Anticandidal Therapeutics Discovery And Development

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• Author : Awanish Kumar,Anubhuti Jha
• Publisher : Elsevier
• Release Date : 2023-01-31
• Total pages : 198
• ISBN : 9780443187452
• File Size : 35,8 Mb
• Total Download : 732
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Download Anticandidal Therapeutics in PDF, Epub, and Kindle

Developments of antifungal agents have declined as compared to other antibiotics that have displayed a potent development with time. There is an urgent need for both prophylactic and therapeutic treatments worldwide to control the severity of infections caused by Candida. Anticandidal Therapeutics provides the readers with a compiled knowledge of the fungal human infection Candida and the development of anticandidal drugs. Anticandidal Therapeutics helps researchers form the basis for the discovery and development of novel anticandidal therapies. In 14 chapters this book provides collective information on anticandidal agents and their discovery and development with respect to major drug transporter families, different stages of anticandidal agent development, recent trends and progress in antifungal translational research, clinical studies status of anticandidal therapeutic agents, and drug repurposing for development of novel anticandidal agents. • Highlights the mechanistic actions of some therapeutic agents against Candida. • Focuses on anticandidal agents rather than general antifungal agents. • Discusses the stage of development of new antifungal drugs, the repositioning of drugs, and how this could help in treatment.

• Author : Awanish Kumar
• Publisher : Academic Press
• Release Date : 2016-09-12
• Total pages : 94
• ISBN : 9780128113127
• File Size : 53,7 Mb
• Total Download : 994
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Download Anticandidal Agents in PDF, Epub, and Kindle

Anticandidal Agents provides the latest information on candida drug resistance and its remedial implications. In this compilation, users will find a comprehensive view on overcoming resistance in anticandidal drugs, along with information on novel molecules. Candida albicans is an opportunistic pathogenic fungus responsible for life threating invasive and nosocomial infections across the globe. Candidiasis is a major cause of morbidity among immunocompromised patients. Infections caused by non-albicans candida like C. glabrata, C. parapsilosis, and C. tropicalis have also imposed a serious threat in the last few decades. Current treatment of candidiasis relies primarily on antifungal agents broadly categorized as azoles, polyenes, echinocandins, allylamines, and pyrimidines. Lately, antifungal resistance has emerged to be an obstruction of current treatment regime. A number of reasons are described in detail. Understanding the mechanisms of resistance is crucial for developing strategies for overcoming the hindrance in current therapeutics. Presents a complete understanding of candida resistance to help in the development of therapeutic expansion and novel drugs Provides thorough information on candida drug resistance and its remedial implications Covers crucial mechanisms of resistance that will help develop strategies for overcoming the hindrance in current therapeutics

• Author : Marina Sokovic,Konstantinos Liaras
• Publisher : Elsevier
• Release Date : 2020-09-18
• Total pages : 290
• ISBN : 9780128158258
• File Size : 55,7 Mb
• Total Download : 223
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Download Antifungal Compounds Discovery in PDF, Epub, and Kindle

Fungi are both the cause of many major health problems and an incredible source of compounds for developing new medicinal treatments, and with the increasing emergence of multidrug resistance, the need for new antimicrobial agents is greater than ever. Antifungal Compounds Discovery provides researchers with a detailed study of both natural and synthetic compounds that can be effective against a variety of fungal species, supporting and encouraging the design of innovative, potent new drug candidates for the treatment of fungal infections. Beginning with an introduction to both the history and latest developments in this field, the book goes on to provide helpful background information on key fungal species before outlining current antifungal therapies and reasons further development is needed. Detailed chapters then follow reviewing a broad range of natural and synthetic antifungal agents, and discussing the synergistic effect of working with both simultaneously. Finally, the book concludes by considering potential future developments in this important field. Supported with detailed schemes and key information on the biological activity of all selected compounds, Antifungal Compounds Discovery is a comprehensive guide helping researchers understand the relationship between specific chemical structures and their antifungal potency, and a key tool for all those involved in the identification and development of antimicrobial compounds. Provides an overview of the most specific mycotic infections and fungal species as background for compound development Presents the chemical formulas of all natural and synthetic compounds reviewed Combines detailed information about origin, isolation and possible therapeutic uses of all indexed compounds, including biological activity, mechanism of action and SAR information

