Hematopoietic Stem Cell Transplantation For Neurological Diseases

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Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases

Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases
  • Author : Richard K. Burt,Dominique Farge,Milton A. Ruiz,Riccardo Saccardi,John A. Snowden
  • Publisher : CRC Press
  • Release Date : 2021-11-15
  • Total pages : 686
  • ISBN : 9781351364751
  • File Size : 11,6 Mb
  • Total Download : 489
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This book summarizes the global progress in medical and scientific research toward converting traditionally chronic autoimmune diseases into a drug-free reversible illness using hematopoietic stem cell transplantation (HSCT) and other cellular therapies such as T regulatory cells (Treg), mesenchymal stromal/stem cells, and chimeric antigen receptor T (CAR T) cells in order to reintroduce sustained immune tolerance. This title provides information on different types of stem cells and immune cells; post-transplant immune regeneration; cellular regulatory requirements; ethical and economic considerations; and the advantages and disadvantages of HSCT in the treatment of a variety of autoimmune diseases versus current conventional treatments. Arranged by disease, the text provides a comprehensive guide to HSCT for all types of autoimmune/immune disorders including monogenetic autoimmune diseases; autoimmune aplastic anemia; neurologic immune diseases including multiple sclerosis, chronic inflammatory demyelinating polyneuropathy, neuromyelitis optica, and stiff person syndrome; rheumatologic diseases such as systemic sclerosis and systemic lupus erythematosus; dermatologic diseases such as pemphigus; gastrointestinal disorders such as Crohn’s disease and celiac disease; and immune-mediated endocrinologic disease type I diabetes mellitus. Guidance is provided on the transplantation technique, cell collection and processing, conditioning regimens, infections, and early and late complications. Key Features Outlines therapies and techniques for HSCT for autoimmune diseases Discusses the advantages of HSCT over conventional therapies Reviews the entire process of stem cell therapy from harvest and ethics to indications, efficacy, and regulatory oversight

Sickle Cell Disease and Hematopoietic Stem Cell Transplantation

Sickle Cell Disease and Hematopoietic Stem Cell Transplantation
  • Author : Emily Riehm Meier,Allistair Abraham,Ross M. Fasano
  • Publisher : Springer
  • Release Date : 2017-09-19
  • Total pages : 334
  • ISBN : 9783319623283
  • File Size : 29,5 Mb
  • Total Download : 717
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This book provides a comprehensive, state-of-the art review of hematopoietic stem cell transplantation (HSCT) for sickle cell disease (SCD). The book reviews new data about risk prediction for severe SCD, outlines the unique challenges of HSCT for patients with SCD, profiles the supportive care guidelines for patients who are undergoing HSCT, highlights our current understanding of the best transfusion support for SCD patients prior to, during and after HSCT, and provides new perspectives about the ethics of HSCT for pediatric patients with SCD. Published in the last few years, several landmark phase III trials that utilize matched unrelated and haploidentical donors for HSCT in SCD patients are also placed in context with respect to current management. Written by experts in the field, Sickle Cell Disease and Hematopoietic Stem Cell Transplantation is a valuable resource for physicians and researchers dealing with and interested in this challenging, yet exciting, curative therapy for sickle cell disease, that will help guide patient management and stimulate investigative efforts.

Human Neural Stem Cells

Human Neural Stem Cells
  • Author : Leonora Buzanska
  • Publisher : Springer
  • Release Date : 2018-09-12
  • Total pages : 329
  • ISBN : 9783319934853
  • File Size : 54,6 Mb
  • Total Download : 990
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This book summarizes early pioneering achievements in the field of human neural stem cell (hNSC) research and combines them with the latest advances in stem cell technology, including reprogramming and gene editing. The powerful potential of hNSC to generate and repair the developing and adult CNS has been confirmed by numerous experimental in vitro and in vivo studies. The book presents methods for hNSC derivation and discusses the mechanisms underlying NSC in vitro fate decisions and their in vivo therapeutic mode of action. The long-standing dogma that the human central nervous system (CNS) lacks the ability to regenerate was refuted at the end of the 20th century, when evidence of the presence of neurogenic zones in the adult human brain was found. These neurogenic zones are home to human neural stem cells (hNSCs), which are capable of self-renewing and differentiating into neurons, astrocytes and oligodendrocytes. NSCs isolated from human CNS have a number of clinical advantages, especially the innate potential to differentiate into functional neural cells. Nevertheless, their full clinical exploitation has been hindered by limited access to the tissue and low expansion potential. The search for an alternative to CNS sources of autologous, therapeutically competent hNSCs was the driving force for the many studies proving the in vitro plasticity of different somatic stem cells to generate NSCs and their functional progeny. Now the era of induced pluripotent stem cells has opened entirely new opportunities to achieve research and therapeutic goals with the aid of hNSCs.

