Innovative Brain Tumor Therapy
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Innovative Brain Tumor Therapy
- Author : Gerardo Caruso,Lucia Merlo,Maria Caffo
- Publisher : Woodhead Publishing
- Release Date : 2014-10-10
- Total pages : 196
- ISBN : 9781908818744
- File Size : 55,7 Mb
- Total Download : 606
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Despite recent advances, therapeutic efforts have not been successful establishing a definitive strategy of treatment for brain gliomas, because of the presence of the blood-brain barrier. Innovative Brain Tumor Therapy presents a synopsis of the studies on nanoparticles as ideal devices for brain tumor treatment. Their nanometric size, electrostatic charge, and lipophilic characteristics allow them to penetrate into the brain tissue freely. Promising in-vitro results have been reported, but remain to be validated in humans. This title focuses on the blood-brain barrier pathophysiology in brain tumors, and the possibilities of overcoming this with nanoparticle-based systems. Relevant patents of nanoparticles used as drug delivery carriers are also reported, as well as future scenarios in nanoparticles and stem cells.
Nanotherapy for Brain Tumor Drug Delivery
- Author : Vivek Agrahari,Anthony Kim,Vibhuti Agrahari
- Publisher : Unknown
- Release Date : 2021
- Total pages : 298
- ISBN : 107161052X
- File Size : 32,7 Mb
- Total Download : 539
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This volume provides a guide on nanoformulations and other drug delivery approaches for both academic and industry scientists. The chapters in this book cover diverse topics and techniques in nanoparticle drug delivery, gene therapy, neurosurgical brain implant, exosomes, MRI-guided focused ultrasound (MRgFUS), and advanced preclinical glioblastoma multiforme animal models. Some chapters discuss state-of-the-art and innovative nanomedicines for glioblastoma, surface-modified nanoparticle drug carriers for brain cancer treatment, focused ultrasound (FUS)-mediated blood-brain barrier disruption for enhanced drug delivery to brain tumors; gene therapy delivery approaches to treat brain cancer, and a liposome-template hydrogel nanoparticles (LHNPs) as a powerful CRISPR/Cas9 delivery vehicle. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and thorough, Nanotherapy for Brain Tumor Drug Delivery is a valuable resource for the scientific community working on this important therapeutic field, and will help fast-track the clinical translation of revolutionary nanotechnologies for treating brain tumors. .
Malignant Brain Tumors
- Author : Jennifer Moliterno Gunel,Joseph M Piepmeier,Joachim M. Baehring
- Publisher : Springer
- Release Date : 2016-12-28
- Total pages : 297
- ISBN : 9783319498645
- File Size : 34,6 Mb
- Total Download : 679
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This text addresses all aspects of patient evaluation and care. This includes new findings in imaging that provide a better understanding of the extent of the lesion as well as its relationship with critical neuroanatomic function. The evolution of intraoperative imaging, functional brain mapping,and technology to identify tumor from brain is covered. This has significantly improved the ability of surgeons to more safely and aggressively remove tumors.More importantly, a better understanding of tumor biology and genomics has created an opportunity to significantly revise tumor classification and better select optimal therapy for individual patients. The text covers novel and innovative treatment options including immunotherapy, tumor vaccines, antiangiogenic agents,and personalized cancer treatment. In addition, novel agent delivery techniques are covered to offer the potential for increasing the effectiveness of treatment by delivering active agents directly where they are needed most. Malignant Brain Tumors: State-of-the-Art Treatment provides a comprehensive overview of treatment for malignant gliomas, and will prove useful by updating physicians on new therapeutic paradigms and what is on the horizon for the near future. This text will be informative for surgeons, oncologists, neurologists, residents and students who treat these patients,as well as those who are training for a career in managing patients with these challenging tumors.
