Computational Methods In Drug Discovery And Repurposing For Cancer Therapy

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• Author : Ganji Purnachandra Nagaraju,Venkatesan Amouda,Ampasala Dinakara Rao
• Publisher : Elsevier
• Release Date : 2023-03
• Total pages : 458
• ISBN : 9780443152801
• File Size : 45,5 Mb
• Total Download : 902
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Download Computational Methods in Drug Discovery and Repurposing for Cancer Therapy in PDF, Epub, and Kindle

Computational Methods in Drug Discovery and Repurposing for Cancer Therapy provides knowledge about ongoing research as well as computational approaches for drug discovery and repurposing for cancer therapy. The book also provides detailed descriptions about target molecules, pathways, and their inhibitors for easy understanding and applicability. The book discusses tools and techniques such as integrated bioinformatics approaches, systems biology tools, molecular docking, computational chemistry, artificial intelligence, machine learning, structure-based virtual screening, biomarkers, and transcriptome; those are discussed in the context of different cancer types, such as colon, pancreatic, glioblastoma, endometrial, and retinoblastoma, among others. This book is a valuable resource for researchers, students, and members of the biomedical and medical fields who want to learn more about the use of computational modeling to better tailor the treatment for cancer patients.

• Author : Kenneth K.W. To,William C.S. Cho
• Publisher : Academic Press
• Release Date : 2020-07-29
• Total pages : 458
• ISBN : 9780128199039
• File Size : 51,7 Mb
• Total Download : 365
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Download Drug Repurposing in Cancer Therapy in PDF, Epub, and Kindle

Drug Repurposing in Cancer Therapy: Approaches and Applications provides comprehensive and updated information from experts in basic science research and clinical practice on how existing drugs can be repurposed for cancer treatment. The book summarizes successful stories that may assist researchers in the field to better design their studies for new repurposing projects. Sections discuss specific topics such as in silico prediction and high throughput screening of repurposed drugs, drug repurposing for overcoming chemoresistance and eradicating cancer stem cells, and clinical investigation on combination of repurposed drug and anticancer therapy. Cancer researchers, oncologists, pharmacologists and several members of biomedical field who are interested in learning more about the use of existing drugs for different purposes in cancer therapy will find this to be a valuable resource. Presents a systematic and up-to-date collection of the research underpinning the various drug repurposing approaches for a quick, but in-depth understanding on current trends in drug repurposing research Brings better understanding of the drug repurposing process in a holistic way, combining both basic and clinical sciences Encompasses a collection of successful stories of drug repurposing for cancer therapy in different cancer types

• Author : Ganji Purnachandra Nagaraju,Venkatesan Amouda,Ampasala Dinakara Rao
• Publisher : Elsevier
• Release Date : 2023-03-22
• Total pages : 460
• ISBN : 9780443152818
• File Size : 28,8 Mb
• Total Download : 962
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Download Computational Methods in Drug Discovery and Repurposing for Cancer Therapy in PDF, Epub, and Kindle

Computational Methods in Drug Discovery and Repurposing for Cancer Therapy provides knowledge about ongoing research as well as computational approaches for drug discovery and repurposing for cancer therapy. The book also provides detailed descriptions about target molecules, pathways, and their inhibitors for easy understanding and applicability. The book discusses tools and techniques such as integrated bioinformatics approaches, systems biology tools, molecular docking, computational chemistry, artificial intelligence, machine learning, structure-based virtual screening, biomarkers, and transcriptome; those are discussed in the context of different cancer types, such as colon, pancreatic, glioblastoma, endometrial, and retinoblastoma, among others. This book is a valuable resource for researchers, students, and members of the biomedical and medical fields who want to learn more about the use of computational modeling to better tailor the treatment for cancer patients. Discusses in silico remodeling of effective phytochemical compounds for discovering improved anticancer agents for substantial/significant cancer therapy Covers potential tools of bioinformatics that are applied toward discovering new targets by drug repurposing and strategies to cure different types of cancers Demonstrates the significance of computational and artificial intelligence approaches in anticancer drug discovery Explores how these various advances can be integrated into a precision and personalized medicine approach that can eventually enhance patient care

