Essentials Of Translational Pediatric Drug Development

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Essentials of Translational Pediatric Drug Development

Essentials of Translational Pediatric Drug Development
  • Author : Elke Gasthuys,Karel Allegaert,Lien Dossche,Mark Turner
  • Publisher : Academic Press
  • Release Date : 2023-01-17
  • Total pages : 670
  • ISBN : 0323884598
  • File Size : 9,7 Mb
  • Total Download : 945
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Despite the broad consensus that children merit the same quality of drug treatment as any other age group, children remain frequently neglected during drug research and development. Even with the adoption of multiple legislations addressing this problem, the lack of efficacy and safety data of marketed as well as newly developed drugs still remain in the pediatric population. Essentials of Translational Pediatric Drug Development: From Past needs to Future Opportunities provides integrated up-to-date insights relevant for both translational researchers and clinicians active in the field of pediatric drug development. The book covers all key aspects of pediatric drug development from different stakeholder perspectives and will provide a literature overview and careful reflection of the state-of-the-art approaches that are used. The book will be a guide for researchers in the field to design and to perform high quality, innovative pediatric-adapted drug development by defining needs/challenges as well as possible solutions to advance and to harmonize pediatric drug development. Covers both theoretical and practical aspects of translational pediatric drug development Approaches the topic from different stakeholder perspectives (academics, industry, regulators, clinicians, patient/parent advocacy groups) Offers best practices and future perspectives for improvement of translational pediatric drug development

Animal and Translational Models for CNS Drug Discovery: Neurological Disorders

Animal and Translational Models for CNS Drug Discovery: Neurological Disorders
  • Author : Robert A. McArthur,Franco Borsini
  • Publisher : Academic Press
  • Release Date : 2008-11-18
  • Total pages : 416
  • ISBN : 0080920381
  • File Size : 10,7 Mb
  • Total Download : 422
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Neurological Disorders is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for neurological disorders such as neurofibromatosis, Alzheimer’s disease, Parkinson’s disease, Huntington disease, ALS, and the epilepsies. Neurological Disorders has introductory chapters expressing the view of the role and relevance of animal models for drug discovery and development for the treatment of psychiatric disorders from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical drug discovery and development, and (c) issues of clinical trial design and regulatory agencies limitations. Each volume examines the rationale, use, robustness and limitations of animal models in each therapeutic area covered and discuss the use of animal models for target identification and validation. The clinical relevance of animal models is discussed in terms of major limitations in cross-species comparisons, clinical trial design of drug candidates, and how clinical trial endpoints could be improved. The aim of this series of volumes on Animal and Translational Models for CNS Drug Discovery is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. This is the second volume in the three volume-set, Animal and Translational Models for CNS Drug Discovery 978-0-12-373861-5, which is also available for purchase individually. Clinical, academic, government and industry perspectives fostering integrated communication between principle participants at all stages of the drug discovery process Critical evaluation of animal and translational models improving transition from drug discovery and clinical development Emphasis on what results mean to the overall drug discovery process Exploration of issues in clinical trial design and conductance in each therapeutic area

Pediatric Drug Development

Pediatric Drug Development
  • Author : Andrew E. Mulberg,Dianne Murphy,Julia Dunne,Lisa L. Mathis
  • Publisher : John Wiley & Sons
  • Release Date : 2013-05-20
  • Total pages : 624
  • ISBN : 9781118312056
  • File Size : 14,6 Mb
  • Total Download : 252
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Pediatric Drug Development, Second Edition, encompasses the new regulatory initiatives across EU, US and ROW designed to encourage improved access to safe and effective medicines for children. It includes new developments in biomarkers and surrogate endpoints, developmental pharmacology and other novel aspects of pediatric drug development.