Intracranial Gliomas Part III - Innovative Treatment Modalities
- Author : M.F. Chernov,Y. Muragaki,S. Kesari,I.E. McCutcheon
- Publisher : Karger Medical and Scientific Publishers
- Release Date : 2018-07-10
- Total pages : 222
- ISBN : 9783318060638
- File Size : 34,6 Mb
- Total Download : 923
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At present most intracranial gliomas are considered incurable with current treatment strategies, and the search for new modalities that may effectively control tumor growth continues. The chapters in this volume describe basic principles and therapeutic possibilities of several innovative techniques, including photodynamic therapy, laser-induced interstitial thermotherapy, stereotactic cryodestruction, high-intensity focused ultrasound ablation, boron neutron capture therapy, proton and carbon ion irradiation, targeted therapy, immunotherapy, gene therapy, local chemotherapy, and alternating electric fields therapy. Potential applications of extracellular vesicles and nanotechnology for management of gliomas are highlighted as well. Many of these methods have already demonstrated antitumor efficacy in clinical testing, whereas others are still under development. The materials presented in this book are mainly directed at clinicians treating patients with brain tumors, as well as clinical and basic researchers working in the field of neuro-oncology.
Tumors of the Brain and Spine
- Author : Franco DeMonte,Mark R. Gilbert,Anita Mahajan,Ian Earle McCutcheon
- Publisher : Springer Science & Business Media
- Release Date : 2007-05-10
- Total pages : 364
- ISBN : 9780387292021
- File Size : 42,8 Mb
- Total Download : 370
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Tumors of the Brain and Spine focuses primarily on approaches to the treatment of benign, primary low-grade to high-grade, and metastatic tumors in the brain and spine, as practiced by surgeons and clinicians at the University of Texas M. D. Anderson Cancer Center. The book is written mainly for the primary care oncologist, general neurologist, and general neurosurgeon. Discussion of treatment coverage focuses on neurosurgery, chemotherapy, and radiation therapy, singly and in combination. Also included are chapters on symptom management, molecular genetics and neuropathology of intracranial tumors, leptomeningeal dissemination of systemic cancer, epidemiology of brain tumors, and innovative treatment strategies.
Glioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies
- Author : Ramasamy Paulmurugan,Tarik F. Massoud
- Publisher : Academic Press
- Release Date : 2021-06-25
- Total pages : 828
- ISBN : 9780128215685
- File Size : 50,9 Mb
- Total Download : 143
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Glioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies brings current knowledge from an international team of experts on the science and clinical management of glioblastoma chemoresistance. The book discusses topics such as molecular mechanisms of chemoresistance, experimental models to study chemoresistance, chemoresistance to drugs other than Temozolomide, and specific strategies to reverse chemoresistance. Additionally, it encompasses information on how to mitigate chemoresistance by targeted enhancement of p53 function. This book is a valuable resource for cancer researchers, oncologists, neuro-oncologists and other members of the biomedical field. Glioblastoma (GBM) is the most invasive and malignant primary brain tumor in humans with poor survival after diagnosis, therefore it is imperative that molecular and cellular mechanisms behind therapy resistant GBM cells, as well as the therapeutic strategies available to counter the resistance are comprehensively understood. Provides comprehensive, core knowledge related to the entire discipline of glioblastoma chemoresistance, from its many etiological mechanisms, to specific strategies to reverse resistance Presents current information from an international team of experts on the basic science, pre-clinical research, and clinical management of glioblastoma chemoresistance Discusses molecular and cellular mechanisms behind therapy resistant glioblastoma cells, as well as the therapeutic strategies available to counter this resistance
Atlas of Pediatric Brain Tumors
- Author : Adekunle M. Adesina,Tarik Tihan,Christine E. Fuller,Tina Young Poussaint
- Publisher : Springer Science & Business Media
- Release Date : 2010-01-24
- Total pages : 400
- ISBN : 9781441910622
- File Size : 34,8 Mb
- Total Download : 658
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Recent evidence indicates that the physiology and response to various drugs in the pediatric population differs from that of the adult and must be appreciated to be able to fully address the health needs of the pediatric population. Atlas of Pediatric Brain Tumors covers areas ranging from neuroimaging, the use of crush and touch preps during introperative consultation, classic histological features of brain tumors, tumor variants, and a miscellaneous group of challenging tumors. Chapters consist of essential diagnostic information and features highlighting recognized variants and their differential diagnoses. A section on molecular pathology and electron microscopy is also included for each tumor category; along with a list of classic reviews and innovative articles on each of the tumor entities as suggested reading at the end of each chapter. Created to fill a void in the practice of pediatric neuropathology, this practical and well-illustrated Atlas of Pediatric Brain Tumors represents a collection of interesting, common and unusual tumors for a diagnostic exercise by the reader.
