Epi Informatics

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• Author : Jose Medina-Franco
• Publisher : Academic Press
• Release Date : 2016-02-24
• Total pages : 440
• ISBN : 9780128028094
• File Size : 21,5 Mb
• Total Download : 801
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Download Epi-Informatics in PDF, Epub, and Kindle

Epi-Informatics: Discovery and Development of Small Molecule Epigenetic Drugs and Probes features multidisciplinary strategies with strong computational approaches that have led to the successful discovery and/or optimization of compounds that act as modulators of epigenetic targets. This book is intended for all those using or wanting to learn more about computational methodologies in epigenetic drug discovery, including molecular modelers, informaticians, pharmaceutical scientists, and medicinal chemists. With a better understanding of different molecular modeling and cheminformatic approaches, readers can incorporate these techniques into their own drug discovery projects that may involve chemical synthesis and medium- or high-throughput screening. In addition, this book highlights the significance of epigenetic targets to the public health for molecular modelers and chemoinformatians. The goal of this reference is to stimulate ongoing multidisciplinary research and to further improve current computational methodologies and workflows in order to accelerate the discovery and development of epi-drugs and epi-probes. Focuses on the discovery of epi-drugs as candidates to be used in therapy including combined therapies Describes new computational methodologies and screening assays utilizing recent and emerging novel structural data Highlights the discovery, development and optimization of epi-probes, which are molecular probes that elucidate epigenetic mechanisms Includes important topics such as computational-guided optimization of epi-hits, virtual screening to identify novel compounds for epigenetic targets, development and mining of epigenetic molecular databases, SAR modeling of screening data and much more

• Author : Thomas Engel,Johann Gasteiger
• Publisher : John Wiley & Sons
• Release Date : 2018-06-05
• Total pages : 646
• ISBN : 9783527342013
• File Size : 34,8 Mb
• Total Download : 864
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Download Applied Chemoinformatics in PDF, Epub, and Kindle

Edited by world-famous pioneers in chemoinformatics, this is a clearly structured and applications-oriented approach to the topic, providing up-to-date and focused information on the wide range of applications in this exciting field. The authors explain methods and software tools, such that the reader will not only learn the basics but also how to use the different software packages available. Experts describe applications in such different fields as structure-spectra correlations, virtual screening, prediction of active sites, library design, the prediction of the properties of chemicals, the development of new cosmetics products, quality control in food, the design of new materials with improved properties, toxicity modeling, assessment of the risk of chemicals, and the control of chemical processes. The book is aimed at advanced students as well as lectures but also at scientists that want to learn how chemoinformatics could assist them in solving their daily scientific tasks. Together with the corresponding textbook Chemoinformatics - Basic Concepts and Methods (ISBN 9783527331093) on the fundamentals of chemoinformatics readers will have a comprehensive overview of the field.

• Author : Anonim
• Publisher : Academic Press
• Release Date : 2018-08-24
• Total pages : 152
• ISBN : 9780128139172
• File Size : 20,5 Mb
• Total Download : 920
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Download Computational Molecular Modelling in Structural Biology in PDF, Epub, and Kindle

Computational Molecular modelling in Structural Biology, Volume 113, the latest release in the Advances in Protein Chemistry and Structural Biology, highlights new advances in the field, with this new volume presenting interesting chapters on charting the Bromodomain BRD4: Towards the Identification of Novel Inhibitors with Molecular Similarity and Receptor Mapping, and Computational Methods to Discover Compounds for the Treatment of Chagas Disease. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Advances in Protein Chemistry and Structural Biology series Updated, with the latest information on Computational Molecular Modelling in Structural Biology

• Author : Kunal Roy
• Publisher : Springer
• Release Date : 2017-05-22
• Total pages : 555
• ISBN : 9783319568508
• File Size : 11,9 Mb
• Total Download : 346
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Download Advances in QSAR Modeling in PDF, Epub, and Kindle

The book covers theoretical background and methodology as well as all current applications of Quantitative Structure-Activity Relationships (QSAR). Written by an international group of recognized researchers, this edited volume discusses applications of QSAR in multiple disciplines such as chemistry, pharmacy, environmental and agricultural sciences addressing data gaps and modern regulatory requirements. Additionally, the applications of QSAR in food science and nanoscience have been included – two areas which have only recently been able to exploit this versatile tool. This timely addition to the series is aimed at graduate students, academics and industrial scientists interested in the latest advances and applications of QSAR.

