Dna Interactions With Drugs And Other Ligands

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• Author : Anonim
• Publisher : Elsevier
• Release Date : 2001-07-31
• Total pages : 705
• ISBN : 9780080496900
• File Size : 22,6 Mb
• Total Download : 584
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Download Drug-Nucleic Acid Interactions in PDF, Epub, and Kindle

This volume consolidates the key methods for studying ligand-nucleic acid interactions into a convenient source. Techniques that are examined range from biophysical and chemical approaches to methods rooted in molecular and cell biology.

• Author : W. Guschlbauer
• Publisher : Springer Science & Business Media
• Release Date : 2013-06-29
• Total pages : 290
• ISBN : 9781468453836
• File Size : 14,5 Mb
• Total Download : 138
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Download DNA-Ligand Interactions in PDF, Epub, and Kindle

This volume contains the texts of the nineteen lectures presented at the NATO-ASI - FEBS Course on "DNA - ligand interactions: from drugs to proteins." The Advanced Study Institute (ASIl was held from August 30th to September 11th. 1986 in the Abbey of Fontevraud (France). The ASI was attended by 112 participants from a wide scientific horizon and from twentyone different countries. It was in some way a follow-up of the ASI held in Maratea. Italy in May 1981 and which was published in the NATO ASI Life Science series as volume 45. While much has been learned about the way the cellular machinery maintains and transmits the genetic heritage. as well as how these processes are regulated. little is Known about how the interactions between the various partners involved are taKing place. The interactions of drugs and proteins with nucleic acids are of evident importance in the understanding of these problems. The spectacular advances in recombinant DNA technology and the increased sophistication of biophysical techniques. in particular >:-ray diffraction and nuclear magnetic resonance. have created a scientific environment which is highly promising for the future of research in molecular biology. These advances permH the serious hope that biology on the molecular level may become a r-eality. Some of the contributions at the ASI presented the most recent advances in this e>:citing field.

• Author : Marcio Santos Rocha
• Publisher : Elsevier
• Release Date : 2023-03-15
• Total pages : 268
• ISBN : 9780323993852
• File Size : 22,9 Mb
• Total Download : 152
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Download DNA Interactions with Drugs and Other Small Ligands in PDF, Epub, and Kindle

DNA Interactions With Drugs and Other Small Ligands: Single Molecule Approaches and Techniques provides the reader with all the main information, a "state-of-the-art" of sorts and an overall review of the field. There is no other book currently available that covers all these subjects together. On the contrary, the different subjects that are developed in this book are currently scattered in journal articles and other books. Presents a review of the fundamental knowledge, techniques and relevant information surrounding the field of DNA interactions with drugs and other ligands Provides a resource like no other book available Includes valuable information from the author who is a highly experienced researcher in the field

• Author : Keith R. Fox
• Publisher : Springer Science & Business Media
• Release Date : 1997-10-07
• Total pages : 296
• ISBN : UOM:39015040372446
• File Size : 31,6 Mb
• Total Download : 543
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Download Drug'DNA Interaction Protocols in PDF, Epub, and Kindle

A collection of useful molecular techniques to illuminate and explore the interaction of drugs and ligands with DNA. These easily reproducible methods involve sequence recognition properties, as well as the physical approaches for measuring both the strength of interaction and the mode of drug binding to DNA. The interactions are also examined from a cellular perspective and for their usefulness in the design of new therapeutic agents. The powerful techniques detailed here will be particularly useful in elucidating the action of existing therapeutic agents, as well as in the design of new anti-cancer drugs with improved action and reduced toxicity.

