Drug Design And Discovery In Alzheimers Disease

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• Author : Atta-ur-Rahman,Muhammad Iqbal Choudhary
• Publisher : Elsevier
• Release Date : 2015-06-27
• Total pages : 784
• ISBN : 9780128039601
• File Size : 32,9 Mb
• Total Download : 818
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Download Drug Design and Discovery in Alzheimer’s Disease in PDF, Epub, and Kindle

Drug Design and Discovery in Alzheimer’s Disease includes expert reviews of recent developments in Alzheimer's disease (AD) and neurodegenerative disease research. Originally published by Bentham as Frontiers in Drug Design and Discovery, Volume 6and now distributed by Elsevier, this compilation of the sixteen articles, written by leading global researchers, focuses on key developments in the understanding of the disease at molecular levels, identification and validation of molecular targets, as well as innovative approaches towards drug discovery, development, and delivery. Beginning with an overview of AD pharmacotherapy and existing blockbuster drugs, the reviews cover the potential of both natural and synthetic small molecules; the role of cholinesterases in the on-set and progression of AD and their inhibition; the role of beta-site APP clearing enzyme-1 (BACE-1) in the production of ß-amyloid proteins, one of the key reasons of the progression of AD; and other targets identified for AD drug discovery. Edited and written by leading experts in Alzheimer’s disease (AD) and other neurodegenerative disease drug development Describes existing drugs for AD and current molecular understanding of the condition Reviews recent advances in the field, including coverage of cholinesterases, BACE-1, and other drug development targets

• Author : Jeffrey Cummings,Jefferson Kinney,Howard Fillit
• Publisher : Cambridge University Press
• Release Date : 2022-03-31
• Total pages : 575
• ISBN : 9781108838665
• File Size : 43,7 Mb
• Total Download : 968
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Download Alzheimer's Disease Drug Development in PDF, Epub, and Kindle

Provides a definitive overview of the complex ecosystem facilitating Alzheimer's Disease drug research and development. Demonstrates a drug's journey from in the lab, clinical trial testing, regulatory review, and marketing by pharmaceutical companies. Details the use of artificial intelligence, clinical trial management, and financing models.

• Author : Adeboye Adejare
• Publisher : Academic Press
• Release Date : 2016-09-20
• Total pages : 316
• ISBN : 9780128028117
• File Size : 35,5 Mb
• Total Download : 683
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Download Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders in PDF, Epub, and Kindle

Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders: Alzheimer’s Disease examines the drug discovery process for neurodegenerative diseases by focusing specifically on Alzheimer’s Disease and illustrating the paradigm necessary to ensure future research and treatment success. The book explores diagnosis, epidemiology, drug discovery strategies, current therapeutics, and much more to provide a holistic approach to the discovery, development, and treatment of Alzheimer’s Disease. Through its coverage of the latest research in targeted drug design, preclinical studies, and mouse and rat models, the book is a must-have resource for all pharmaceutical scientists, pharmacologists, neuroscientists, and clinical researchers working in this area. It illustrates why these drugs tend to fail at the clinical stage, and examines Alzheimer’s Disease within the overall context of improving the drug discovery process for the treatment of other neurodegenerative disorders. Provides a compilation of chemical considerations required in drug discovery for the treatment of neurodegenerative disorders Examines different classes of compounds currently being used in discovery and development stages Explores in vitro and in vivo models with respect to their ability to translate these models to human conditions Distills the most significant information across multiple areas of Alzheimer’s disease research to provide a single, comprehensive, and balanced resource

• Author : Xudong Huang
• Publisher : Unknown
• Release Date : 2020-12-31
• Total pages : 229
• ISBN : 0645001708
• File Size : 29,5 Mb
• Total Download : 596
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Download Alzheimer's Disease in PDF, Epub, and Kindle

PDF book entitled Alzheimer's Disease written by Xudong Huang and published by Unknown which was released on 2020-12-31 with total hardcover pages 229, the book become popular and critical acclaim.