Safe and Effective Medicines for Children

Safe and Effective Medicines for Children
  • Author : Institute of Medicine,Board on Health Sciences Policy,Committee on Pediatric Studies Conducted Under the Best Pharmaceuticals for Children Act (BPCA) and the Pediatric Research Equity Act (PREA)
  • Publisher : National Academies Press
  • Release Date : 2012-10-13
  • Total pages : 432
  • ISBN : 9780309225496
  • File Size : 12,5 Mb
  • Total Download : 458
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The Best Pharmaceuticals for Children Act (BPCA) and the Pediatric Research Equity Act (PREA) were designed to encourage more pediatric studies of drugs used for children. The FDA asked the IOM to review aspects of pediatric studies and changes in product labeling that resulted from BPCA and PREA and their predecessor policies, as well as assess the incentives for pediatric studies of biologics and the extent to which biologics have been studied in children. The IOM committee concludes that these policies have helped provide clinicians who care for children with better information about the efficacy, safety, and appropriate prescribing of drugs. The IOM suggests that more can be done to increase knowledge about drugs used by children and thereby improve the clinical care, health, and well-being of the nation's children.

Recent Advances in Molecular and Translational Medicine: Updates in Precision Medicine

Recent Advances in Molecular and Translational Medicine: Updates in Precision Medicine
  • Author : Somchai Chutipongtanate
  • Publisher : Bentham Science Publishers
  • Release Date : 2021-12-13
  • Total pages : 256
  • ISBN : 9789815036763
  • File Size : 38,7 Mb
  • Total Download : 972
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Precision medicine is a disruptive innovation with a fast-evolving pace in the healthcare ecosystem. Precision medicine enables precise diagnosis and targeted treatment by considering individual variability in the abnormalities of causative genes and molecular drivers behind biochemical mechanisms. A vast amount of data created by advanced omics technologies is a foundation of precision medicine’s success, and the implications of the findings from these technologies can potentially improve clinical outcomes. Recent Advances in Molecular and Translational Medicine: Updates in Precision Medicine presents essential information of molecular and translational research in precision medicine, with a specific focus on pediatrics. This book provides an accessible introduction to omics technologies, gives a detailed explanation of bioinformatics workflows to interpret high-throughput omics profiles for molecular diagnosis, and collects some of the cutting-edge research for precise therapeutics. Contributions to the book have been provided by experts in biomedical engineering and clinical practice, thus, bringing an informed perspective to the reader on each topic. The book is a valuable resource for postgraduate students, researchers, data scientists and clinicians interested in precision medicine, as well as researchers in the field of genetics and pediatrics who are interested in understanding the role of precision medicine in clinical practice.

Advancing Regulatory Science for Medical Countermeasure Development

Advancing Regulatory Science for Medical Countermeasure Development
  • Author : Institute of Medicine,Board on Health Sciences Policy,Forum on Medical and Public Health Preparedness for Catastrophic Events,Forum on Drug Discovery, Development, and Translation
  • Publisher : National Academies Press
  • Release Date : 2011-08-27
  • Total pages : 150
  • ISBN : 9780309214902
  • File Size : 12,8 Mb
  • Total Download : 278
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Whether or not the United States has safe and effective medical countermeasures-such as vaccines, drugs, and diagnostic tools-available for use during a disaster can mean the difference between life and death for many Americans. The Food and Drug Administration (FDA) and the scientific community at large could benefit from improved scientific tools and analytic techniques to undertake the complex scientific evaluation and decision making needed to make essential medical countermeasures available. At the request of FDA, the Institute of Medicine (IOM) held a workshop to examine methods to improve the development, evaluation, approval, and regulation of medical countermeasures. During public health emergencies such as influenza or chemical, biological, radiological/nuclear (CBRN) attacks, safe and effective vaccines, treatments, and other medical countermeasures are essential to protecting national security and the well being of the public. Advancing Regulatory Science for Medical Countermeasure Development examines current medical countermeasures, and investigates the future of research and development in this area. Convened on March 29-30, 2011, this workshop identified regulatory science tools and methods that are available or under development, as well as major gaps in currently available regulatory science tools. Advancing Regulatory Science for Medical Countermeasure Development is a valuable resource for federal agencies including the Food and Drug Administration (FDA), the Department of Health and Human Services (HHS), the Department of Defense (DoD), as well as health professionals, and public and private health organizations.