Targeted Radionuclide Therapy
- Author : Tod W. Speer
- Publisher : Lippincott Williams & Wilkins
- Release Date : 2012-03-28
- Total pages : 608
- ISBN : 9781451153262
- File Size : 35,9 Mb
- Total Download : 220
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Radioimmunotherapy, also known as systemic targeted radiation therapy, uses antibodies, antibody fragments, or compounds as carriers to guide radiation to the targets. It is a topic rapidly increasing in importance and success in treatment of cancer patients. This book represents a comprehensive amalgamation of the radiation physics, chemistry, radiobiology, tumor models, and clinical data for targeted radionuclide therapy. It outlines the current challenges and provides a glimpse at future directions. With significant advances in cell biology and molecular engineering, many targeting constructs are now available that will safely deliver these highly cytotoxic radionuclides in a targeted fashion. A companion website includes the full text and an image bank.
Handbook of Brain Tumor Chemotherapy
- Author : Herbert B. Newton
- Publisher : Academic Press
- Release Date : 2006
- Total pages : 510
- ISBN : 0120884100
- File Size : 34,7 Mb
- Total Download : 789
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The book provides a broad overview of the current "state-of-the-art" in the use of chemotherapy for primary and metastatic brain tumors and includes information on traditional (e.g., alkylating agents, spindle poisons, topoisomerase inhibitors, etc) and non-traditional (e.g., intra-arterial approaches, blood-brain barrier disruption, etc) forms of chemotherapy. In addition, newer molecular-based chemotherapeutic agents (e.g., tyrosine kinase inhibitors, ras pathway inhibitors, PI3 kinase inhibitors, mTOR inhibitors, angiogenesis inhibitors, etc) are included. Well-founded in basic science and pharmacology, the chapters provide an overview of relevant background material in critical areas such as drug pharmacology and mechanisms of action, molecular biology (e.g., critical oncogenes, tumor suppressor genes), signal transduction pathways, angiogenesis pathways, and developmental pharmacology.
Biophysical Effects of Cold Atmospheric Plasma on Glial Tumor Cells
- Author : Julia Köritzer
- Publisher : Springer
- Release Date : 2014-04-21
- Total pages : 74
- ISBN : 9783319062242
- File Size : 52,5 Mb
- Total Download : 561
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Cold atmospheric plasma is an auspicious new candidate in cancer treatment. Cold atmospheric plasma (CAP) is a partially ionized gas in which the ion temperature is close to room temperature. It contains electrons, charged particles, radicals, various excited molecules and UV photons. These various compositional elements have the potential to inhibit cancer cell activity whilst doing no harm to healthy cells. Glioblastoma (GBM) is the most common and lethal primary brain tumor in adults; treatment including surgery, radio- and chemotherapy remains palliative for most patients as a cure remains elusive. The successful combination of the standard chemotherapeutic temozolomide (TMZ) and CAP treatment features synergistic effects even in resistant glioma cells. In particular in glioma therapy, CAP could offer an innovative approach allowing specific cancer cell / tumor tissue inhibition without damaging healthy cells. Thus CAP is a promising candidate for combination therapy especially for patients suffering from GBMs showing TMZ resistance.
