Cannabis Cannabinoids And Endocannabinoids

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The Health Effects of Cannabis and Cannabinoids

The Health Effects of Cannabis and Cannabinoids
  • Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Population Health and Public Health Practice,Committee on the Health Effects of Marijuana: An Evidence Review and Research Agenda
  • Publisher : National Academies Press
  • Release Date : 2017-03-31
  • Total pages : 486
  • ISBN : 9780309453073
  • File Size : 32,9 Mb
  • Total Download : 498
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Significant changes have taken place in the policy landscape surrounding cannabis legalization, production, and use. During the past 20 years, 25 states and the District of Columbia have legalized cannabis and/or cannabidiol (a component of cannabis) for medical conditions or retail sales at the state level and 4 states have legalized both the medical and recreational use of cannabis. These landmark changes in policy have impacted cannabis use patterns and perceived levels of risk. However, despite this changing landscape, evidence regarding the short- and long-term health effects of cannabis use remains elusive. While a myriad of studies have examined cannabis use in all its various forms, often these research conclusions are not appropriately synthesized, translated for, or communicated to policy makers, health care providers, state health officials, or other stakeholders who have been charged with influencing and enacting policies, procedures, and laws related to cannabis use. Unlike other controlled substances such as alcohol or tobacco, no accepted standards for safe use or appropriate dose are available to help guide individuals as they make choices regarding the issues of if, when, where, and how to use cannabis safely and, in regard to therapeutic uses, effectively. Shifting public sentiment, conflicting and impeded scientific research, and legislative battles have fueled the debate about what, if any, harms or benefits can be attributed to the use of cannabis or its derivatives, and this lack of aggregated knowledge has broad public health implications. The Health Effects of Cannabis and Cannabinoids provides a comprehensive review of scientific evidence related to the health effects and potential therapeutic benefits of cannabis. This report provides a research agendaâ€"outlining gaps in current knowledge and opportunities for providing additional insight into these issuesâ€"that summarizes and prioritizes pressing research needs.

Therapeutic Uses of Cannabis

Therapeutic Uses of Cannabis
  • Author : British Medical Association
  • Publisher : CRC Press
  • Release Date : 2020-08-12
  • Total pages : 160
  • ISBN : 9781000159653
  • File Size : 11,7 Mb
  • Total Download : 682
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At the last Annual Representative Meeting of the British Medical Association a motion was passed that `certain additional cannabinoids should be legalized for wider medicinal use.'' This report supports this landmark statement by reviewing the scientific evidence for the therapeutic use of cannabinoids and sets the agenda for change. It will be welcomed by those who believe that cannabinoids can be used in medical treatment. The report discusses in a clear and readable form the use and adverse effects of the drug for nausea, multiple sclerosis, pain, epilepsy, glaucoma, and asthma.

Cannabinoids and Pain

Cannabinoids and Pain
  • Author : Samer N. Narouze
  • Publisher : Springer Nature
  • Release Date : 2021-07-01
  • Total pages : 339
  • ISBN : 9783030691868
  • File Size : 38,9 Mb
  • Total Download : 940
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This book presents a well-balanced view of the potential medical use of cannabinoids in pain. It comprehensively covers the current challenges with medical cannabis utilization and provides recommendations for research and future directions. Organized into nine sections, the book begins with an introduction to medical cannabis, including its history, regulations, and the general attitudes of pain physicians on cannabis. Section two explores the biological effects of marijuana via the endocannabinoid system and its complex structure of receptors and enzymes. Sections three, four, and five then delve further into pharmacology and the mechanisms of action applicable to cannabinoids in managing pain. Timely and socially conscious, section six examines the benefits of substituting opioids with cannabinoids for preoperative management. Echoing the book's well-rounded content, sections seven and eight consider the challenges with medical cannabis, including safety and quality control, brain development risks, vaping hazards, and withdrawal. The book then closes with a look at the future of cannabis in medical research. Thoroughly and equitably composed, Cannabinoids and Pain is an invaluable resource for primary care physicians, pain and palliative care physicians, and oncologists.