• Author : Anonim
• Publisher : Academic Press
• Release Date : 2016-08-24
• Total pages : 212
• ISBN : 9780128052419
• File Size : 28,8 Mb
• Total Download : 923
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Download Insights into Enzyme Mechanisms and Functions from Experimental and Computational Methods in PDF, Epub, and Kindle

Insights into Enzyme Mechanisms and Functions from Experimental and Computational Methods is the latest volume in the popular Advances in Protein Chemistry and Structural Biology series, an essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins, with each thematically organized volume guest edited by leading experts in a broad range of protein-related topics. Provides cutting-edge developments in protein chemistry and structural biology Written by authorities in their respective fields Targeted to a wide audience of researchers, specialists, and students

• Author : Anonim
• Publisher : Hotcourses
• Release Date : 2007
• Total pages : 614
• ISBN : 1904735312
• File Size : 16,8 Mb
• Total Download : 719
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Download Postgraduate UK study and funding guide in PDF, Epub, and Kindle

Features information on studying at Postgraduate level in the UK, what is involved, what opportunities there are, lists details £75 million of funding available to Postgraduate students.

• Author : Alma D. Campos-Parra,Carlos Pérez-Plasencia,Teresita Padilla-Benavides,Eduardo López-Urrutia
• Publisher : Frontiers Media SA
• Release Date : 2021-08-26
• Total pages : 158
• ISBN : 9782889712397
• File Size : 9,7 Mb
• Total Download : 874
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Download Repurposed Drugs Targeting Cancer Signaling Pathways: Clinical Insights to Improve Oncologic Therapies in PDF, Epub, and Kindle

PDF book entitled Repurposed Drugs Targeting Cancer Signaling Pathways: Clinical Insights to Improve Oncologic Therapies written by Alma D. Campos-Parra,Carlos Pérez-Plasencia,Teresita Padilla-Benavides,Eduardo López-Urrutia and published by Frontiers Media SA which was released on 2021-08-26 with total hardcover pages 158, the book become popular and critical acclaim.

• Author : Anonim
• Publisher : Academic Press
• Release Date : 2020-09-21
• Total pages : 330
• ISBN : 9780128177631
• File Size : 55,7 Mb
• Total Download : 496
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Download Enzymes – Mechanisms, Dynamics and Inhibition in PDF, Epub, and Kindle

Enzymes – Mechanisms, Dynamics and Inhibition, Volume 122, the latest release in the Advances in Protein Chemistry and Structural Biology series, highlights new advances in the field, with this new volume presenting new and interesting chapters on the topics. Each chapter is written by an international board of authors. Provides a targeted approach to a very wide audience of specialists, researchers and students Contains timely chapters written by well-renowned authorities in their field Includes a number of high quality illustrations, figures and tables

• Author : José L. Medina-Franco
• Publisher : MDPI
• Release Date : 2019-07-01
• Total pages : 158
• ISBN : 9783039211043
• File Size : 49,9 Mb
• Total Download : 689
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Download New Approaches for the Discovery of Pharmacologically-Active Natural Compounds in PDF, Epub, and Kindle

A major source of active compounds, natural products from different sources supply a large variety of molecules that have been approved for clinical use or used as the starting points of optimization programs. This book features nine papers (eight full articles and one review paper) written by more than 45 scientists from around the world. These papers illustrate the development and application of a broad range of computational and experimental techniques applied to natural product research. On behalf of the contributors to the book, our hope is that the research presented here contributes to advancements in the field, and encourages multidisciplinary teams, young scientists, and students to further advance in the discovery of pharmacologically-active natural compounds

• Author : Pulok K. Mukherjee
• Publisher : Elsevier
• Release Date : 2022-07-12
• Total pages : 858
• ISBN : 9780323984560
• File Size : 47,5 Mb
• Total Download : 471
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Download Evidence-Based Validation of Herbal Medicine in PDF, Epub, and Kindle

