Biofilms And Implantable Medical Devices

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• Author : Ying Deng,Wei Lv
• Publisher : Woodhead Publishing
• Release Date : 2016-10-24
• Total pages : 238
• ISBN : 9780081003985
• File Size : 48,9 Mb
• Total Download : 806
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Download Biofilms and Implantable Medical Devices in PDF, Epub, and Kindle

Biofilms and Implantable Medical Devices: Infection and Control explores the increasing use of permanent and semi-permanent implants and indwelling medical devices. As an understanding of the growth and impact of biofilm formation on these medical devices and biomaterials is vital for protecting the health of the human host, this book provides readers with a comprehensive treatise on biofilms and their relationship with medical devices, also reporting on infections and associated strategies for prevention. Provides useful information on the fundamentals of biofilm problems in medical devices Discusses biofilm problems in a range of medical devices Focuses on strategies for prevention of biofilm formation

• Author : Sunil Kumar,Niharika Chandra,Leena Singh,Muhammad Zaffar Hashmi,Ajit Varma
• Publisher : Springer Nature
• Release Date : 2019-11-19
• Total pages : 311
• ISBN : 9783030307578
• File Size : 21,6 Mb
• Total Download : 382
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Download Biofilms in Human Diseases: Treatment and Control in PDF, Epub, and Kindle

This book highlights treatment strategies for bacterial biofilms in connection with a variety of human diseases. In particular, it reviews bacterial biofilm formation and its mechanism. Topics covered include biofilms in human health, the role of biofilms in mediating human diseases, and methods for testing bacterial biofilms. Further sections concentrate on biofilm-mediated diseases in different parts of the human gastrointestinal tract, while therapeutic strategies for biofilm control and natural agents that disrupt bacterial biofilms are also covered. Readers will also find the latest advances in probiotics and biofilms, as well as the use of probiotics to counteract biofilm-associated infections. Biofilms and antimicrobial resistance are discussed. Subsequent chapters address the management of inflammatory bowel disease via probiotics biofilms, as well as the role of probiotics bacteria in the treatment of human diseases associated with bacterial biofilms. The book is chiefly intended for clinicians/scientists in the fields of medical microbiology, applied microbiology, biochemistry, and biotechnology.

• Author : Mahmoud Ghannoum,Matthew Parsek,Marvin Whiteley,Pranab K. Mukherjee
• Publisher : John Wiley & Sons
• Release Date : 2020-08-11
• Total pages : 404
• ISBN : 9781555817466
• File Size : 36,9 Mb
• Total Download : 198
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Download Microbial Biofilms in PDF, Epub, and Kindle

An examination of the research and translational application to prevent and treat biofilm-associated diseases In the decade since the first edition of Microbial Biofilms was published, the interest in this field has expanded, spurring breakthrough research that has advanced the treatment of biofilm-associated diseases. This second edition takes the reader on an exciting, extensive review of bacterial and fungal biofilms, ranging from basic molecular interactions to innovative therapies, with particular emphasis on the division of labor in biofilms, new approaches to combat the threat of microbial biofilms, and how biofilms evade the host defense. Chapters written by established investigators cover recent findings, and contributions from investigators new to the field provide unique and fresh insights. Specifically, Microbial Biofilms provides state-of-the-art research in the field of bacterial and fungal biofilms detailed descriptions of the in vitro and in vivo models available to evaluate microbial biofilms future areas of research and their translational and clinical applications Microbial Biofilms is a useful reference for researchers and clinicians. It will also provide insight in the dynamic field of microbial biofilms for graduate and postgraduate students.