Cannabinoids and the Brain

Cannabinoids and the Brain
  • Author : Linda A. Parker
  • Publisher : MIT Press
  • Release Date : 2018-09-25
  • Total pages : 249
  • ISBN : 9780262536608
  • File Size : 25,8 Mb
  • Total Download : 422
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A review of the scientific evidence on the effects of cannabinoids on brain and behavioral functioning, with an emphasis on potential therapeutic use. The cannabis plant has been used for recreational and medicinal purposes for more than 4,000 years, but the scientific investigation into its effects has only recently yielded useful results. In this book, Linda Parker offers a review of the scientific evidence on the effects of cannabinoids on brain and behavioral functioning, with an emphasis on potential therapeutic uses. Parker describes the discovery of tetrahydocannbinol (THC), the main psychoactive component of cannabis, and the further discovery of cannabinoid receptors in the brain. She explains that the brain produces chemicals similar to THC, which act on the same receptors as THC, and shows that the endocannabinoid system is involved in all aspects of brain functioning. Parker reports that cannabis contains not only the psychoactive compound THC, but also other compounds of potential therapeutic benefit, and that one of them, cannabidiol (CBD), shows promise for the treatment of pain, anxiety, and epilepsy. Parker reviews the evidence on cannabinoids and anxiety, depression, mood, sleep, schizophrenia, learning and memory, addiction, sex, appetite and obesity, chemotherapy-induced nausea, epilepsy, and such neurodegenerative disorders as multiple sclerosis and Alzheimer's Disease. Each chapter also links the scientific evidence to historical and anecdotal reports of the medicinal use of cannabis. As debate about the medical use of marijuana continues, Parker's balanced and objective review of the fundamental science and potential therapeutic effects of cannabis is especially timely.

Endocannabinoids

Endocannabinoids
  • Author : Emmanuel S Onaivi,Takayuki Sugiura,Vincenzo Di Marzo
  • Publisher : CRC Press
  • Release Date : 2005-11-01
  • Total pages : 592
  • ISBN : 1420023640
  • File Size : 10,8 Mb
  • Total Download : 484
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Over the past decade, there have been major advances in understanding the mechanisms whereby marijuana interacts with the brain in producing psychoactive and potentially therapeutic effects. The discovery of specific gene coding for cannabinoid receptors activated by smoking marijuana, and the finding of endogenous cannabinoids, which also activate the receptors, have transformed cannabinoid research into mainstream science with significant implications in human health and disease Endocannabinoids: The Brain and Body’s Marijuana and Beyond documentsadvances in the discovery and functioning of naturally occurring marijuana-like substances in human biology. It explores recent findings that point to the existence of an endocannabinoid physiological control system (EPCS) that directly impacts human development, health, and disease. While cannabinoid effects on the brain have received the greatest attention throughout the literature, this work looks at research on the endogenous cannabinoid system’s association across all of human physiology, including the immune, endocrine, and reproductive systems. With thoroughly researched and exceptionally insightful contributions from more than three-dozen top-flight researchers representing a cross-section of disciplines from molecular biology, genetics, and neurology to gynecology, physiology, and pharmacology, this work explores a range of topics as wide as the human body is complex. These topics include the EPCS’s relation to cell development and regulation, CNS function, immune function modulation, reproduction, and digestion, as well as its function in mental illness, neurodegenerative diseases, and cancer. The final section in the book considers the significance of endogenous cannabinoids found in some of the simplest multicellular organisms in the animal kingdom, as well as in mammalian cells at the earliest stages of development, all of which suggests that they play a fundamental role in human biology. Enocannabinoids: The Brain and Body’s Marijuana and Beyond explores areas that few books have ventured into, providing cutting-edge information that will ultimately help us better understand human biology at the systemic and perhaps even cellular level, as well as lead to the development of a whole new range of medications.