• Author : Michael J. Barratt,Donald E. Frail
• Publisher : John Wiley & Sons
• Release Date : 2012-05-29
• Total pages : 499
• ISBN : 9780470878279
• File Size : 15,9 Mb
• Total Download : 439
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Download Drug Repositioning in PDF, Epub, and Kindle

The how's and why's of successful drug repositioning Drug repositioning, also known as drug reprofiling or repurposing, has become an increasingly important part of the drug development process. This book examines the business, technical, scientific, and operational challenges and opportunities that drug repositioning offers. Readers will learn how to perform the latest experimental and computational methods that support drug repositioning, and detailed case studies throughout the book demonstrate how these methods fit within the context of a comprehensive drug repositioning strategy. Drug Repositioning is divided into three parts: Part 1, Drug Repositioning: Business Case, Strategies, and Operational Considerations, examines the medical and commercial drivers underpinning the quest to reposition existing drugs, guiding readers through the key strategic, technical, operational, and regulatory decisions needed for successful drug repositioning programs. Part 2, Application of Technology Platforms to Uncover New Indications and Repurpose Existing Drugs, sets forth computational-based strategies, tools, and databases that have been designed for repositioning studies, screening approaches, including combinations of existing drugs, and a look at the development of chemically modified analogs of approved agents. Part 3, Academic and Non-Profit Initiatives & the Role of Alliances in the Drug Repositioning Industry, explores current investigations for repositioning drugs to treat rare and neglected diseases, which are frequently overlooked by for-profit pharmaceutical companies due to their lack of commercial return. The book's appendix provides valuable resources for drug repositioning researchers, including information on drug repositioning and reformulation companies, databases, government resources and organizations, regulatory agencies, and drug repositioning initiatives from academia and non-profits. With this book as their guide, students and pharmaceutical researchers can learn how to use drug repositioning techniques to extend the lifespan and applications of existing drugs as well as maximize the return on investment in drug research and development.

• Author : Farid A. Badria
• Publisher : BoD – Books on Demand
• Release Date : 2020-12-02
• Total pages : 236
• ISBN : 9781839685200
• File Size : 19,9 Mb
• Total Download : 815
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Download Drug Repurposing in PDF, Epub, and Kindle

Drug repurposing or drug repositioning is a new approach to presenting new indications for common commercial and clinically approved existing drugs. For example, chloroquine, an old antimalarial drug, showed promising results for treating COVID-19, interfering with MDR in several types of cancer, and chemosensitizing human leukemic cells.This book focuses on the hypothesis, risk/benefits, and economic impacts of drug repurposing on drug discovery in dermatology, infectious diseases, neurological disorders, cancer, and orphan diseases. It brings together up-to-date research to provide readers with an informative, illustrative, and easy-to-read book useful for students, clinicians, and the pharmaceutical industry.

• Author : Kunal Roy
• Publisher : Academic Press
• Release Date : 2019-02-12
• Total pages : 886
• ISBN : 9780128163771
• File Size : 25,6 Mb
• Total Download : 915
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Download In Silico Drug Design in PDF, Epub, and Kindle

In Silico Drug Design: Repurposing Techniques and Methodologies explores the application of computational tools that can be utilized for this approach. The book covers theoretical background and methodologies of chem-bioinformatic techniques and network modeling and discusses the various applied strategies to systematically retrieve, integrate and analyze datasets from diverse sources. Other topics include in silico drug design methods, computational workflows for drug repurposing, and network-based in silico screening for drug efficacy. With contributions from experts in the field and the inclusion of practical case studies, this book gives scientists, researchers and R&D professionals in the pharmaceutical industry valuable insights into drug design. Discusses the theoretical background and methodologies of useful techniques of cheminformatics and bioinformatics that can be applied for drug repurposing Offers case studies relating to the in silico modeling of FDA-approved drugs for the discovery of antifungal, anticancer, antiplatelet agents, and for drug therapies against diseases Covers tools and databases that can be utilized to facilitate in silico methods for drug repurposing