Essentials of 3D Biofabrication and Translation

Essentials of 3D Biofabrication and Translation
  • Author : Anthony Atala,James J Yoo
  • Publisher : Academic Press
  • Release Date : 2015-07-17
  • Total pages : 440
  • ISBN : 9780128010150
  • File Size : 50,9 Mb
  • Total Download : 786
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Essentials of 3D Biofabrication and Translation discusses the techniques that are making bioprinting a viable alternative in regenerative medicine. The book runs the gamut of topics related to the subject, including hydrogels and polymers, nanotechnology, toxicity testing, and drug screening platforms, also introducing current applications in the cardiac, skeletal, and nervous systems, and organ construction. Leaders in clinical medicine and translational science provide a global perspective of the transformative nature of this field, including the use of cells, biomaterials, and macromolecules to create basic building blocks of tissues and organs, all of which are driving the field of biofabrication to transform regenerative medicine. Provides a new and versatile method to fabricating living tissue Discusses future applications for 3D bioprinting technologies, including use in the cardiac, skeletal, and nervous systems, and organ construction Describes current approaches and future challenges for translational science Runs the gamut of topics related to the subject, from hydrogels and polymers to nanotechnology, toxicity testing, and drug screening platforms

Drug Discovery and Development

Drug Discovery and Development
  • Author : Vishwanath Gaitonde,Partha Karmakar,Ashit Trivedi
  • Publisher : BoD – Books on Demand
  • Release Date : 2020-03-11
  • Total pages : 166
  • ISBN : 9781789239751
  • File Size : 35,5 Mb
  • Total Download : 201
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The process of drug discovery and development is a complex multistage logistics project spanned over 10-15 years with an average budget exceeding 1 billion USD. Starting with target identification and synthesizing anywhere between 10k to 15k synthetic compounds to potentially obtain the final drug that reaches the market involves a complicated maze with multiple inter- and intra-operative fields. Topics described in this book emphasize the progresses in computational applications, pharmacokinetics advances, and molecular modeling developments. In addition the book also contains special topics describing target deorphaning in Mycobacterium tuberculosis, therapy treatment of some rare diseases, and developments in the pediatric drug discovery process.

Broadly Engaged Team Science in Clinical and Translational Research

Broadly Engaged Team Science in Clinical and Translational Research
  • Author : Debra Lerner,Marisha E. Palm,Thomas W. Concannon
  • Publisher : Springer Nature
  • Release Date : 2022-02-27
  • Total pages : 254
  • ISBN : 9783030830281
  • File Size : 48,6 Mb
  • Total Download : 573
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Despite the large U.S. investment in health science, and the vast and growing body of peer-reviewed research findings it has produced, a compelling body of evidence suggests that research too often has been slow, inefficient, and fallen short of desired impacts on health. A key question is how research might be changed to be more innovative, less wasteful, and more responsive to unmet health needs. One emerging response within clinical and translational science is to advance an approach that attempts to close the gap between research scientists and key stakeholders; the individuals and groups responsible for or affected by health-related decisions. Broadly engaged team science promises to support this aim by transforming the gold standard, multi-disciplinary team science, to include key stakeholders in activities across the research spectrum. These new roles and responsibilities range from generating research questions to implementing research projects, to aiding in the translation of discoveries from the laboratory to the community. A transition to broadly engaged team science reflects the idea that inclusivity and a diversity of perspectives are necessary to achieving progress in addressing complex health issues while representing a new benchmark for ethical research practice. This is one of the first collections of papers describing how clinical and translational science researchers are defining and implementing new research practices, and the successes and challenges involved. This book represents a first and critical step towards organizing knowledge of broadly engaged team science and advancing the development of evidence-based practices. Written in an accessible style, this book is intended to highlight the breadth of broadly engaged team science within one community, motivate researchers and stakeholders to build inclusive teams, bring rigor to often informal stakeholder engagement research practices and encourage people to think more broadly about the development of scientific knowledge. It includes examples of multi-disciplinary, broadly engaged team science projects, the perspectives of academic leaders about the changes needed to encourage scientists to conduct broadly engaged team science, and a resource directory.