Neuroscience in the 21st Century

Neuroscience in the 21st Century
  • Author : Donald W. Pfaff,Nora D. Volkow
  • Publisher : Springer
  • Release Date : 2016-10-21
  • Total pages : 4144
  • ISBN : 1493934732
  • File Size : 16,9 Mb
  • Total Download : 374
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Edited and authored by a wealth of international experts in neuroscience and related disciplines, this key new resource aims to offer medical students and graduate researchers around the world a comprehensive introduction and overview of modern neuroscience. Neuroscience research is certain to prove a vital element in combating mental illness in its various incarnations, a strategic battleground in the future of medicine, as the prevalence of mental disorders is becoming better understood each year. Hundreds of millions of people worldwide are affected by mental, behavioral, neurological and substance use disorders. The World Health Organization estimated in 2002 that 154 million people globally suffer from depression and 25 million people from schizophrenia; 91 million people are affected by alcohol use disorders and 15 million by drug use disorders. A more recent WHO report shows that 50 million people suffer from epilepsy and 24 million from Alzheimer’s and other dementias. Because neuroscience takes the etiology of disease—the complex interplay between biological, psychological, and sociocultural factors—as its object of inquiry, it is increasingly valuable in understanding an array of medical conditions. A recent report by the United States’ Surgeon General cites several such diseases: schizophrenia, bipolar disorder, early-onset depression, autism, attention deficit/ hyperactivity disorder, anorexia nervosa, and panic disorder, among many others. Not only is this volume a boon to those wishing to understand the future of neuroscience, it also aims to encourage the initiation of neuroscience programs in developing countries, featuring as it does an appendix full of advice on how to develop such programs. With broad coverage of both basic science and clinical issues, comprising around 150 chapters from a diversity of international authors and including complementary video components, Neuroscience in the 21st Century in its second edition serves as a comprehensive resource to students and researchers alike.

The Endocannabinoid System

The Endocannabinoid System
  • Author : Eric Murillo-Rodríguez
  • Publisher : Academic Press
  • Release Date : 2017-05-12
  • Total pages : 256
  • ISBN : 9780128096673
  • File Size : 9,7 Mb
  • Total Download : 760
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The Endocannabinoid System: Genetics, Biochemistry, Brain Disorders, and Therapy examines the cellular, biochemical, genetic, and therapeutic aspects of the endocannabinoid system. The chapters cover significant conceptual advances in the endocannabinoid field and shed light on the many brain disorders in which this biological system is involved. Written by world-leading experts in the field, the topics covered in this book will have a positive impact on the area of molecular biology, including, but not limited to, cell biology, neuroscience, pharmacology, signaling, disease mechanisms, and therapeutics. Provides an introduction to endocannabinoids in the central nervous system and an overview to their functions in the brain Presents information on neurobiological and cellular studies on the role of the cannabinoid signaling system and its implications in human diseases Includes well-written overviews of the basics of endocannabinoid system structure and function Contains well-illustrated material, with diagrams, charts, and tables Explores compelling case studies and their application to chapters written by experts

Marijuana and Madness

Marijuana and Madness
  • Author : David Castle,Robin M. Murray,Deepak Cyril D'Souza
  • Publisher : Cambridge University Press
  • Release Date : 2011-10-27
  • Total pages : 229
  • ISBN : 9781139502672
  • File Size : 50,6 Mb
  • Total Download : 275
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The second edition of this critically acclaimed and award-winning text provides a comprehensive overview of the psychiatry and neuroscience of Cannabis sativa (marijuana). It outlines the very latest developments in our understanding of the human cannabinoid system, and links this knowledge to clinical and epidemiological facts about the impact of cannabis on mental health. Clinically focused chapters review not only the direct psychomimetic properties of cannabis, but also the impact consumption has on the courses of evolving or established mental illnesses such as schizophrenia. Effects of cannabis on mood are reviewed, as are its effects on cognition. This new edition has been extensively updated and expanded with 10 new chapters to incorporate major new research findings. This book will be of interest to all members of the mental health team, as well as to neuroscientists, epidemiologists, public health specialists and those involved in drug and alcohol research.

Phytocannabinoids

Phytocannabinoids
  • Author : A. Douglas Kinghorn,Heinz Falk,Simon Gibbons,Jun'ichi Kobayashi
  • Publisher : Springer
  • Release Date : 2017-01-24
  • Total pages : 131
  • ISBN : 9783319455419
  • File Size : 14,9 Mb
  • Total Download : 999
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The book presents the current state of the art on phytocannnabinoid chemistry and pharmacology and will be of much use to those wishing to understand the current landscape of the exciting and intriguing phytocannabinoid science. The focus is on natural product cannabinoids which have been demonstrated to act at specific receptor targets in the CNS.

