Genome Chaos

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Genome Chaos

Genome Chaos
  • Author : Henry H. Heng
  • Publisher : Academic Press
  • Release Date : 2019-05-25
  • Total pages : 556
  • ISBN : 9780128136362
  • File Size : 46,9 Mb
  • Total Download : 837
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Genome Chaos: Rethinking Genetics, Evolution, and Molecular Medicine transports readers from Mendelian Genetics to 4D-genomics, building a case for genes and genomes as distinct biological entities, and positing that the genome, rather than individual genes, defines system inheritance and represents a clear unit of selection for macro-evolution. In authoring this thought-provoking text, Dr. Heng invigorates fresh discussions in genome theory and helps readers reevaluate their current understanding of human genetics, evolution, and new pathways for advancing molecular and precision medicine. Bridges basic research and clinical application and provides a foundation for re-examining the results of large-scale omics studies and advancing molecular medicine Gathers the most pressing questions in genomic and cytogenomic research Offers alternative explanations to timely puzzles in the field Contains eight evidence-based chapters that discuss 4d-genomics, genes and genomes as distinct biological entities, genome chaos and macro-cellular evolution, evolutionary cytogenetics and cancer, chromosomal coding and fuzzy inheritance, and more

Chromosome Biology as a Key to Understand Disease Mechanisms, Genome Architecture and Evolution

Chromosome Biology as a Key to Understand Disease Mechanisms, Genome Architecture and Evolution
  • Author : Anja Weise,Philipp G. Maass,Ron Hochstenbach
  • Publisher : Frontiers Media SA
  • Release Date : 2021-04-16
  • Total pages : 94
  • ISBN : 9782889666812
  • File Size : 48,8 Mb
  • Total Download : 404
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This topic has been realized, and is in collaboration with Dr. Constanze Pentzold, Post Doctoral Researcher at the Institute of Human Genetics, University Hospital Jena.

Intratumor Diversity and Clonal Evolution in Cancer

Intratumor Diversity and Clonal Evolution in Cancer
  • Author : David Gisselsson
  • Publisher : Academic Press
  • Release Date : 2011-09-29
  • Total pages : 368
  • ISBN : 9780123877086
  • File Size : 27,6 Mb
  • Total Download : 151
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This specialized volume of Advances in Cancer Research is dedicated to the complex and largely unexplored field of intratumor diversity, with respect to differences in both genotype and phenotype among cell populations within tumors. Unique subject matter: there are relatively few previous publications covering this complex topic, even though it has been a matter of much speculation ever since cancers were first studied under the microscope more than a century ago. This volume is an attempt to update the reader on novel findings as well as giving a historical perspective to the field. It thereby offers an excellent starting point for young scientists entering this field of research Contributors: many of the contributors are renowned cancer researchers with long-term experience. To bring in new ideas to the field, these experienced authors have been blended with young bright minds who might provide novel starting points for solving old problems Technical aspects: some chapters will be focused on specific techniques to address intratumor diversity and will therefore be helpful for colleagues wanting to broaden their technical expertise