Evidence-Based Validation of Herbal Medicines: Translational Research on Botanicals brings together current thinking and practice in the characterization and validation of natural products. The book describes different approaches and techniques for evaluating the quality, safety and efficacy of herbal medicine, particularly methods to assess their activity and understand compounds responsible and their probable underlying mechanisms of action. This book brings together the views, expertise and experiences of scientific experts in the field of medicinal plant research, hence it will be useful for researcher who want to know more about the natural lead with their validation and also useful to exploit traditional medicines. Includes state-of-the-art methods for detecting, isolating and performing structure elucidation by degradation and spectroscopic techniques Highlights the trends in validation and value addition of herbal medicine with different scientific approaches used in therapeutics Contains several all-new chapters on topics such as traditional-medicine-inspired drug development to treat emerging viral diseases, medicinal plants in antimicrobial resistance, TLC bio profiling, botanicals as medicinal foods, bioprospecting and bioassay-guided isolation of medicinal plants, immunomodulators from medicinal plants, and more

• Author : Simon Jones,Richard Beamish
• Publisher : John Wiley & Sons
• Release Date : 2011-08-02
• Total pages : 360
• ISBN : 9780470961544
• File Size : 38,9 Mb
• Total Download : 815
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Download Salmon Lice in PDF, Epub, and Kindle

The salmon louse Lepeophtheirus salmonis is adapted to survive in hostile marine environments of the northern hemisphere, including an ability to parasitize several species of salmon. Salmonids are some of the most economically important and sought after fish for human consumption, and louse parasitism has a significant impact both on cultured and wild fish populations. Salmon Lice is a timely collection of the latest research on the cause and spread of lice infestations and management techniques being designed and implemented to combat this issue. Salmon Lice provides a thorough single volume review of Lepeophtheirus salmonis, the key parasite standing in the way of sustainable and profitable production of salmonid fishes including salmon, trout and charr. Opening with a review of the biology, morphology, life cycle, and larval behavior of the parasite, Salmon Lice proceeds to review the distribution of planktonic larvae of salmon lice, addresses management techniques used in salmonid aquaculture and capture fisheries, provides a practical assessment of the salmon lice issue and explores potential solutions to the problem. With comprehensive coverage of the biology and distribution of this harmful and ubiquitous parasite, Salmon Lice will be of value to fish health researchers, aquaculture and fisheries professionals, and seafood industry personnel to inform the management of both cultured and wild salmonid populations. Key Features: In-depth coverage of a key parasite impacting viability and sustainability of salmonid fisheries and aquaculture Integrates parasite biology and hydrodynamic models in diverse coastal ecosystems Provides a practical assessment of the salmon louse issue Reviews international salmon louse monitoring and management techniques used in salmonid fisheries and aquaculture

• Author : Rudy Schreiber
• Publisher : Springer Nature
• Release Date : 2021-06-17
• Total pages : 283
• ISBN : 9783030623517
• File Size : 43,5 Mb
• Total Download : 992
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Download Modern CNS Drug Discovery in PDF, Epub, and Kindle

This textbook provides a comprehensive overview of the currently used concepts, approaches and technologies in the discovery and development of new treatments for the full spectrum of disorders of the central nervous system. It guides the reader through all essential steps, from finding an innovative idea, to the registration of a new drug. Divided into four sections, the book starts by presenting a broad perspective on current approaches in central nervous system (CNS) drug discovery. The second section addresses the generation of ideas for the identification of targets and novel treatment strategies; covers core functions in early discovery, and provides an example of a novel treatment paradigm: brain stimulation. The third section highlights strategies and technologies in translational CNS drug discovery. In an effort to bridge the gap between discovery and clinical development, it also covers brain imaging, EEG and cognitive testing approaches. The fourth section extensively discusses the clinical phase of drug development, covering the basics of early clinical testing for psychopharmacological drugs. The book’s final chapter addresses the registration for newly developed drugs. Written by experts from academia and industry, the book covers important basics and best practices, as well as recent developments in drug discovery. Offering in-depth insights into the world of drug development, it represents essential reading for early researchers who want to prepare for a career in drug discovery in academia or industry.