Medical Cannabis Handbook for Healthcare Professionals

Medical Cannabis Handbook for Healthcare Professionals
  • Author : Christine Nazarenus
  • Publisher : Springer Publishing Company
  • Release Date : 2020-01-15
  • Total pages : 300
  • ISBN : 9780826135735
  • File Size : 21,9 Mb
  • Total Download : 958
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Helps healthcare professionals to navigate the maze of information and disinformation about medical cannabis Written for all healthcare professionals who are considering including medical cannabis in their treatment plans, this is the first handbook to disseminate all the information needed to advise patients safely and legally. Replete with evidence-based guidelines firmly grounded in the most up-to-date research, this resource covers the historical, legal, and biological context of medical cannabis so healthcare professionals can confidently discuss possible plans with their patients. Medical Cannabis Handbook for Healthcare Professionals delves into the biology of the endocannabinoid system addressing how cannabis interacts with the body, its effects and side effects, and how to manage cannabis-drug interactions. Chapters discuss in detail how to talk to patients, what language providers can and cannot use, protocols for patient-centered dosing, and the variety of available cannabinoid pharmaceuticals. Based on the latest research, this book demonstrates the efficacy of cannabis in treating a broad range of symptoms and conditions. Written for any healthcare professional who might have to answer patient questions about medical cannabis, this handbook dispels common myths and confirms little-known facts about medical cannabis. KEY FEATURES: Delivers the most up-to-date, evidence-based research on medical cannabis to enhance understanding of this complex topic Provides historical, legal, and biological content so that healthcare providers can confidently discuss medical cannabis with patients Dispels common cannabis myths and misinformation Discusses pain management regarding cannabis and opioids Co-published with Medical Marijuana 411, the leading medical cannabis education provider to offer online CME, CPE and CNE courses to health professionals worldwide; and required certifications for dispensary consultants

New Tools to Interrogate Endocannabinoid Signalling

New Tools to Interrogate Endocannabinoid Signalling
  • Author : Mauro Maccarrone
  • Publisher : Royal Society of Chemistry
  • Release Date : 2020-11-13
  • Total pages : 458
  • ISBN : 9781839160851
  • File Size : 9,6 Mb
  • Total Download : 645
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Legalization of cannabis extracts around the world has led to a resurgence of interest into research surrounding endocannabinoids (eCBs) and the endocannabinoid system. This system is formed of a complex array of receptors, metabolic enzymes and transporters that finely tune the manifold biological activities of eCBs and there is an urgent need for the development of selective drugs to dissect the contribution of eCBs to the aetiology of various diseases. New Tools to Interrogate Endocannabinoid Signalling comprehensively covers the innovative research into both natural and synthetic compounds that affect this pathway and taking a target-based approach, assesses their potential for therapeutic use. With contributions from global leaders in the field, this timely volume will be a valuable resource to pharmaceutical researchers and medicinal chemists working in natural products and endocannabinoid drug discovery in academia and industry.

Cannabinoids in Health and Disease

Cannabinoids in Health and Disease
  • Author : Rosaria Meccariello,Rosanna Chianese
  • Publisher : BoD – Books on Demand
  • Release Date : 2016-06-15
  • Total pages : 260
  • ISBN : 9789535124290
  • File Size : 28,5 Mb
  • Total Download : 441
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This book provides a comprehensive overview of current knowledge of cannabinoid activity in human physiology and points out the importance of endocannabinoid system for the maintenance of human health and treatment of diseases. Each chapter has been organized with the aim to cover basic concepts in the modulation of endocannabinoid system in both physiological and pathological conditions, thanks to the integration of data from experimental animal models and clinical observations. A special focus has been put on the medical use of cannabinoids and on the targeting of endocannabinoid system as new therapeutic strategy for the prevention and treatment of human diseases. Taken together, this book targets a wide audience of basic and clinical scientists, teachers and students interested in gaining a better understanding in the field of cannabinoids.

Marijuana and Medicine

Marijuana and Medicine
  • Author : Institute of Medicine
  • Publisher : National Academies Press
  • Release Date : 1999-07-10
  • Total pages : 288
  • ISBN : 9780309071550
  • File Size : 54,7 Mb
  • Total Download : 485
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The medical use of marijuana is surrounded by a cloud of social, political, and religious controversy, which obscures the facts that should be considered in the debate. This book summarizes what we know about marijuana from evidence-based medicineâ€"the harm it may do and the relief it may bring to patients. The book helps the reader understand not only what science has to say about medical marijuana but also the logic behind the scientific conclusions. Marijuana and Medicine addresses the science base and the therapeutic effects of marijuana use for medical conditions such as glaucoma and multiple sclerosis. It covers marijuana's mechanism of action, acute and chronic effects on health and behavior, potential adverse effects, efficacy of different delivery systems, analysis of the data about marijuana as a gateway drug, and the prospects for developing cannabinoid drugs. The book evaluates how well marijuana meets accepted standards for medicine and considers the conclusions of other blue-ribbon panels. Full of useful facts, this volume will be important to anyone interested in informed debate about the medical use of marijuana: advocates and opponents as well as policymakers, regulators, and health care providers.