Brain Repair

Brain Repair
  • Author : Mathias Bähr
  • Publisher : Springer Science & Business Media
  • Release Date : 2007-03-06
  • Total pages : 252
  • ISBN : 9780387301280
  • File Size : 15,8 Mb
  • Total Download : 817
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Brain Repair, addresses all relevant issues underlying the mechanisms of brain damage, brain plasticity and post-traumatic reorganisation after CNS lesions. This book is divided the three major sections that follow; cellular and molecular basis of brain repair, plasticity and reorganisation of neural networks, and experimental therapy strategies. Brain Repair is written by high profile, international experts who describe in detail the newest results from basic research and highlight new model systems, techniques and therapy approaches. Based on a careful analysis of the cellular and molecular reaction patterns of the CNS to lesions, the contributions cover possibilities for endogenous reorganisation and repair as well as exciting new therapies emerging from basic research, some of which have already been introduced into the clinics. Thus, this book is unique in bridging the gap between basic and clinical research. It will be a valuable tool for all students, researchers and clinicians interested in understanding the brain's capacity to cope with lesions and interested in learning about emerging new therapy concepts.

Cutting-Edge Approaches for CNS Protection and Repair: Focus on Vascular and Degenerative Disorders

Cutting-Edge Approaches for CNS Protection and Repair: Focus on Vascular and Degenerative Disorders
  • Author : Johannes Boltze,Marietta Zille,Stephan Schilling,Mathias Gelderblom,Gregory Jaye Bix,Piotr Walczak,Christoph Harms,Paulo Henrique Rosado-de-Castro,Emmanuel Pinteaux
  • Publisher : Frontiers Media SA
  • Release Date : 2021-08-19
  • Total pages : 1044
  • ISBN : 9782889711772
  • File Size : 22,7 Mb
  • Total Download : 754
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PDF book entitled Cutting-Edge Approaches for CNS Protection and Repair: Focus on Vascular and Degenerative Disorders written by Johannes Boltze,Marietta Zille,Stephan Schilling,Mathias Gelderblom,Gregory Jaye Bix,Piotr Walczak,Christoph Harms,Paulo Henrique Rosado-de-Castro,Emmanuel Pinteaux and published by Frontiers Media SA which was released on 2021-08-19 with total hardcover pages 1044, the book become popular and critical acclaim.

Glioblastoma: State of the Art and Future Perspectives

Glioblastoma: State of the Art and Future Perspectives
  • Author : Ghazaleh Tabatabai ,Hiroaki Wakimoto
  • Publisher : MDPI
  • Release Date : 2020-12-10
  • Total pages : 784
  • ISBN : 9783039282609
  • File Size : 25,7 Mb
  • Total Download : 135
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Glioblastoma is an aggressive incurable primary tumor of the central nervous system. Median overall survival is in the range of 1.5 years even in selected clinical trials populations. Many features contribute to this therapeutic challenge including high intratumoral and intertumoral heterogeneity, resistance to therapy, migration and invasion, immunosuppression. With the access of novel highthroughput technologies, significant progress has been made to understand molecular and immunological signatures underlying the pathology of glioblastoma. Clinical trial designs have shifted from investigating broad “one-for-all” treatment approaches to precision oncology designs. The collection of contributions in this book aim at providing researchers and clinicians an update on different aspects of glioblastoma, i.e. progress in basic, preclinical and clinical research.