• Author : A. Pullman,Joshua Jortner
• Publisher : Springer Science & Business Media
• Release Date : 2012-12-06
• Total pages : 603
• ISBN : 9789401137287
• File Size : 23,8 Mb
• Total Download : 954
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Download Molecular Basis of Specificity in Nucleic Acid-Drug Interactions in PDF, Epub, and Kindle

One of the central problems in the study of the mechanism of DNA-ligand interactions is the existence and nature of sequence specificity with respect to the base pairs of DNA. The presence of such a specificity could be of particular significance because it might possibly mean the involvement of specific genes in the effectiveness of the different drugs. The elucidation of the factors responsible for the specificity could then be important for the development of compounds susceptible to contribute to the control of gene expression and also to the development of rationally conceived, improved new generations of effective and specific chemotherapeutic agents. Important recent achievements, experimental and theoretical, in the analysis of such sequence specificities open prospects for possible rapid progress in this field. The 23rd Jerusalem symposium was devoted to the exploration of these recent achievements in relation to many types of ligand, with special emphasis on antitumor drugs. All major types of interaction, intercalation, groove binding, covalent linking, coordination, have been considered. So was also the effect of the interaction on the structure and properties of the nucleic acids and the relationship between the interaction and biological or pharmacological activities. We feel that this Volume presents a relatively complete up-to-date account of the state of the art in this important field of research.

• Author : Meni Wanunu,Yitzhak Tor
• Publisher : CRC Press
• Release Date : 2016-04-19
• Total pages : 392
• ISBN : 9781439839744
• File Size : 27,5 Mb
• Total Download : 111
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Download Methods for Studying Nucleic Acid/Drug Interactions in PDF, Epub, and Kindle

Since most therapeutic efforts have been predominantly focused on pharmaceuticals that target proteins, there is an unmet need to develop drugs that intercept cellular pathways that critically involve nucleic acids. Progress in the discovery of nucleic acid binding drugs naturally relies on the availability of analytical methods that assess the efficacy and nature of interactions between nucleic acids and their putative ligands. This progress can benefit tremendously from new methods that probe nucleic acid/ligand interactions both rapidly and quantitatively. A variety of novel methods for these studies have emerged in recent years, and Methods for Studying DNA/Drug Interactions highlights new and non-conventional methods for exploring nucleic acid/ligand interactions. Designed to present drug-developing companies with a survey of possible future techniques, the book compares their drawbacks and advantages with respect to commonly used tools. Perhaps more importantly, this book was written to inspire young scientists to continue to advance these methods into fruition, especially in light of current capabilities for assay miniaturization and enhanced sensitivity using microfluidics and nanomaterials.

• Author : Neville R. Kallenbach
• Publisher : Unknown
• Release Date : 1990
• Total pages : 236
• ISBN : UOM:39015017963151
• File Size : 37,9 Mb
• Total Download : 913
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Download Chemistry & Physics of DNA-ligand Interactions in PDF, Epub, and Kindle

PDF book entitled Chemistry & Physics of DNA-ligand Interactions written by Neville R. Kallenbach and published by Unknown which was released on 1990 with total hardcover pages 236, the book become popular and critical acclaim.

• Author : Keith R. Fox
• Publisher : Humana Press
• Release Date : 2012-03-07
• Total pages : 0
• ISBN : 1617796743
• File Size : 23,7 Mb
• Total Download : 980
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Download Drug-DNA Interaction Protocols in PDF, Epub, and Kindle

DNA has been known to be the cellular target for many cytotoxic anticancer agents for several decades. The knowledge of its structure in atomic detail and the ease with which DNA fragments (both synthetic oligonucleotides and natural sequences) can be prepared and manipulated has aided the design of compounds that bind to it with improved sel- tivity. On the basis of this information, new generations of sequence reading compounds (including triplex forming oligonucleotides and minor groove binding ligands) have been prepared, which have the potential for targeting specifc DNA sequences as anti-gene agents. Within the last 10 years, it has also become apparent that the familiar DNA duplex is not the only structure that can be targeted by DNA-binding ligands and there has been increased interest in triplex and quadruplex structures as drug targets, as well as protein- DNA complexes, such as those with nucleosomes or topoisomerases. Each of these advances has required the availability and development of an arsenal of techniques for probing the interactions in both qualitative and quantitative terms. This v- ume of Methods in Molecular Biology brings together several techniques that are currently useful for examining these interactions. Some of these are updates on ones that were included in the earlier volume (Methods in Molecular Biology 90), published 12 years ago, while others are new.