Debating Cancer

Debating Cancer
  • Author : Henry H Heng
  • Publisher : World Scientific
  • Release Date : 2015-10-08
  • Total pages : 464
  • ISBN : 9789814520867
  • File Size : 11,8 Mb
  • Total Download : 594
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Cancer research is at a crossroads. Traditionally, cancer has been thought of as a disease of gene mutation, where the stepwise accumulation of cancer gene mutations is the key, and the identification of common gene mutations has been considered to be essential for diagnosis and treatment. Despite extensive research efforts and accumulated knowledge on cancer genes and pathways, the clinical benefits of this traditional approach have been limited. Recently, cancer genome sequencing has revealed an extensive amount of genetic heterogeneity where the long-expected common mutation drivers have been difficult, if not impossible, to identify. These realities ultimately challenge the conceptual framework of current cancer biology. This book introduces a new concept of genome theory of cancer evolution, in an attempt to unify the field. Many important and representative, but often confusing, questions and paradoxes are critically analyzed. By comparing gene- and genome-based theories, the hidden flaws of many popular viewpoints are addressed. This discussion is intended to initiate a much-needed critical re-evaluation of current cancer research. Contents:Introduction: Why Debate Cancer, and Why Now?The Gene Mutation Theory of CancerAlternative Theories to Explain CancerThe Surprise Cancer Genome Landscape Revealed by Cancer Genome Sequencing ProjectsUnraveling the Mystery of Cancer: Understanding Genome Variation Mediated Cancer EvolutionSignificance of the Insignificant: Why "Noise" is Essential for Cancer EvolutionDo Different Cancers Represent Different Species?Facts vs. Myths Readership: This book will be appreciated by the research community at large. It will also serve as an excellent resource for a wide range of readers, including researchers, graduate students, physicians, science reporters, and even policy-makers. Key Features:Currently, there exists no such book. This title represents a much-needed effort to systematically re-examine many concepts in cancer research which have remained relatively the same for decadesThe topics discussed are well-known paradoxes to researchers (over 50 of them). Addressing these questions will not only provide answers to key puzzles in the field but also introduce a new conceptual framework, the genome-based cancer evolution theoryThis book will encourage new ideas/approaches that bridge basic research and clinical applications. The analysis of provocative questions will spur a long overdue debate on this subjectKeywords:Cancer Evolution;Genome Theory;Cancer Heterogeneity;Cancer Landscape;Cancer Theories;Drug Resistance;Cancer Diagnosis;Cancer Research

Human Interphase Chromosomes

Human Interphase Chromosomes
  • Author : Yuri B. Yurov,Svetlana G. Vorsanova,Ivan Y. Iourov
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-04-03
  • Total pages : 216
  • ISBN : 9781461465584
  • File Size : 42,9 Mb
  • Total Download : 215
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This title will focus on the study of human interphase chromosomes and its relation to health and disease. Orchestrated organization and human genome function in interphase nuclei at the chromosomal level have been repeatedly shown to play a significant role in a variety of basic biological processes involved in realization and inheritance of genetic information within and between species. Current biomedical sciences of post-genomic era refocus basic and applied studies of interphase nuclei genetics and genomics with special attention to interphase chromosome behavior in health and disease. Additionally, related processes are a target of studies elucidating the role of interphase chromosome behavior during development, chromosome/DNA replication, DNA reparation etc. Studies of interphase nuclei have an appreciable impact on different areas of biomedical sciences such as cell biology, neurobiology, cancer research, developmental biology, epigenetics, cytogenetics, and medical genetics, as a whole. Moreover, development of innovative and emergent technologies to analyze interphase nuclei are closely associated with application of these techniques in clinical, diagnostic and research practice to solve reproductive problems (including infertility and spontaneous abortions), to investigate congenital malformations (including those produced by aneuploidy and other chromosome abnormalities); genetic diseases (including cardiac, immune, neurological and psychiatric diseases), and cancer. This title will serve as a source of new valuable information and promising ideas for a wide audience of professionals in biomedicine including researchers, scientists, and healthcare professionals in human genetics, cytogenetics, and developmental biology. ​

Embracing Complexity in Health

Embracing Complexity in Health
  • Author : Joachim P. Sturmberg
  • Publisher : Springer
  • Release Date : 2019-05-16
  • Total pages : 335
  • ISBN : 9783030109400
  • File Size : 44,9 Mb
  • Total Download : 657
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This detailed volume illustrates the transformative nature of systems and complexity sciences for practice, research, education, and health system organization. Researchers highlight the fresh perspectives and novel approaches offered by these interdisciplinary fields in addressing the complexities of global, national, and community health challenges in the 21st century. With the implications that these emerging fields hold for health still relatively underexplored, researchers from a wide variety of disciplines, including physiological, social, environmental, clinical, prevention, educational, organizational, finance, and policy domains, aim in this book to suggest future directions in health care and highlight recent advances in basic and clinical physiology, education, policy-making, and leadership. Among the topics discussed: Impact of genomic heterogeneity on bio-emergent properties Harnessing Big Data to improve health services Decision-making of women in violent relationships Co-producing healthcare interventions A socio-ecological solution to physician burnout Embracing Complexity in Health: The Transformation of Science, Practice, and Policy is a highly relevant resource to practitioners in the field, students, instructors, and policy makers, and also should find an engaged audience among health and disease researchers, healthcare planners, health system financiers, health system administrators, health services administrators, health professional educators, and other health professionals. The trans- and interdisciplinary natures of health and health care are fostering a broad discourse amongst all concerned with improving patient care in an equitable and sustainable way.