• Author : Robert A. Fromtling
• Publisher : Unknown
• Release Date : 1987
• Total pages : 728
• ISBN : UOM:39015035784159
• File Size : 18,9 Mb
• Total Download : 182
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Download Recent Trends in the Discovery, Development and Evaluation of Antifungal Agents in PDF, Epub, and Kindle

PDF book entitled Recent Trends in the Discovery, Development and Evaluation of Antifungal Agents written by Robert A. Fromtling and published by Unknown which was released on 1987 with total hardcover pages 728, the book become popular and critical acclaim.

• Author : Valdir Cechinel-Filho
• Publisher : John Wiley & Sons
• Release Date : 2012-05-22
• Total pages : 592
• ISBN : 9780470582268
• File Size : 20,8 Mb
• Total Download : 946
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Download Plant Bioactives and Drug Discovery in PDF, Epub, and Kindle

An in-depth exploration of the applications of plant bioactive metabolites in drug research and development Highlighting the complexity and applications of plant bioactive metabolites in organic and medicinal chemistry, Plant Bioactives and Drug Discovery: Principles, Practice, and Perspectives provides an in-depth overview of the ways in which plants can inform drug research and development. An edited volume featuring multidisciplinary international contributions from acclaimed scientists researching bioactive natural products, the book provides an incisive overview of one of the most important topics in pharmaceutical studies today. With coverage of strategic methods of natural compound isolation, structural manipulation, natural products in clinical trials, quality control, and more, and featuring case studies on medicinal plants, the book serves as a definitive guide to the field of plant biodiversity as it relates to medicine. In addition, chapters on using natural products as drugs that target specific disease areas, including neurological disorders, inflammation, infectious diseases, and cancer, illustrate the myriad possibilities for therapeutic applications. Wide ranging and comprehensive, Plant Bioactives and Drug Discovery also includes important information on marketing, regulations, intellectual property rights, and academic-industry collaboration as they relate to plant-based drug research, making it an essential resource for advanced students and academic and industry professionals working in biochemical, pharmaceutical, and related fields.

• Author : Lixin Zhang,Arnold L. Demain
• Publisher : Springer Science & Business Media
• Release Date : 2007-11-17
• Total pages : 386
• ISBN : 9781592599769
• File Size : 39,8 Mb
• Total Download : 106
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Download Natural Products in PDF, Epub, and Kindle

A fresh examination of the past successes of natural products as medicines and their new future from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms. The authors apply these methods to new natural product drug discoveries, to microbial diversity, to specific groups of products (Chinese herbal drugs, antitumor drugs from microbes and plants, terpenoids, and arsenic compounds), and to specific sources (the sea, rainforest, and endophytes). These new opportunities show how research and development trends in the pharmaceutical industry can advance to include both synthetic compounds and natural products, and how this paradigm shift can be more productive and efficacious.

• Author : Luisa W. Cheng,Jong Heon Kim,Kirkwood Land
• Publisher : Mdpi AG
• Release Date : 2022-07-20
• Total pages : 0
• ISBN : 3036547681
• File Size : 24,8 Mb
• Total Download : 552
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Download Advances in Antifungal Development in PDF, Epub, and Kindle

This reprint describes recent advances made in the field of antifungal development, especially the discovery of new drugs and drug repurposing. The articles presented in this book provide useful information and insight for the development of new antifungal drugs or intervention strategies. The identification of new, safe molecules, and cellular targets, as well as the elucidation of their antifungal mechanisms of action, will further the effective control of fungal pathogens, especially those resistant to current therapeutic agents.