Essential CNS Drug Development

Essential CNS Drug Development
  • Author : Amir Kalali,Sheldon Preskorn,Joseph Kwentus,Stephen M. Stahl
  • Publisher : Cambridge University Press
  • Release Date : 2012-06-07
  • Total pages : 229
  • ISBN : 9781139576529
  • File Size : 27,6 Mb
  • Total Download : 878
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Central Nervous System disorders have an enormous impact on individuals and on society as a whole. The development of better treatments is crucial and is a major focus of pharmaceutical and biotechnology companies. This book explains the complicated process of CNS drug development in a way that is engaging for any interested professional or student. Chapters cover each stage of drug development, from pre-clinical research through all phases of clinical trials, to reporting to the regulatory authorities. Other key issues covered include strategic considerations, regulatory constraints, dissemination of results and ethical considerations. The user-friendly format and style enable readers to find important information quickly and easily. Written and edited by experts from different sectors actively engaged in CNS drug development, this is a unique resource for drug developers, investigators, academics and clinicians.

The Essentials of Lifespan Development

The Essentials of Lifespan Development
  • Author : Tara L. Kuther
  • Publisher : SAGE Publications
  • Release Date : 2022-05-24
  • Total pages : 808
  • ISBN : 9781071851852
  • File Size : 35,8 Mb
  • Total Download : 926
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In The Essentials of Lifespan Development, best-selling author Tara L. Kuther examines the ways in which contexts—culture, society, socioeconomic status, home, family, and even community—impact each stage of a person′s life. With its chronological organization, highly relatable examples, and vivid cross-cultural stories, Kuther connects the latest cutting-edge research to learners’ experiences and interdisciplinary career aspirations. Integrated examples; routine critical thinking questions; and a 16-chapter organization helps make the book engaging and accessible for all students. This title is accompanied by a complete teaching and learning package. Contact your SAGE representative to request a demo. Digital Option / Courseware SAGE Vantage is an intuitive digital platform that delivers this text’s content and course materials in a learning experience that offers auto-graded assignments and interactive multimedia tools, all carefully designed to ignite student engagement and drive critical thinking. Built with you and your students in mind, it offers simple course set-up and enables students to better prepare for class. Learn more. Assignable Video with Assessment Assignable video (available with SAGE Vantage) is tied to learning objectives and curated exclusively for this text to bring concepts to life. Watch a sample video now. LMS Cartridge: Import this title’s instructor resources into your school’s learning management system (LMS) and save time. Don’t use an LMS? You can still access all of the same online resources for this title via the password-protected Instructor Resource Site. Learn more.

Prenatal Stress and Child Development

Prenatal Stress and Child Development
  • Author : Ashley Wazana,Eszter Székely,Tim F. Oberlander
  • Publisher : Springer Nature
  • Release Date : 2021-04-19
  • Total pages : 653
  • ISBN : 9783030601591
  • File Size : 48,5 Mb
  • Total Download : 909
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This book examines the complex impact of prenatal stress and the mechanism of its transmission on children’s development and well-being, including prenatal programming, epigenetics, infl ammatory processes, and the brain-gut microbiome. It analyzes current findings on prenatal stressors affecting pregnancy, including preconception stress, prenatal maternal depression, anxiety, and pregnancy-specific anxieties. Chapters explore how prenatal stress affects cognitive, affective, behavioral, and neurobiological development in children while pinpointing core processes of adaptation, resilience, and interventions that may reduce negative behaviors and promote optimal outcomes in children. Th is complex perspective on mechanisms by which early environmental influences interact with prenatal programming of susceptibility aims to inform clinical strategies and future research targeting prenatal stress and its cyclical impact on subsequent generations. Key areas of coverage include: The developmental effects of prenatal maternal stress on children. Epigenetic effects of prenatal stress. Intergenerational transmission of parental early life stress. The microbiome-gut-brain axis and the effects of prenatal stress on early neurodevelopment. The effect of prenatal stress on parenting. Gestational stress and resilience. Prenatal stress and children’s sleeping behavior. Prenatal, perinatal, and population-based interventions to prevent psychopathology. Prenatal Stress and Child Development is an essential resource for researchers, professors and graduate students as well as clinicians, therapists, and related professionals in infancy and early childhood development, maternal and child health, developmental psychology, pediatrics, social work, child and adolescent psychiatry, developmental neuroscience, and related behavioral and social sciences and medical disciplines. Excerpt from the foreword: “I would make the plea that in addition to anyone with an interest in child development, this book should be essential reading for researchers pursuing “pre-clinical, basic science models of neurodevelopment and brain health”.... This book provides what in my mind is the most advanced compilation of existing knowledge and state-of-the-art science in the field of prenatal psychiatry/psychology (and perhaps in the entire field of prenatal medicine). This volume can brilliantly serve to focus future directions in our understanding of the perinatal determinants of brain health.” Michael J Meaney James McGill Professor of Medicine Translational Neuroscience Programme Adjunct Professor of Paediatrics