• Author : Karen Vickery
• Publisher : MDPI
• Release Date : 2020-03-16
• Total pages : 166
• ISBN : 9783039284108
• File Size : 34,6 Mb
• Total Download : 135
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Download Microbial Biofilms in Healthcare in PDF, Epub, and Kindle

Biofilms are ubiquitous and their presence in industry can lead to production losses. However, nowhere do biofilms impact human health and welfare as much as those that are found contaminating the healthcare environment, surgical instruments, equipment, and medical implantable devices. Approximately 70% of healthcare-associated infections are due to biofilm formation, resulting in increased patient morbidity and mortality. Biofilms formed on medical implants are recalcitrant to antibiotic treatment, which leaves implant removal as the principal treatment option. In this book, we investigate the role of biofilms in breast and dental implant disease and cancer. We include in vitro models for investigating treatment of chronic wounds and disinfectant action against Candida sp. Also included are papers on the most recent strategies for treating biofilm infection ranging from antibiotics incorporated into bone void fillers to antimicrobial peptides and quorum sensing.

• Author : Zheng Zhang,Victoria E. Wagner
• Publisher : Springer
• Release Date : 2017-05-24
• Total pages : 273
• ISBN : 9783319574943
• File Size : 14,8 Mb
• Total Download : 509
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Download Antimicrobial Coatings and Modifications on Medical Devices in PDF, Epub, and Kindle

Based on a fundamental understanding of the interaction between bacteria and materials, this timely volume emphasizes the latest research in the antimicrobial interfacial design and provides an invaluable blueprint for improving antimicrobial performance on devices and products. Antimicrobial Coatings and Modifications targets reduction of microbial accumulation on biomedical and industrial materials through changing interfacial characteristics. Applying a viable antimicrobial coating or modification to resist alarming threats is a highly demanding requirement for many medical and engineering applications. Many contemporary books in the area of antimicrobial solution focus on applying antimicrobial agents or materials that can kill bacteria. The volume pays more attention to eliminating bacterial contamination and biofilm formation through surface characteristics with minimized bacterial resistance and environmental impact.

• Author : Rina Rani Ray,Moupriya Nag,Dibyajit Lahiri
• Publisher : Springer Nature
• Release Date : 2021-05-05
• Total pages : 284
• ISBN : 9789811607455
• File Size : 30,6 Mb
• Total Download : 488
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Download Biofilm-Mediated Diseases: Causes and Controls in PDF, Epub, and Kindle

This book reviews the current concepts in biofilm formation and its implications in human health and disease. The initial chapters introduce the mechanisms of biofilm formation and its composition. Subsequently, the chapters discuss the role of biofilm in acute and chronic infections. It also explores the pivotal role of both innate and adaptive immunity on the course of biofilm infection. In addition, the book elucidates the bacterial biofilm formation on implantable devices and the current approaches to its treatment and prevention. It analyzes the possible relationship between antimicrobial resistance and biofilm formation. Finally, the book also summarizes the current state-of-the-art therapeutic approaches for preventing and treating biofilms. This book is a useful resource for researchers in the field of microbiology, clinical microbiology, and also medical practitioners.

• Author : L Barnes,Ian Cooper
• Publisher : Elsevier
• Release Date : 2014-11-21
• Total pages : 278
• ISBN : 9780857097224
• File Size : 9,7 Mb
• Total Download : 229
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Download Biomaterials and Medical Device - Associated Infections in PDF, Epub, and Kindle

Despite advances in materials and sterilisation, patients who receive biomaterials of medical device implants are still at risk of developing an infection around the implantation site. This book reviews the fundamentals of biomaterials and medical device related infections and methods and materials for the treatment and prevention of infection. The first part of the book provides readers with an introduction to the topic including analyses of biofilms, diagnosis and treatment of infection, pathology and topography. The second part of the book discusses a range of established and novel technologies and materials which have been designed to prevent infection. Provides analysis of biofilms and their relevance to implant associated infections. Assesses technologies for controlling biofilms. Considers advantages and disadvantages of in vivo infection studies.