• Author : John F. Ryley
• Publisher : Springer Science & Business Media
• Release Date : 2012-12-06
• Total pages : 558
• ISBN : 9783642754586
• File Size : 38,6 Mb
• Total Download : 286
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Download Chemotherapy of Fungal Diseases in PDF, Epub, and Kindle

Fungal diseases have been with us from antiquity; interest in the chemo therapy of fungal disease has exploded in the past decade. To plan and pro duce a book on the topic of antifungal chemotherapy has come as a personal challenge - and something of an eye-opener - towards the end of my re search career. A landmark publication which still merits reading is Antifungal Chemotherapy (John Wiley & Sons, Chichester, UK), edited by David Speller, which appeared in 1980. However, the fact that ketoconazole, the first of the modern, orally active, wide-spectrum antifungals, attracted no more than two sentences in it indicates just how far we have come in the 1980s. A steady stream of original papers and a number of conference proceedings have chronicled this progress in drug research; outstanding among the latter are the proceedings of an international telesymposium, entitled Recent Trends in the Discovery, Development and Evaluation of Antifungal Agents, edited by Robert Fromtling (J.R. Prous, Barcelona, 1987) and volume 544 of the Annals of the New York Academy of Sciences, entitled Antifungal Drugs, edited by Vassil St. Georgiev, and containing papers and posters presented at a most enjoyable 3-day conference held at Garden City, New York, in the autumn of 1987.

• Author : Olga Genilloud,Francisca Vicente
• Publisher : Royal Society of Chemistry
• Release Date : 2012-08-21
• Total pages : 432
• ISBN : 9781849734950
• File Size : 17,6 Mb
• Total Download : 643
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Download Drug Discovery from Natural Products in PDF, Epub, and Kindle

This book offers an integrated review of the most recent trends in natural products drug discovery and key lead candidates that are outstanding for their chemistry and biology as a starting point in novel drug development. The authors focus on different trends that are and will continue to be impacting multiples stages of modern drug discovery from NPs that have not been included in other works. This is complemented with a series of case studies from leading experts from industry and academia on key molecules and derivatives that have been chosen for their novelty in chemistry, biology and clinical applications. The book intends to reflect the current confluence of different disciplines in chemical biology and synthetic chemistry supported by a more profound knowledge of systems biology that ensures the concurrency and synergisms of expertise from different research fields that impact in the discovery of novel molecules. In the first section the chapters reflect recent approaches to exploit the biosynthetic potential of microbial resources (including genome mining, metagenomic and epigenetic approaches), as well as biosynthetic chemistry tools to respond to product supply and novel screening alternatives that have lead to the discovery of novel chemistry. The second part reviews, in the form of case studies, some examples of bioactive molecules in the important therapeutic areas of antiinfectives, oncology and antiparasitics.

• Author : Mahmoud Ghannoum,John R. Perfect
• Publisher : CRC Press
• Release Date : 2016-04-19
• Total pages : 484
• ISBN : 9780849387869
• File Size : 41,6 Mb
• Total Download : 103
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Download Antifungal Therapy in PDF, Epub, and Kindle

A concise one-stop-practical reference for the various physicians dealing with fungal infections, Antifungal Therapy appeals to infectious disease physicians, transplant surgeons, dermatologists, and intensivists, as well as basic scientists and pharmaceutical company researchers interested in the state of antifungal therapy. This book provides a c

• Author : Valdir Cechinel Filho
• Publisher : Springer
• Release Date : 2018-12-07
• Total pages : 531
• ISBN : 9783030005450
• File Size : 37,9 Mb
• Total Download : 287
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Download Natural Products as Source of Molecules with Therapeutic Potential in PDF, Epub, and Kindle

This book addresses the highly relevant and complex subject of research on drugs from natural products, discussing the current hot topics in the field. It also provides a detailed overview of the strategies used to research and develop these drugs. Respected experts explore issues involved in the production chain and when looking for new medicinal agents, including aspects such as therapeutic potential, functional foods, ethnopharmacology, metabolomics, virtual screening and regulatory scenarios. Further, the book describes strategic methods of isolation and characterization of active principles, biological assays, biotechnology of plants, synthesis, clinical trials and the use of tools to identity active principles.