Ecology and Evolution of Cancer

Ecology and Evolution of Cancer
  • Author : Beata Ujvari,Benjamin Roche,Frederic Thomas
  • Publisher : Academic Press
  • Release Date : 2017-02-08
  • Total pages : 290
  • ISBN : 9780128043806
  • File Size : 10,5 Mb
  • Total Download : 525
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Ecology and Evolution of Cancer is a timely work outlining ideas that not only represent a substantial and original contribution to the fields of evolution, ecology, and cancer, but also goes beyond by connecting the interfaces of these disciplines. This work engages the expertise of a multidisciplinary research team to collate and review the latest knowledge and developments in this exciting research field. The evolutionary perspective of cancer has gained significant international recognition and interest, which is fully understandable given that somatic cellular selection and evolution are elegant explanations for carcinogenesis. Cancer is now generally accepted to be an evolutionary and ecological process with complex interactions between tumor cells and their environment sharing many similarities with organismal evolution. As a critical contribution to this field of research the book is important and relevant for the applications of evolutionary biology to understand the origin of cancers, to control neoplastic progression, and to prevent therapeutic failures. Covers all aspects of the evolution of cancer, appealing to researchers seeking to understand its origins and effects of treatments on its progression, as well as to lecturers in evolutionary medicine Functions as both an introduction to cancer and evolution and a review of the current research on this burgeoning, exciting field, presented by an international group of leading editors and contributors Improves understanding of the origin and the evolution of cancer, aiding efforts to determine how this disease interferes with biotic interactions that govern ecosystems Highlights research that intends to apply evolutionary principles to help predict emergence and metastatic progression with the aim of improving therapies

Atlas of Hematopathology

Atlas of Hematopathology
  • Author : Faramarz Naeim,P. Nagesh Rao,Sophie X. Song,Ryan T. Phan
  • Publisher : Academic Press
  • Release Date : 2018-06-22
  • Total pages : 984
  • ISBN : 9780128098448
  • File Size : 44,9 Mb
  • Total Download : 875
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Atlas of Hematopathology: Morphology, Immunophenotype, Cytogenetics, and Molecular Approaches, Second Edition, will appeal to both a wide range of people undergoing training in a variety of medical fields and practicing non-hematopathologists. For clinicians, fellows and residents, correct diagnosis (and therefore correct treatment) of diseases depends on a strong understanding of the molecular basis for the disease, making this book a crucial resource. This atlas contains hundreds of high-quality color images that mirror the findings that fellows and clinicians encounter in practice. In addition, it provides information in a quick, simple and user-friendly manner, attracting both those in training and non- experts. Residents, fellows, practicing clinicians, and researchers in pathology, hematology and hematology/oncology will find this a useful resource. Covers both non-neoplastic hematopathology and neoplastic hematopathology in all organs and tissues Demonstrates results of important complementary diagnostic tests, such as immunophenotyping (immunohistochemical stains and flow cytometry), karyotyping, FISH and DNA/molecular studies Provides tables to summarize the most important clinicopathological features Saves clinicians and researchers time in quickly accessing the very latest details on the diverse clinical and scientific aspects of hematopathology

Somatic Genomic Mosaicism & Human Disease

Somatic Genomic Mosaicism & Human Disease
  • Author : Ivan Y. Iourov,Henry H. Heng,Svetlana G. Vorsanova
  • Publisher : Frontiers Media SA
  • Release Date : 2022-11-14
  • Total pages : 82
  • ISBN : 9782832505625
  • File Size : 31,6 Mb
  • Total Download : 259
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PDF book entitled Somatic Genomic Mosaicism & Human Disease written by Ivan Y. Iourov,Henry H. Heng,Svetlana G. Vorsanova and published by Frontiers Media SA which was released on 2022-11-14 with total hardcover pages 82, the book become popular and critical acclaim.