• Author : Gianfranco Donelli
• Publisher : Springer
• Release Date : 2014-11-10
• Total pages : 195
• ISBN : 9783319097824
• File Size : 44,6 Mb
• Total Download : 214
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Download Biofilm-based Healthcare-associated Infections in PDF, Epub, and Kindle

The aim of this book is to provide readers with a wide overview of the main healthcare-associated infections caused by bacteria and fungi able to grow as biofilm. The recently acquired knowledge on the pivotal role played by biofilm-growing microorganisms in healthcare-related infections has given a new dynamic to detection, prevention and treatment of these infections in patients admitted to both acute care hospitals and long-term care facilities. Clinicians, hygienists and microbiologists will be updated by leading scientists on the state-of-art of biofilm-based infections and on the most innovative strategies for prevention and treatment of these infections, often caused by emerging multidrug-resistant biofilm-growing microorganisms.

• Author : Amedea Seabra
• Publisher : Academic Press
• Release Date : 2017-03-17
• Total pages : 364
• ISBN : 9780128134597
• File Size : 38,5 Mb
• Total Download : 782
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Download Nitric Oxide Donors in PDF, Epub, and Kindle

Nitric Oxide Donors: Biomedical Applications and Perspectives presents the current state of art, challenges and innovations in the design of therapeutics nitric oxide donors with great impact in several aspects of human physiology and pathophysiology. Although considerable innovative progress has been achieved using Nitric Oxide donors in biomedical applications, certain drawbacks still need to be overcome to successfully translate these research innovations into clinical applications. This book encompasses several topics on nitric oxide such as its sources and biological properties; its performance in the cardiovascular and neurologic systems, in the human skin and its application in the treatment of neglected diseases, neurodegenerative disorders, and cancer. Additionally, it covers its role in inflammation and immunity, penile erection function, photodynamic therapy, antimicrobial activities. It also discusses the future of nitric oxide donors in combination with other therapeutic drugs, in implantable sensors, and nitric oxide releasing hydrogels and medical devices for topical applications. The book is a valuable source for researchers on different areas of biomedical field who are interested in the improvements that these molecules can make in the treatment of several conditions. Provides background information about biology and chemistry of nitric oxide Discusses the state-of-the-art in the design of nitric oxide releasing nanomaterials for biomedical applications Covers the usage of nitric oxide donors in the treatment of several conditions, such as cancer, human skin, cardiovascular system, and immunity Discusses the future of nitric oxide donors and their FDA approval

• Author : Thomas Bjarnsholt,Peter Østrup Jensen,Claus Moser,Niels Høiby
• Publisher : Springer
• Release Date : 2014-10-11
• Total pages : 0
• ISBN : 1489982280
• File Size : 20,7 Mb
• Total Download : 966
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Download Biofilm Infections in PDF, Epub, and Kindle

This book will cover both the evidence for biofilms in many chronic bacterial infections as well as the problems facing these infections such as diagnostics and treatment regimes. A still increasing interest and emphasis on the sessile bacterial lifestyle biofilms has been seen since it was realized that that less than 0.1% of the total microbial biomass lives in the planktonic mode of growth. The term was coined in 1978 by Costerton et al. who defined the term biofilm for the first time.In 1993 the American Society for Microbiology (ASM) recognised that the biofilmmode of growth was relevant to microbiology. Lately many articles have been published on the clinical implications of bacterial biofilms. Both original articles and reviews concerning the biofilm problem are available.

• Author : Tony Romeo
• Publisher : Springer Science & Business Media
• Release Date : 2008-02-26
• Total pages : 294
• ISBN : 9783540754183
• File Size : 18,9 Mb
• Total Download : 455
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Download Bacterial Biofilms in PDF, Epub, and Kindle