• Author : Chaminda Jayampath Seneviratne,Edvaldo Antonio Ribeiro Rosa
• Publisher : Frontiers Media SA
• Release Date : 2016-09-13
• Total pages : 138
• ISBN : 9782889199501
• File Size : 55,7 Mb
• Total Download : 641
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Download Antifungal Drug Discovery: New Theories and New Therapies in PDF, Epub, and Kindle

Fungal infections such as candidoses can range from superficial mucous membrane infection to life-threatening systemic mycoses. Candida infections are a significant clinical problem globally due to rapid rise in compromised host populations including HIV/AIDS, organ transplant recipients and patients on chemotherapy. In addition, sharp increase in aging populations which are susceptible to fungal infections is expected in next few decades. Antifungal drugs are relatively difficult to develop compared to the antibacterial drugs owing to the eukaryotic nature of the cells. Therefore, only a handful of antifungal agents are currently available to treat the myriad of fungal infections. Moreover, rising antifungal resistance and host-related adverse reactions have limited the antifungal arsenal against fungal pathogens. In this research topic, we tried to update the theoretical aspects pertaining to the antifungal drug discovery i.e. proposed novel mechanisms, new drug targets and pathways. In addition, invited authors explored the new antifungal drugs derived from natural and synthetic sources which are currently under development. Contributors were encouraged to bring new insight into the antifungal drug discovery. We hope the reader may arrive at a general consensus on the possible strategies to combat ever increasing ubiquitous fungal infection in this new century.

• Author : Joginder Singh,Vineet Meshram,Mahiti Gupta
• Publisher : Springer Nature
• Release Date : 2020-04-30
• Total pages : 733
• ISBN : 9789811513947
• File Size : 10,9 Mb
• Total Download : 866
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Download Bioactive Natural products in Drug Discovery in PDF, Epub, and Kindle

This book highlights different natural products that are derived from the plants and microbes that have shown potential as the lead compounds against infectious diseases and cancer. Natural products represent an untapped source of strikingly diverse chemotypes with novel mechanisms of action and the potential to serve as anticancer and anti-infective agents. The book discusses a range of biotechnologically valuable bioactive compounds and secondary metabolites that have been derived from plant and microorganisms from various ecological niches. It also reviews the latest developments in the field of genomics, bioinformatics and industrial fermentation for harnessing the microbial products for commercial applications. In turn, the book’s closing section reviews important biotechnological applications of various natural products. Combining the expertise of specialists in this field, the book’s goal is to promote the further investigation of natural sources for the development of standardized, safe and effective therapies.

• Author : Mahmoud A. Ghannoum,John R. Perfect
• Publisher : CRC Press
• Release Date : 2009-11-24
• Total pages : 0
• ISBN : 0849387876
• File Size : 12,7 Mb
• Total Download : 779
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Download Antifungal Therapy in PDF, Epub, and Kindle

A concise one-stop-practical reference for the various physicians dealing with fungal infections, Antifungal Therapy appeals to infectious disease physicians, transplant surgeons, dermatologists, and intensivists, as well as basic scientists and pharmaceutical company researchers interested in the state of antifungal therapy. This book provides a comprehensive, up-to-date overview of the pertinent issues pertaining to antifungal treatment. Divided into four interrelated sections for a cohesive discussion covers: history of antifungals from the discovery of the polyenes to the echinocandins antifungal susceptibility methods patient management animal models in drug development therapeutic strategies pharmacokinetic and pharmacogenomics trends in resistance