Epigenetics in Cancer

Epigenetics in Cancer
  • Author : Wiley
  • Publisher : John Wiley & Sons
  • Release Date : 2013-07-12
  • Total pages : 174
  • ISBN : 9781118734391
  • File Size : 32,5 Mb
  • Total Download : 681
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Epigenetics is the study of heritable changes in gene expression or cellular phenotype, caused by mechanisms other than changes in the DNA sequence. Examples include DNA methylation and histone modification. These changes may remain through cell divisions and multiple generations. Epigenetic differences among individuals may account for some of the differences between monozygotic (identical) twins. Aberrant DNA methylation is also frequently associated with human aging and diseases, such as cancer. This collection of overviews and laboratory protocols provides crucial, distilled information about the roles of epigenetics in cancer development. The overviews are geared for research scientists who need to learn more about the current understanding of epigenetic variation in humans and how the processes of DNA methylation and histone modification are regulated. The protocols give step-by-step instructions on how to detect DNA methylation using various methods such as MAPit, CHARM (arrays) and methylation-specific PCR. This e-book — a curated collection from eLS, WIREs, and Current Protocols — offers a fantastic introduction to the fields of genetics, genomics, and oncogenesis for students or interdisciplinary collaborators. Table of Contents: Introduction Epigenetic Variation in Humans eLS Jon F. Wilkins Genetic and Epigenetic Heterogeneity in Cancer eLS Joshua B. Stevens, Batoul Y. Abdallah, Steven D. Horne, Guo Liu, Steven W. Bremer and Henry H. Heng Techniques & Applications Mediators and Dynamics of DNA Methylation WIREs Systems Biology and Medicine Robert Shoemaker, Wei Wang and Kun Zhang DNA Methylation Alterations in Multiple Myeloma as a Model for Epigenetic Changes in Cancer WIREs Systems Biology and Medicine Amy Sharma, Christoph J. Heuck, Melissa J. Fazzari, Jayesh Mehta, Seema Singhal, John M. Greally and Amit Verma Ink4?-Arf Locus in Cancer and Aging WIREs Developmental Biology Charles J. Sherr Protocols Simultaneous Single-Molecule Mapping of Protein-DNA Interactions and DNA Methylation by MAPit Current Protocols in Molecular Biology Carolina E. Pardo, Russell P. Darst, Nancy H. Nabilsi, Amber L. Delmas and Michael P. Kladde Comprehensive High-Throughput Arrays for Relative Methylation (CHARM) Current Protocols in Human Genetics Christine Ladd-Acosta, Martin J. Aryee, Jared M. Ordway and Andrew P. Feinberg Methylation-specific PCR Current Protocols in Human Genetics Bradford Coffee

Human Interphase Chromosomes

Human Interphase Chromosomes
  • Author : Ivan Iourov,Svetlana Vorsanova,Yuri Yurov
  • Publisher : Springer Nature
  • Release Date : 2021-01-29
  • Total pages : 178
  • ISBN : 9783030625320
  • File Size : 26,5 Mb
  • Total Download : 798
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This second edition focuses on the study of human interphase chromosomes and its relation to health and disease. Orchestrated organization and behavior of the human genome in interphase nuclei at chromosomal level has been repeatedly shown to play a significant role in almost all basic biological processes involved in the processing and inheritance of genetic information within and between species. Accordingly, post-genomic bioscience appeals to basic and applied studies of interphase nuclei genetics and genomics with special attention to interphase chromosome behavior in health and disease. Additionally, elucidating the role of interphase chromosome behavior during development, chromosome/DNA replication, DNA reparation opens new horizons for basic and applied bioscience Studies of interphase nuclei have an appreciable impact on different areas of biomedical sciences such as cell biology, neurobiology, cancer research, developmental biology, epigenetics, cytogenetics, and medical genetics, as a whole. Moreover, development of innovative and emergent technologies to analyze interphase nuclei are closely associated with application of these techniques in diagnostic and research practices to solve reproductive problems (including infertility and spontaneous abortions), to investigate congenital malformations (including those produced by aneuploidy and other chromosome abnormalities); genetic diseases (including cardiac, immune, neurological and psychiatric diseases), and cancer. This second edition serves as a source of updated valuable information and promising ideas for a wide audience of professionals in biomedicine including researchers, scientists, and healthcare professionals in human genetics, cytogenetics, and developmental biology.