Throughout the biological world, bacteria thrive predominantly in surface-attached, matrix-enclosed, multicellular communities or biofilms, as opposed to isolated planktonic cells. This choice of lifestyle is not trivial, as it involves major shifts in the use of genetic information and cellular energy, and has profound consequences for bacterial physiology and survival. Growth within a biofilm can thwart immune function and antibiotic therapy and thereby complicate the treatment of infectious diseases, especially chronic and foreign device-associated infections. Modern studies of many important biofilms have advanced well beyond the descriptive stage, and have begun to provide molecular details of the structural, biochemical, and genetic processes that drive biofilm formation and its dispersion. There is much diversity in the details of biofilm development among various species, but there are also commonalities. In most species, environmental and nutritional conditions greatly influence biofilm development. Similar kinds of adhesive molecules often promote biofilm formation in diverse species. Signaling and regulatory processes that drive biofilm development are often conserved, especially among related bacteria. Knowledge of such processes holds great promise for efforts to control biofilm growth and combat biofilm-associated infections. This volume focuses on the biology of biofilms that affect human disease, although it is by no means comprehensive. It opens with chapters that provide the reader with current perspectives on biofilm development, physiology, environmental, and regulatory effects, the role of quorum sensing, and resistance/phenotypic persistence to antimicrobial agents during biofilm growth.

• Author : Kendra P. Rumbaugh,Iqbal Ahmad
• Publisher : Springer Science & Business Media
• Release Date : 2014-05-08
• Total pages : 497
• ISBN : 9783642538339
• File Size : 32,5 Mb
• Total Download : 996
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Download Antibiofilm Agents in PDF, Epub, and Kindle

This book provides a survey of recent advances in the development of antibiofilm agents for clinical and environmental applications. The fact that microbes exist in structured communities called biofilms has slowly become accepted within the medical community. We now know that over 80% of all infectious diseases are biofilm-related; however, significant challenges still lie in our ability to diagnose and treat these extremely recalcitrant infections. Written by experts from around the globe, this book offers a valuable resource for medical professionals seeking to treat biofilm-related disease, academic and industry researchers interested in drug discovery and instructors who teach courses on microbial pathogenesis and medical microbiology.

• Author : Samuel P. Sawan,Gurusamy Manivannan
• Publisher : CRC Press
• Release Date : 1999-12-10
• Total pages : 346
• ISBN : 9781482293944
• File Size : 23,5 Mb
• Total Download : 580
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Download Antimicrobial/Anti-Infective Materials in PDF, Epub, and Kindle

As our consciousness of microbes increases, it appears that our desire to control our interactions with germs also increases in proportion. This is clearly demonstrated by examining the incredible growth in the number and sales volume of consumer products with antimicrobial claims. In the medical field as well, there is much interest in the use of

• Author : Christopher Spicer
• Publisher : Royal Society of Chemistry
• Release Date : 2021-08-18
• Total pages : 323
• ISBN : 9781788017534
• File Size : 20,8 Mb
• Total Download : 180
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Download The Chemistry of Inorganic Biomaterials in PDF, Epub, and Kindle

This book overviews the underlying chemistry behind the most common and cutting-edge inorganic materials in current use, or approaching use, in vivo.

• Author : Mark Shirtliff,Jeff G. Leid
• Publisher : Springer Science & Business Media
• Release Date : 2008-12-19
• Total pages : 272
• ISBN : 9783540681199
• File Size : 35,9 Mb
• Total Download : 160
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Download The Role of Biofilms in Device-Related Infections in PDF, Epub, and Kindle

Approximately 60% of all hospital-associated infections, over one million cases per year, are due to biofilms that have formed on indwelling medical devices. Device-related biofilm infections increase hospital stays and add over one billion dollars/year to U.S. hospitalization costs. Since the use and the types of indwelling medical devices commonly used in modern healthcare are continuously expanding, especially with an aging population, the incidence of biofilm infections will also continue to rise. The central problem with microbial biofilm infections of foreign bodies is their propensity to resist clearance by the host immune system and all antimicrobial agents tested to date. In fact, compared to their free floating, planktonic counterparts, microbes within a biofilm are 50 – 500 times more resistant to antimicrobial agents. Therefore, achieving therapeutic and non-lethal dosing regimens within the human host is impossible. The end result is a conversion from an acute infection to one that is persistent, chronic, and recurrent, most often requiring device removal in order to eliminate the infection. This text will describe the major types of device-related infections, and will explain the host, pathogen, and the unique properties of their interactions in order to gain a better understanding of these recalcitrant infections.