• Author : Albert Jeltsch,Renata Z. Jurkowska
• Publisher : Springer Nature
• Release Date : 2022-12-11
• Total pages : 562
• ISBN : 9783031114540
• File Size : 49,5 Mb
• Total Download : 243
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Download DNA Methyltransferases - Role and Function in PDF, Epub, and Kindle

This 2nd edition of the book on DNA methyltransferases has been comprehensively updated to reflect many novel research findings regarding the structure, function, and technology of these enzymes that have emerged over the past 6 years. Like the previous edition, this 2nd edition explains the biochemical properties of DNA methyltransferases, describing their structures, mechanisms and biological roles in bacteria, humans and plants. It also discusses the biological processes of reading DNA methylation and the mechanisms of DNA demethylation. This volume highlights the newest findings on DNA methyltransferase inhibitors and their use in cancer therapy as well as the latest epigenome editing systems based on these enzymes. Overall, this 2nd edition comprehensively summarizes the current state of research in the field of DNA methylation and DNA methyltransferase and is essential reading for early career and advanced researchers in this exciting field.

• Author : Diego Oliva
• Publisher : Springer Nature
• Release Date : 2023
• Total pages : 765
• ISBN : 9783030705428
• File Size : 24,9 Mb
• Total Download : 743
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Download Metaheuristics in Machine Learning: Theory and Applications in PDF, Epub, and Kindle

This book is a collection of the most recent approaches that combine metaheuristics and machine learning. Some of the methods considered in this book are evolutionary, swarm, machine learning, and deep learning. The chapters were classified based on the content; then, the sections are thematic. Different applications and implementations are included; in this sense, the book provides theory and practical content with novel machine learning and metaheuristic algorithms. The chapters were compiled using a scientific perspective. Accordingly, the book is primarily intended for undergraduate and postgraduate students of Science, Engineering, and Computational Mathematics and is useful in courses on Artificial Intelligence, Advanced Machine Learning, among others. Likewise, the book is useful for research from the evolutionary computation, artificial intelligence, and image processing communities.

• Author : Anonim
• Publisher : PediaPress
• Release Date : 2023
• Total pages : 979
• ISBN : 1230987654XX
• File Size : 50,9 Mb
• Total Download : 961
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Download Wikipedia Handbook of Biomedical Informatics in PDF, Epub, and Kindle

PDF book entitled Wikipedia Handbook of Biomedical Informatics written by Anonim and published by PediaPress which was released on 2023 with total hardcover pages 979, the book become popular and critical acclaim.

• Author : Huixiao Hong
• Publisher : Springer Nature
• Release Date : 2023-03-11
• Total pages : 654
• ISBN : 9783031207303
• File Size : 15,5 Mb
• Total Download : 210
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Download Machine Learning and Deep Learning in Computational Toxicology in PDF, Epub, and Kindle

This book is a collection of machine learning and deep learning algorithms, methods, architectures, and software tools that have been developed and widely applied in predictive toxicology. It compiles a set of recent applications using state-of-the-art machine learning and deep learning techniques in analysis of a variety of toxicological endpoint data. The contents illustrate those machine learning and deep learning algorithms, methods, and software tools and summarise the applications of machine learning and deep learning in predictive toxicology with informative text, figures, and tables that are contributed by the first tier of experts. One of the major features is the case studies of applications of machine learning and deep learning in toxicological research that serve as examples for readers to learn how to apply machine learning and deep learning techniques in predictive toxicology. This book is expected to provide a reference for practical applications of machine learning and deep learning in toxicological research. It is a useful guide for toxicologists, chemists, drug discovery and development researchers, regulatory scientists, government reviewers, and graduate students. The main benefit for the readers is understanding the widely used machine learning and deep learning techniques and gaining practical procedures for applying machine learning and deep learning in predictive toxicology.