Therapeutic Ribonucleic Acids in Brain Tumors
- Author : Volker A. Erdmann,Guido Reifenberger,Jan Barciszewski
- Publisher : Springer Science & Business Media
- Release Date : 2009-08-11
- Total pages : 494
- ISBN : 364200475X
- File Size : 18,5 Mb
- Total Download : 752
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In the past few years nucleic acids technologies have grown into a powerful analytical and also increasingly therapeutic tool. It has been applied not only to the uncovering of gene functions in many organisms, but also to pathogenetic analysis and recently also for the treatment of human diseases. The book discusses in depth the potential of these innovative methods in the broad field of central nervous system and brain tumours particularly. Whereas there is currently no comprehensive overview on potential and challenges of nucleic acids technologies for basic brain tumours and for the clinical management of patients with brain tumours, this book does explicitly cover the many other aspects of the "RNA World" (pathogenic and therapeutic potential of microRNAs, aptamer technology, etc.), too. With this significantly broadened scope as compared to currently existing books it appears to be an urgently needed new publication.
Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy
- Author : Herbert B. Newton
- Publisher : Academic Press
- Release Date : 2018-03-28
- Total pages : 848
- ISBN : 9780128121016
- File Size : 24,9 Mb
- Total Download : 954
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Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy, Second Edition, provides a comprehensive overview of the molecular methodologies in the neuro-oncology field. There have been profound changes in the landscape of approaches to brain tumor therapy since the first edition—mainly in the areas of molecular biology and molecular therapeutics, as well as in the maturation of immunotherapy approaches (e.g., vaccines). This updated edition has a new, primary focus on multidisciplinary molecular methods, and is broadened to include the latest cutting-edge molecular biology, therapeutics, immunobiology and immunotherapy approaches. As the first comprehensive book to address the molecular research into these concepts, users will find it to be an invaluable resource on the topics discussed. Provides the most up-to-date information regarding conventional forms of cytotoxic chemotherapy, as well as the basic science and clinical application of molecular therapeutics for the treatment of brain tumors Broadly appeals to anyone interested in neuro-oncology and the treatment of brain tumors Features updated chapters on molecular biology, molecular therapeutics, maturation of immunotherapy approaches, and a focus on multidisciplinary molecular methods Includes a new section on the basic science of immunology, as well as thorough updates on the use of vaccine technology and immunotherapy for the treatment of brain tumors
Innovations in Radiation Oncology
- Author : H. Rodney Withers,Lester J. Peters
- Publisher : Springer Science & Business Media
- Release Date : 2012-12-06
- Total pages : 329
- ISBN : 9783642831010
- File Size : 38,5 Mb
- Total Download : 146
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The series "Medical Radiology - Diagnostic Imaging and Radiation Oncology" is the successor to the well known "Encyclopedia of Medical RadiologyjHandbuch der medizinischen Radiologie". This international handbook with its unique compila tion of data in more than fifty volumes lags behind the fast developing knowledge in radiology today. "Medical Radiology" brings the state of the art on special topics in a timely fashion. The first volume of the series was "Lung cancer", edited by Scarantino. This volume "Innovation in Radiation Oncology", edited by H.R. Withers and L.J. Peters, presents data on the development of new therapeutic strategies in different oncologic diseases. 57 authors wrote 32 chapters covering a broad range of topics. The innovations are at various levels of development, but were all chosen with the practicing radiation oncologist in mind. Perhaps not all of the innovations will survive the test of time, others have now become well established standard procedure in some centers. Also discussed is the assessment of the effectiveness of standard treat ment and how it effects the quality of a patient's survival. The contributions have been grouped into 9 broad sections as outlined in the table of contents. We think the second volume, as the whole series, will provide valuable reading for the general community of radiation oncologists.
Innovative Medicine
- Author : Kazuwa Nakao,Nagahiro Minato,Shinji Uemoto
- Publisher : Springer
- Release Date : 2015-10-13
- Total pages : 339
- ISBN : 9784431556510
- File Size : 28,6 Mb
- Total Download : 483
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This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.