• Author : W. Zimmerli
• Publisher : John Wiley & Sons
• Release Date : 2015-01-27
• Total pages : 429
• ISBN : 9781118581773
• File Size : 41,8 Mb
• Total Download : 843
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Download Bone and Joint Infections in PDF, Epub, and Kindle

Infections of the bones (osteomyelitis) and joints (septic arthritis) are serious health problems which require antibiotics and often surgery. Awareness among health professionals of the causes and treatment options for various types of bone and joint infections is essential for effective resolution. Bone and Joint Infections takes a multidisciplinary approach in covering the diagnostic and therapeutic treatment of osteomyelitis and septic arthritis, including different types of implant-associated infections. Correct and rapid diagnosis of bone and joint infection is crucial, and requires the input of a variety of specialists. Bone and Joint Infection takes a similarly collaborative and comprehensive approach, including chapters authored by clinicians, laboratory specialists, and surgeons. Covering the basic microbiology and clinical aspects of bone and joint infection, this book will be a valuable resource both for researchers in the lab and for physicians and surgeons seeking a comprehensive reference on osteomyelitis and septic arthritis.

• Author : Karen Vickery
• Publisher : Unknown
• Release Date : 2020
• Total pages : 166
• ISBN : 3039284118
• File Size : 55,9 Mb
• Total Download : 672
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Download Microbial Biofilms in Healthcare: Formation, Prevention and Treatment in PDF, Epub, and Kindle

Biofilms are ubiquitous and their presence in industry can lead to production losses. However, nowhere do biofilms impact human health and welfare as much as those that are found contaminating the healthcare environment, surgical instruments, equipment, and medical implantable devices. Approximately 70% of healthcare-associated infections are due to biofilm formation, resulting in increased patient morbidity and mortality. Biofilms formed on medical implants are recalcitrant to antibiotic treatment, which leaves implant removal as the principal treatment option. In this book, we investigate the role of biofilms in breast and dental implant disease and cancer. We include in vitro models for investigating treatment of chronic wounds and disinfectant action against Candida sp. Also included are papers on the most recent strategies for treating biofilm infection ranging from antibiotics incorporated into bone void fillers to antimicrobial peptides and quorum sensing.

• Author : Sadik Dincer,Melis Sümengen Özdenefe,Afet Arkut
• Publisher : BoD – Books on Demand
• Release Date : 2020-10-07
• Total pages : 362
• ISBN : 9781789858990
• File Size : 41,8 Mb
• Total Download : 698
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Download Bacterial Biofilms in PDF, Epub, and Kindle

This book examines biofilms in nature. Organized into four parts, this book addresses biofilms in wastewater treatment, inhibition of biofilm formation, biofilms and infection, and ecology of biofilms. It is designed for clinicians, researchers, and industry professionals in the fields of microbiology, biotechnology, ecology, and medicine as well as graduate and postgraduate students.

• Author : J Denstedt,A Atala
• Publisher : Elsevier
• Release Date : 2009-04-29
• Total pages : 592
• ISBN : 9781845696375
• File Size : 55,7 Mb
• Total Download : 393
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Download Biomaterials and Tissue Engineering in Urology in PDF, Epub, and Kindle