• Author : John Cassidy,Belle Taylor
• Publisher : BoD – Books on Demand
• Release Date : 2020-09-09
• Total pages : 194
• ISBN : 9781789846898
• File Size : 22,9 Mb
• Total Download : 804
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Download Artificial Intelligence in Oncology Drug Discovery and Development in PDF, Epub, and Kindle

There exists a profound conflict at the heart of oncology drug development. The efficiency of the drug development process is falling, leading to higher costs per approved drug, at the same time personalised medicine is limiting the target market of each new medicine. Even as the global economic burden of cancer increases, the current paradigm in drug development is unsustainable. In this book, we discuss the development of techniques in machine learning for improving the efficiency of oncology drug development and delivering cost-effective precision treatment. We consider how to structure data for drug repurposing and target identification, how to improve clinical trials and how patients may view artificial intelligence.

• Author : Alma D. Campos-Parra,Carlos Pérez-Plasencia,Teresita Padilla-Benavides,Eduardo López-Urrutia
• Publisher : Frontiers Media SA
• Release Date : 2021-08-26
• Total pages : 158
• ISBN : 9782889712397
• File Size : 45,7 Mb
• Total Download : 433
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Download Repurposed Drugs Targeting Cancer Signaling Pathways: Clinical Insights to Improve Oncologic Therapies in PDF, Epub, and Kindle

PDF book entitled Repurposed Drugs Targeting Cancer Signaling Pathways: Clinical Insights to Improve Oncologic Therapies written by Alma D. Campos-Parra,Carlos Pérez-Plasencia,Teresita Padilla-Benavides,Eduardo López-Urrutia and published by Frontiers Media SA which was released on 2021-08-26 with total hardcover pages 158, the book become popular and critical acclaim.

• Author : David Cavalla
• Publisher : Royal Society of Chemistry
• Release Date : 2022-02-09
• Total pages : 351
• ISBN : 9781788019033
• File Size : 51,8 Mb
• Total Download : 318
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Download Drug Repurposing in PDF, Epub, and Kindle

Drug repurposing, or repositioning, is the development of existing drugs for new uses: given that 9 in 10 drugs that enter drug development are never marketed and therefore represent wasted effort, it is an attractive as well as inherently more efficient process. Three repurposed drugs can be brought to market for the same cost as one new chemical entity; and they can also be identified more quickly, an important benefit for patients whose diseases are progressing faster than therapeutic innovation. But repurposing also requires a fresh look at configuring pharmaceutical R&D, considering clinical, regulatory and patent issues much earlier than would otherwise be the case. In addition to new ways of thinking, the discovery of repurposing opportunities can take advantage of artificial intelligence techniques to match the perfect new use for an existing drug. This book provides an ideal introduction to the field of drug repurposing with contributions from world-renowned experts culminating in an excellent resource for any drug discovery or medicinal chemist.

• Author : Chukwuebuka Egbuna,Mithun Rudrapal,Habibu Tijjani
• Publisher : Elsevier
• Release Date : 2022-12-09
• Total pages : 494
• ISBN : 9780323907163
• File Size : 33,9 Mb
• Total Download : 138
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Download Phytochemistry, Computational Tools, and Databases in Drug Discovery in PDF, Epub, and Kindle