Handbook of Cannabis and Related Pathologies

Handbook of Cannabis and Related Pathologies
  • Author : Victor R. Preedy
  • Publisher : Academic Press
  • Release Date : 2016-12-31
  • Total pages : 1170
  • ISBN : 9780128008270
  • File Size : 34,5 Mb
  • Total Download : 152
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Handbook of Cannabis and Related Pathologies: Biology, Pharmacology, Diagnosis, and Treatment is the first book to take an interdisciplinary approach to the understanding of cannabis use and misuse. Recent worldwide trends toward decriminalizing marijuana for medical use have increased legal use of the drug and recreational use remains high, making cannabis one of the most commonly used drugs. Cannabis has a wide range of adverse neurological effects, and use and abuse can lead to physical, social, and psychopathological issues that are multifarious and complex. Effective understanding and treatment requires knowledge of the drug’s effects from across scientific disciplines. This book provides an overview of the biological and pharmacological components of the cannabis plant, outlines its neurological, social, and psychopathological effects, assists in the diagnosis and screening for use and dependency, and aids researchers in developing effective treatments for cannabis-related issues and disorders. Fully illustrated, with contributions from internationally recognized experts, it is the go-to resource for neuroscientists, pharmacologists, pathologists, public-health workers, and any other researcher who needs an in-depth and cross-disciplinary understanding of cannabis and its effects. Comprehensive chapters include an abstract, key facts, mini dictionary of terms, and summary points Presents illustrations with at least six figures, tables, and diagrams per chapter Provides a one-stop-shopping synopsis of everything to do with cannabis and its related pathology, from chemicals and cells, individuals and communities, and diagnosis and treatment Offers an integrated and informed synopsis of the complex issues surrounding cannabis as a substance, its use, and its misuse

Endocannabinoid Signaling

Endocannabinoid Signaling
  • Author : Mauro Maccarrone
  • Publisher : Humana Press
  • Release Date : 2016-03-11
  • Total pages : 267
  • ISBN : 1493935372
  • File Size : 41,6 Mb
  • Total Download : 628
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This volume encompasses all major methodologies to interrogate endocannabinoid systems (ECS) and endocannabinoids (eCBs) signaling. With increasing interest towards the manifold activities of eCBs, this book discusses the chemical, biochemical, and molecular biological assays, and activity of distinct elements of the ECS. These include membrane, nuclear receptors, biosynthetic and hydrolytic enzymes, and membrane transporters and oxidative enzymes. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Timely and cutting edge, Endocannabinoid Signaling: Methods and Protocols is a valuable resource and will help chemists, drug designers, biochemists, molecular biologists, cell biologists, pharmacologists, and (electro) physiologists navigate the mare magnum of endocannabinoid research.