Progressive Multiple Sclerosis

Progressive Multiple Sclerosis
  • Author : Alastair Wilkins
  • Publisher : Springer
  • Release Date : 2017-11-24
  • Total pages : 307
  • ISBN : 9783319659213
  • File Size : 33,6 Mb
  • Total Download : 849
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This revised, updated second edition draws together the basic science, pathology, epidemiology and treatment possibilities in progressive multiple sclerosis. Each chapter addresses specific aspects of progressive multiple sclerosis providing an extensive review of the current literature and a discussion of the likely mechanisms of tissue injury relevant to the disease. New additions to the second edition include a description of clinical scales used to determine levels of disability; recent trials specifically directed at reducing disease progression; rehabilitation; and an in depth discussion of the similarities and differences between primary and secondary multiple sclerosis. The biological processes underlying disease progression are elucidated as are specific pathophysiological mechanisms. The basic science of axonal degeneration and the clinical understanding of progressive multiple sclerosis are discussed in the context of emerging and future therapies for disease progression as are trials which have been and will be conducted for progressive multiple sclerosis. An overview of biomarkers for the disease is included and existing symptomatic therapies for progressive multiple sclerosis are covered in detail. Progressive Multiple Sclerosis, Second Edition is ideal for both general neurologists and those with a specialist interest in multiple sclerosis. It will also be of interest to neurologists in training and other medical professionals treating this common disease.

The European Blood and Marrow Transplantation Textbook for Nurses

The European Blood and Marrow Transplantation Textbook for Nurses
  • Author : Michelle Kenyon,Aleksandra Babic
  • Publisher : Springer
  • Release Date : 2018-03-14
  • Total pages : 311
  • ISBN : 9783319500263
  • File Size : 24,5 Mb
  • Total Download : 766
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This book is open access under a CC BY 4.0 license. This textbook, endorsed by the European Society for Blood and Marrow Transplantation (EBMT), provides adult and paediatric nurses with a full and informative guide covering all aspects of transplant nursing, from basic principles to advanced concepts. It takes the reader on a journey through the history of transplant nursing, including essential and progressive elements to help nurses improve their knowledge and benefit the patient experience, as well as a comprehensive introduction to research and auditing methods. This new volume specifically intended for nurses, complements the ESH-EBMT reference title, a popular educational resource originally developed in 2003 for physicians to accompany an annual training course also serving as an educational tool in its own right. This title is designed to develop the knowledge of nurses in transplantation. It is the first book of its kind specifically targeted at nurses in this specialist field and acknowledges the valuable contribution that nursing makes in this area. This volume presents information that is essential for the education of nurses new to transplantation, while also offering a valuable resource for more experienced nurses who wish to update their knowledge.

Chronic Graft Versus Host Disease

Chronic Graft Versus Host Disease
  • Author : Georgia B. Vogelsang,Steven Z. Pavletic
  • Publisher : Cambridge University Press
  • Release Date : 2009-04-20
  • Total pages : 473
  • ISBN : 9780521884235
  • File Size : 18,8 Mb
  • Total Download : 322
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Chronic graft versus host disease (GVHD) is the most common complication of allogenic bone marrow transplantation. Because of the protracted clinical course of chronic GVHD, transplant centers and hematology/oncology offices are inadequately equipped to manage these immuno-incompetent patients with a multi-system disorder. Practitioners need to be able to recognize and effectively manage chronic GVHD as a late effect of more than half of allogenic transplantations. The text is oriented for the clinician, with chapters covering staging, organ site and system-specific manifestations, treatment options, and supportive care. Drs. Georgia B. Vogelsang and Steven Z. Pavletic have been pioneers in the recognition of the multi-organ complexity of this disease and have gathered the input of a variety of subspecialist physicians for this book. This book fills the gap in practical literature on chronic GVHD, providing a comprehensive, up-to-date, and clinically relevant resource for anyone who deals with cancer patients post-transplant.

The EBMT Handbook

The EBMT Handbook
  • Author : Nicolaus Kröger,Mohamad Mohty,Carlo Dufour
  • Publisher : Unknown
  • Release Date : 2020-10-08
  • Total pages : 688
  • ISBN : 1013273664
  • File Size : 46,5 Mb
  • Total Download : 153
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This Open Access edition of the European Society for Blood and Marrow Transplantation (EBMT) handbook addresses the latest developments and innovations in hematopoietic stem cell transplantation and cellular therapy. Consisting of 93 chapters, it has been written by 175 leading experts in the field. Discussing all types of stem cell and bone marrow transplantation, including haplo-identical stem cell and cord blood transplantation, it also covers the indications for transplantation, the management of early and late complications as well as the new and rapidly evolving field of cellular therapies. This book provides an unparalleled description of current practices to enhance readers' knowledge and practice skills. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.