Smith's Anesthesia for Infants and Children E-Book

Smith's Anesthesia for Infants and Children E-Book
  • Author : Peter J. Davis,Franklyn P. Cladis
  • Publisher : Elsevier Health Sciences
  • Release Date : 2021-11-30
  • Total pages : 1450
  • ISBN : 9780323698269
  • File Size : 31,9 Mb
  • Total Download : 900
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Written and edited by renowned experts in pediatric anesthesia, Smith's Anesthesia for Infants and Children provides clear, concise guidance on effective perioperative care for any type of pediatric surgery. The 10th Edition contains significantly revised content throughout, bringing you fully up to date with recent advances in clinical and basic science that have led to changes in today’s clinical practice. Offers comprehensive coverage of physiology, pharmacology, and clinical anesthetic management of infants and children of all ages. Contains new chapters on Airway Physiology and Development, Normal and Difficult Airway Management, Ultrasound, Acute Pain Management, Chronic Pain Management, Palliative Pain Management, Infectious Diseases, and Education; plus extensively revised content on cardiovascular physiology; induction, maintenance, and recovery; organ transplantation, and more. Features more than 100 video demonstrations, including regional anesthesia videos, echocardiograms of congenital heart lesions, anatomic dissections of various congenital heart specimens with audio explanations, various pediatric surgical operative procedures, airway management, and much more. Provides outstanding visual guidance throughout, including full-color photographs, drawings, graphs and charts, and radiographic images. Includes quick-reference appendices online: drug dosages, growth curves, normal values for pulmonary function tests, and a listing of common and uncommon syndromes. Provides an interactive question bank online for review and self-assessment.

Porth's Essentials of Pathophysiology

Porth's Essentials of Pathophysiology
  • Author : Tommie Norris
  • Publisher : Lippincott Williams & Wilkins
  • Release Date : 2019-10-17
  • Total pages : 1248
  • ISBN : 9781975107208
  • File Size : 51,7 Mb
  • Total Download : 876
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Vital Disease Information for Your Success in Nursing Ready yourself for the realities of professional nursing practice with this proven approach to pathophysiology. Distilling need-to-know disease content in a clear, accessible format, Porth’sEssentials of Pathophysiology offers concise yet complete coverage of how the body works to help you establish the scientific foundation essential to success in your nursing career. Approachable presentation builds understanding from basic to advanced concepts and defines key terms as you progress. “Chunked” content--including Learning Objectives, Key Points boxes, and Summary Concepts sections--highlights critical points for reflection. Full-color illustrations clarify the clinical manifestations of diseases and disease processes. Review Exercises at the end of each chapter test your retention and identify areas for further study. References provide fast, efficient access to normal laboratory values in both conventional and SI units, as well as a comprehensive glossary. Narrated animations referenced by icons in the text and available online enhance your understanding of the most challenging and clinically relevant concepts.