Phytochemistry, Computational Tools and Databases in Drug Discovery presents the state-of-the-art in computational methods and techniques for drug discovery studies from medicinal plants. Various tools and databases for virtual screening and characterization of plant bioactive compounds and their subsequent predictions on biological targets for the discovery of new drugs against specific diseases are presented, along with computational tools for the prediction of the toxic effects of phytochemicals on living systems. The book also provides in-depth insight on the applications of these computational tools as well as the databases that describe the interactions of phytochemicals with diseases along with predictions for druggable bioactive compounds. Useful for drug developers, medicinal chemists, toxicologists, phytochemists, plant biochemists and analytical chemists, this book clearly presents the various computational techniques, tools and databases for phytochemical research. Provides the various databases, methods and procedures for computational drug discovery in plants Includes insights into the predictors for properties of phytochemicals against different diseases Discusses the applications of computational tools and their databases

• Author : Anonim
• Publisher : Academic Press
• Release Date : 2020-08-24
• Total pages : 1589
• ISBN : 9780128160787
• File Size : 16,5 Mb
• Total Download : 413
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Download Systems Medicine in PDF, Epub, and Kindle

Technological advances in generated molecular and cell biological data are transforming biomedical research. Sequencing, multi-omics and imaging technologies are likely to have deep impact on the future of medical practice. In parallel to technological developments, methodologies to gather, integrate, visualize and analyze heterogeneous and large-scale data sets are needed to develop new approaches for diagnosis, prognosis and therapy. Systems Medicine: Integrative, Qualitative and Computational Approaches is an innovative, interdisciplinary and integrative approach that extends the concept of systems biology and the unprecedented insights that computational methods and mathematical modeling offer of the interactions and network behavior of complex biological systems, to novel clinically relevant applications for the design of more successful prognostic, diagnostic and therapeutic approaches. This 3 volume work features 132 entries from renowned experts in the fields and covers the tools, methods, algorithms and data analysis workflows used for integrating and analyzing multi-dimensional data routinely generated in clinical settings with the aim of providing medical practitioners with robust clinical decision support systems. Importantly the work delves into the applications of systems medicine in areas such as tumor systems biology, metabolic and cardiovascular diseases as well as immunology and infectious diseases amongst others. This is a fundamental resource for biomedical students and researchers as well as medical practitioners who need to need to adopt advances in computational tools and methods into the clinical practice. Encyclopedic coverage: ‘one-stop’ resource for access to information written by world-leading scholars in the field of Systems Biology and Systems Medicine, with easy cross-referencing of related articles to promote understanding and further research Authoritative: the whole work is authored and edited by recognized experts in the field, with a range of different expertise, ensuring a high quality standard Digitally innovative: Hyperlinked references and further readings, cross-references and diagrams/images will allow readers to easily navigate a wealth of information

• Author : Shailendra K. Saxena
• Publisher : BoD – Books on Demand
• Release Date : 2022-06-01
• Total pages : 385
• ISBN : 9781839699573
• File Size : 19,9 Mb
• Total Download : 650
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Download Drug Repurposing in PDF, Epub, and Kindle

This book focuses on various aspects and applications of drug repurposing, the understanding of which is important for treating diseases. Due to the high costs and time associated with the new drug discovery process, the inclination toward drug repurposing is increasing for common as well as rare diseases. A major focus of this book is understanding the role of drug repurposing to develop drugs for infectious diseases, including antivirals, antibacterial and anticancer drugs, as well as immunotherapeutics.

• Author : Simone Brogi,Teodorico Castro Ramalho,José L. Medina-Franco,Kamil Kuca,Marian Valko
• Publisher : Frontiers Media SA
• Release Date : 2020-10-09
• Total pages : 504
• ISBN : 9782889660575
• File Size : 48,9 Mb
• Total Download : 433
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Download In Silico Methods for Drug Design and Discovery in PDF, Epub, and Kindle

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

• Author : Yuhei Nishimura,Hideaki Hara
• Publisher : Frontiers Media SA
• Release Date : 2019-01-11
• Total pages : 153
• ISBN : 9782889456963
• File Size : 29,7 Mb
• Total Download : 891
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Download Drug Repositioning: Current Advances and Future Perspectives in PDF, Epub, and Kindle