Cell Therapy for Neurological Disorders

Cell Therapy for Neurological Disorders
  • Author : Zhiguo Chen,Wei-Ming Duan,Jia-Yi Li,Xibin LIang
  • Publisher : Frontiers Media SA
  • Release Date : 2022-11-04
  • Total pages : 175
  • ISBN : 9782832503850
  • File Size : 52,8 Mb
  • Total Download : 676
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PDF book entitled Cell Therapy for Neurological Disorders written by Zhiguo Chen,Wei-Ming Duan,Jia-Yi Li,Xibin LIang and published by Frontiers Media SA which was released on 2022-11-04 with total hardcover pages 175, the book become popular and critical acclaim.

Allogeneic Stem Cell Transplantation

Allogeneic Stem Cell Transplantation
  • Author : Hillard M. Lazarus,Mary J. Laughlin
  • Publisher : Springer Science & Business Media
  • Release Date : 2010-03-02
  • Total pages : 881
  • ISBN : 9781597454780
  • File Size : 19,9 Mb
  • Total Download : 232
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Since the original publication of Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Allogeneic hematopoietic stem cell transplantation (HSC) has undergone several fast-paced changes. In this second edition, the editors have focused on topics relevant to evolving knowledge in the field in order to better guide clinicians in decision-making and management of their patients, as well as help lead laboratory investigators in new directions emanating from clinical observations. Some of the most respected clinicians and scientists in this discipline have responded to the recent advances in the field by providing state-of-the-art discussions addressing these topics in the second edition. The text covers the scope of human genomic variation, the methods of HLA typing and interpretation of high-resolution HLA results. Comprehensive and up-to-date, Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Second Edition offers concise advice on today's best clinical practice and will be of significant benefit to all clinicians and researchers in allogeneic HSC transplantation.

Non-Myeloablative Allogeneic Transplantation

Non-Myeloablative Allogeneic Transplantation
  • Author : Asad Bashey,Edward D. Ball
  • Publisher : Springer Science & Business Media
  • Release Date : 2002-02-28
  • Total pages : 240
  • ISBN : 0792376463
  • File Size : 25,8 Mb
  • Total Download : 222
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Non-myeloablative allogeneic stem cell transplantation (also known as mini-transplantation or reduced-intensity conditioning transplantation) is a major advance in the field of hematopoietic transplantation within the last 5 years. This approach uses non-cytotoxic or reduced-intensity cytotoxic therapy to prepare patients for allografting of hematopoietic stem cells and lymphocytes. It has the potential to deliver the potent anti-tumor immunotherapy and bone marrow replacement capacity of allogeneic stem cell transplantation to patients with reduced treatment-related morbidity and mortality. It may also enable allogeneic transplantation in patients who would be considered ineligible for conventional transplants because of co-morbidity or advanced age. However, this approach may necessitate more careful monitoring of post-transplant chimerism and malignant disease-status than is usual with conventional allografting. There is also controversy regarding the best preparative regimen and graft-versus-host disease prophylaxis to use.

Towards New Therapies for Parkinson's Disease

Towards New Therapies for Parkinson's Disease
  • Author : David Finkelstein
  • Publisher : BoD – Books on Demand
  • Release Date : 2011-11-02
  • Total pages : 412
  • ISBN : 9789533074634
  • File Size : 14,6 Mb
  • Total Download : 670
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Parkinson's disease (PD) is characterised clinically by various non-motor and progressive motor symptoms, pathologically by loss of dopamine producing cells and intraneuronal cytoplasmic inclusions composed primarily of ?-synuclein. By the time a patient first presents with symptoms of Parkinson's disease at the clinic, a significant proportion of the cells in the substantia nigra have already been destroyed. This degeneration progresses despite the current therapies until the cell loss is so great that the quality of normal life is compromised. The dopamine precursor levodopa is the most valuable drug currently available for the treatment of PD. However for most PD patients, the optimal clinical benefit from levodopa decreases around five to six years of treatment. The aim of the chapters of this book is to work towards an understanding in the mechanisms of degeneration and to develop disease modifying therapies.