Endocannabinoids: Molecular, Pharmacological, Behavioral and Clinical Features

Endocannabinoids: Molecular, Pharmacological, Behavioral and Clinical Features
  • Author : Eric Murillo-Rodríguez,Emmanuel S. Onaivi,Nissar A. Darmani,Edward Wagner
  • Publisher : Bentham Science Publishers
  • Release Date : 2013-09-10
  • Total pages : 223
  • ISBN : 9781608050284
  • File Size : 15,9 Mb
  • Total Download : 335
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The endocannabinoid system comprises at least two G-protein-coupled receptors (the cannabinoid CB1 and CB2 receptors) activated by marijuana’s psychoactive principle ∆9-tetrahydrocannabinol (THC) and the endogenous ligands known as endocannabinoids. The apex of endocannabinoid research seems to have been reached with the clinical development, and also in some cases, the marketing, of synthetic or natural pharmaceuticals targeting this signalling system, which followed the understanding of the physiological and pathological role of endocannabinoids in several conditions, a role that was investigated first in rodent experimental models and then in humans. Endocannabinoids: Molecular, Pharmacological, Behavioral and Clinical Features is a monograph that presents interesting manuscripts selected by the editor on the subject. Chapters in this book include original research or reviews which report the relevance of the endocannabinoid system by describing the results of experimental evidence about the neurobiological role of the endocannabinoid system. The main topics include, but are not limited to: *The genetics of cannabinoid CB1 and CB2 receptors and their tissue distribution, their splicing variants and polymorphisms, and the possible implications of all this in determining different behaviours as well as various pathological conditions and the addiction to substances of abuse. *Pharmacological approaches describing the potential use in the central nervous system disorders of endocannabinoid-based drugs, such as cannabinoid receptor agonists and antagonists, inhibitors of endocannabinoid inactivation processes, and even plant cannabinoids other than THC and with a molecular mechanism of action. *The role of the endocannabinoid system in several neurological and neuropsychiatric conditions, such as epilepsy. The volume would be a great interest to neuropharmacologists, physiologists and biochemists who aim to learn about the endocannabinoid system in detail. Endocannabinoids: Molecular, Pharmacological, Behavioral and Clinical Features is a monograph that presents interesting manuscripts selected by the editor on the subject. Chapters in this book include original research or reviews which report the relevance of the endocannabinoid system by describing the results of experimental evidence about the neurobiological role of the endocannabinoid system. The main topics include, but are not limited to: *The genetics of cannabinoid CB1 and CB2 receptors and their tissue distribution, their splicing variants and polymorphisms, and the possible implications of all this in determining different behaviours as well as various pathological conditions and the addiction to substances of abuse. *Pharmacological approaches describing the potential use in the central nervous system disorders of endocannabinoid-based drugs, such as cannabinoid receptor agonists and antagonists, inhibitors of endocannabinoid inactivation processes, and even plant cannabinoids other than THC and with a molecular mechanism of action. *The role of the endocannabinoid system in several neurological and neuropsychiatric conditions, such as epilepsy. The volume would be a great interest to neuropharmacologists, physiologists and biochemists who aim to learn about the endocannabinoid system in detail. Endocannabinoids: Molecular, Pharmacological, Behavioral and Clinical Features is a monograph that presents interesting manuscripts selected by the editor on the subject. Chapters in this book include original research or reviews which report the relevance of the endocannabinoid system by describing the results of experimental evidence about the neurobiological role of the endocannabinoid system. The main topics include, but are not limited to: *The genetics of cannabinoid CB1 and CB2 receptors and their tissue distribution, their splicing variants and polymorphisms, and the possible implications of all this in determining different behaviours as well as various pathological conditions and the addiction to substances of abuse. *Pharmacological approaches describing the potential use in the central nervous system disorders of endocannabinoid-based drugs, such as cannabinoid receptor agonists and antagonists, inhibitors of endocannabinoid inactivation processes, and even plant cannabinoids other than THC and with a molecular mechanism of action. *The role of the endocannabinoid system in several neurological and neuropsychiatric conditions, such as epilepsy. The volume would be a great interest to neuropharmacologists, physiologists and biochemists who aim to learn about the endocannabinoid system in detail.

Cannabinoids

Cannabinoids
  • Author : Vincenzo Di Marzo
  • Publisher : John Wiley & Sons
  • Release Date : 2014-07-18
  • Total pages : 320
  • ISBN : 9781118451274
  • File Size : 31,5 Mb
  • Total Download : 645
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‘Cannabinoids’ is a broad term covering a group ofnatural products from Cannabis sativa, one of which locks on tospecific receptors – protein molecules on the surface ofcells – known as cannabinoid receptors. Over the past decadesscientists have found that cannabinoid receptors and theirendogenous ligands, the endocannabinoids, are involved in a vastarray of physiological functions, including helping to controlbrain activity, energy metabolism, heart function, the immunesystem and even reproduction. In Cannabinoids, Vincenzo Di Marzo has assembled contributionsfrom international experts to provide the definitive guide to whatcontinues to be a rapidly developing research field. After anintroductory historical chapter, the book continues by looking atthe biochemical, genetic and molecular elements of cannabinoids,followed by chapters covering their role in health anddisease. The final chapter outlines the need for a newnomenclature to reflect the complex and multi-disciplinary natureof this area.