Genome Stability

Genome Stability
  • Author : Igor Kovalchuk,Olga Kovalchuk
  • Publisher : Academic Press
  • Release Date : 2021-07-17
  • Total pages : 760
  • ISBN : 9780323856805
  • File Size : 30,5 Mb
  • Total Download : 115
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Genome Stability: From Virus to Human Application, Second Edition, a volume in the Translational Epigenetics series, explores how various species maintain genome stability and genome diversification in response to environmental factors. Here, across thirty-eight chapters, leading researchers provide a deep analysis of genome stability in DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes, and mammals, examining how epigenetic factors contribute to genome stability and how these species pass memories of encounters to progeny. Topics also include major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability, and genome stability in response to aging. This second edition has been fully revised to address evolving research trends, including CRISPRs/Cas9 genome editing; conventional versus transgenic genome instability; breeding and genetic diseases associated with abnormal DNA repair; RNA and extrachromosomal DNA; cloning, stem cells, and embryo development; programmed genome instability; and conserved and divergent features of repair. This volume is an essential resource for geneticists, epigeneticists, and molecular biologists who are looking to gain a deeper understanding of this rapidly expanding field, and can also be of great use to advanced students who are looking to gain additional expertise in genome stability. A deep analysis of genome stability research from various kingdoms, including epigenetics and transgenerational effects Provides comprehensive coverage of mechanisms utilized by different organisms to maintain genomic stability Contains applications of genome instability research and outcomes for human disease Features all-new chapters on evolving areas of genome stability research, including CRISPRs/Cas9 genome editing, RNA and extrachromosomal DNA, programmed genome instability, and conserved and divergent features of repair

Handbook of Systems and Complexity in Health

Handbook of Systems and Complexity in Health
  • Author : Joachim P Sturmberg,Carmel Martin
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-01-09
  • Total pages : 954
  • ISBN : 9781461449980
  • File Size : 24,7 Mb
  • Total Download : 501
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This book is an introduction to health care as a complex adaptive system, a system that feeds back on itself. The first section introduces systems and complexity theory from a science, historical, epistemological, and technical perspective, describing the principles and mathematics. Subsequent sections build on the health applications of systems science theory, from human physiology to medical decision making, population health and health services research. The aim of the book is to introduce and expand on important population health issues from a systems and complexity perspective, highlight current research developments and their implications for health care delivery, consider their ethical implications, and to suggest directions for and potential pitfalls in the future.

Evolutionary Computation in Bioinformatics

Evolutionary Computation in Bioinformatics
  • Author : Gary B. Fogel,David W. Corne
  • Publisher : Morgan Kaufmann
  • Release Date : 2003
  • Total pages : 432
  • ISBN : 1558607978
  • File Size : 46,7 Mb
  • Total Download : 993
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This book offers a definitive resource that bridges biology and evolutionary computation. The authors have written an introduction to biology and bioinformatics for computer scientists, plus an introduction to evolutionary computation for biologists and for computer scientists unfamiliar with these techniques.

Dear Professor Dyson

Dear Professor Dyson
  • Author : Freeman John Dyson
  • Publisher : World Scientific
  • Release Date : 2016
  • Total pages : 386
  • ISBN : 9789814759090
  • File Size : 48,7 Mb
  • Total Download : 743
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"Freeman Dyson has designed nuclear reactors and bomb-powered spacecraft; he has studied the origins of life and the possibilities for the long-term future; he showed quantum mechanics to be consistent with electrodynamics and started cosmological eschatology; he has won international recognition for his work in science and for his work in reconciling science to religion; he has advised generals and congressional committees. An STS (Science, Technology, Society) curriculum or discussion group that engages topics such as nuclear policies, genetic technologies, environmental sustainability, the role of religion in a scientific society, and a hard look towards the future, would count itself privileged to include Professor Dyson as a class participant and mentor. In this book, STS topics are not discussed as objectified abstractions, but through personal stories. The reader is invited to observe Dyson's influence on a generation of young people as they wrestle with issues of science, technology, society, life in general and our place in the universe. The book is filled with personal anecdotes, student questions and responses, honest doubts and passions"--