• Author : Michael J. Clarke,Peter J. Sadler
• Publisher : Springer Science & Business Media
• Release Date : 2013-03-14
• Total pages : 200
• ISBN : 9783662038154
• File Size : 20,6 Mb
• Total Download : 859
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Download Metallopharmaceuticals I in PDF, Epub, and Kindle

Each volume provides the reader, whether engaged in chemistry, biochemistry, biology or molecular medicine, with a comprehensive summary and critical overview of a topic of great current interest written by leading international experts.

• Author : Michael J. Clarke,Peter J. Sadler
• Publisher : Springer Science & Business Media
• Release Date : 1999-05-21
• Total pages : 218
• ISBN : 3540648895
• File Size : 14,9 Mb
• Total Download : 150
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Download Metallopharmaceuticals I in PDF, Epub, and Kindle

Each volume provides the reader, whether engaged in chemistry, biochemistry, biology or molecular medicine, with a comprehensive summary and critical overview of a topic of great current interest written by leading international experts.

• Author : Kazuo Nakamoto,Masamichi Tsuboi,Gary D. Strahan
• Publisher : John Wiley & Sons
• Release Date : 2008-09-08
• Total pages : 475
• ISBN : 9780470369166
• File Size : 44,6 Mb
• Total Download : 886
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Download Drug-DNA Interactions in PDF, Epub, and Kindle

Learn vital information about drug-DNA interactions from Drug-DNA Interactions: Structures and Spectra, the only comprehensive book written about this topic. Understand the types of structural and bonding information that can be obtained using specific physico-chemical methods and discover how to design new drugs that are more effective than current treatments and have fewer side effects. Find detailed information about X-ray crystallography, NMR spectroscopy, molecular modeling, and optical spectroscopy such as UV-Visible absorption, fluorescence, circular dichroism (CD), flow linear dichroism (FLD), infrared (IR) and Raman spectroscopy.

• Author : Anonim
• Publisher : Unknown
• Release Date : 1986
• Total pages : 290
• ISBN : OCLC:748995426
• File Size : 9,7 Mb
• Total Download : 952
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Download NATO ASI/FEBS Course on DNA-LIGAND Interactions in PDF, Epub, and Kindle

PDF book entitled NATO ASI/FEBS Course on DNA-LIGAND Interactions written by Anonim and published by Unknown which was released on 1986 with total hardcover pages 290, the book become popular and critical acclaim.

• Author : J.B. Chaires
• Publisher : Elsevier
• Release Date : 1996-07-09
• Total pages : 246
• ISBN : 0080526144
• File Size : 23,9 Mb
• Total Download : 867
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Download Advances in DNA Sequence-specific Agents in PDF, Epub, and Kindle

DNA sequence specificity is a sub-specialty in the general area of molecular recognition. This area includes macromolecular-molecular interactions (e.g., protein-DNA), oligomer-DNA interacitons (e.g., triple strands), and ligand-DNA interactions (e.g., drug-DNA). It is this latter group of DNA sequence specificity interactions that is the subject of Volumes 1 and 2 of Advances in DNA Sequence Specific Agents. As was the case for Volume 1, Part A also covers methodology, but in Volume 2 we include calorimetric titrations, molecular modeling, X-ray crystallographic and NMR structural studies, and transcriptional assays. Part B also follows the same format as Volume 1 and describes the sequence specificities and covalent and noncovalent interactions of small ligands with DNA. This volume is aimed in general at scientists who have an interest in deciphering the molecular mechanisms for sequence recognition of DNA. The methods have general applicability to small molecules as well as oligomers and proteins, while the examples provide general principles involved in sequence recognition.