• Author : Atta-ur-Rahman,M. Iqbal Choudhary
• Publisher : Bentham Science Publishers
• Release Date : 2013-09-10
• Total pages : 433
• ISBN : 9781608057672
• File Size : 54,8 Mb
• Total Download : 832
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Download Frontiers in CNS Drug Discovery in PDF, Epub, and Kindle

“Frontiers in CNS Drug Discovery” is an eBook series devoted to publishing the latest and the most important advances in Central Nervous System (CNS) drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. The eBook series should prove to be of interest to all pharmaceutical scientists involved in research in CNS drug design and discovery. Each volume is devoted to the major advances in CNS drug design and discovery. The eBook series is essential reading to all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field.

• Author : Ana Martínez
• Publisher : Royal Society of Chemistry
• Release Date : 2010
• Total pages : 343
• ISBN : 9781849730631
• File Size : 20,7 Mb
• Total Download : 886
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Download Emerging Drugs and Targets for Alzheimer's Disease in PDF, Epub, and Kindle

This volume describes the discovery and development history of the most promising drugs now in development for combating Alzheimer's disease.

• Author : Rona R. Ramsay,Giuseppe Di Giovanni
• Publisher : Frontiers Media SA
• Release Date : 2017-03-24
• Total pages : 206
• ISBN : 9782889451234
• File Size : 47,7 Mb
• Total Download : 684
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Download Structure-Based Drug Design for Diagnosis and Treatment of Neurological Diseases in PDF, Epub, and Kindle

European Cooperation in Science and Technology (COST) supports the collaboration of nationally-funded science and technology research through the creation of networks. COST is the longest-running European framework enhancing cooperation among researchers, engineers and scholars across Europe. The COST Action CM1103 “Structure-based drug design for diagnosis and treatment of neurological diseases: dissecting and modulating complex function in the monoaminergic systems of the brain” is a good example of the advances possible through interdisciplinary collaboration on difficult problems. COST Action CM1103 brought together 28 research groups from 18 countries to collaborate for four years on multi-target drug design for complex neuropathologies. The interdisciplinary expertise of the members is spans the range from computational enzymology to human studies, providing outstanding opportunities for the interdisciplinary development of trainees, and is reflected in the articles in this e-book. This Research Topic covers progress in multi-target drug design for the complex neuropathologies of the monoamine system that are apparent, for example, in Alzheimer’s disease. After a mini-review to introduce the topic of multi-target drug design, the other articles review the Research topic from their own perspective, two from computational approaches, three from medicinal chemistry, two from molecular pharmacology, and two from studies in whole brain. This multi-faceted approach describes new compounds, new methodology, and advances in the basic science of understanding the brain. This Ebook is based upon work from COST Action (CM1103 “Structure-based drug design for diagnosis and treatment of neurological diseases: dissecting and modulating complex function in the monoaminergic systems of the brain"), supported by COST (European Cooperation in Science and Technology). COST (European Cooperation in Science and Technology) is a pan-European intergovernmental framework. Its mission is to enable break-through scientific and technological developments leading to new concepts and products and thereby contribute to strengthening Europe’s research and innovation capacities. It allows researchers, engineers and scholars to jointly develop their own ideas and take new initiatives across all fields of science and technology, while promoting multi- and interdisciplinary approaches. COST aims at fostering a better integration of less research intensive countries to the knowledge hubs of the European Research Area. The COST Association, an International not-for-profit Association under Belgian Law, integrates all management, governing and administrative functions necessary for the operation of the framework. The COST Association has currently 36 Member Countries. www.cost.eu

• Author : David Borsook,Lino R. Beccera,Edward Bullmore,Richard J. Hargreaves
• Publisher : Springer Science & Business Media
• Release Date : 2010-03-10
• Total pages : 396
• ISBN : 9781441901347
• File Size : 32,6 Mb
• Total Download : 630
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Download Imaging in CNS Drug Discovery and Development in PDF, Epub, and Kindle