Bone and Cartilage Regeneration

Bone and Cartilage Regeneration
  • Author : Phuc Van Pham
  • Publisher : Springer
  • Release Date : 2017-01-24
  • Total pages : 315
  • ISBN : 9783319401447
  • File Size : 21,9 Mb
  • Total Download : 892
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This invaluable resource discusses clinical applications with effects and side-effects of applications of stem cells in bone and cartilage regeneration. Each chapter is contributed by a pre-eminent scientist in the field and covers such topics as skeletal regeneration by mesenchymal stem cells, clinical improvement of mesenchymal stem cell injection in injured cartilage and osteoarthritis, Good manufacturing practice (GMP), minimal critera of stem cells for clinical applications, future directions of the discussed therapies and much more. Bone & Cartilage Regeneration and the other books in the Stem Cells in Clinical Applications series will be invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue engineering.

Mesenchymal Stem Cell Therapy

Mesenchymal Stem Cell Therapy
  • Author : Lucas G. Chase,Mohan C Vemuri
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-12
  • Total pages : 456
  • ISBN : 9781627032001
  • File Size : 43,5 Mb
  • Total Download : 563
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Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), appear to hold great promise in regards to a regenerative cell-based therapy for the treatment of these diseases. Currently, more than 200 clinical trials are underway worldwide exploring the use of MSCs for the treatment of a wide range of disorders including bone, cartilage and tendon damage, myocardial infarction, graft-versus-host disease, Crohn’s disease, diabetes, multiple sclerosis, critical limb ischemia and many others. MSCs were first identified by Friendenstein and colleagues as an adherent stromal cell population within the bone marrow with the ability to form clonogenic colonies in vitro. In regards to the basic biology associated with MSCs, there has been tremendous progress towards understanding this cell population’s phenotype and function from a range of tissue sources. Despite enormous progress and an overall increased understanding of MSCs at the molecular and cellular level, several critical questions remain to be answered in regards to the use of these cells in therapeutic applications. Clinically, both autologous and allogenic approaches for the transplantation of MSCs are being explored. Several of the processing steps needed for the clinical application of MSCs, including isolation from various tissues, scalable in vitro expansion, cell banking, dose preparation, quality control parameters, delivery methods and numerous others are being extensively studied. Despite a significant number of ongoing clinical trials, none of the current therapeutic approaches have, at this point, become a standard of care treatment. Although exceptionally promising, the clinical translation of MSC-based therapies is still a work in progress. The extensive number of ongoing clinical trials is expected to provide a clearer path forward for the realization and implementation of MSCs in regenerative medicine. Towards this end, reviews of current clinical trial results and discussions of relevant topics association with the clinical application of MSCs are compiled in this book from some of the leading researchers in this exciting and rapidly advancing field. Although not absolutely all-inclusive, we hope the chapters within this book can promote and enable a better understanding of the translation of MSCs from bench-to-bedside and inspire researchers to further explore this promising and quickly evolving field.

Therapeutic Intranasal Delivery for Stroke and Neurological Disorders

Therapeutic Intranasal Delivery for Stroke and Neurological Disorders
  • Author : Jun Chen,Jian Wang,Ling Wei,John H. Zhang
  • Publisher : Springer
  • Release Date : 2019-06-03
  • Total pages : 153
  • ISBN : 9783030167158
  • File Size : 25,7 Mb
  • Total Download : 611
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The blood-brain-barrier serves to encapsulate and protect the central nervous system, but it also presents a major barricade to therapeutic drug delivery. Poor penetration is the most common hurdle to translating a promising experimental therapy that uses invasive delivery methods to a clinically useful application. In the last 10 years, intranasal delivery of various therapeutic compounds including small chemicals, large proteins, and even stem cells has proven to be very effective in bypassing the blood-brain-barrier and has led to some important advances in translational research for stroke and other neurological diseases. The proposed book will bring together reports from various labs around the world who have had successes in pre-clinical studies of intranasal therapies for various diseases including adult and perinatal stroke, Alzheimer's, Parkinson's, and others.​

Immune Profile after Autologous Hematopoietic Stem Cell Transplantation for Autoimmune Diseases: Where Do We Stand?

