understanding of MSCs at the molecular and cellular level, several critical questions remain to be answered in regards to the use of these cells in therapeutic applications. Clinically, both autologous and allogenic approaches for the transplantation of MSCs are being explored. Several of the processing steps needed for the clinical application of MSCs, including isolation from various tissues, scalable in vitro expansion, cell banking, dose preparation, quality control parameters, delivery methods and numerous others are being extensively studied. Despite a significant number of ongoing clinical trials, none of the current therapeutic approaches have, at this point, become a standard of care treatment. Although exceptionally promising, the clinical translation of MSC-based therapies is still a work in progress. The extensive number of ongoing clinical trials is expected to provide a clearer path forward for the realization and implementation of MSCs in regenerative medicine. Towards this end, reviews of current clinical trial results and discussions of relevant topics association with the clinical application of MSCs are compiled in this book from some of the leading researchers in this exciting and rapidly advancing field. Although not absolutely all-inclusive, we hope the chapters within this book can promote and enable a better understanding of the translation of MSCs from bench-to-bedside and inspire researchers to further explore this promising and quickly evolving field.

• Author : Oliver Yuan
• Publisher : Unknown
• Release Date : 2018
• Total pages : 229
• ISBN : 043829100X
• File Size : 50,9 Mb
• Total Download : 633
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Download Mesenchymal Stem Cell-derived Exosomes Ameliorate Disease in a Model of Relapsing-remitting Multiple Sclerosis in PDF, Epub, and Kindle

Multiple sclerosis (MS) is a demyelinating autoimmune disease that results in neurological disability. There are now 15 medications approved to treat relapsing-remitting MS, however, none of the available therapies halts disease progression or directly reverses central nervous system damage. The two salient features of MS pathology involve an over-activation of the inflammatory response in the central nervous system (CNS) and auto-antibody targeting of the myelin sheath that insulates axons. Remyelination in MS does not occur due to the lack of differentiation of oligodendrocyte progenitor cells (OPCs) into myelin-secreting mature oligodendrocytes. Mesenchymal stem cell-derived exosomes (mExo) are small extracellular vesicles secreted by mesenchymal stem cells (MSCs) and are capable of recapitulating many of the anti-inflammatory and neuroprotective effects of MSCs with a potentially simplified path to commercialization. Here we demonstrate that mExo significantly reduces the inflammatory response of lymphocytes, potentiates upregulation of regulatory T cells (Tregs) and induces OPC maturation. mExo significantly reduced symptoms in a murine model of relapsing-remitting MS, and increased Treg engraftment. These data indicate that mExo warrant further preclinical investigation as a regenerative therapy for the future treatment of MS.

• Author : Alexander Birbrair
• Publisher : Springer Nature
• Release Date : 2020-02-10
• Total pages : 129
• ISBN : 9783030371845
• File Size : 51,6 Mb
• Total Download : 197
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Download Tumor Microenvironment in PDF, Epub, and Kindle

Revealing essential roles of the tumor microenvironment in cancer progression, this volume focuses on non-hematopoietic cells within the tumor microenvironment.Further, it teaches readers about the roles of distinct constituents of the tumor microenvironment and how they affect cancer development. Topics include fibroblasts, adipocytes, mesenchymal stem cells, stellate cells, and more. Taken alongside its companion volumes, Tumor Microenvironment: Non-Hematopoietic Cells updates us on what we know about the different aspects of the tumor microenvironment as well as future directions. Useful for introducing the newer generation of researchers to the history of how scientists focused in the tumor microenvironment and how this knowledge is currently applied for cancer treatments, it will be essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment. All of the chapter authors are renowned international experts in the cancer biology field in specific subfields that will be the focus of their chapters.

• Author : Dr Wojciech Chrzanowski,Professor Chwee Teck Lim,Dr Sally Yunsun Kim
• Publisher : Royal Society of Chemistry
• Release Date : 2021-10-29
• Total pages : 358
• ISBN : 9781788018944
• File Size : 45,8 Mb
• Total Download : 617
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Download Extracellular Vesicles in PDF, Epub, and Kindle

Extracellular and biofluids vesicles (EVs) are highly specialised yet ubiquitous nanoscale messengers secreted by cells. With the development of stem cell engineering, EVs promise to deliver next generation tools in regenerative medicine and tissue engineering, as well as in diagnostics. A vibrant and promising field, this book provides the first resource to the field. Covering basic cell biology, including EV production and intracellular communication, this book will provide material scientists and engineers with a foundation to the necessary biology. The reader will then learn about the isolation of extracellular vesicles their physicochemical characterisation and therapeutic application of EVs in regenerative medicine as well as their potential as biomarkers in medical diagnostic. This book will also discuss the regulatory landscape of EVs. Bridging cell biology, biomaterials, biophysics and biomedical engineering the content of this book is written with a broad interdisciplinary audience in mind. Researchers, new and established will find this a must-have on their shelf.