Drug repositioning is the process of identifying new indications for existing drugs. At present, the conventional de novo drug discovery process requires an average of about 14 years and US$2.5 billion to approve and launch a drug. Drug repositioning can reduce the time and cost of this process because it takes advantage of drugs already in clinical use for other indications or drugs that have cleared phase I safety trials but have failed to show efficacy in the intended diseases. Historically, drug repositioning has been realized through serendipitous clinical observations or improved understanding of disease mechanisms. However, recent technological advances have enabled a more systematic approach to drug repositioning. This eBook collects 16 articles from 112 authors, providing readers with current advances and future perspectives of drug repositioning.

• Author : Joel Dudley,Laura Berliocchi
• Publisher : CRC Press
• Release Date : 2017-07-14
• Total pages : 313
• ISBN : 9781482220841
• File Size : 34,9 Mb
• Total Download : 250
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Download Drug Repositioning in PDF, Epub, and Kindle

Nervous system diseases represent a major health concern worldwide. Although important financial and professional investment, their etiology and pathophysiology still remain mostly elusive. Moreover, the clinical need of disease-modifying therapies is still unmet. In the last decades, traditional R&D has failed in identifying new effective therapies in many medical areas and drug repositioning has recently emerged as a promising alternative strategy to de novo drug discovery to improve and accelerate therapeutic development. For the first time, Drug Repositioning: Approaches and Applications for Neurotherapeutics reviews history and advances in drug repositioning, with a special focus on therapeutics for nervous system diseases. International experts from Academia, Industry and Non-profit organisations will provide different views on drug repositioning advantages, challenges and specific applications, which will be covered for nervous system diseases including Alzheimer's, Parkinson's, Huntington's diseases, Amyotrophic Lateral Sclerosis, Spinal Muscular Atrophy, ischemic stroke, and psychiatric disorders. This book provides a balanced overview and synthesis of drug repositioning concept, methods and applications for neurotherapeutics. It represents a valuable resource for students, scientists and clinicians working in academic settings, industry and government agencies within the fields of neuroscience, pharmacology, neurology, pharmaceutical sciences, drug discovery and development.

• Author : Mithun Rudrapal,Rudra Pangeni,Keshav Raj Paudel
• Publisher : Frontiers Media SA
• Release Date : 2023-01-30
• Total pages : 170
• ISBN : 9782832512623
• File Size : 40,7 Mb
• Total Download : 835
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Download Drug repurposing and polypharmacology: A synergistic approach in multi-target based drug discovery in PDF, Epub, and Kindle

PDF book entitled Drug repurposing and polypharmacology: A synergistic approach in multi-target based drug discovery written by Mithun Rudrapal,Rudra Pangeni,Keshav Raj Paudel and published by Frontiers Media SA which was released on 2023-01-30 with total hardcover pages 170, the book become popular and critical acclaim.

• Author : Ranbir Chander Sobti,Sunil K. Lal,Ramesh K. Goyal
• Publisher : Springer Nature
• Release Date : 2023-02-07
• Total pages : 664
• ISBN : 9789811953996
• File Size : 36,9 Mb
• Total Download : 697
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Download Drug Repurposing for Emerging Infectious Diseases and Cancer in PDF, Epub, and Kindle

​This book presents drug repurposing strategies to combat infectious diseases and cancer. It discusses key experimental and in silico approaches for modern drug repositioning, including signature matching, molecular docking, genome-wide associated studies, and network-based approaches aided by artificial intelligence. Further, the book presents various computational and experimental strategies for better understanding disease mechanisms and identify repurposed drug candidates for personalized pharmacotherapy. It also explores the databases for drug repositioning, summarizes the approaches taken for drug repositioning, and highlights and compares their characteristics and challenges. Towards the end, the book discusses challenges and limitations encountered in computational drug repositioning.