• Author : Gromiha M Michael
• Publisher : World Scientific
• Release Date : 2020-03-05
• Total pages : 424
• ISBN : 9789811211881
• File Size : 12,7 Mb
• Total Download : 151
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Download Protein Interactions: Computational Methods, Analysis And Applications in PDF, Epub, and Kindle

PDF book entitled Protein Interactions: Computational Methods, Analysis And Applications written by Gromiha M Michael and published by World Scientific which was released on 2020-03-05 with total hardcover pages 424, the book become popular and critical acclaim.

• Author : Iain J. McEwan,Raj Kumar
• Publisher : Springer
• Release Date : 2015-08-20
• Total pages : 236
• ISBN : 9783319187297
• File Size : 46,5 Mb
• Total Download : 404
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Download Nuclear Receptors: From Structure to the Clinic in PDF, Epub, and Kindle

Nuclear Receptors focuses on the structural analysis of nuclear receptors from the initial work using isolated protein domains to the more recent exciting developments investigating the conformational shape of full-length receptor complexes. The book also reviews the structure of key nuclear receptor co-regulatory proteins. It brings together, for the first time, a comprehensive review of nuclear receptor structure and the importance of receptor conformation underpinning allosteric regulation by different ligands (hormone, drugs, DNA response elements, protein-protein interactions) and receptor activity. The nuclear receptor superfamily, including receptors for steroid hormones and non-steroid ligands, are pivotal to normal physiology, regulating processes as diverse as reproduction, metabolism, the immune system and brain development. The first members of the family were cloned over 25 years ago, which heralded in the idea of a superfamily of intracellular receptor proteins that bound small molecule ligands: classical steroid hormones, vitamins, fatty acids and other products of metabolism. These signals are then transmitted through multiprotein receptor-DNA complexes, leading to the regulation of target genes, often in a cell-selective manner. The cloning of the receptor cDNAs also ushered in an era of unparalleled analysis of the mechanisms of action of these ligand-activated transcription factors. ​

• Author : Carolyn Leigh Mazzitelli
• Publisher : Unknown
• Release Date : 2007
• Total pages : 390
• ISBN : OCLC:173520891
• File Size : 37,5 Mb
• Total Download : 562
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Download Electrospray Ionization Tandem Mass Spectrometric Techniques for the Analysis of Drug/DNa Complexes in PDF, Epub, and Kindle

Many anticancer and antibacterial therapies are based on the interaction of small molecule drugs with DNA. Increasing interest in the development of DNA-interactive agents has fostered the need for sensitive and versatile analytical techniques that are capable of characterizing the DNA/ligand interactions and are compatible with librarybased screening methods. Electrospray ionization mass spectrometry (ESI-MS) has emerged as a useful technique for the analysis of non-covalent complexes formed between DNA and small molecules due to its low sample consumption and fast analysis time. The work presented in this dissertation is aimed at exploring, optimizing, and validating ESI-MS methods for characterizing DNA-ligand interactions. ESI-MS is first used to assess the binding of threading bis-intercalators to duplexes containing different sequences to determine high affinity binding sites of the ligands. Preliminary DNAse footprinting experiments identified possible specific binding sites of the ligands and ESI-MS experiments revealed that the ligands bound to DNA duplexes containing the respective specific binding sequences. The metal-mediated binding of benzoxazole ligands with different side chains to duplex DNA is also examined. Cu2 and Ni were found to promote the most dramatic increase in ligand binding, and ligands exhibiting the most dramatic metal-mediated or metal-enhanced binding were also determined to be the most cytotoxic. The quadruplex DNA binding selectivity of perylene diimides is evaluated by screening the binding of the ligands to quadruplex, duplex and single strand DNA by ESI-MS. Three ligands, one containing basic side chains, one containing anionic sidechains, and one benzannulated compound were determined to be the most-quadruplex selective. The ESI-MS results correlated well with spectroscopic experiments. The relative gas-phase stabilities of different quadruplex DNA structures were investigated using molecular dynamics simulations and ESI-MS. The stabilities from the E[subscript 1/2] values generally paralleled the RMSD and relative free energies of the quadruplexes based on MD energy analysis. Finally an ESI-MS technique employing the KMnO4 reaction with DNA to determine conformational changes to the duplex structure upon ligand binding is detailed. Thymines in most intercalator/duplex complexes are more susceptible to oxidation by KMnO4 than those in duplex DNA. CAD and IRMPD experiments are used to identify the site of oxidation.