• Author : Karl L. Mettinger,Pranela Rameshwar,Vinod Kumar
• Publisher : Springer
• Release Date : 2018-05-12
• Total pages : 154
• ISBN : 9783319744704
• File Size : 38,7 Mb
• Total Download : 815
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Download Exosomes, Stem Cells and MicroRNA in PDF, Epub, and Kindle

This volume provides insight into the pivotal roles of stem cells, exosomes and other microvesicles in biofunction and molecular mechanisms and their therapeutic potential in translational nanomedicine. It further highlights evidence from recent studies as to how stem cell derived exosomes and microRNAs may restore and maintain tissue homeostasis, enable cells to recover critical cellular functions and begin repair regeneration. These early studies in animal models of aging also show evidence of improved immune, cardiovascular and cognitive functions as well as improved health span and life span. The use of exosomes from body fluids to define specific biomarkers for various tumors may also clear the path to patient-targeted treatments by developing exosome-derived microRNA based cancer therapeutics. It is essential reading for graduate students, research fellow and biomedical researchers in academia or the pharmaceutical or biotech industries.

• Author : Babak Arjmand
• Publisher : Springer Nature
• Release Date : 2019-11-14
• Total pages : 199
• ISBN : 9783030277277
• File Size : 12,6 Mb
• Total Download : 450
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Download Genomics, Proteomics, and Metabolomics in PDF, Epub, and Kindle

This book provides thorough coverage of high-throughput OMICs technologies for the monitoring of stem cells and regenerative medicine. Specific topics covered include the genomics, proteomics, and metabolomics aspects of regenerative medicine, metabolic profiling of mesenchymal stem cells, genome profiling of mesenchymal stem cells, OMICs monitoring of stem cell-derived exosomes, stem cell proteomics, lipidomics, OMICs profiling of cancer (stem) cells, and finally ethical considerations of OMICs-based investigations. Chapters are authored by world-renowned scientists who have valuable expertise in the field of OMICs and regenerative medicine. Genomics, Proteomics, and Metabolomics: Stem Cells Monitoring in Regenerative Medicine, part of Springer’s Stem Cell Biology and Regenerative Medicine series, is essential reading for researchers, clinicians, biologists, biochemists, and pharmaceutical experts conducting research in the fields of stem cell biology, molecular aspects of stem cell research, tissue engineering, regenerative medicine, cellular therapy, OMICs, bioinformatics, and ethics.

• Author : Dr. R. K. Freinkel,D.T. Woodley
• Publisher : CRC Press
• Release Date : 2001-03-15
• Total pages : 438
• ISBN : 1850700060
• File Size : 9,8 Mb
• Total Download : 239
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Download The Biology of the Skin in PDF, Epub, and Kindle

An authoritative, extensively illustrated clinician's textbook, The Biology of the Skin is written expressly for practitioners and residents in dermatology, plastic surgery, and otolaryngology. Essentially an expansion of the editors' and contributing authors' popular "Structure and Function" course given annually at the meetings of the American Academy of Dermatology, the book teaches skin biology in the context of practical clinical settings. This book covers the basic biology of the skin, how the skin functions, effects of the environment, the molecules that direct cutaneous function, genetic influences, and methods in cutaneous research. The Biology of the Skin provides a selective review of all biologic processes involving the skin and will foster an appreciation of how the skin works based on our knowledge of the basic science of skin structure and function in the 21st century.

• Author : Khawaja H. Haider
• Publisher : Springer Nature
• Release Date : 2022-01-01
• Total pages : 255
• ISBN : 9783030770525
• File Size : 47,7 Mb
• Total Download : 908
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Download Stem Cells in PDF, Epub, and Kindle

In this volume, the contributing authors from top labs involved in stem cell theranostics share the latest advances in the field of stem cell research. The book covers many aspects of stem cell-based therapy and the progress made toward stem cell therapy for liver, ocular, and cardiovascular diseases as well as cancer. This volume serves as a continuation of Prof. Khawaja Husnain Haider’s previously edited books pertaining to stem cells-based therapnostics. This is an ideal book for researchers involved in drug development as well as regenerative medicine and stem cell-based therapy. The secondary audience includes graduate and postgraduate medical students, doctors, cellular pharmacology, drug industry, and researchers involved in using stem cells as ex-vivo disease models for drug development.