Central Nervous System Metastases
- Author : Manmeet Ahluwalia,Philippe Metellus,Riccardo Soffietti
- Publisher : Springer Nature
- Release Date : 2019-11-05
- Total pages : 421
- ISBN : 9783030234171
- File Size : 44,6 Mb
- Total Download : 179
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This book provides a comprehensive overview of brain metastases, from the molecular biology aspects to therapeutic management and perspectives. Due to the increasing incidence of these tumors and the urgent need to effectively control brain metastatic diseases in these patients, new therapeutic strategies have emerged in recent years. The volume discusses all these innovative approaches combined with new surgical techniques (fluorescence, functional mapping, integrated navigation), novel radiation therapy techniques (stereotactic radiosurgery) and new systemic treatment approaches such as targeted- and immunotherapy. These combination strategies represent a new therapeutic model in brain metastatic patients in which each medical practitioner (neurosurgeon, neurologist, medical oncologist, radiation oncologist) plays a pivotal role in defining the optimal treatment in a multidisciplinary approach. Written by recognized experts in the field, this book is a valuable tool for neurosurgeons, neuro-oncologists, neuroradiologists, medical oncologists, radiation oncologists, cognitive therapists, basic scientists and students working in the area of brain tumors.
Design and Application of Innovative Local Treatments in Glioblastoma and Other Cancers
- Author : Emmanuel Garcion,Carmen Alvarez-Lorenzo
- Publisher : Frontiers Media SA
- Release Date : 2021-04-01
- Total pages : 125
- ISBN : 9782889666584
- File Size : 51,9 Mb
- Total Download : 111
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PDF book entitled Design and Application of Innovative Local Treatments in Glioblastoma and Other Cancers written by Emmanuel Garcion,Carmen Alvarez-Lorenzo and published by Frontiers Media SA which was released on 2021-04-01 with total hardcover pages 125, the book become popular and critical acclaim.
Glioma
- Author : ryuya yamanaka
- Publisher : Springer Science & Business Media
- Release Date : 2012-05-27
- Total pages : 232
- ISBN : 9781461431466
- File Size : 12,6 Mb
- Total Download : 729
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Treatment of glioma is currently one of the most challenging problems in oncology, as well as in neurosurgery. Despite major advances in our understanding of the pathomechanism, diagnosis by imaging and the availability of powerful therapeutic tools, the life expectancy of patients with glioblastoma has only been slightly prolonged and a cure remains elusive. None of the currently available surgical tools, including operative microscopes, lasers and image-guided surgery, can enable the detection and removal of all of the tumor tissue. In recent years, however, the landscape has been changing immeasurably, and molecular studies over the past two decades have identified a variety of genetic aberrations that are specifically associated with individual types of gliomas. In addition, certain molecular abnormalities have been linked to therapy responses, thereby establishing clinical biomarkers and molecular targets, and the use of novel agents is being investigated. These agents have been specifically engineered to exert specific cytotoxicity against gliomas, either on their own as single agents or in combination with other modalities. Moreover, there has been an enormous surge of interest in the area of immunology and immunotherapy, which has been facilitated by our understanding of the molecular basis of gliomas. Although several kinds of immunotherapeutic trials have been undertaken, we still await a great breakthrough in terms of clinical efficacy to prolong the survival time of glioma patients.