Drug development today needs to balance agility, speed, and risk in defining probability of success for molecules, mechanisms, and therapeutic concepts. New techniques such as fMRI promise to be part of a sequence that could transform drug development. Although numerous review articles exist that discuss the use of imaging in drug development, no one source is available that combines the various techniques and includes a discussion of disease mapping. Imaging in CNS Drug Discovery and Development, Implications for Disease and Therapy will serve to distill the most salient developments in the use of imaging in drug development and disease mapping. It will launch evolving concepts that integrate new imaging technologies and paradigms with molecular medicine and molecular profiling ("monics") as well as consider the ethical issues that arise as a result of disease or state diagnosis and the use of imaging in the public eye.

• Author : Tamas Bartfai,Graham V. Lees
• Publisher : Academic Press
• Release Date : 2013-05-18
• Total pages : 376
• ISBN : 9780124095199
• File Size : 29,7 Mb
• Total Download : 302
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Download The Future of Drug Discovery in PDF, Epub, and Kindle

The Future of Drug Discovery: Who decides which diseases to treat? provides a timely and detailed look at the efforts of the pharmaceutical industry and how they relate, or should relate, to societal needs. The authors posit that as a result of increasing risk aversion and accelerated savings in research and development, the industry is not developing drugs for increasingly prevalent diseases, such as Alzheimer’s disease, untreatable pain, antibiotics and more. This book carefully exposes the gap between the medicines and therapies we need and the current business path. By analyzing the situation and discussing prospects for the next decade, the The Future of Drug Discovery is a timely book for all those who care about the development needs for drugs for disease. Provides an in-depth, broad perspective on the crisis in drug industry Exposes the disconnect between what society needs and what the drug companies are working on Analyses and projects over 10 years into the future Explains what it means for scientists and society Determines what is needed to be done to make sure that the industry responds to society's needs, remains commercially attractive and answers the question as to who decides which diseases to treat

• Author : Michael Decker
• Publisher : Elsevier
• Release Date : 2017-04-05
• Total pages : 352
• ISBN : 9780081011188
• File Size : 19,5 Mb
• Total Download : 702
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Download Design of Hybrid Molecules for Drug Development in PDF, Epub, and Kindle

Design of Hybrid Molecules for Drug Development reviews the principles, advantages, and limitations involved with designing these groundbreaking compounds. Beginning with an introduction to hybrid molecule design and background as to their need, the book goes on to explore a range of important hybrids, with hybrids containing natural products, molecules containing NO- and H2S-donors, dual-acting compounds acting as receptor ligands and enzyme inhibitors, and the design of photoresponsive drugs all discussed. Drawing on practical case studies, the hybridization of molecules for development as treatments for a number of key diseases is then outlined, including the design of hybrids for Alzheimer's, cancer, and malaria. With its cutting-edge reviews of breaking developments in this exciting field, the book offers a novel approach for all those working in the design, development, and administration of drugs for a range of debilitating disorders. Highlights an approach unimpaired by the limitations of the classical search for lead structures - one of the core problems in modern drug development processes, making the content of high relevance for both academic and non-academic drug development processes Pulls together research and design techniques in a novel way to give researchers the best possible platform from which to review the approaches and techniques applied Compares the advantages and disadvantages of these compounds Includes the very latest developments, such as photoactivatable and photo-responsive drugs

• Author : Tamas Bartfai,Graham V. Lees
• Publisher : Academic Press
• Release Date : 2010-07-26
• Total pages : 329
• ISBN : 9780080919232
• File Size : 37,9 Mb
• Total Download : 776
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Download Drug Discovery in PDF, Epub, and Kindle