Peregrinations from Physics to Phylogeny

Peregrinations from Physics to Phylogeny
  • Author : Kok Khoo Phua,Molin Ge
  • Publisher : World Scientific
  • Release Date : 2016-02-29
  • Total pages : 300
  • ISBN : 9789814759106
  • File Size : 35,7 Mb
  • Total Download : 392
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' "Professor Hao Bailin is one of China''s most talented and most versatile theoretical physicists. He has made important contributions to a wide variety of research fields, including biology in which he pioneered a multidimensional method for studying the evolutionary pathways of bacteria. Indeed he calls himself, appreciatively I believe, a guerrilla fighter." Nobel Laureate, Chen-Ning Yang Contents: C N Yang on Hao Bailin, 2015 (Chen-Ning Yang)Skeleton Graph Expansion of Critical Exponents in "Cultural Revolution" Years (Hao Bailin)The Virial Expansion Re-visited: A New Interpretation (Fa-Yueh Wu and Ron Aaron)Chaos in the Belousov–Zhabotinsky Reaction (Richard J Field)Discrete Resonances (Franco Vivaldi)Exact Solution of the Planar Motion of Three Arbitrary Point Vortices (Robert Conte and Laurent de Seze)A Cognitive Network for Oracle-Bone Characters Related to Animals (Andreas Dress, Stefan Grünewald and Zhenbing Zeng)Periodic Oscillations of the Forced Brusselator (Jason A C Gallas)Genomes: At the Edge of Chaos with Maximum Information Capacity (Sing-Guan Kong, Hong-Da Chen, Andrew Torda, and H C Lee)Low Temperature Glassy Systems: Present Understanding, Open Problems and Future Developments (Giorgio Parisi)CVTrees Support the Bergey''s Systematics and Provide High Resolution at Species Levels and Below (Bailin Hao)My Days as a Student of Prof. Hao (1982–1986) (Mingzhou Ding)Teacher and Friend (Yong-Shi Wu) Readership: This book is suitable for students of physics and mathematics and all members of the general public interested in science. Keywords:Hao Bailin;Virial Expansion;Chaos;Complex Systems;Glassy Systems'

Molecular Chemistry and Biomolecular Engineering

Molecular Chemistry and Biomolecular Engineering
  • Author : Lionello Pogliani,Francisco Torrens,A. K. Haghi
  • Publisher : CRC Press
  • Release Date : 2019-09-12
  • Total pages : 242
  • ISBN : 9780429595318
  • File Size : 24,7 Mb
  • Total Download : 998
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This new volume is devoted to molecular chemistry and its applications to the fields of biology. It looks at the integration of molecular chemistry with biomolecular engineering, with the goal of creating new biological or physical properties to address scientific or societal challenges. It takes a both multidisciplinary and interdisciplinary perspective on the interface between molecular biology, biophysical chemistry, and chemical engineering. Molecular Chemistry and Biomolecular Engineering: Integrating Theory and Research with Practice provides effective support for the development of the laboratory and data analysis skills that researchers will draw on time and again for the practical aspects and also gives a solid grounding in the broader transferable skills.

Nuclear, Chromosomal, and Genomic Architecture in Biology and Medicine

Nuclear, Chromosomal, and Genomic Architecture in Biology and Medicine
  • Author : Malgorzata Kloc,Jacek Z. Kubiak
  • Publisher : Springer Nature
  • Release Date : 2022-11-08
  • Total pages : 657
  • ISBN : 9783031065736
  • File Size : 29,7 Mb
  • Total Download : 128
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This volume reviews the latest research on the functional implications of nuclear, chromosomal and genomic organization and architecture on cell and organismal biology, and development and progression of diseases. The architecture of the cell nucleus and non-random arrangement of chromosomes, genes, and the non-membranous nuclear bodies in the three-dimensional (3D) space alters in response to the environmental, mechanical, chemical, and temporal cues. The changes in the nuclear, chromosomal, or genomic compaction and configuration modify the gene expression program and induce or inhibit epigenetic modifications. The intrinsically programmed rearrangements of the nuclear architecture are necessary for cell differentiation, the establishment of cell fate during development and maturation of tissues and organs including the immune, muscle, and nervous systems. The non-programmed changes in the nuclear architecture can lead to fragmentation of the nucleus and instability of the genome and thus cause cancer. Microbial and viral infections can lead to a clustering of centromeres, telomeres and ribosomal DNA and alter the properties of the nuclear membrane, allowing large immobile macromolecules to enter the nucleus. Recent advances in next-generation sequencing technologies combined with nucleus/chromosome conformation capture, super-resolution imaging, chromosomal contact maps methods, integrative modeling, and genetic approaches, are uncovering novel features and importance of nuclear, chromosomal and genomic architecture. This book is an interesting read for cell biologists, researchers studying the structure and function of chromosomes, and anyone else who wants to get an overview of the field of nuclear, chromosomal and genomic architecture.