Emerging Electromagnetic Technologies for Brain Diseases Diagnostics, Monitoring and Therapy
- Author : Lorenzo Crocco,Irene Karanasiou,Michael L James,Raquel Cruz Conceição
- Publisher : Springer
- Release Date : 2018-03-10
- Total pages : 241
- ISBN : 9783319750071
- File Size : 29,8 Mb
- Total Download : 477
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This timely book presents innovative technologies for use in the diagnosis, monitoring, and treatment of brain disease. These technologies offer exciting possibilities in the medical field owing to their low-cost, portability and safety. The authors address cerebrovascular diseases such as stroke, ischemia, haemorrhage, and vasospasm, these diseases having an ever-increasing societal relevance due to the global ageing population. The authors describe the potential of novel techniques such as microwave imaging and present innovative modalities for treatment of brain tumours using electromagnetic fields and nano-composites, as well as for monitoring brain temperature during surgery. Finally, Emerging Electromagnetic Technologies for Brain Diseases Diagnostics, Monitoring and Therapy addresses the perspectives which arise from multi-modal multi-spectral EM modalities, which make a synergic use of the different portions of the electromagnetic spectrum. This text will be of interest to readers from various different areas, given the fundamental interdisciplinarity of the subject matter. This includes researchers or practitioners in the field of electrical engineering, applied physicists, and applied mathematicians working on imaging applications for biomedical and electromagnetic technologies. Neurologists and radiologists may also find this book of interest, as may graduate students in these areas.
Oncology of CNS Tumors
- Author : Jörg-Christian Tonn,Manfred Westphal,J. T. Rutka
- Publisher : Springer Science & Business Media
- Release Date : 2010-02-03
- Total pages : 793
- ISBN : 9783642028748
- File Size : 47,7 Mb
- Total Download : 102
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Knowledge about the etiology and diagnosis as well as treatment concepts of neu- oncologic diseases is rapidly growing. This turnover of knowledge makes it dif? cult for the physician engaged in the treatment to keep up to date with current therapies. This book sets out to close the gap and pursues several innovative concepts. As a comprehensive text on neuro-oncology, its chapters are interconnected, but at the same time some chapters or subdivisions are so thoroughly assembled that the whole volume gives the impression of several books combined into one. Neuropathology is treated in an extensive and clearly structured section. The int- ested reader ? nds for each tumor entity the latest well-referenced consensus rega- ing histologic and molecular pathology. Through this “book-in-the-book” concept, information on neuropathology is readily at hand in a concise form and without ov- loading the single chapters. Pediatric neuro-oncology differs in many entities from tumors in adult patients; also, certain tumors of the CNS are typically or mainly found only in the child. Therefore, pediatric neuro-oncology was granted its own, book-like section. Tumor entities that are treated differently in children and adults are included both in the pediatric neuro-oncology section and in the general section. Entities that typically occur only in the child and adolescent are found in the pediatric section in order to avoid redundancies.
Innovative theranostic approaches towards neuro-immunology in gliomas
- Author : Lijie Zhai,Chunsheng Kang
- Publisher : Frontiers Media SA
- Release Date : 2023-04-05
- Total pages : 225
- ISBN : 9782832518359
- File Size : 36,9 Mb
- Total Download : 876
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PDF book entitled Innovative theranostic approaches towards neuro-immunology in gliomas written by Lijie Zhai,Chunsheng Kang and published by Frontiers Media SA which was released on 2023-04-05 with total hardcover pages 225, the book become popular and critical acclaim.
Brain Tumors in Children
- Author : Amar Gajjar,Gregory H. Reaman,Judy M. Racadio,Franklin O. Smith
- Publisher : Springer
- Release Date : 2018-09-29
- Total pages : 426
- ISBN : 9783319432052
- File Size : 16,7 Mb
- Total Download : 706
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This book is a comprehensive and up-to-date compendium of all aspects of brain tumors in children. After introductory chapters on the epidemiology of brain tumors, the book will provide readers with state-of-the art chapters on the principals of radiation therapy, neurosurgery and neuroimaging. Subsequent chapters discuss the biology and treatment of specific types of brain tumors. The concluding chapters present critical information relevant to survivorship, neurocognitive and other late effects, and the global challenges to better diagnosis and treatment of brain tumors in children. This book is co-authored by experts in the treatment of pediatric brain tumors. All of the authors are internationally recognized authorities and they offer an evidence-based consensus on the biology and treatment of brain tumors. This handbook has far-reaching applicability to the clinical diagnosis and management of brain tumors in children and will prove valuable to specialists, generalists and trainees alike.