• Author : Giovanna Scapin,Disha Patel,Eddy Arnold
• Publisher : Springer
• Release Date : 2015-02-27
• Total pages : 240
• ISBN : 9789401797191
• File Size : 40,9 Mb
• Total Download : 635
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Download Multifaceted Roles of Crystallography in Modern Drug Discovery in PDF, Epub, and Kindle

The present work offers a snapshot of the state-of-the-art of crystallographic, analytical, and computational methods used in modern drug design and development. Topics discussed include: drug design against complex systems (membrane proteins, cell surface receptors, epigenetic targets, and ribosomes); modulation of protein-protein interactions; the impact of small molecule structures in drug discovery and the application of concepts such as molecular geometry, conformation, and flexibility to drug design; methodologies for understanding and characterizing protein states and protein-ligand interactions during the drug design process; and monoclonal antibody therapies. These methods are illustrated through their application to problems of medical and biological significance, such as viral and bacterial infections, diabetes, autoimmune disease, and CNS diseases. As approaches to drug discovery have changed over time, so have the methodologies used to solve the varied, new, and difficult problems encountered in drug discovery. In recent years we have seen great progress in the fields of genetics, biology, chemistry, and medicine, but there are still many unmet medical needs, from bacterial infections to cancer to chronic maladies, that require novel, different, or better therapies. This work will be of interest to researchers and policy makers interested in the latest developments in drug design.

• Author : Martine Demeunynck,Christian Bailly,W. David Wilson
• Publisher : John Wiley & Sons
• Release Date : 2006-03-06
• Total pages : 754
• ISBN : 9783527605668
• File Size : 51,6 Mb
• Total Download : 624
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Download Small Molecule DNA and RNA Binders in PDF, Epub, and Kindle

The development of molecules that selectively bind to nucleic acids has provided many details about DNA and RNA recognition. The range of such substances, such as metal complexes, peptides, oligonucleotides and a wide array of synthetic organic compounds, is as manifold as the functions of nucleic acids. Nucleic acid recognition sequences are often found in the major or minor groove of a double strand, while other typical interactions include intercalation between base pairs or the formation of triple or quadruple helices. One example of a binding mode that has recently been proposed is end stacking on such complex structures as the telomere tetraplex. In this comprehensive book, internationally recognized experts describe in detail the important aspects of nucleic acid binding, and in so doing present impressive approaches to drug design. Since typical substances may be created naturally or synthetically, emphasis is placed on natural products, chemical synthesis, the use of combinatorial libraries, and structural characterization. The whole is rounded off by contributions on molecular modeling, as well as investigations into the way in which any given drug interacts with its nucleic acid recognition site.

• Author : Bernhard Lippert
• Publisher : John Wiley & Sons
• Release Date : 1999
• Total pages : 628
• ISBN : 3906390209
• File Size : 46,8 Mb
• Total Download : 382
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Download Cisplatin in PDF, Epub, and Kindle