• Author : Junjie Xiao,Sanda Cretoiu
• Publisher : Unknown
• Release Date : 2017
• Total pages : 307
• ISBN : 9811043981
• File Size : 17,6 Mb
• Total Download : 694
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Download Exosomes in Cardiovascular Diseases in PDF, Epub, and Kindle

PDF book entitled Exosomes in Cardiovascular Diseases written by Junjie Xiao,Sanda Cretoiu and published by Unknown which was released on 2017 with total hardcover pages 307, the book become popular and critical acclaim.

• Author : Jorge L. Alió,Jorge L. Alió del Barrio,Francisco Arnalich-Montiel
• Publisher : Springer
• Release Date : 2019-02-20
• Total pages : 507
• ISBN : 9783030013042
• File Size : 19,5 Mb
• Total Download : 249
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Download Corneal Regeneration in PDF, Epub, and Kindle

This text provides expert instruction on the varying surgical techniques currently employed for the regeneration of the ocular surface. Corneal Regeneration: Therapy and Surgery begins with a thorough discussion of current research based on data obtained in clinical human studies, and discusses the potential clinical implications for this promising new stage of eye surgery. Sections devoted to the stem cell, regenerative surgery and therapy of the ocular surface epithelium, corneal stroma, and corneal endothelium follow, each section comprehensively covering applied anatomy, current therapy and regenerative techniques, with a look to future directions of the field including eventual cell therapy. Corneal Regeneration: Therapy and Surgery is the first book of its kind, systematically covering the developments the medical community has achieved in corneal regeneration from all angles. Written and edited by leading experts in the field, researchers and ophthalmologists alike will find this to be a unique source of information on corneal regeneration, as well as a thoughtful reflection on potential applications of regenerative surgery in ophthalmology as a whole.

• Author : Kang-Ping Lin,Ren-Shyan Liu,Bang-Hung Yang
• Publisher : Springer Nature
• Release Date : 2022-02-22
• Total pages : 90
• ISBN : 9783030927868
• File Size : 52,5 Mb
• Total Download : 951
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Download Future Trends and Challenges of Molecular Imaging and AI Innovation in PDF, Epub, and Kindle

This volumes presents the proceedings of the FASMI 2020 conference, held at Taipei Veterans General Hospital on November 20-22, 2020. It presents contributions on all aspects of molecular imaging, discovered by leading academic scientists and researchers. It also provides a premier interdisciplinary treatment of recent innovations, trend, and concerns as well as practical challenges and solutions in Molecular Imaging and put an emphasis on Artificial Intelligence applied to Imaging Data. FASMI is the annual meeting of the Federation of Asian Societies for Molecular Imaging

• Author : Phuc Van Pham
• Publisher : Springer
• Release Date : 2018-10-25
• Total pages : 157
• ISBN : 9783319993287
• File Size : 39,6 Mb
• Total Download : 406
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Download Stem Cell Drugs - A New Generation of Biopharmaceuticals in PDF, Epub, and Kindle

This invaluable resource discusses the current revolution in stem cell-based drugs and their potential use in clinical applications. Each chapter is contributed by a pre-eminent scientist in the field. An introductory section presents current stem cell drugs and stem cell-based products and a discussion of production, quality control, mechanisms, and efficacy. Following sections include discussions on stem cell-derived microvesicles based products, and derived exosomes based products. Stem Cell Drugs - A New Generation of Biopharmaceuticals and the other books in the Stem Cells in Clinical Applications series are invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue engineering. This groundbreaking volume is also essential reading for those researching or studying drug development or pharmaceutical science.

• Author : Matteo Santin
• Publisher : Springer Science & Business Media
• Release Date : 2009-02-28
• Total pages : 605
• ISBN : 9780387746609
• File Size : 39,8 Mb
• Total Download : 573
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Download Strategies in Regenerative Medicine in PDF, Epub, and Kindle

The profound transformations occurred in our modern age have been made possible by the unique combination of new technologies. Among them, me- cine has completely changed our perception of life. Longevity has been signi- cantly extended and linked to new lifestyles. The negative impact that pathologies and ageing have always had on the quality of our life is now mitigated by the availability of treatments daily applied to many individuals worldwide. For many years, pharmacological and surgical treatments have been supported by the introduction of biomedical devices. Biomedical implants have played a key role in the development of these treatments and achieved the objective of replacing tissue and organ structures and functionalities. Gra- ally, the scientific and clinical communities have understood that replacement could be improved by materials able to interact with the tissues and to parti- pate in their metabolism and functions. This approach soon led to biomedical implants with improved clinical performances, but also to a new aspiration; rather than replacing damaged tissues and organs scientists and clinicians nowadays aim at their partial or complete regeneration. As a consequence of this ambition, the disciplines of tissue engineering and regenerative medicine have recently emerged. It is the dawn of a fascinating era where scientists from various disciplines, clinicians, and industry will need to intensify their col- borative efforts to provide our society with new and affordable solutions.