• Author : S. Mohane Coumar
• Publisher : Academic Press
• Release Date : 2021-02-17
• Total pages : 520
• ISBN : 9780128223130
• File Size : 30,9 Mb
• Total Download : 562
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Download Molecular Docking for Computer-Aided Drug Design in PDF, Epub, and Kindle

Molecular Docking for Computer-Aided Drug Design: Fundamentals, Techniques, Resources and Applications offers in-depth coverage on the use of molecular docking for drug design. The book is divided into three main sections that cover basic techniques, tools, web servers and applications. It is an essential reference for students and researchers involved in drug design and discovery. Covers the latest information and state-of-the-art trends in structure-based drug design methodologies Includes case studies that complement learning Consolidates fundamental concepts and current practice of molecular docking into one convenient resource

• Author : Rishabha Malviya,Sonali Sundram
• Publisher : Springer Nature
• Release Date : 2023-04-11
• Total pages : 949
• ISBN : 9789811997860
• File Size : 25,5 Mb
• Total Download : 827
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Download Targeted Cancer Therapy in Biomedical Engineering in PDF, Epub, and Kindle

This book highlights the role of Biomedical Engineering (BME) used in diagnosis (e.g., body scanners) and treatment (radiation therapy and minimal access surgery in order to prevent various diseases). In recent years, an important progress has been made in the expansion of biomedical microdevices which has a major role in diagnosis and therapy of cancer. When fighting cancer, efficacy and speed are of the utmost importance. A recently developed microfluidic chip has enabled a breakthrough in testing the efficacy of specialized cancer drugs. Effective cancer-targeting therapies will require both passive and active targeting strategies and a thorough understanding of physiologic barriers to targeted drug delivery. Targeted cancer treatments in development and the new combinatorial approaches show promise for improving targeted anticancer drug delivery and improving treatment outcomes. This book discusses the advancements and innovations in the field of BME that improve the diagnosis and treatment of cancer. This book is focused on bioengineering approaches to improve targeted delivery for cancer therapeutics, which include particles, targeting moieties, and stimuli-responsive drug release mechanisms. This book is a useful resource for students, researchers, and professionals in BME and medicine.

• Author : Alessandro Laganà
• Publisher : Springer Nature
• Release Date : 2022-03-01
• Total pages : 336
• ISBN : 9783030918361
• File Size : 32,6 Mb
• Total Download : 619
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Download Computational Methods for Precision Oncology in PDF, Epub, and Kindle

Precision medicine holds great promise for the treatment of cancer and represents a unique opportunity for accelerated development and application of novel and repurposed therapeutic approaches. Current studies and clinical trials demonstrate the benefits of genomic profiling for patients whose cancer is driven by specific, targetable alterations. However, precision oncologists continue to be challenged by the widespread heterogeneity of cancer genomes and drug responses in designing personalized treatments. Chapters provide a comprehensive overview of the computational approaches, methods, and tools that enable precision oncology, as well as related biological concepts. Covered topics include genome sequencing, the architecture of a precision oncology workflow, and introduces cutting-edge research topics in the field of precision oncology. This book is intended for computational biologists, bioinformaticians, biostatisticians and computational pathologists working in precision oncology and related fields, including cancer genomics, systems biology, and immuno-oncology.

• Author : Anonim
• Publisher : Academic Press
• Release Date : 2016-08-24
• Total pages : 212
• ISBN : 9780128052419
• File Size : 18,6 Mb
• Total Download : 675
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Download Insights into Enzyme Mechanisms and Functions from Experimental and Computational Methods in PDF, Epub, and Kindle

Insights into Enzyme Mechanisms and Functions from Experimental and Computational Methods is the latest volume in the popular Advances in Protein Chemistry and Structural Biology series, an essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins, with each thematically organized volume guest edited by leading experts in a broad range of protein-related topics. Provides cutting-edge developments in protein chemistry and structural biology Written by authorities in their respective fields Targeted to a wide audience of researchers, specialists, and students