The Value of Systems and Complexity Sciences for Healthcare

The Value of Systems and Complexity Sciences for Healthcare
  • Author : Joachim P Sturmberg
  • Publisher : Springer
  • Release Date : 2016-03-01
  • Total pages : 285
  • ISBN : 9783319262215
  • File Size : 9,9 Mb
  • Total Download : 575
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This visionary reframing of health and healthcare uses a complexity science approach to building healthcare systems that are accessible, effective, and prepared for change and challenges. Its holistic map for understanding the human organism emphasizes the interconnectedness of the individual’s physical, psychological, cognitive, and sociocultural functioning. Applications of this approach are described in primary, specialist, and emergency care and at the organizational and policy levels, from translating findings to practice, to problem solving and evaluation. In this model, the differences between disease and illness and treating illness and restoring health are not mere wordplay, but instead are robust concepts reflecting real-world issues and their solutions. Based on the Proceedings of the 1st International Conference of Systems and Complexity for Healthcare, topics covered include: • Coping with complexity and uncertainty: insights from studying epidemiology in family medicine • Anticipation in complex systems: potential implications for improving safety and quality in healthcare • Monitoring variability and complexity at the bedside • Viewing mental health through the lens of complexity science • Ethical complexities in systems healthcare: what care and for whom? • The value of systems and complexity thinking to enable change in adaptive healthcare organizations supported by informatics • If the facts don’t fit the theory, change the theory: implications for health system reform The Value of Systems and Complexity Sciences for Healthcare will interest and inspire health and disease researchers, health professionals, health care planners, health system financiers, health system administrators, health services administrators, health professional educators, and, last but not least, current and future patients.

Evolutionary Thinking in Medicine

Evolutionary Thinking in Medicine
  • Author : Alexandra Alvergne,Crispin Jenkinson,Charlotte Faurie
  • Publisher : Springer
  • Release Date : 2016-05-13
  • Total pages : 382
  • ISBN : 9783319297163
  • File Size : 52,8 Mb
  • Total Download : 819
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The aim of this edited book is to provide health professionals, across a wide variety of specialisms, with a targeted access to evolutionary medicine. Throughout the book, the views of both medical and evolutionary scientists on the latest relevant research is presented with a focus on practical implications. The inclusion of boxes explaining the theoretical background as well as both a glossary for technical terms and a lay summary for non- specialists enable medical researchers, public health professionals, policy makers, physicians, students, scholars and the public alike to quickly and easily access appropriate information. This edited volume is thus relevant to anyone keen on finding out how evolutionary medicine can improve the health and well-being of people.

Mitonuclear Ecology

Mitonuclear Ecology
  • Author : Geoffrey E. Hill
  • Publisher : Oxford University Press
  • Release Date : 2019-04-30
  • Total pages : 336
  • ISBN : 9780192550361
  • File Size : 53,6 Mb
  • Total Download : 138
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Download Mitonuclear Ecology in PDF, Epub, and Kindle

This novel text provides a concise synthesis of how the interactions between mitochondrial and nuclear genes have played a major role in shaping the ecology and evolution of eukaryotes. The foundation for this new focus on mitonuclear interactions originated from research in biochemistry and cell biology laboratories, although the broader ecological and evolutionary implications have yet to be fully explored. The imperative for mitonuclear coadaptation is proposed to be a major selective force in the evolution of sexual reproduction and two mating types in eukaryotes, in the formation of species, in the evolution of ornaments and sexual selection, in the process of adaptation, and in the evolution of senescence. The book highlights the importance of mitonuclear coadaptation to the evolution of complex life and champions mitonuclear ecology as an important subdiscipline in ecology and evolution.