30 years after its discovery as an antitumor agent, cisplatin represents today one of the most successful drugs in chemotherapy. This book is intended to reminisce this event, to take inventory, and to point out new lines of development in this field. Divided in 6 sections and 22 chapters, the book provides an up-to-date account on topics such as - the chemistry and biochemistry of cisplatin, - the clinical status of Pt anticancer drugs, - the impact of cisplatin on inorganic and coordination chemistry, - new developments in drug design, testing and delivery. It also includes a chapter describing the historical development of the discovery of cisplatin. The ultimate question - How does cisplatin kill a cell? - is yet to be answered, but there are now new links suggesting how Pt binding to DNA may trigger a cascade of cellular reactions that eventually result in apoptosis. p53 and a series of damage recognition proteins of the HMG-domain family appear to be involved. The book addresses the problem of mutagenicity of Pt drugs and raises the question of the possible relevance of the minor DNA adducts, e.g. of interstrand cross-links, and the possible use of trans-(NH3)2Pt(II)-modified oligonucleotides in antisense and antigene strategies. Our present understanding of reactions of cisplatin with DNA is based upon numerous model studies (from isolated model nucleobases to short DNA fragments) and application of a large body of spectroscopic and other physico-chemical techniques. Thanks to these efforts there is presently no other metal ion whose reactions with nucleic acids are better understood than Pt. In a series of chapters, basic studies on the interactions of Pt electrophiles with nucleobases, oligonucleotides, DNA, amino acids, peptides and proteins are reported, which use, among others, sophisticated NMR techniques or X-ray crystallography, to get remarkable understanding of details on such reactions. Reactivity of cisplatin, once bound to DNA and formerly believed to be inert enough to stay, is an emerging phenomenon. It has (not yet) widely been studied but is potentially extremely important. Medicinal bioinorganic chemistry - the role of metal compounds in medicine - has received an enormous boost from cisplatin, and so has bioinorganic chemistry as a whole. There is hardly a better example than cisplatin to demonstrate what bioinorganic chemistry is all about: The marriage between classic inorganic (coordination) chemistry and the other life sciences - medicine, pharmacy, biology, biochemistry. Cisplatin has left its mark also on areas that are generally considered largely inorganic. The subject of mixed-valance Pt compounds is an example: From the sleeping beauty it made its way to the headlines of scientific journals, thanks to a class of novel Pt antitumor agents, the so-called "platinum pyrimidine blues". In the aftermath diplatinum (III) compounds were recognized and studies in large numbers, and now an organometalic chemistry of these diplatinum (III) species is beginning to emerge. The final section of the book is concerned with new developments such as novel di- and trinuclear Pt(II) drugs with DNA binding properties different from those of cisplatin, with orally active Pt(IV) drugs which are presently in clinical studies, and with attempts to modify combinatorial chemistry in such a way that it may become applicable to fast screening of Pt antitumor drugs. The potential of including computational methods in solving questions of Pt-DNA interactions is critically dealt with in the concluding chapter.

• Author : Ana Cecília A. Roque
• Publisher : Methods in Molecular Biology
• Release Date : 2010-03-23
• Total pages : 316
• ISBN : STANFORD:36105211741447
• File Size : 48,9 Mb
• Total Download : 741
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Download Ligand-Macromolecular Interactions in Drug Discovery in PDF, Epub, and Kindle

In this authoritative book, experts in the field highlight the main principles and methodologies currently utilized in the study of molecular interactions between compounds. This is as an ideal guide to those striving to further our knowledge of medicines.

• Author : Laurence H. Hurley,J. B. Chaires
• Publisher : Elsevier Science Limited
• Release Date : 1996
• Total pages : 246
• ISBN : 9781559381666
• File Size : 33,8 Mb
• Total Download : 194
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Download Advances in DNA Sequence Specific Agents in PDF, Epub, and Kindle

DNA sequence specificity is a sub-specialty in the general area of molecular recognition. This area includes macromolecular-molecular interactions (e.g., protein-DNA), oligomer-DNA interacitons (e.g., triple strands), and ligand-DNA interactions (e.g., drug-DNA). It is this latter group of DNA sequence specificity interactions that is the subject of Volumes 1 and 2 of Advances in DNA Sequence Specific Agents. As was the case for Volume 1, Part A also covers methodology, but in Volume 2 we include calorimetric titrations, molecular modeling, X-ray crystallographic and NMR structural studies, and transcriptional assays. Part B also follows the same format as Volume 1 and describes the sequence specificities and covalent and noncovalent interactions of small ligands with DNA. This volume is aimed in general at scientists who have an interest in deciphering the molecular mechanisms for sequence recognition of DNA. The methods have general applicability to small molecules as well as oligomers and proteins, while the examples provide general principles involved in sequence recognition.