• Author : Anonim
• Publisher : Academic Press
• Release Date : 2017-11-21
• Total pages : 690
• ISBN : 9780128130704
• File Size : 17,5 Mb
• Total Download : 359
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Download Platform Technologies in Drug Discovery and Validation in PDF, Epub, and Kindle

Platform Technologies in Drug Discovery and Validation, Volume 50, the latest release in the Annual Reports in Medicinal Chemistry series, provides timely and critical reviews of important topics in medicinal chemistry, with an emphasis on emerging topics in the biological sciences. Topics covered in this new volume include DELT, Oligos: ASO, siRNA, CRISPR, Micro-fluidic chemistry, High throughput screening, Kinase-centric computational drug development, Virtual Screening, Phenotypic screening, PROTACS, Chemical Biology, Fragment-based lead generation, Antibody-Drug Conjugates, Antibody-recruiting small molecules, Deuteration, and Peptides. Unique for its treatment of platform technologies for medicinal chemistry and target validation Provides a single, rich volume that summaries a broad spectrum of expertise relevant to the field Presents state-of-the-art summaries of platform technologies

• Author : Juan Bueno
• Publisher : Academic Press
• Release Date : 2020-01-22
• Total pages : 192
• ISBN : 9780128189290
• File Size : 13,7 Mb
• Total Download : 878
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Download Molecular Evolutionary Models in Drug Discovery in PDF, Epub, and Kindle

Molecular Evolutionary Models in Drug Discovery explores the application of evolutionary molecular models in drug discovery in which secondary metabolites play a fundamental role. Secondary metabolites are not produced in isolation, they are the result of the interaction of genes, metabolism and the environment. The book examines the role of secondary metabolites as leads in drug discovery and on the development of a rational bioprospecting model for new medicines based on the evolution of secondary metabolism. These evolutionary models are part of biological systems and are the most reliable expression of the functioning of living beings. Examines the integration and application of evolutionary models in the pharmaceutical industry to create new drug development platforms Investigates the biotechnological prospecting of secondary metabolites and their potential use in the discovery of new drugs Evaluates the ecosystem of living beings and how its molecular adaptation might improve the success of therapies

• Author : Ashok Kumar Chaturvedi
• Publisher : Unknown
• Release Date : 2017
• Total pages : 229
• ISBN : OCLC:1250420102
• File Size : 38,9 Mb
• Total Download : 143
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Download Repurposing FDA-Approved Ebselen And Auranofin As Anti-Fungal Drugs in PDF, Epub, and Kindle

Ojectives: Fungal infections represent an increasing threat to an expanding population of at risk patients; but the impact of these diseases on human health is not widely appreciated. The mortality associated with some of these infections remain unacceptably high. Because fungi are eukaryotic, there is a paucity of selective targets that can be exploited for antifungal drug development. As a result, the current antifungal armamentarium is very limited. Furthermore, the antifungal drug pipeline is mostly dry. There is no doubt that novel antifungals and new approaches to develop them are urgently warranted. Unlike the costly and time consuming process of de novo drug discovery, drug repurposing is a novel method to reduce the time, cost and risk associated with drug innovation. Methods: The present studies build upon the recent discovery by our group of the potent antifungal activity of FDA-approved drug Auranofin, which we originally identified in high content screenings of the Prestwick library against Candida albicans biofilms. MICs were determined in accordance with the CLSI M27-A3 (for yeast) and M38-A2 (for filamentous fungi) reference standards for antifungal susceptibility testing. We also performed in-vivo evaluation of these drugs in the murine models of systemic cryptococcosis and hematogenously disseminated candidiasis Results: Screening the same library against other pathogenic fungi resulted in the identification of Ebselen as a leading compound displaying potent antifungal activity against different fungi. We observed increased survival of mice in groups treated with Auranofin and Ebselen compared to mock treated groups. Both drugs are organometallics and have many advantageous qualities including oral bioavailability, potent microbicidal activity in a clinical range and very low frequency of resistance Conclusion: In conclusion, repositioning old drugs can significantly decrease the time and effort that it takes to develop novel antifungal therapeutics, which represents a pressing and unmet clinical need due to the devastating nature of fungal infections. Thus, the present study seeks to provide further valuable evidence that both drugs have significant promise to be repositioned as novel antifungals for the treatment of fungal infections.