• Author : Surajit Das,Hirak Ranjan Dash
• Publisher : Academic Press
• Release Date : 2020-09-15
• Total pages : 862
• ISBN : 9780128200858
• File Size : 42,5 Mb
• Total Download : 645
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Download Microbial and Natural Macromolecules in PDF, Epub, and Kindle

Microbial and Natural Macromolecules: Synthesis and Applications brings together active scientists and academicians in the field who share updated information and research outcomes from global experts. Microbial macromolecular diversity, molecular composure, genetics, usability of advanced molecular tools and techniques for their study as well as their applicability are discussed with detailed research perspectives. Illustrates fundamental discoveries and methodological advancements Discusses novel functional attributes of macromolecules Updates progress on microbial macromolecular research

• Author : Norbert Handler
• Publisher : John Wiley & Sons
• Release Date : 2018-02-27
• Total pages : 538
• ISBN : 9783527335381
• File Size : 24,5 Mb
• Total Download : 758
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Download Drug Selectivity in PDF, Epub, and Kindle

The book "Drug Selectivity - An Evolving Concept in Medicinal Chemistry" provides a current overview and comprehensive compilation for medicinal chemists that discusses the effects of aiming for multiple targets on the entire drug development process. The result is a broad survey of current and future strategies for drug selectivity in medicinal chemistry with theoretical but also practical aspects. Different strategies are presented and evaluated, such as various design approaches, merged multiple ligands, discovery technologies and a broad range of successful examples of unselective drugs taken from all major disease areas. With its wide-ranging view of an emerging new paradigm in drug development, this handbook is of prime importance for every medicinal and pharmaceutical chemist.

• Author : Patrick T. K. Woo,Kurt Buchmann
• Publisher : CABI
• Release Date : 2012
• Total pages : 395
• ISBN : 9781845938062
• File Size : 24,9 Mb
• Total Download : 861
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Download Fish Parasites in PDF, Epub, and Kindle

Focusing on pathobiology and protective strategies against protozoan and metazoan parasites of fish, this book reviews the latest research on important parasites: those that cause financial hardships to the aquaculture industry, have been introduced to new geographical regions through transportation of infected fish, are pathogenic to groups of finfish and detrimental to production, are highly adaptable and not host-specific with worldwide distributions, and that may serve as disease models for studies on other pathogens. It also highlights gaps in the knowledge to help direct future research.

• Author : Yashpal Singh Malik,Raj Kumar Singh,Mahendra Pal Yadav
• Publisher : Springer Nature
• Release Date : 2019-11-14
• Total pages : 471
• ISBN : 9789811390739
• File Size : 40,8 Mb
• Total Download : 672
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Download Recent Advances in Animal Virology in PDF, Epub, and Kindle

This book discusses the prominence and implication of the viral diseases that are a major threat to animals around the globe. A number of these diseases have also shown links with human populations, which has implications for public health. This book offers detailed and up-to-date information on viral diseases in livestock and poultry that were and/or are still a problem. Including cutting-edge developments, it also highlights several landmark contributions in the field of virology from India. Additionally, the book features tables and figures showing important clinical data and recommendations, with references for further information. It also explores the economic impact of viral diseases for farmers and the livestock industry, providing several examples. Further, it presents the latest information on viral diseases in global context, with a focus on state-of-art, molecular tools for the development of diagnostics, prophylactics and therapeutics. Lastly, the book also describes the challenges posed by the emerging and transboundary viral infections and our preparedness to counter them.

• Author : Mithun Rudrapal,Chukwuebuka Egbuna
• Publisher : Elsevier
• Release Date : 2022-06-01
• Total pages : 322
• ISBN : 9780323914338
• File Size : 40,6 Mb
• Total Download : 823
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Download Computer Aided Drug Design (CADD): From Ligand-Based Methods to Structure-Based Approaches in PDF, Epub, and Kindle

Computer-Aided Drug Design (CADD): From Ligand-Based Methods to Structure-Based Approaches outlines the basic theoretical principles, methodologies and applications of different fundamental and advanced CADD approaches and techniques. Including information on current protocols as well as recent developments in the computational methods, tools and techniques used for rational drug design, the book explains the fundamental aspects of CADD, combining this with a practical understanding of the various in silico approaches used in modern drug discovery processes to assess the field in a comprehensive and systematic manner. Providing up-to-date, information and guidance for scientists, researchers, students and teachers, the book helps readers address specific academic and research related problems using illustrative explanations, examples and case studies, which are systematically reviewed. Highlights in silico approaches to drug design and discovery using computational tools and techniques Details ligand-based and structure-based drug design in a comprehensive and systematic approach Summarizes recent developments in computational drug design strategy as novel approaches of rational drug designing