Cannabis and Cannabinoids

Cannabis and Cannabinoids
  • Author : Ethan B Russo
  • Publisher : Routledge
  • Release Date : 2013-09-05
  • Total pages : 478
  • ISBN : 9781136614934
  • File Size : 28,7 Mb
  • Total Download : 382
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Study the latest research findings by international experts! This comprehensive volume presents state-of-the-art scientific research on the therapeutic uses of cannabis and its derivatives. All too often, discussions of the potential medical uses of this substance are distorted by political considerations that have no place in a medical debate. Cannabis and Cannabinoids: Pharmacology, Toxicology, and Therapeutic Potential features fair, equitable discussion of this emerging and controversial medical topic by the world’s foremost researchers. Cannabis and Cannabinoids examines the benefits, drawbacks, and side effects of medical marijuana as a treatment for various conditions and diseases. This book discusses the scientific basis for marijuana’s use in cases of pain, nausea, anorexia, and cachexia. It also explores its possible benefits in glaucoma, ischemia, spastic disorders, and migraine. Cannabis and Cannabinoids examines all facets of the medical use of marijuana, including: botany history biochemistry pharmacology clinical use toxicology side effects Cannabis and Cannabinoids is a reference work that will become indispensable to physicians, psychologists, researchers, biochemists, graduate students, and interested members of the public. No other book available offers this comprehensive, even-handed look at a deeply divisive subject.

Cannabinoids

Cannabinoids
  • Author : Roger G. Pertwee
  • Publisher : Springer Science & Business Media
  • Release Date : 2006-01-14
  • Total pages : 772
  • ISBN : 9783540265733
  • File Size : 55,5 Mb
  • Total Download : 952
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Less than 20 years ago the ?eld of cannabis and the cannabinoids was still c- sidered a minor, somewhat quaint, area of research. A few groups were active in the ?eld, but it was already being viewed as stagnating. The chemistry of cannabis 9 9 was well known, ? -tetrahydrocannabinol (? -THC), identi?ed in 1964, being the only major psychoactive constituent and cannabidiol, which is not psychoactive, possibly contributing to some of the effects. These cannabinoids and several s- thetic analogs had been thoroughly investigated for their pharmacological effects. Their mode of action was considered to be non-speci?c. The reasons for this - sumption were both technical and conceptual. On the technical side, it had been shown that THC was active in both enantiomeric forms (though with a different level of potency) and this observation was incompatible with action on biological substrates—a receptor, an enzyme, an ion channel—which react with a single stereoisomer only. The conceptual problem related to THC activity. This had been pointed out by several highly regarded research groups that had shown that many of the effects seen with cannabinoids were related to those of biologically active lipophiles, and that many of the effects of THC, particularly chronic ones, were comparable to those seen with anaesthetics and solvents.

A Psychiatrist's View of Marijuana

A Psychiatrist's View of Marijuana
  • Author : Timmen Cermak
  • Publisher : Cambridge University Press
  • Release Date : 2020-04-02
  • Total pages : 257
  • ISBN : 9781108735735
  • File Size : 23,5 Mb
  • Total Download : 233
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An essential guide covering the scientific knowledge and communication skills required to deliver objective patient advice about marijuana use.

Cannabinoids as Therapeutics

Cannabinoids as Therapeutics
  • Author : Raphael Mechoulam
  • Publisher : Springer Science & Business Media
  • Release Date : 2005-05-19
  • Total pages : 302
  • ISBN : 3764370556
  • File Size : 52,8 Mb
  • Total Download : 564
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Only a few years ago the endocannabinoid system was unknown. Today we are aware that endocannabinoids are involved in many of the functions of the mammalian body - in neuroprotection, appetite and suckling, pain, reproduction, anxiety, memory, bone formation etc. This volume presents an up-to-date picture of some of the major fields of endocannabinoid research. It summarizes the actions of the endocannabinoids on various physiological systems and opens new therapeutic windows to a large number of diseases. The first chapter, on the use of Cannabis in India, can be viewed as an expression of thanks to the herbal practitioners, who for centuries passed on the medical traditions associated with the drug. The chapter on chemistry is a short summary of active plant, synthetic and endogenous cannabinoids being investigated today, many of which are mentioned later in the book. Cannabidiol is an unusual cannabinoid - it does not bind to the known receptors and yet exerts a variety of effects. Hence a chapter is devoted to it. Further chapters deal with the endocannabinoid system and the endocannabinoids in a variety of conditions and physiological systems. The concluding chapter describes the research done on Sativex®, a standardized plant extract, shortly to be introduced in Canada as a drug for multiple sclerosis. The intended audience is drug researchers (medicinal chemists, pharmacologists, clinicians), neuroscientists, physiologists, and clinicians interested in the effect of the endocannabinoid system in various physiological systems.