Immune Profile after Autologous Hematopoietic Stem Cell Transplantation for Autoimmune Diseases: Where Do We Stand?
  • Author : Kelen Cristina Ribeiro Malmegrim,Maria Carolina Oliveira,Antoine Toubert,Dominique Farge-Bancel
  • Publisher : Frontiers Media SA
  • Release Date : 2020-02-12
  • Total pages : 135
  • ISBN : 9782889634729
  • File Size : 53,6 Mb
  • Total Download : 788
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Autologous hematopoietic stem cell transplantation (AHSCT) was proposed 20 years ago as an alternative therapeutic approach for patients with severe and refractory autoimmune diseases. Since then, this innovative therapy has been successfully used to treat several autoimmune diseases, such as neurological disorders (Multiple Sclerosis), connective tissue diseases (Systemic Sclerosis and Systemic Lupus Erythematous), gastrointestinal inflammatory diseases (Crohn’s Disease) and others (Juvenile Arthritis, Type 1 Diabetes, Vasculitis). Experience in phase I-II and III clinical trials over the years has led to increased safety and efficacy of this procedure. Recent studies have demonstrated superior therapeutic efficacy of AHSCT versus conventional therapies, showing that transplantation can induce long-term disease remission in the absence of any further immunosuppressive treatment. Immune monitoring studies have showed that AHSCT is able to reduce the inflammatory milieu, to reset the immune balance and to promote the generation of a new auto-tolerant immune repertoire. However, some patients fail to remain in remission, and disease is re-activated after some time post-transplantation. This scenario indicates that further immunological interventions may be still required to improve AHSCT efficacy. Clear understanding of the operating immune mechanisms that contribute to specific clinical outcomes is vital to enable improvement of AHSCT protocols for autoimmune diseases.

Advances in Stem Cell Therapy

Advances in Stem Cell Therapy
  • Author : Nagwa El-Badri
  • Publisher : Humana Press
  • Release Date : 2016-11-18
  • Total pages : 310
  • ISBN : 9783319291499
  • File Size : 51,9 Mb
  • Total Download : 892
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The book reviews the main approaches for generation of differentiated cells from various types of stem cells, including embryonic, placental and cord blood stem cells through marrow, adipose tissue and dental pulp. The book starts with an overview of experimental protocols applied to generate insulin secreting cells, neural cells, heart cells, and other tissue specific cells ex vivo and in experimental animals. This is followed by exhaustive review of clinical trials in these pathologies. It continues with a comparison of the merits of successful transplantation in humans versus animal experimentation, and highlights the most promising clinical applications in the field. Special chapters are devoted to the topic of tissue engineering and modern synthetic and biological scaffolds. It is essential reading for scientists and researchers in tissue engineering and stem cell research as well as clinicians who are involved in developing or testing stem cell therapies.

Physical Disabilities

Physical Disabilities
  • Author : Uner Tan
  • Publisher : BoD – Books on Demand
  • Release Date : 2017-06-14
  • Total pages : 180
  • ISBN : 9789535132479
  • File Size : 22,8 Mb
  • Total Download : 206
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This book, Physical Disabilities - Therapeutic Implications, presents reports on a wide range of areas in the field of neurobiological disabilities, including movement disorders (Uner Tan syndrome, genetic and environmental influences, chronic brain damage, stroke, and pediatric disabilities) related to physical and stem cell therapy. Studies are presented from researchers around the world, looking at aspects as wide-ranging as the genetics, wheelchair, and robotics behind the conditions to new and innovative therapeutic approaches.

Childhood Acute Lymphoblastic Leukemia

Childhood Acute Lymphoblastic Leukemia
  • Author : Ajay Vora
  • Publisher : Springer
  • Release Date : 2017-04-21
  • Total pages : 342
  • ISBN : 9783319397085
  • File Size : 33,9 Mb
  • Total Download : 143
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This book provides a comprehensive and up-to-date review of all aspects of childhood Acute Lymphoblastic Leukemia, from basic biology to supportive care. It offers new insights into the genetic pre-disposition to the condition and discusses how response to early therapy and its basic biology are utilized to develop new prognostic stratification systems and target therapy. Readers will learn about current treatment and outcomes, such as immunotherapy and targeted therapy approaches. Supportive care and management of the condition in resource poor countries are also discussed in detail. This is an indispensable guide for research and laboratory scientists, pediatric hematologists as well as specialist nurses involved in the care of childhood leukemia.