Everyone expects something from the drug industry. Physicians and patients, investors, regulators and administrators all have an active interest. Everyone wants to know what makes drugs ‘work’ medically and economically. Why are drugs so expensive? Is it the drug companies or investors who demand high profits? What governs the pharmacoeconomics? Why are so few diseases treatable? Drug Discovery opens the windows and doors of the industry telling the story of drug development by using real stories from inside the process. Co-written by Graham Lees and Tamas Bartfai who has been involved in the development of drugs taken by more that 20 million people every day Opens the windows and doors of the most regulated industry in the world, the pharmaceutical industry Tells the story of drug development by using real examples based on current research and events Provides an objective, lucid account of the successes and failures, shortcomings and constraints of the pharmaceutical and biotech industries Gives insights into the development of new drugs to combat multiple conditions including cancer and pain Balanced, unbiased account of how better to translate basic science into drug discovery

• Author : Institute of Medicine,Board on Health Sciences Policy,Forum on Drug Discovery, Development, and Translation,Robert Giffin,Sally Robinson,Theresa Wizemann
• Publisher : National Academies Press
• Release Date : 2009-03-17
• Total pages : 150
• ISBN : 9780309120883
• File Size : 47,5 Mb
• Total Download : 888
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Download Breakthrough Business Models in PDF, Epub, and Kindle

The process for developing new drug and biologic products is extraordinarily expensive and time-consuming. Although large pharmaceutical companies may be able to afford the cost of development because they can expect a large return on investment, organizations developing drugs to treat rare and neglected diseases are unable to rely on such returns. On June 23, 2008, the Institute of Medicine's Forum on Drug Discovery, Development, and Translation held a public workshop, "Breakthrough Business Models: Drug Development for Rare and Neglected Diseases and Individualized Therapies," which sought to explore new and innovative strategies for developing drugs for rare and neglected diseases.

• Author : Howard M. Fillit, MD,Alan W. O'Connell, PhD
• Publisher : Springer Publishing Company
• Release Date : 2002-01-03
• Total pages : 296
• ISBN : 0826115349
• File Size : 38,5 Mb
• Total Download : 749
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Download Drug Discovery and Development for Alzheimer's Disease, 2000 in PDF, Epub, and Kindle

This prestigious volume presents the findings of an international group of academic and biotechnological researchers. Topics range from early detection programs focusing on genetic factors, novel probes for detecting B-amyloid in the living brain, and the use of telephonic screening and MRI's to the diversity of therapeutic areas such as antioxidants, estrogen agonists and various anti-B-amyloid and anti-tangle approaches. The volume is still an indispensable resource for the psychogeriatrician, psychiatrist, clinical investigator, and neurobiologist, and a must for medical libraries.

• Author : Radha Mahendran,Suganya Jeyabaskar,Astral Gabriella Francis
• Publisher : Anchor Academic Publishing
• Release Date : 2017-05
• Total pages : 73
• ISBN : 9783960671381
• File Size : 38,9 Mb
• Total Download : 852
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Download Computational Approaches for Identifying Drugs Against Alzheimer's Disease in PDF, Epub, and Kindle

Alzheimer’s disease is the most common form of dementia which is incurable. Although some kinds of memory loss are normal during aging, these are not severe enough to interfere with the level of function. ß-Secretase is an important protease in the pathogenesis of Alzheimer’s disease. Some statine-based peptidomimetics show inhibitory activities to the ß-secretase. To explore the inhibitory mechanism, molecular docking and three-dimensional quantitative structure-activity relationship (3D-QSAR) studies on these analogues were performed. Quantitative structure-activity relationship (QSAR) modeling pertains to the construction of predictive models of biological activities as a function of structural and molecular information of a compound library. The concept of QSAR has typically been used for drug discovery and development and has gained wide applicability for correlating molecular information with not only biological activities but also with other physicochemical properties, which has therefore been termed quantitative structure-property relationship (QSPR). In this study, 3D QSAR and pharmacophore mapping studies were carried out using Accelrys Discovery Studio 2.1. The best nine drugs were selected from the 16 ligands and pharmacophore features were generated.