Urology is the branch of medicine dealing with disorders or diseases of the male genitor-urinary tract and the female urinary tract. This important book summarises the wealth of recent research on the use of biomaterials and tissue engineering to treat urological disorders. Part one reviews the fundamentals with chapters on such topics as biofilms and encrustation formation. Part two then discusses recent advances in biomaterials and design of urological devices such as metal ureteral stents, self-lubricating catheter materials and penile implants. Chapters in Part three address urological tissue engineering with coverage of themes such as artificial and natural biomaterials, nano-technology and placental stem cells for tissue engineering the regeneration of urological tissue and organs. With its eminent editors and international team of contributors, Biomaterials and tissue engineering in urology is an invaluable resource to researchers of urological biomaterials, devices and regenerative medicine in both industry and academia, as well as an important reference for medical practitioners. Provides a comprehensive review of biomaterials and tissue engineering in urology Explores the fundamentals of urology, focusing on biofilms and encrustation and formation Discusses recent advances in biomaterials and the design of urological devices, catheters and stents

• Author : S. Eick
• Publisher : Karger Medical and Scientific Publishers
• Release Date : 2020-12-21
• Total pages : 232
• ISBN : 9783318068528
• File Size : 15,6 Mb
• Total Download : 987
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Download Oral Biofilms in PDF, Epub, and Kindle

Biofilms are highly organized polymicrobial communities that are embedded in an extracellular matrix and formed on natural and artificial surfaces. In the oral cavity, biofilms are formed not only on natural teeth, but also on restorative materials, prosthetic constructions, and dental implants. Oral diseases like caries, gingivitis, periodontitis, and also pulp inflammation are associated with biofilms. This publication is an up-to-date overview on oral biofilms from different clinically relevant perspectives. Experts comprising basic researchers and clinicians report on recent research relating to biofilms - from general summaries to recommendations for daily clinical work. This book covers all aspects of oral biofilms, including models used in the laboratory, biofilms in dental water unit lines, periodontal and peri-implant biofilms, caries-related biofilms, halitosis, endodontic biofilms, and Candida infections, as well as biofilms on dental materials and on orthodontic appliances. Several chapters deal with anti-biofilm therapy, from the efficacy of mechanical methods and the use of antimicrobials, to alternative concepts. This publication is particularly recommended to dental medicine students, practitioners, other oral healthcare professionals, and scientists with an interest in translational research on biofilms.

• Author : John L. Pace,Mark E. Rupp,Roger G. Finch
• Publisher : CRC Press
• Release Date : 2005-08-29
• Total pages : 512
• ISBN : 9781420028232
• File Size : 39,7 Mb
• Total Download : 890
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Download Biofilms, Infection, and Antimicrobial Therapy in PDF, Epub, and Kindle

Rather than existing in a planktonic or free-living form, evidence indicates that microbes show a preference for living in a sessile form within complex communities called biofilms. Biofilms appear to afford microbes a survival advantage by optimizing nutrition, offering protection against hostile elements, and providing a network for cell-to-cell signaling and genetic exchange. Biofilms, Infection, and Antimicrobial Therapy provides an in-depth exploration of biofilms, offering broad background information, as well a detailed look at the serious concerns to which biofilm-associated infections give rise. Prosthetic device infections, such as those involving artificial heart valves, intravascular catheters, or prosthetic joints, are prime examples of biofilm-associated infections. With the increasing use of such devices in the modern practice of medicine, the prevalence of these infections is expected to increase. Unfortunately, one of the most troubling characteristics of microbes found in biofilms is a profound resistance to antimicrobial agents. As biofilm-associated infections are particularly difficult to treat, they result in significant mortality, morbidity, and increased economic burden. Clearly, a better understanding of the pathogenesis of these infections and improved means for prevention and treatment are urgently needed! InBiofilms, Infection, and Antimicrobial Therapy, Drs Pace, Rupp, and Finch assemble the contributions of more than 50 of the world’s leading authorities on microbial biofilms who present recent findings on antibacterial tolerance and bacterial persistence associated with biofilms and discuses the implications of those findings with regard to human health. They explore the molecular mechanisms of bacterial adherence, biofilm formation, regulation of biofilm maintenance, and cell-to-cell communication and present the latest information on various treatment protocols that should aid physicians in the treatment of these refractory and often difficult-to-treat infections.