Fundamentals of Drug Development

Fundamentals of Drug Development
  • Author : Jeffrey S. Barrett
  • Publisher : John Wiley & Sons
  • Release Date : 2022-09-07
  • Total pages : 516
  • ISBN : 9781119691693
  • File Size : 20,7 Mb
  • Total Download : 216
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Fundamentals of DRUG DEVELOPMENT Enables readers to understand the process of pharmaceutical research, its regulatory basis, and how it fits into the global healthcare environment This book discusses how to conduct pharmaceutical research and the context for how the industry fits into global healthcare. Holistically, the well-qualified author helps readers and students of drug development appreciate the time and expense of the process. Specifically, the work identifies the emerging trends shaping the future of drug development, along with important related topics like generic drugs, data sharing, and collaboration. To aid in seamless reader comprehension, the book includes a glossary of terms and a self-assessment quiz for each chapter at the end. PowerPoint slides are also available as an online ancillary for adopting professors. Sample topics covered in the book include: Drug development and its phases Decision-making processes, drug development milestones, and compound progression metrics The various disciplines involved along with an assessment of the complexity and risks associated across the stages of development Differences in the nature and scope of development programs due to the therapeutic area of interest Associated costs and resources required Graduate students and professors teaching courses in drug development, drug discovery, pharmaceuticals, medicinal chemistry, and drug synthesis will be able to use this book as a complete resource for understanding all the complexities and nuances involved in the drug development process.

The CTSA Program at NIH

The CTSA Program at NIH
  • Author : Institute of Medicine,Board on Health Sciences Policy,Committee to Review the Clinical and Translational Science Awards Program at the National Center for Advancing Translational Sciences
  • Publisher : National Academies Press
  • Release Date : 2013-10-09
  • Total pages : 179
  • ISBN : 9780309284745
  • File Size : 34,7 Mb
  • Total Download : 254
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In 2006 the National Institutes of Health (NIH) established the Clinical and Translational Science Awards (CTSA) Program, recognizing the need for a new impetus to encourage clinical and translational research. At the time it was very difficult to translate basic and clinical research into clinical and community practice; making it difficult for individual patients and communities to receive its benefits. Since its creation the CTSA Program has expanded, with 61 sites spread across the nation's academic health centers and other institutions, hoping to provide catalysts and test beds for policies and practices that can benefit clinical and translation research organizations throughout the country. The NIH contracted with the Institute of Medicine (IOM) in 2012 to conduct a study to assess and provide recommendations on appropriateness of the CTSA Program's mission and strategic goals and whether changes were needed. The study was also address the implementation of the program by the National Center for Advancing Translational Sciences (NCATS) while exploring the CTSA's contributions in the acceleration of the development of new therapeutics. A 13-member committee was established to head this task; the committee had collective expertise in community outreach and engagement, public health and health policy, bioethics, education and training, pharmaceutical research and development, program evaluation, clinical and biomedical research, and child health research. The CTSA Program at NIH: Opportunities for Advancing Clinical and Translational Research is the result of investigations into previous program evaluations and assessments, open-session meetings and conference class, and the review of scientific literature. Overall, the committee believes that the CTSA Program is significant to the advancement of clinical and translational research through its contributions. The Program would benefit from a variety of revisions, however, to make it more efficient and effective.

'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine

'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine
  • Author : Nosheen Masood,Saima Shakil Malik
  • Publisher : Springer Nature
  • Release Date : 2020-03-20
  • Total pages : 499
  • ISBN : 9789811510670
  • File Size : 17,9 Mb
  • Total Download : 463
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This book concisely describes the role of omics in precision medicine for cancer therapies. It outlines our current understanding of cancer genomics, shares insights into the process of oncogenesis, and discusses emerging technologies and clinical applications of cancer genomics in prognosis and precision-medicine treatment strategies. It then elaborates on recent advances concerning transcriptomics and translational genomics in cancer diagnosis, clinical applications, and personalized medicine in oncology. Importantly, it also explains the importance of high-performance analytics, predictive modeling, and system biology in cancer research. Lastly, the book discusses current and potential future applications of pharmacogenomics in clinical cancer therapy and cancer drug development.

COVID-19: Targeting Essential SARS-CoV-2 Proteins for Drug Discovery

COVID-19: Targeting Essential SARS-CoV-2 Proteins for Drug Discovery
  • Author : Andrzej Joachimiak
  • Publisher : Frontiers Media SA
  • Release Date : 2023-03-10
  • Total pages : 206
  • ISBN : 9782832517031
  • File Size : 9,6 Mb
  • Total Download : 993
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PDF book entitled COVID-19: Targeting Essential SARS-CoV-2 Proteins for Drug Discovery written by Andrzej Joachimiak and published by Frontiers Media SA which was released on 2023-03-10 with total hardcover pages 206, the book become popular and critical acclaim.