• Author : Arli Aditya Parikesit
• Publisher : BoD – Books on Demand
• Release Date : 2018-08-29
• Total pages : 132
• ISBN : 9781789236323
• File Size : 25,9 Mb
• Total Download : 834
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Download Molecular Insight of Drug Design in PDF, Epub, and Kindle

The approaches in drug design are mainly comprised of these three multidisciplinary sciences. First, Bioinformatics has successfully gather biological data in form of biomolecular sequences, in order to construct knowledge on drug and vaccine design. It is of considerable importance for drug designers to comprehend the utilization of bioinformatics tools for resolving their research questions. Second, Nanotechnology has made possible the design and delivery of the nano-based drug. Third, Pharmaceutical Chemistry made it possible to investigate the adsorption, distribution, metabolism, and toxicology of the drug candidates in a fine-grained resolution.

• Author : Institute of Medicine,Board on Health Sciences Policy,Forum on Drug Discovery, Development, and Translation
• Publisher : National Academies Press
• Release Date : 2009-07-20
• Total pages : 100
• ISBN : 0309142318
• File Size : 9,7 Mb
• Total Download : 856
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Download Accelerating the Development of Biomarkers for Drug Safety in PDF, Epub, and Kindle

Biomarkers can be defined as indicators of any biologic state, and they are central to the future of medicine. As the cost of developing drugs has risen in recent years, reducing the number of new drugs approved for use, biomarker development may be a way to cut costs, enhance safety, and provide a more focused and rational pathway to drug development. On October 24, 2008, the IOM's Forum on Drug Discovery, Development, and Translation held "Assessing and Accelerating Development of Biomarkers for Drug Safety," a one-day workshop, summarized in this volume, on the value of biomarkers in helping to determine drug safety during development.

• Author : Philip H. Elsinga
• Publisher : World Scientific
• Release Date : 2012
• Total pages : 799
• ISBN : 9789814317733
• File Size : 26,9 Mb
• Total Download : 159
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Download Trends on the Role of PET in Drug Development in PDF, Epub, and Kindle

Drug development is very expensive and a fight against time. PET offers possibilities to speed up this process by adding unique in vivo information on pharmacokinetics/dynamics of a drug at an early stage. This information can help decision makers to move the drug in the drug development process or to decide to stop further developments. This unique and complete book highlights the different ways PET can be used and describes the latest trends in the various disciplines within nuclear medicine to further improve methodologies and increase the number of tools to accelerate drug development. Various topics within tracer development, instrumentation, data analysis and many clinical and preclinical topics are described by leading scientists from industry and academia.

• Author : Norbert Handler
• Publisher : John Wiley & Sons
• Release Date : 2017-11-16
• Total pages : 536
• ISBN : 9783527674411
• File Size : 44,5 Mb
• Total Download : 306
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Download Drug Selectivity in PDF, Epub, and Kindle

The book "Drug Selectivity - An Evolving Concept in Medicinal Chemistry" provides a current overview and comprehensive compilation for medicinal chemists that discusses the effects of aiming for multiple targets on the entire drug development process. The result is a broad survey of current and future strategies for drug selectivity in medicinal chemistry with theoretical but also practical aspects. Different strategies are presented and evaluated, such as various design approaches, merged multiple ligands, discovery technologies and a broad range of successful examples of unselective drugs taken from all major disease areas. With its wide-ranging view of an emerging new paradigm in drug development, this handbook is of prime importance for every medicinal and pharmaceutical chemist.