• Author : Atta-ur Rahman,M. Iqbal Choudhary
• Publisher : Bentham Science Publishers
• Release Date : 2017-04-28
• Total pages : 211
• ISBN : 9781681082912
• File Size : 33,7 Mb
• Total Download : 480
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Download Frontiers in Anti-Infective Drug Discovery in PDF, Epub, and Kindle

This eBook series brings updated reviews to readers interested in advances in the development of anti-infective drug design and discovery. The scope of the eBook series covers a range of topics including rational drug design and drug discovery, medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. Frontiers in Anti-Infective Drug Discovery is a valuable resource for pharmaceutical scientists and post-graduate students seeking updated and critically important information for developing clinical trials and devising research plans in this field. The fifth volume of this series features 6 chapters that cover the following topics: - Virus infection pathways in living cells - Antimicrobial activity of natural products (essential oils and food products) - Medicinal plants that produce immunomodulators of veterinary interest - In silico approaches for determination of drug targets

• Author : Atta-ur- Rahman,Shazia Anjum,Hesham El-Seedi
• Publisher : Bentham Science Publishers
• Release Date : 2018-03-03
• Total pages : 253
• ISBN : 9781681082134
• File Size : 22,9 Mb
• Total Download : 250
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Download Natural Products in Clinical Trials in PDF, Epub, and Kindle

Natural products continue to play a key role in drug development. A recent analysis of the drug market in the developed world revealed that 40% of total clinically approved drugs were either unmodified natural products or their semi-synthetic derivatives. This book series focuses on reviews of exciting new bioactive natural products that have huge potential as drugs. It highlights the everlasting importance of natural products in our lives. Each volume brings reviews contributed by eminent scientists in the field. The first volume covers the following topics: - bioactive compounds from marine invertebrates - natural product derived drugs for immunological and inflammatory diseases - clinical trials of curcumin, camptothecin, astaxanthin, and biochanin - antibacterial and antifungal drugs from natural sources - natural products as anti-HIV medicines.

• Author : Goutam Brahmachari
• Publisher : World Scientific
• Release Date : 2012
• Total pages : 695
• ISBN : 9789814335379
• File Size : 11,9 Mb
• Total Download : 436
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Download Bioactive Natural Products in PDF, Epub, and Kindle

Bioactive natural products are a rich source of novel therapeutics. Thus, the search for bioactive molecules from nature continues to play an important role in fashioning new medicinal agents. This volume, which comprises sixteen chapters written by active researchers and leading experts in natural products chemistry, brings together an overview of current discoveries in this remarkable field. It also provides information on the industrial application of natural products for medicinal purposes. This book will serve as a valuable resource for researchers to predict promising leads for developing pharmaceuticals to treat various ailments and disease manifestations.

• Author : Thomas J. Dougherty,Steven J. Projan
• Publisher : CRC Press
• Release Date : 2003-05-14
• Total pages : 272
• ISBN : 0203911466
• File Size : 20,6 Mb
• Total Download : 971
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Download Microbial Genomics and Drug Discovery in PDF, Epub, and Kindle

Exploring innovative routes of drug discovery in the postgenomic era, Microbial Genomics and Drug Discovery examines bioinformatic and genomic approaches for the identification, detection, selection, and validation of new antibacterial targets and vaccine candidates. The book discusses potential pathways for effective infection control, inhibition of antibacterial resistance, and acceleration of the drug discovery process. This comprehensive reference describes procedures to recognize common targets in various bacterial species for the design of broad-spectrum antibiotics and clearly illustrates the use of pathway tools in a genomics-based drug discovery project.