Fundamentals of Pediatric Neuroanesthesia

Fundamentals of Pediatric Neuroanesthesia
  • Author : Girija Prasad Rath
  • Publisher : Springer Nature
  • Release Date : 2021-09-07
  • Total pages : 722
  • ISBN : 9789811633768
  • File Size : 34,6 Mb
  • Total Download : 944
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The book provides an excellent review of all the clinical aspects of neuroanesthesia in children, including neurosurgeries during fetal state to neonatal, infancy, toddler, and school-going age groups. To provide optimal anesthetic care in children undergoing neurosurgery, the care provider must have adequate knowledge on the developing brain and spinal cord, and the effect of anesthetics on the neuronal tissue, and the inherent issues pertaining to neurologic lesions. This book covers the diagnostic, imaging, surgical as well as anesthetic managements of all the neurosurgical problems in children. The chapters include a wide range of topics from basic neurophysiology to general concerns for pediatric neuroanesthesia, including fluid management, blood transfusion, temperature regulation, and surgical positioning, as well as specific issues such as anesthesia for brain tumor surgery, hydrocephalus, neural tube defects, cerebrovascular surgeries such as aneurysmal surgery, arteriovenous malformations (AVMs), Moyamoya disease, and vein of Galen malformation, functional neurosurgery, epilepsy surgery, neuroendoscopy, craniovertebral junction anomalies, spinal surgeries, neurotrauma, and brain abscess with congenital heart diseases. Interesting topics like neuroanesthesia in remote locations, regional anesthesia during neurosurgery, and anesthesia for children with neuromuscular disease are also discussed. Moreover, the book elaborates on advanced neuroanesthesia techniques during fetal neurosurgery and craniopagus separation surgery; and the postoperative intensive care management aspects in each chapter. It is supplemented with figures depicting surgical procedures and positioning, neuroimages, tables and illustrations for easy understanding. This book caters to neuroanesthesiologists, pediatric anesthesiologists, residents, and fellows of anesthesia or neuroanesthesia, practicing anesthesiologists, pediatric neurointensivists, nurse anesthetists, neurosurgeons, and pediatric neurosurgeons. It also serves as a reference book for the DM (neuroanesthesiology and neurocritical care), DNB-SS (neuroanesthesiology), and MD (anesthesiology) curriculums apart from anesthesia residency and pediatric anesthesia/ neurosurgery fellowship programs offered at various Institutions worldwide.

The Role of NIH in Drug Development Innovation and Its Impact on Patient Access

The Role of NIH in Drug Development Innovation and Its Impact on Patient Access
  • Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Board on Health Care Services
  • Publisher : National Academies Press
  • Release Date : 2020-02-27
  • Total pages : 103
  • ISBN : 9780309498487
  • File Size : 24,8 Mb
  • Total Download : 142
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To explore the role of the National Institutes of Health (NIH) in innovative drug development and its impact on patient access, the Board on Health Care Services and the Board on Health Sciences Policy of the National Academies jointly hosted a public workshop on July 24â€"25, 2019, in Washington, DC. Workshop speakers and participants discussed the ways in which federal investments in biomedical research are translated into innovative therapies and considered approaches to ensure that the public has affordable access to the resulting new drugs. This publication summarizes the presentations and discussions from the workshop.

Public Engagement and Clinical Trials

Public Engagement and Clinical Trials
  • Author : Institute of Medicine,Board on Health Sciences Policy,Forum on Drug Discovery, Development, and Translation
  • Publisher : National Academies Press
  • Release Date : 2012-03-17
  • Total pages : 140
  • ISBN : 9780309219297
  • File Size : 53,6 Mb
  • Total Download : 400
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Clinical trials provide essential information needed to turn basic medical research findings into patient treatments. New treatments must be studied in large numbers of humans to find out whether they are effective and to assess any harm that may arise from treatment. There is growing recognition among many stakeholders that the U.S. clinical trials enterprise is unable to keep pace with the national demand for research results. The IOM, along with the Mount Sinai School of Medicine, held a workshop June 27-28, 2011, to engage stakeholders and experts in a discussion about possible solutions to improve public engagement in clinical trials.