• Author : Alexander Alex,C. John Harris,Dennis A. Smith
• Publisher : John Wiley & Sons
• Release Date : 2015-10-26
• Total pages : 352
• ISBN : 9781118914342
• File Size : 18,6 Mb
• Total Download : 659
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Download Attrition in the Pharmaceutical Industry in PDF, Epub, and Kindle

With a focus on case studies of R&D programs in a variety of disease areas, the book highlights fundamental productivity issues the pharmaceutical industry has been facing and explores potential ways of improving research effectiveness and efficiency. • Takes a comprehensive and holistic approach to the problems and potential solutions to drug compound attrition • Tackles a problem that adds billions of dollars to drug development programs and health care costs • Guides discovery and development scientists through R&D stages, teaching requirements and reasons why drugs can fail • Discusses potential ways forward utilizing new approaches and opportunities to reduce attrition

• Author : Atta-ur-Rahman
• Publisher : Bentham Science Publishers
• Release Date : 2014-11-24
• Total pages : 246
• ISBN : 9781608058709
• File Size : 13,5 Mb
• Total Download : 849
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Download Frontiers in Clinical Drug Research - Alzheimer Disorders in PDF, Epub, and Kindle

Frontiers in Clinical Drug Research - Alzheimer Disorders is an e-Book series concerned with Alzheimer's disease (AD) that causes dementia, or loss of brain function. The disease affects the parts of the brain that deal with memory, thought, and language. Chapters in each volume focus on (Alzheimer Disorders) drug research with special emphasis on clinical trials, research on drugs in advanced stages of development and cure for Alzheimer’s disease and related disorders. Frontiers in Clinical Drug Research - Alzheimer Disorders will be of particular interest to readers interested in drug therapy of this specific neurodegenerative condition and related brain disorders as the series provides relevant reviews written by experts in field of Alzheimer’s Disease research.

• Author : Cesare Mancuso,Silvana Gaetani
• Publisher : Frontiers Media SA
• Release Date : 2015-03-03
• Total pages : 101
• ISBN : 9782889194339
• File Size : 46,6 Mb
• Total Download : 291
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Download Preclinical and clinical issues in Alzheimer’s disease drug research and development in PDF, Epub, and Kindle

Alzheimer’s disease (AD) is a chronic neurodegenerative disorder characterized by progressive cognitive dysfunction and memory loss, inability to perform the activities of daily living and mood disorders. According to the so-called “amyloid cascade hypothesis”, amyloid-ß- peptide (Aß), produced by beta- and gamma- secretase-mediated cleavages of the amyloid precursor protein (APP), plays a pivotal role in the pathogenesis of AD. Aß was also shown to contribute to AD pathology by stimulating the hyperphosphorylation of tau which is responsible for the formation of neurofibrillary tangles. However, the “amyloid cascade hypothesis” was challenged by other theories which lend support to the idea that Aß is not causative but can be considered as an “innocent bystander” in AD. Although preclinical research generated impressive lines of evidence about the several intracellular mechanism(s) whose impairment leads to the onset and progression of AD, clinical research aimed at the development of new drugs capable of preventing or delaying the onset of neuronal damage in AD patients has produced limited results. The drugs currently available for the treatment of AD are acetylcholinesterase inhibitors (AChEI) and the NMDA glutamate receptor antagonist memantine. The AChEI increase acetylcholine levels in the synaptic cleft, which are reduced because of the progressive damage of cholinergic neurons in cognitive brain areas (e.g. amygdala, hippocampus, and frontal cortex), whereas memantine is used to prevent/reduce calcium-dependent excitotoxic neuronal cell death. Both classes of drugs have been shown to improve symptoms related to cognitive decline, but their effects are confined largely to patients with mild to moderate AD, in particular during the first year or so of treatment. An alternative to this symptomatic treatments involves the use of drugs that intervene in the pathogenesis of the disease. Recently, monoclonal antibodies against Aß were proposed as novel agents capable to remove Aß from the brain thus preventing neuronal damage. The research topic focuses on the preclinical and clinical evidence about the several factors that contribute to the pathogenesis of AD as well as the potential therapeutic role of new classes of drugs still under preclinical or clinical development.